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Protein

SWR1-complex protein 4

Gene

SWC4

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processDNA damage, DNA repair, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SWR1-complex protein 4
Gene namesi
Name:SWC4
Ordered Locus Names:CAALFM_CR00400CA
ORF Names:CaO19.7492
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome R

Organism-specific databases

CGDiCAL0000199374 SWC4
EuPathDBiFungiDB:CR_00400C_A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000763371 – 635SWR1-complex protein 4Add BLAST635

Proteomic databases

PRIDEiQ5AAJ7

Interactioni

Subunit structurei

Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini303 – 353SANTAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi177 – 191Gln-richAdd BLAST15

Sequence similaritiesi

Belongs to the SWC4 family.Curated

Phylogenomic databases

InParanoidiQ5AAJ7
KOiK11324
OMAiYNRLDYP
OrthoDBiEOG092C2QC9

Family and domain databases

InterProiView protein in InterPro
IPR032563 DAMP1_SANT-like
IPR009057 Homeobox-like_sf
IPR017877 Myb-like_dom
IPR001005 SANT/Myb
PfamiView protein in Pfam
PF16282 SANT_DAMP1_like, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit

Sequencei

Sequence statusi: Complete.

Q5AAJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSANDILDVL NIQRDESNQP PKKKQKSSST PTLPDGKQLT GMARELYNLV
60 70 80 90 100
GPNTPPINLN SNSYTANKEK MKKFKPSPWT RMPFTPKQGI ELNHWVKGSK
110 120 130 140 150
ELIEQQEFEE DGTPKPYFFE KYNVQLEIPE FVDEDTYDLY MIEIKEYESK
160 170 180 190 200
MKEERARREK ERKEREKRDL EEKKKKQQQQ QQKSQQNPQN QIKDDEKNQD
210 220 230 240 250
TRNNTDKKDS EQKSEDKPTV EAKKETDEKK DDVVLKDNTN ETKPVTETTK
260 270 280 290 300
SETETTEQNN SEKTNENETN KTNDKDGEGN LTKSKDSATE DQSNNKKEND
310 320 330 340 350
EDTESEWTYK ETKHLFELCQ AFELKWPIIH DRFPNPNRTA EDLKEQFYRI
360 370 380 390 400
CIKILENQKN KNQALIDSLK AYCKPRELER KQYLENLLKR TPAEIAEEES
410 420 430 440 450
LVIEARRFEI AAKKMLMERS NLLTLLDSPQ TTQNVSQYQS SQGITNLYNN
460 470 480 490 500
LLIYDKHQKK KQMANKSNPQ QEPVPPPIPL AASSSVKRDR GFQTQLQQYL
510 520 530 540 550
SSFLKQNHHT NPAVKQEINS IQQLLMKRLT QKEEEAYGLY FHGTEKLNPG
560 570 580 590 600
VMLRSQQKLP GLNQRQSILK SVNILLQEMD IPTGGGTSWK PIMPTRKTMA
610 620 630
KYDELIRSVV TLLDVKKAKD KLESEIKLIK SQRGL
Length:635
Mass (Da):74,039
Last modified:April 26, 2005 - v1
Checksum:i63D13B88267DBBF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017630 Genomic DNA Translation: AOW30811.1
RefSeqiXP_718649.1, XM_713556.1

Genome annotation databases

EnsemblFungiiAOW30811; AOW30811; CAALFM_CR00400CA
GeneIDi3639679
KEGGical:CAALFM_CR00400CA

Similar proteinsi

Entry informationi

Entry nameiSWC4_CANAL
AccessioniPrimary (citable) accession number: Q5AAJ7
Secondary accession number(s): A0A1D8PRQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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