Sterol 3-beta-glucosyltransferase - Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Sterol 3-beta-glucosyltransferase
EC=2.4.1.173

Alternative name(s):
Autophagy-related protein 26
UDP-glycosyltransferase 51

Gene names

Name:	ATG26
Synonyms:	UGT51, UGT51C, UGT51C1
ORF Names:	CaO19.2616, CaO19.10147

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	1513 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May be involved in decane metabolism and autophagy By similarity. Involved in the biosynthesis of sterol glucoside.
Catalytic activity	UDP-glucose + a sterol = UDP + a sterol 3-beta-D-glucoside.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 28 family. Contains 2 GRAM domains. Contains 1 PH domain.

Ontologies

Keywords
Biological process	Autophagy Lipid synthesis Protein transport Steroid biosynthesis Sterol biosynthesis Transport
Cellular component	Cytoplasm Membrane
Domain	Repeat
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW lipid glycosylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW sterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sterol 3-beta-glucosyltransferase activity Inferred from direct assay Ref.1. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1513

1513

Sterol 3-beta-glucosyltransferase

PRO_0000215607

Regions

Domain

296 – 331

36

GRAM 1

Domain

359 – 520

162

PH

Domain

816 – 880

65

GRAM 2

Compositional bias

57 – 62

6

Poly-Asp

Compositional bias

190 – 234

45

Thr-rich

Compositional bias

1466 – 1485

20

Asp-rich

Compositional bias

1486 – 1492

7

Poly-Glu

Natural variations

Natural variant

164

1

E → K in allele CaO19.10147.

Natural variant

203

1

K → R in allele CaO19.10147.

Natural variant

206

1

T → TAT in allele CaO19.10147.

Natural variant

235

1

E → K in allele CaO19.10147.

Experimental info

Sequence conflict

561

1

V → A in AAD29571. Ref.1

Sequence conflict

625

1

S → L in AAD29571. Ref.1

Sequence conflict

810

1

D → E in AAD29571. Ref.1

Sequence conflict

1130

1

A → G in AAD29571. Ref.1

Sequence conflict

1290

1

K → R in AAD29571. Ref.1

Sequence conflict

1492

1

E → EE in AAD29571. Ref.1

Sequence conflict

1507

1

P → R in AAD29571. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q5A950 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: DEE886A8BF9319FA
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FASTA

1,513

170,545

        10         20         30         40         50         60 
MSFYKKVTRG LATPLQGSIN LFSGSPNVSG DEGTDADNEN PEHRTTYHSL SGRVNHDDDD 

        70         80         90        100        110        120 
EDVAKLEDIV GFFTGLLNTT TVCAGLGSLN NLKKHYLDEF IKKSALNPLR PQNYGPETSS 

       130        140        150        160        170        180 
KLNNNSIEEL LNNGDTSLEK VRKMSLYDFD EHTSDSEEED SADEEEESIA ENLKPGKSGK 

       190        200        210        220        230        240 
ARNHPRDSRT TATLITTQIT RTKTATTATP TPTPTSSVDT DVTDVTEPIG KVTTEIPEEQ 

       250        260        270        280        290        300 
LQGLNPLQKS VVKNLDPHHV REGVLIKVKN SETPLKNDRQ ELLEKIQLRL KIADKLQRVF 

       310        320        330        340        350        360 
DLSDEDTFCG NYSAWLIKDV LLQGHVYLTK DALLYFAFLP KRFSLENSSE VLDEDNSSSI 

       370        380        390        400        410        420 
VYSGNLGLKS AKYGEVVLNT VLQHRYWAVL RAETLSIYSS STNLYFPVLV IDIKKCLYTE 

       430        440        450        460        470        480 
IIDKEKLNRE AISPVNRGTY SPNGGLSGTA TPRASTLENT ASELNSMLSG DSYSPTEDNV 

       490        500        510        520        530        540 
ETTASTVWFK LVTKKKTYKF SCDSSFSARQ WCNNITKLIF QHNNANSNGE VLIKIPISKI 

       550        560        570        580        590        600 
AEYNKRALFS EEEEEDRTLD VTMNDIPLNV TIKYLGDNDN ERKRDKLKRK YKGEEPTIEE 

       610        620        630        640        650        660 
VHFLFPKSGV EFFETFDKLV NPVVSDNDNQ SSKSSITSTN FSEKAISTLS KSPNHLVQTV 

