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Protein

Mitochondrial inner membrane magnesium transporter MRS2

Gene

MRS2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing (By similarity).By similarity

GO - Molecular functioni

  1. magnesium ion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. mitochondrial magnesium ion transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial inner membrane magnesium transporter MRS2
Alternative name(s):
RNA-splicing protein MRS2
Gene namesi
Name:MRS2
ORF Names:CaO19.10128, CaO19.2597
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0002570. MRS2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei327 – 34721HelicalSequence AnalysisAdd
BLAST
Transmembranei365 – 38521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3333MitochondrionSequence AnalysisAdd
BLAST
Chaini34 – 468435Mitochondrial inner membrane magnesium transporter MRS2PRO_0000043242Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0002570.

Structurei

3D structure databases

ProteinModelPortaliQ5A970.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi351 – 3544YGMN

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG284534.
InParanoidiQ5A970.
KOiK16075.
OrthoDBiEOG7SXWCP.

Family and domain databases

InterProiIPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
IPR026573. MRS2/LPE10.
[Graphical view]
PANTHERiPTHR13890. PTHR13890. 1 hit.
PfamiPF01544. CorA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5A970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYHIHRLLAP IRSNSVFFSL AQLPKPSLIG CRYKSNNVGS QDSKRTSKNS
60 70 80 90 100
ILHNLGSYSN SAESEILNKL KPITPNDLYV SCTSFDRIGN ITAVSRKYPK
110 120 130 140 150
MQFLKENHLF PRDLRKIDTS SIDVVPVIMI RPSSAILVNL LHIKAIIKKD
160 170 180 190 200
NVMVFDTSKS EVATKLGIFM YDLELKLKSP ANNVCYEFRA LESILVSVTS
210 220 230 240 250
YLEAEIKLHR QQCGIILAEL EDEVDRAKLQ ELLIRSKKLS SFHQRAILIR
260 270 280 290 300
DVLEELLEND EDLAGMYLTD LKRFEPEEEN YEEIESILES YYNQCDEYVQ
310 320 330 340 350
QAGSLLSDIK ATEEIVNIIL DANRNSLMLF ELKITVYTLG FTVATLVPAF
360 370 380 390 400
YGMNLKNYIE ETNWGFGLVL VVSLLQGLAI TWLNFRKLHK VQKLTMMGTS
410 420 430 440 450
NSSKAGTGLS RHIPPTSRVD RWKRGSFLYR LFYGSGGKYS KPSKKFDRPT
460
NREKDAMWRM INDDKAMK
Length:468
Mass (Da):53,554
Last modified:April 25, 2005 - v1
Checksum:i7723CB02ABE77784
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000043 Genomic DNA. Translation: EAK99431.1.
AACQ01000044 Genomic DNA. Translation: EAK99333.1.
RefSeqiXP_718262.1. XM_713169.1.
XP_718357.1. XM_713264.1.

Genome annotation databases

GeneIDi3640047.
3640110.
KEGGical:CaO19.10128.
cal:CaO19.2597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000043 Genomic DNA. Translation: EAK99431.1.
AACQ01000044 Genomic DNA. Translation: EAK99333.1.
RefSeqiXP_718262.1. XM_713169.1.
XP_718357.1. XM_713264.1.

3D structure databases

ProteinModelPortaliQ5A970.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0002570.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3640047.
3640110.
KEGGical:CaO19.10128.
cal:CaO19.2597.

Organism-specific databases

CGDiCAL0002570. MRS2.

Phylogenomic databases

eggNOGiNOG284534.
InParanoidiQ5A970.
KOiK16075.
OrthoDBiEOG7SXWCP.

Family and domain databases

InterProiIPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
IPR026573. MRS2/LPE10.
[Graphical view]
PANTHERiPTHR13890. PTHR13890. 1 hit.
PfamiPF01544. CorA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiMRS2_CANAL
AccessioniPrimary (citable) accession number: Q5A970
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2005
Last sequence update: April 25, 2005
Last modified: January 6, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.