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Q5A970 (MRS2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial inner membrane magnesium transporter MRS2
Alternative name(s):
RNA-splicing protein MRS2
Gene names
Name:MRS2
ORF Names:CaO19.10128, CaO19.2597
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3333Mitochondrion Potential
Chain34 – 468435Mitochondrial inner membrane magnesium transporter MRS2
PRO_0000043242

Regions

Transmembrane327 – 34721Helical; Potential
Transmembrane365 – 38521Helical; Potential
Motif351 – 3544YGMN

Sequences

Sequence LengthMass (Da)Tools
Q5A970 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 7723CB02ABE77784

FASTA46853,554
        10         20         30         40         50         60 
MYHIHRLLAP IRSNSVFFSL AQLPKPSLIG CRYKSNNVGS QDSKRTSKNS ILHNLGSYSN 

        70         80         90        100        110        120 
SAESEILNKL KPITPNDLYV SCTSFDRIGN ITAVSRKYPK MQFLKENHLF PRDLRKIDTS 

       130        140        150        160        170        180 
SIDVVPVIMI RPSSAILVNL LHIKAIIKKD NVMVFDTSKS EVATKLGIFM YDLELKLKSP 

       190        200        210        220        230        240 
ANNVCYEFRA LESILVSVTS YLEAEIKLHR QQCGIILAEL EDEVDRAKLQ ELLIRSKKLS 

       250        260        270        280        290        300 
SFHQRAILIR DVLEELLEND EDLAGMYLTD LKRFEPEEEN YEEIESILES YYNQCDEYVQ 

       310        320        330        340        350        360 
QAGSLLSDIK ATEEIVNIIL DANRNSLMLF ELKITVYTLG FTVATLVPAF YGMNLKNYIE 

       370        380        390        400        410        420 
ETNWGFGLVL VVSLLQGLAI TWLNFRKLHK VQKLTMMGTS NSSKAGTGLS RHIPPTSRVD 

       430        440        450        460 
RWKRGSFLYR LFYGSGGKYS KPSKKFDRPT NREKDAMWRM INDDKAMK 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000043 Genomic DNA. Translation: EAK99431.1.
AACQ01000044 Genomic DNA. Translation: EAK99333.1.
RefSeqXP_718262.1. XM_713169.1.
XP_718357.1. XM_713264.1.

3D structure databases

ProteinModelPortalQ5A970.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0002570.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3640047.
3640110.
KEGGcal:CaO19.10128.
cal:CaO19.2597.

Organism-specific databases

CGDCAL0002570. MRS2.

Phylogenomic databases

eggNOGNOG284534.
KOK16075.
OrthoDBEOG7SXWCP.

Family and domain databases

InterProIPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
IPR026573. MRS2/LPE10.
[Graphical view]
PANTHERPTHR13890. PTHR13890. 1 hit.
PfamPF01544. CorA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRS2_CANAL
AccessionPrimary (citable) accession number: Q5A970
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: April 26, 2005
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names