Q5A970 (MRS2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial inner membrane magnesium transporter MRS2

Alternative name(s):
RNA-splicing protein MRS2

Gene names

Name:	MRS2
ORF Names:	CaO19.10128, CaO19.2597

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing By similarity.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane Transmembrane helix
Ligand	Magnesium
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrial magnesium ion transport Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	magnesium ion transmembrane transporter activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 33	33	Mitochondrion Potential
	Chain	34 – 468	435	Mitochondrial inner membrane magnesium transporter MRS2		PRO_0000043242
Regions
	Transmembrane	327 – 347	21	Helical; Potential
	Transmembrane	365 – 385	21	Helical; Potential
	Motif	351 – 354	4	YGMN

Sequences

	Sequence		Length	Mass (Da)
	Q5A970 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 7723CB02ABE77784	FASTA	468	53,554
	10 20 30 40 50 60 MYHIHRLLAP IRSNSVFFSL AQLPKPSLIG CRYKSNNVGS QDSKRTSKNS ILHNLGSYSN 70 80 90 100 110 120 SAESEILNKL KPITPNDLYV SCTSFDRIGN ITAVSRKYPK MQFLKENHLF PRDLRKIDTS 130 140 150 160 170 180 SIDVVPVIMI RPSSAILVNL LHIKAIIKKD NVMVFDTSKS EVATKLGIFM YDLELKLKSP 190 200 210 220 230 240 ANNVCYEFRA LESILVSVTS YLEAEIKLHR QQCGIILAEL EDEVDRAKLQ ELLIRSKKLS 250 260 270 280 290 300 SFHQRAILIR DVLEELLEND EDLAGMYLTD LKRFEPEEEN YEEIESILES YYNQCDEYVQ 310 320 330 340 350 360 QAGSLLSDIK ATEEIVNIIL DANRNSLMLF ELKITVYTLG FTVATLVPAF YGMNLKNYIE 370 380 390 400 410 420 ETNWGFGLVL VVSLLQGLAI TWLNFRKLHK VQKLTMMGTS NSSKAGTGLS RHIPPTSRVD 430 440 450 460 RWKRGSFLYR LFYGSGGKYS KPSKKFDRPT NREKDAMWRM INDDKAMK

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000043 Genomic DNA. Translation: EAK99431.1. AACQ01000044 Genomic DNA. Translation: EAK99333.1.
RefSeq	XP_718262.1. XM_713169.1. XP_718357.1. XM_713264.1.
3D structure databases
ProteinModelPortal	Q5A970.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0002570.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3640047. 3640110.
KEGG	cal:CaO19.10128. cal:CaO19.2597.
Organism-specific databases
CGD	CAL0002570. MRS2.
Phylogenomic databases
eggNOG	NOG284534.
KO	K16075.
Family and domain databases
InterPro	IPR002523. MgTranspt_CorA/ZnTranspt_ZntB. IPR026573. MRS2/LPE10. [Graphical view]
PANTHER	PTHR13890. PTHR13890. 1 hit.
Pfam	PF01544. CorA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MRS2_CANAL

Accession

Primary (citable) accession number: Q5A970

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	April 26, 2005
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program