Reviewed, UniProtKB/Swiss-Prot Q5A847 (JHD1_CANAL)

Names and origin

Protein names

Recommended name:
    JmjC domain-containing histone demethylation protein 1
    EC=1.14.11.27
Alternative name(s):
    [Histone-H3]-lysine-36 demethylase 1

Gene names

Name:	JHD1
ORF Names:	CaO19.3281, CaO19.10791

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code By similarity.
Catalytic activity	Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO(2). Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) = protein L-lysine + succinate + formaldehyde + CO(2).
Cofactor	Binds 1 Fe(2+) ion per subunit By similarity.
Subcellular location	NucleusBy similarity.
Domain	The JmjC domain mediates the demethylation activity By similarity.
Sequence similarities	Belongs to the JHDM1 histone demethylase family. Contains 1 JmjC domain. Contains 1 PHD-type zinc finger.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	Iron Metal-binding Zinc
Molecular function	Chromatin regulator Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	histone demethylase activity (H3-K36 specific) Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 478	478	JmjC domain-containing histone demethylation protein 1		PRO_0000226793
Regions
	Domain	217 – 383	167	JmjC
	Zinc finger	5 – 68	64	PHD-type
Sites
	Metal binding	269	1	Iron; catalytic By similarity
	Metal binding	271	1	Iron; catalytic By similarity
	Metal binding	351	1	Iron; catalytic By similarity
	Binding site	266	1	Substrate By similarity
	Binding site	286	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5A847-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 5DA6D1654795CF5D	FASTA	478	55,460
	10 20 30 40 50 60 MPINSESCPL CKVHSNTIKK EDEDEEDNKT SWIQCSKCKV WYHVHCLDLP TDEIDQIVIY 70 80 90 100 110 120 HCPECVPKYG ESTYKRKSKR ARVSIDYQSL NEGDTFAIDK SSHFHLHNFL NFKGETNINV 130 140 150 160 170 180 IDKLTKTYAL NTQMEKPILI PQADLSKNGM QLPIEKNEIT IDYITDCCGE DTPLEVMDVI 190 200 210 220 230 240 SQQGISPPWK LKQWREYFKT NEEKRDRIRN VISLEISDVA KLGVDFTRPK CVRDMDVVDR 250 260 270 280 290 300 VWIEEDEQKR SKVTKYCLMS VKNSFTDFHI DFGGTSVYYT VLSGAKTFLF FPPTDNNLEL 310 320 330 340 350 360 YKSWCLEPSQ NFIWYPEYTI TKNKKKIKPT GGFKVDLQPG DLFIIPSGWI HAVHTPQDSI 370 380 390 400 410 420 VIGGNYLTIR DMVMQLKINE IERETKVPTK FRFPMFNKVL WLTAWYYYNH QNEFQSDIGE 430 440 450 460 470 DEDGNAILTR LIGHLQGHLE LSKTNATAKR SIPKTIGKPM VFINKLLAWK EDLYGTAV

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000049 Genomic DNA. Translation: EAK98956.1. AACQ01000048 Genomic DNA. Translation: EAK99023.1.
RefSeq	XP_717905.1. XP_717971.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3640438. 3640450.
KEGG	cal:CaO19.10791. cal:CaO19.3281.
Organism-specific databases
CGD	CAL0003411. orf19.3281.
Family and domain databases
InterPro	IPR013129. TF_JmjC. IPR003347. TF_JmjC_AAH. IPR001965. Znf_PHD. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Gene3D	G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
Pfam	PF02373. JmjC. 1 hit. PF00628. PHD. 1 hit. [Graphical view]
SMART	SM00558. JmjC. 1 hit. SM00249. PHD. 1 hit. [Graphical view]
PROSITE	PS51184. JMJC. 1 hit. PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

JHD1_CANAL

Accession

Primary (citable) accession number: Q5A847

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	April 26, 2005
Last modified:	November 25, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)