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Protein

Signal peptidase complex catalytic subunit SEC11

Gene

SEC11

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity).By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiS26.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11 (EC:3.4.21.89)
Alternative name(s):
Signal peptidase I
Gene namesi
Name:SEC11
ORF Names:CaO19.10769, CaO19.3259
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000184794. orf19.3259.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini31 – 166LumenalSequence analysisAdd BLAST136

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004123201 – 166Signal peptidase complex catalytic subunit SEC11Add BLAST166

Proteomic databases

PRIDEiQ5A869.

Interactioni

Subunit structurei

Component of the signal peptidase complex (SPC).By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000111516.
InParanoidiQ5A869.
KOiK13280.
OrthoDBiEOG092C4ZUJ.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5A869-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIRQQITQF LSLAYVFSSA FMLWKTLSVI ANSHSPIVVV LSGSMEPAFQ
60 70 80 90 100
RGDILFLWNR DHQQKVGDIV VYEIDGKSIP IVHRVLREHH NSEKQLLLTK
110 120 130 140 150
GDNNAVDDLS LYAKKQQYLN QKQDLVGTVK GYLPFIGYVT ILISENVYFK
160
YGMLGLLGLS SLFSNE
Length:166
Mass (Da):18,867
Last modified:April 26, 2005 - v1
Checksum:i9620CF24C3827A6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000049 Genomic DNA. Translation: EAK98934.1.
AACQ01000048 Genomic DNA. Translation: EAK99001.1.
RefSeqiXP_717883.1. XM_712790.1.
XP_717949.1. XM_712856.1.

Genome annotation databases

EnsemblFungiiEAK98934; EAK98934; CaO19.10769.
EAK99001; EAK99001; CaO19.3259.
GeneIDi3640425.
3640488.
KEGGical:CaO19.10769.
cal:CaO19.3259.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000049 Genomic DNA. Translation: EAK98934.1.
AACQ01000048 Genomic DNA. Translation: EAK99001.1.
RefSeqiXP_717883.1. XM_712790.1.
XP_717949.1. XM_712856.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS26.010.

Proteomic databases

PRIDEiQ5A869.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK98934; EAK98934; CaO19.10769.
EAK99001; EAK99001; CaO19.3259.
GeneIDi3640425.
3640488.
KEGGical:CaO19.10769.
cal:CaO19.3259.

Organism-specific databases

CGDiCAL0000184794. orf19.3259.

Phylogenomic databases

HOGENOMiHOG000111516.
InParanoidiQ5A869.
KOiK13280.
OrthoDBiEOG092C4ZUJ.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEC11_CANAL
AccessioniPrimary (citable) accession number: Q5A869
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: April 26, 2005
Last modified: November 30, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.