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Q5A847 (JHD1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
JmjC domain-containing histone demethylation protein 1

EC=1.14.11.27
Alternative name(s):
[Histone-H3]-lysine-36 demethylase 1
Gene names
Name:JHD1
ORF Names:CaO19.10791, CaO19.3281
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code By similarity.

Catalytic activity

Protein N6,N(6)-dimethyl-L-lysine + 2-oxoglutarate + O2 = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO2.

Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O2 = protein L-lysine + succinate + formaldehyde + CO2.

Cofactor

Binds 1 Fe2+ ion per subunit By similarity.

Subcellular location

Nucleus By similarity.

Domain

The JmjC domain mediates the demethylation activity By similarity.

Sequence similarities

Belongs to the JHDM1 histone demethylase family.

Contains 1 JmjC domain.

Contains 1 PHD-type zinc finger.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 478478JmjC domain-containing histone demethylation protein 1
PRO_0000226793

Regions

Domain217 – 383167JmjC
Zinc finger5 – 6864PHD-type

Sites

Metal binding2691Iron; catalytic By similarity
Metal binding2711Iron; catalytic By similarity
Metal binding3511Iron; catalytic By similarity
Binding site2661Substrate By similarity
Binding site2861Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5A847 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 5DA6D1654795CF5D

FASTA47855,460
        10         20         30         40         50         60 
MPINSESCPL CKVHSNTIKK EDEDEEDNKT SWIQCSKCKV WYHVHCLDLP TDEIDQIVIY 

        70         80         90        100        110        120 
HCPECVPKYG ESTYKRKSKR ARVSIDYQSL NEGDTFAIDK SSHFHLHNFL NFKGETNINV 

       130        140        150        160        170        180 
IDKLTKTYAL NTQMEKPILI PQADLSKNGM QLPIEKNEIT IDYITDCCGE DTPLEVMDVI 

       190        200        210        220        230        240 
SQQGISPPWK LKQWREYFKT NEEKRDRIRN VISLEISDVA KLGVDFTRPK CVRDMDVVDR 

       250        260        270        280        290        300 
VWIEEDEQKR SKVTKYCLMS VKNSFTDFHI DFGGTSVYYT VLSGAKTFLF FPPTDNNLEL 

       310        320        330        340        350        360 
YKSWCLEPSQ NFIWYPEYTI TKNKKKIKPT GGFKVDLQPG DLFIIPSGWI HAVHTPQDSI 

       370        380        390        400        410        420 
VIGGNYLTIR DMVMQLKINE IERETKVPTK FRFPMFNKVL WLTAWYYYNH QNEFQSDIGE 

       430        440        450        460        470 
DEDGNAILTR LIGHLQGHLE LSKTNATAKR SIPKTIGKPM VFINKLLAWK EDLYGTAV 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000049 Genomic DNA. Translation: EAK98956.1.
AACQ01000048 Genomic DNA. Translation: EAK99023.1.
RefSeqXP_717905.1. XM_712812.1.
XP_717971.1. XM_712878.1.

3D structure databases

ProteinModelPortalQ5A847.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0003411.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3640438.
3640450.
KEGGcal:CaO19.10791.
cal:CaO19.3281.

Organism-specific databases

CGDCAL0003411. orf19.3281.

Phylogenomic databases

eggNOGNOG290496.
KOK10276.
OrthoDBEOG73NGDR.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR003347. JmjC_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
SMARTSM00558. JmjC. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMSSF57903. SSF57903. 1 hit.
PROSITEPS51184. JMJC. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameJHD1_CANAL
AccessionPrimary (citable) accession number: Q5A847
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names