ID   MRS2_CANAL              Reviewed;         468 AA.
AC   Q5A970; A0A1D8PS35;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-MAY-2023, entry version 100.
DE   RecName: Full=Mitochondrial inner membrane magnesium transporter MRS2;
DE   AltName: Full=RNA-splicing protein MRS2;
DE   Flags: Precursor;
GN   Name=MRS2; OrderedLocusNames=CAALFM_CR01960CA;
GN   ORFNames=CaO19.10128, CaO19.2597;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: High-conductance magnesium-selective channel that mediates
CC       the influx of magnesium into the mitochondrial matrix. Essential for
CC       the splicing of mRNA group II introns in mitochondria by affecting
CC       mitochondrial magnesium concentrations, which are critical for group II
CC       intron splicing. It also suppresses a variety of mitochondrial intron
CC       mutations and its absence may disturb the assembly of mitochondrial
CC       membrane complexes. {ECO:0000250|UniProtKB:Q01926}.
CC   -!- SUBUNIT: Homopentamer. Forms homooligomers. Interacts with MFM1.
CC       {ECO:0000250|UniProtKB:Q01926}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q01926}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q01926}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC       family. {ECO:0000305}.
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DR   EMBL; CP017630; AOW30948.1; -; Genomic_DNA.
DR   RefSeq; XP_718262.1; XM_713169.2.
DR   AlphaFoldDB; Q5A970; -.
DR   SMR; Q5A970; -.
DR   STRING; 237561.Q5A970; -.
DR   EnsemblFungi; CR_01960C_A-T; CR_01960C_A-T-p1; CR_01960C_A.
DR   GeneID; 3640110; -.
DR   KEGG; cal:CAALFM_CR01960CA; -.
DR   CGD; CAL0000174046; MRS2.
DR   VEuPathDB; FungiDB:CR_01960C_A; -.
DR   eggNOG; KOG2662; Eukaryota.
DR   HOGENOM; CLU_025144_1_0_1; -.
DR   InParanoid; Q5A970; -.
DR   OMA; MATMFLT; -.
DR   OrthoDB; 73031at2759; -.
DR   PRO; PR:Q5A970; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0045016; P:mitochondrial magnesium ion transmembrane transport; ISS:UniProtKB.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 1.
DR   InterPro; IPR045863; CorA_TM1_TM2.
DR   InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890:SF27; MAGNESIUM TRANSPORTER MRS2, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR13890; RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL; 1.
DR   Pfam; PF01544; CorA; 1.
DR   SUPFAM; SSF144083; Magnesium transport protein CorA, transmembrane region; 1.
PE   3: Inferred from homology;
KW   Ion transport; Magnesium; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..33
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..468
FT                   /note="Mitochondrial inner membrane magnesium transporter
FT                   MRS2"
FT                   /id="PRO_0000043242"
FT   TRANSMEM        327..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           351..354
FT                   /note="YGMN"
SQ   SEQUENCE   468 AA;  53554 MW;  7723CB02ABE77784 CRC64;
     MYHIHRLLAP IRSNSVFFSL AQLPKPSLIG CRYKSNNVGS QDSKRTSKNS ILHNLGSYSN
     SAESEILNKL KPITPNDLYV SCTSFDRIGN ITAVSRKYPK MQFLKENHLF PRDLRKIDTS
     SIDVVPVIMI RPSSAILVNL LHIKAIIKKD NVMVFDTSKS EVATKLGIFM YDLELKLKSP
     ANNVCYEFRA LESILVSVTS YLEAEIKLHR QQCGIILAEL EDEVDRAKLQ ELLIRSKKLS
     SFHQRAILIR DVLEELLEND EDLAGMYLTD LKRFEPEEEN YEEIESILES YYNQCDEYVQ
     QAGSLLSDIK ATEEIVNIIL DANRNSLMLF ELKITVYTLG FTVATLVPAF YGMNLKNYIE
     ETNWGFGLVL VVSLLQGLAI TWLNFRKLHK VQKLTMMGTS NSSKAGTGLS RHIPPTSRVD
     RWKRGSFLYR LFYGSGGKYS KPSKKFDRPT NREKDAMWRM INDDKAMK
//