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Q5AAJ7

- SWC4_CANAL

UniProt

Q5AAJ7 - SWC4_CANAL

Protein

SWR1-complex protein 4

Gene

SWC4

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair By similarity.By similarity

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. DNA binding Source: InterPro

    GO - Biological processi

    1. chromatin remodeling Source: InterPro
    2. DNA repair Source: UniProtKB-KW
    3. histone H2A acetylation Source: InterPro
    4. histone H4 acetylation Source: CGD
    5. regulation of transcription, DNA-templated Source: UniProtKB-KW
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator

    Keywords - Biological processi

    DNA damage, DNA repair, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SWR1-complex protein 4
    Gene namesi
    Name:SWC4
    ORF Names:CaO19.7492
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0005735. orf19.7492.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. NuA4 histone acetyltransferase complex Source: CGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 635635SWR1-complex protein 4PRO_0000076337Add
    BLAST

    Proteomic databases

    PRIDEiQ5AAJ7.

    Interactioni

    Subunit structurei

    Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0005735.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini303 – 35351SANTAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi177 – 19115Gln-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SWC4 family.Curated
    Contains 1 SANT domain.Curated

    Phylogenomic databases

    eggNOGiNOG298520.
    KOiK11324.
    OrthoDBiEOG70ZZXC.

    Family and domain databases

    InterProiIPR009057. Homeodomain-like.
    IPR017877. Myb-like_dom.
    IPR001005. SANT/Myb.
    IPR027109. Swc4/Dmap1.
    [Graphical view]
    PANTHERiPTHR12855. PTHR12855. 1 hit.
    SMARTiSM00717. SANT. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5AAJ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSANDILDVL NIQRDESNQP PKKKQKSSST PTLPDGKQLT GMARELYNLV    50
    GPNTPPINLN SNSYTANKEK MKKFKPSPWT RMPFTPKQGI ELNHWVKGSK 100
    ELIEQQEFEE DGTPKPYFFE KYNVQLEIPE FVDEDTYDLY MIEIKEYESK 150
    MKEERARREK ERKEREKRDL EEKKKKQQQQ QQKSQQNPQN QIKDDEKNQD 200
    TRNNTDKKDS EQKSEDKPTV EAKKETDEKK DDVVLKDNTN ETKPVTETTK 250
    SETETTEQNN SEKTNENETN KTNDKDGEGN LTKSKDSATE DQSNNKKEND 300
    EDTESEWTYK ETKHLFELCQ AFELKWPIIH DRFPNPNRTA EDLKEQFYRI 350
    CIKILENQKN KNQALIDSLK AYCKPRELER KQYLENLLKR TPAEIAEEES 400
    LVIEARRFEI AAKKMLMERS NLLTLLDSPQ TTQNVSQYQS SQGITNLYNN 450
    LLIYDKHQKK KQMANKSNPQ QEPVPPPIPL AASSSVKRDR GFQTQLQQYL 500
    SSFLKQNHHT NPAVKQEINS IQQLLMKRLT QKEEEAYGLY FHGTEKLNPG 550
    VMLRSQQKLP GLNQRQSILK SVNILLQEMD IPTGGGTSWK PIMPTRKTMA 600
    KYDELIRSVV TLLDVKKAKD KLESEIKLIK SQRGL 635
    Length:635
    Mass (Da):74,039
    Last modified:April 26, 2005 - v1
    Checksum:i63D13B88267DBBF4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000039 Genomic DNA. Translation: EAK99734.1.
    RefSeqiXP_718649.1. XM_713556.1.

    Genome annotation databases

    GeneIDi3639679.
    KEGGical:CaO19.7492.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000039 Genomic DNA. Translation: EAK99734.1 .
    RefSeqi XP_718649.1. XM_713556.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0005735.

    Proteomic databases

    PRIDEi Q5AAJ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3639679.
    KEGGi cal:CaO19.7492.

    Organism-specific databases

    CGDi CAL0005735. orf19.7492.

    Phylogenomic databases

    eggNOGi NOG298520.
    KOi K11324.
    OrthoDBi EOG70ZZXC.

    Family and domain databases

    InterProi IPR009057. Homeodomain-like.
    IPR017877. Myb-like_dom.
    IPR001005. SANT/Myb.
    IPR027109. Swc4/Dmap1.
    [Graphical view ]
    PANTHERi PTHR12855. PTHR12855. 1 hit.
    SMARTi SM00717. SANT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiSWC4_CANAL
    AccessioniPrimary (citable) accession number: Q5AAJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3