       670        680        690        700        710        720 
LDFNKPVDDD ISAFKKFGTT ITSPTRIFKA TITSPEMTSI DETSLRDSFD SDRLHLPRDM 

       730        740        750        760        770        780 
SERALKNLEV SFVTSLKKLE DASKRYEKPH MEHSQTNLAS ILSDPSEVKK ESKTAISKSI 

       790        800        810        820        830        840 
KALYSVGTHW SATPNHYFEL GKYYVNKVQD RDSSQRNFQS HFSTNSKLLA SYYGHLLRTV 

       850        860        870        880        890        900 
PVYGKIYVSE TDVCFRSLLP GVSTKMVLPM TDIEEVRASR GSRLTYHGLR LIVRGSEELD 

       910        920        930        940        950        960 
LEFGSSKSRD DFQKVVLSVL ERLHSKEGFR PEPYQWGSNF EVELYKTRME YSDSENREIQ 

       970        980        990       1000       1010       1020 
QYDNSIDIKF AEKKIEMARV RMFEDRLMAA SGLDVPIILE DSPFFKTELR PSTSYNITLL 

      1030       1040       1050       1060       1070       1080 
TIGSRGDVQP YIALGKGLVK EGHNVTIATH AEFGDWIKTF GLGFKEIAGD PAELMSFMVT 

      1090       1100       1110       1120       1130       1140 
HNSMSVGFLK NAQQKFRSWI SKLLTTSWEA CQGSDILIES PSAMSGIHIA EALGIPYFRA 

      1150       1160       1170       1180       1190       1200 
FTMPWTRTRA YPHAFFVPEQ KKGGSYNYLT HVLFENIFWK GISGQVNKWR VEELDLPKTN 

      1210       1220       1230       1240       1250       1260 
LYRLQQTRVP FLYNVSPAIL PPSVDFPDWI KVTGYWFLDE GSGDYKPPEE LVQFMKKASR 

      1270       1280       1290       1300       1310       1320 
DKKKIVYIGF GSIVVKDAKS LTKAVVSAVK RADVRCILNK GWSDRLDNKD KNEIEIELPP 

      1330       1340       1350       1360       1370       1380 
EIYNSGTIPH DWLFPRIDAA VHHGGSGTTG ATMRAGIPTI IKPFFGDQFF YATRIEDLGA 

      1390       1400       1410       1420       1430       1440 
GIALKKLTAK TLGDALVKAT HDLKIIDKAK RVSQQIKHEH GVLSAIESIY SELEYSRNLI 

      1450       1460       1470       1480       1490       1500 
LIKDIHNQNY KRHHPVPSGV QTPAYDTDSD DYDDDEDDDE SDKDDEEEEE EENSYDGYDG 

      1510 
NGVNNSPSQN SSN

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional expression of UGT genes encoding sterol glucosyltransferases from Saccharomyces cerevisiae, Candida albicans, Pichia pastoris, and Dictyostelium discoideum." Warnecke D.C., Erdmann R., Fahl A., Hube B., Mueller F., Zank T., Zaehringer U., Heinz E. J. Biol. Chem. 274:13048-13059(1999) [PubMed: 10224056] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 1161.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF091398 Genomic DNA. Translation: AAD29571.1. AACQ01000044 Genomic DNA. Translation: EAK99352.1. AACQ01000043 Genomic DNA. Translation: EAK99450.1.
RefSeq	XP_718281.1. XM_713188.1. XP_718376.1. XM_713283.1.
3D structure databases
ProteinModelPortal	Q5A950.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5A950.
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3640058. 3640147.
KEGG	cal:CaO19.10147. cal:CaO19.2616.
Organism-specific databases
CGD	CAL0003385. UGT51C1.
Phylogenomic databases
PhylomeDB	Q5A950.
Enzyme and pathway databases
BRENDA	2.4.1.173. 1096.
Family and domain databases
InterPro	IPR004276. Glyco_trans_28. IPR004182. GRAM. IPR011993. PH_type. IPR001849. Pleckstrin_homology. IPR002213. UDP_glucos_trans. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 2 hits.
KO	K05841.
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF03033. Glyco_transf_28. 1 hit. PF02893. GRAM. 1 hit. PF00169. PH. 1 hit. PF00201. UDPGT. 1 hit. [Graphical view]
SMART	SM00568. GRAM. 2 hits. SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG26_CANAL

Accession

Primary (citable) accession number: Q5A950
Secondary accession number(s): Q5A9F2, Q9Y752

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Candida albicans

Candida albicans: entries and gene names

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents