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Q5A970

- MRS2_CANAL

UniProt

Q5A970 - MRS2_CANAL

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Protein
Mitochondrial inner membrane magnesium transporter MRS2
Gene
MRS2, CaO19.10128, CaO19.2597
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing By similarity.

GO - Molecular functioni

  1. magnesium ion transmembrane transporter activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. mitochondrial magnesium ion transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial inner membrane magnesium transporter MRS2
Alternative name(s):
RNA-splicing protein MRS2
Gene namesi
Name:MRS2
ORF Names:CaO19.10128, CaO19.2597
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0002570. MRS2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei327 – 34721Helical; Reviewed prediction
Add
BLAST
Transmembranei365 – 38521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3333Mitochondrion Reviewed prediction
Add
BLAST
Chaini34 – 468435Mitochondrial inner membrane magnesium transporter MRS2
PRO_0000043242Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0002570.

Structurei

3D structure databases

ProteinModelPortaliQ5A970.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi351 – 3544YGMN

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG284534.
KOiK16075.
OrthoDBiEOG7SXWCP.

Family and domain databases

InterProiIPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
IPR026573. MRS2/LPE10.
[Graphical view]
PANTHERiPTHR13890. PTHR13890. 1 hit.
PfamiPF01544. CorA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5A970-1 [UniParc]FASTAAdd to Basket

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MYHIHRLLAP IRSNSVFFSL AQLPKPSLIG CRYKSNNVGS QDSKRTSKNS    50
ILHNLGSYSN SAESEILNKL KPITPNDLYV SCTSFDRIGN ITAVSRKYPK 100
MQFLKENHLF PRDLRKIDTS SIDVVPVIMI RPSSAILVNL LHIKAIIKKD 150
NVMVFDTSKS EVATKLGIFM YDLELKLKSP ANNVCYEFRA LESILVSVTS 200
YLEAEIKLHR QQCGIILAEL EDEVDRAKLQ ELLIRSKKLS SFHQRAILIR 250
DVLEELLEND EDLAGMYLTD LKRFEPEEEN YEEIESILES YYNQCDEYVQ 300
QAGSLLSDIK ATEEIVNIIL DANRNSLMLF ELKITVYTLG FTVATLVPAF 350
YGMNLKNYIE ETNWGFGLVL VVSLLQGLAI TWLNFRKLHK VQKLTMMGTS 400
NSSKAGTGLS RHIPPTSRVD RWKRGSFLYR LFYGSGGKYS KPSKKFDRPT 450
NREKDAMWRM INDDKAMK 468
Length:468
Mass (Da):53,554
Last modified:April 26, 2005 - v1
Checksum:i7723CB02ABE77784
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000043 Genomic DNA. Translation: EAK99431.1.
AACQ01000044 Genomic DNA. Translation: EAK99333.1.
RefSeqiXP_718262.1. XM_713169.1.
XP_718357.1. XM_713264.1.

Genome annotation databases

GeneIDi3640047.
3640110.
KEGGical:CaO19.10128.
cal:CaO19.2597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000043 Genomic DNA. Translation: EAK99431.1 .
AACQ01000044 Genomic DNA. Translation: EAK99333.1 .
RefSeqi XP_718262.1. XM_713169.1.
XP_718357.1. XM_713264.1.

3D structure databases

ProteinModelPortali Q5A970.
ModBasei Search...

Protein-protein interaction databases

STRINGi 5476.CAL0002570.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3640047.
3640110.
KEGGi cal:CaO19.10128.
cal:CaO19.2597.

Organism-specific databases

CGDi CAL0002570. MRS2.

Phylogenomic databases

eggNOGi NOG284534.
KOi K16075.
OrthoDBi EOG7SXWCP.

Family and domain databases

InterProi IPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
IPR026573. MRS2/LPE10.
[Graphical view ]
PANTHERi PTHR13890. PTHR13890. 1 hit.
Pfami PF01544. CorA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiMRS2_CANAL
AccessioniPrimary (citable) accession number: Q5A970
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: April 26, 2005
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi