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Protein

SWR1-complex protein 4

Gene

SWC4

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processDNA damage, DNA repair, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SWR1-complex protein 4
Gene namesi
Name:SWC4
Ordered Locus Names:CAALFM_CR00400CA
ORF Names:CaO19.7492
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome R

Organism-specific databases

CGDiCAL0000199374. SWC4.
EuPathDBiFungiDB:CR_00400C_A.

Subcellular locationi

GO - Cellular componenti

  • NuA4 histone acetyltransferase complex Source: CGD

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000763371 – 635SWR1-complex protein 4Add BLAST635

Proteomic databases

PRIDEiQ5AAJ7.

Interactioni

Subunit structurei

Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini303 – 353SANTAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi177 – 191Gln-richAdd BLAST15

Sequence similaritiesi

Belongs to the SWC4 family.Curated

Phylogenomic databases

InParanoidiQ5AAJ7.
KOiK11324.
OrthoDBiEOG092C2QC9.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiView protein in InterPro
IPR032563. DAMP1_SANT-like.
IPR009057. Homeobox-like.
IPR017877. Myb-like_dom.
IPR001005. SANT/Myb.
IPR027109. Swc4/Dmap1.
PANTHERiPTHR12855. PTHR12855. 1 hit.
PfamiView protein in Pfam
PF16282. SANT_DAMP1_like. 1 hit.
SMARTiView protein in SMART
SM00717. SANT. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5AAJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSANDILDVL NIQRDESNQP PKKKQKSSST PTLPDGKQLT GMARELYNLV
60 70 80 90 100
GPNTPPINLN SNSYTANKEK MKKFKPSPWT RMPFTPKQGI ELNHWVKGSK
110 120 130 140 150
ELIEQQEFEE DGTPKPYFFE KYNVQLEIPE FVDEDTYDLY MIEIKEYESK
160 170 180 190 200
MKEERARREK ERKEREKRDL EEKKKKQQQQ QQKSQQNPQN QIKDDEKNQD
210 220 230 240 250
TRNNTDKKDS EQKSEDKPTV EAKKETDEKK DDVVLKDNTN ETKPVTETTK
260 270 280 290 300
SETETTEQNN SEKTNENETN KTNDKDGEGN LTKSKDSATE DQSNNKKEND
310 320 330 340 350
EDTESEWTYK ETKHLFELCQ AFELKWPIIH DRFPNPNRTA EDLKEQFYRI
360 370 380 390 400
CIKILENQKN KNQALIDSLK AYCKPRELER KQYLENLLKR TPAEIAEEES
410 420 430 440 450
LVIEARRFEI AAKKMLMERS NLLTLLDSPQ TTQNVSQYQS SQGITNLYNN
460 470 480 490 500
LLIYDKHQKK KQMANKSNPQ QEPVPPPIPL AASSSVKRDR GFQTQLQQYL
510 520 530 540 550
SSFLKQNHHT NPAVKQEINS IQQLLMKRLT QKEEEAYGLY FHGTEKLNPG
560 570 580 590 600
VMLRSQQKLP GLNQRQSILK SVNILLQEMD IPTGGGTSWK PIMPTRKTMA
610 620 630
KYDELIRSVV TLLDVKKAKD KLESEIKLIK SQRGL
Length:635
Mass (Da):74,039
Last modified:April 26, 2005 - v1
Checksum:i63D13B88267DBBF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017630 Genomic DNA. Translation: AOW30811.1.
RefSeqiXP_718649.1. XM_713556.1.

Genome annotation databases

EnsemblFungiiEAK99734; EAK99734; CaO19.7492.
GeneIDi3639679.
KEGGical:CAALFM_CR00400CA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017630 Genomic DNA. Translation: AOW30811.1.
RefSeqiXP_718649.1. XM_713556.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5AAJ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK99734; EAK99734; CaO19.7492.
GeneIDi3639679.
KEGGical:CAALFM_CR00400CA.

Organism-specific databases

CGDiCAL0000199374. SWC4.
EuPathDBiFungiDB:CR_00400C_A.

Phylogenomic databases

InParanoidiQ5AAJ7.
KOiK11324.
OrthoDBiEOG092C2QC9.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiView protein in InterPro
IPR032563. DAMP1_SANT-like.
IPR009057. Homeobox-like.
IPR017877. Myb-like_dom.
IPR001005. SANT/Myb.
IPR027109. Swc4/Dmap1.
PANTHERiPTHR12855. PTHR12855. 1 hit.
PfamiView protein in Pfam
PF16282. SANT_DAMP1_like. 1 hit.
SMARTiView protein in SMART
SM00717. SANT. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSWC4_CANAL
AccessioniPrimary (citable) accession number: Q5AAJ7
Secondary accession number(s): A0A1D8PRQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: April 26, 2005
Last modified: April 12, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.