Q5AAJ7 (SWC4_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SWR1-complex protein 4

Gene names

Name:	SWC4
ORF Names:	CaO19.7492

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	635 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair By similarity.
Subunit structure	Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the SWC4 family. Contains 1 SANT domain.

Ontologies

Keywords
Biological process	DNA damage DNA repair Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Activator Chromatin regulator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin remodeling Inferred from electronic annotation. Source: InterPro histone H2A acetylation Inferred from electronic annotation. Source: InterPro histone H4 acetylation Inferred by curator PubMed 18685084. Source: CGD regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	NuA4 histone acetyltransferase complex Inferred from physical interaction PubMed 18685084. Source: CGD
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro chromatin binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 635	635	SWR1-complex protein 4		PRO_0000076337
Regions
	Domain	303 – 353	51	SANT
	Compositional bias	177 – 191	15	Gln-rich

Sequences

	Sequence		Length	Mass (Da)
	Q5AAJ7 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 63D13B88267DBBF4	FASTA	635	74,039
	10 20 30 40 50 60 MSANDILDVL NIQRDESNQP PKKKQKSSST PTLPDGKQLT GMARELYNLV GPNTPPINLN 70 80 90 100 110 120 SNSYTANKEK MKKFKPSPWT RMPFTPKQGI ELNHWVKGSK ELIEQQEFEE DGTPKPYFFE 130 140 150 160 170 180 KYNVQLEIPE FVDEDTYDLY MIEIKEYESK MKEERARREK ERKEREKRDL EEKKKKQQQQ 190 200 210 220 230 240 QQKSQQNPQN QIKDDEKNQD TRNNTDKKDS EQKSEDKPTV EAKKETDEKK DDVVLKDNTN 250 260 270 280 290 300 ETKPVTETTK SETETTEQNN SEKTNENETN KTNDKDGEGN LTKSKDSATE DQSNNKKEND 310 320 330 340 350 360 EDTESEWTYK ETKHLFELCQ AFELKWPIIH DRFPNPNRTA EDLKEQFYRI CIKILENQKN 370 380 390 400 410 420 KNQALIDSLK AYCKPRELER KQYLENLLKR TPAEIAEEES LVIEARRFEI AAKKMLMERS 430 440 450 460 470 480 NLLTLLDSPQ TTQNVSQYQS SQGITNLYNN LLIYDKHQKK KQMANKSNPQ QEPVPPPIPL 490 500 510 520 530 540 AASSSVKRDR GFQTQLQQYL SSFLKQNHHT NPAVKQEINS IQQLLMKRLT QKEEEAYGLY 550 560 570 580 590 600 FHGTEKLNPG VMLRSQQKLP GLNQRQSILK SVNILLQEMD IPTGGGTSWK PIMPTRKTMA 610 620 630 KYDELIRSVV TLLDVKKAKD KLESEIKLIK SQRGL

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000039 Genomic DNA. Translation: EAK99734.1.
RefSeq	XP_718649.1. XM_713556.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0005735.
Proteomic databases
PRIDE	Q5AAJ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3639679.
KEGG	cal:CaO19.7492.
Organism-specific databases
CGD	CAL0005735. orf19.7492.
Phylogenomic databases
eggNOG	NOG298520.
KO	K11324.
Family and domain databases
InterPro	IPR009057. Homeodomain-like. IPR017877. Myb-like_dom. IPR001005. SANT/Myb. IPR027109. Swc4/Dmap1. [Graphical view]
PANTHER	PTHR12855. PTHR12855. 1 hit.
SMART	SM00717. SANT. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS51293. SANT. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SWC4_CANAL

Accession

Primary (citable) accession number: Q5AAJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	April 26, 2005
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program