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Q5A970

- MRS2_CANAL

UniProt

Q5A970 - MRS2_CANAL

Protein

Mitochondrial inner membrane magnesium transporter MRS2

Gene

MRS2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing By similarity.By similarity

    GO - Molecular functioni

    1. magnesium ion transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. mitochondrial magnesium ion transport Source: UniProtKB

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Magnesium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial inner membrane magnesium transporter MRS2
    Alternative name(s):
    RNA-splicing protein MRS2
    Gene namesi
    Name:MRS2
    ORF Names:CaO19.10128, CaO19.2597
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0002570. MRS2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3333MitochondrionSequence AnalysisAdd
    BLAST
    Chaini34 – 468435Mitochondrial inner membrane magnesium transporter MRS2PRO_0000043242Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0002570.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5A970.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei327 – 34721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei365 – 38521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi351 – 3544YGMN

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG284534.
    KOiK16075.
    OrthoDBiEOG7SXWCP.

    Family and domain databases

    InterProiIPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
    IPR026573. MRS2/LPE10.
    [Graphical view]
    PANTHERiPTHR13890. PTHR13890. 1 hit.
    PfamiPF01544. CorA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5A970-1 [UniParc]FASTAAdd to Basket

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    MYHIHRLLAP IRSNSVFFSL AQLPKPSLIG CRYKSNNVGS QDSKRTSKNS    50
    ILHNLGSYSN SAESEILNKL KPITPNDLYV SCTSFDRIGN ITAVSRKYPK 100
    MQFLKENHLF PRDLRKIDTS SIDVVPVIMI RPSSAILVNL LHIKAIIKKD 150
    NVMVFDTSKS EVATKLGIFM YDLELKLKSP ANNVCYEFRA LESILVSVTS 200
    YLEAEIKLHR QQCGIILAEL EDEVDRAKLQ ELLIRSKKLS SFHQRAILIR 250
    DVLEELLEND EDLAGMYLTD LKRFEPEEEN YEEIESILES YYNQCDEYVQ 300
    QAGSLLSDIK ATEEIVNIIL DANRNSLMLF ELKITVYTLG FTVATLVPAF 350
    YGMNLKNYIE ETNWGFGLVL VVSLLQGLAI TWLNFRKLHK VQKLTMMGTS 400
    NSSKAGTGLS RHIPPTSRVD RWKRGSFLYR LFYGSGGKYS KPSKKFDRPT 450
    NREKDAMWRM INDDKAMK 468
    Length:468
    Mass (Da):53,554
    Last modified:April 26, 2005 - v1
    Checksum:i7723CB02ABE77784
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000043 Genomic DNA. Translation: EAK99431.1.
    AACQ01000044 Genomic DNA. Translation: EAK99333.1.
    RefSeqiXP_718262.1. XM_713169.1.
    XP_718357.1. XM_713264.1.

    Genome annotation databases

    GeneIDi3640047.
    3640110.
    KEGGical:CaO19.10128.
    cal:CaO19.2597.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000043 Genomic DNA. Translation: EAK99431.1 .
    AACQ01000044 Genomic DNA. Translation: EAK99333.1 .
    RefSeqi XP_718262.1. XM_713169.1.
    XP_718357.1. XM_713264.1.

    3D structure databases

    ProteinModelPortali Q5A970.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0002570.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3640047.
    3640110.
    KEGGi cal:CaO19.10128.
    cal:CaO19.2597.

    Organism-specific databases

    CGDi CAL0002570. MRS2.

    Phylogenomic databases

    eggNOGi NOG284534.
    KOi K16075.
    OrthoDBi EOG7SXWCP.

    Family and domain databases

    InterProi IPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
    IPR026573. MRS2/LPE10.
    [Graphical view ]
    PANTHERi PTHR13890. PTHR13890. 1 hit.
    Pfami PF01544. CorA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiMRS2_CANAL
    AccessioniPrimary (citable) accession number: Q5A970
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3