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Protein

Signal peptidase complex catalytic subunit SEC11

Gene

SEC11

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity).By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Protein family/group databases

MEROPSiS26.010

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11 (EC:3.4.21.89)
Alternative name(s):
Signal peptidase I
Gene namesi
Name:SEC11
Ordered Locus Names:CAALFM_CR00990WA
ORF Names:CaO19.10769, CaO19.3259
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome R

Organism-specific databases

CGDiCAL0000184794 orf19.3259

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini31 – 166LumenalSequence analysisAdd BLAST136

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004123201 – 166Signal peptidase complex catalytic subunit SEC11Add BLAST166

Proteomic databases

PRIDEiQ5A869

Interactioni

Subunit structurei

Component of the signal peptidase complex (SPC).By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000111516
InParanoidiQ5A869
KOiK13280
OMAiYIPFVGY
OrthoDBiEOG092C4ZUJ

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR019756 Pept_S26A_signal_pept_1_Ser-AS
IPR015927 Peptidase_S24_S26A/B/C
IPR001733 Peptidase_S26B
PANTHERiPTHR10806 PTHR10806, 1 hit
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00728 SIGNALPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02228 sigpep_I_arch, 1 hit
PROSITEiView protein in PROSITE
PS00501 SPASE_I_1, 1 hit
PS00761 SPASE_I_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5A869-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIRQQITQF LSLAYVFSSA FMLWKTLSVI ANSHSPIVVV LSGSMEPAFQ
60 70 80 90 100
RGDILFLWNR DHQQKVGDIV VYEIDGKSIP IVHRVLREHH NSEKQLLLTK
110 120 130 140 150
GDNNAVDDLS LYAKKQQYLN QKQDLVGTVK GYLPFIGYVT ILISENVYFK
160
YGMLGLLGLS SLFSNE
Length:166
Mass (Da):18,867
Last modified:April 26, 2005 - v1
Checksum:i9620CF24C3827A6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017630 Genomic DNA Translation: AOW30861.1
RefSeqiXP_717949.1, XM_712856.1

Genome annotation databases

EnsemblFungiiAOW30861; AOW30861; CAALFM_CR00990WA
GeneIDi3640425
KEGGical:CAALFM_CR00990WA

Similar proteinsi

Entry informationi

Entry nameiSEC11_CANAL
AccessioniPrimary (citable) accession number: Q5A869
Secondary accession number(s): A0A1D8PRV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health