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Q5A7Q2

- ESA1_CANAL

UniProt

Q5A7Q2 - ESA1_CANAL

Protein

Histone acetyltransferase ESA1

Gene

ESA1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei296 – 2961By similarity
    Active sitei338 – 3381NucleophileBy similarity
    Binding sitei341 – 3411Acetyl-CoABy similarity
    Binding sitei376 – 3761Acetyl-CoABy similarity

    GO - Molecular functioni

    1. H4 histone acetyltransferase activity Source: CGD

    GO - Biological processi

    1. chromatin silencing Source: CGD
    2. filamentous growth of a population of unicellular organisms Source: CGD
    3. histone H4 acetylation Source: CGD
    4. regulation of transcription from RNA polymerase II promoter Source: CGD
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase ESA1 (EC:2.3.1.48)
    Gene namesi
    Name:ESA1
    ORF Names:CaO19.12871, CaO19.5416
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0005186. orf19.5416.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. NuA4 histone acetyltransferase complex Source: CGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 541541Histone acetyltransferase ESA1PRO_0000051553Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei296 – 2961N6-acetyllysine; by autocatalysisBy similarity

    Post-translational modificationi

    Autoacetylation at Lys-296 is required for proper function.By similarity

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Component of the NuA4 histone acetyltransferase complex.By similarity

    Protein-protein interaction databases

    BioGridi1223612. 1 interaction.
    STRINGi5476.CAL0005186.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5A7Q2.
    SMRiQ5A7Q2. Positions 196-530.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini196 – 529334MYST-type HATAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni346 – 3527Acetyl-CoA bindingBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi279 – 30022ESA1-RPD3 motifBy similarityAdd
    BLAST

    Domaini

    The ESA1-RPD3 motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity.

    Sequence similaritiesi

    Belongs to the MYST (SAS/MOZ) family.Curated

    Phylogenomic databases

    eggNOGiCOG5027.
    KOiK11304.
    OrthoDBiEOG7RFTRR.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR002717. MOZ_SAS.
    IPR025995. Tudor-knot.
    [Graphical view]
    PfamiPF01853. MOZ_SAS. 1 hit.
    PF11717. Tudor-knot. 1 hit.
    [Graphical view]
    SMARTiSM00298. CHROMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF54160. SSF54160. 1 hit.
    SSF55729. SSF55729. 2 hits.
    PROSITEiPS51726. MYST_HAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5A7Q2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVAEIKKEK GSSLSPEPSS PIQILSTEPD ANTDIKQEKF TPKDILPGCK    50
    VHVSKDGEFR LAEILQEHIK KGRKVFYVHY QDFNKRLDEW IELDRIDFTR 100
    SLILPEIKAD TKENKSKKKS KSKGQTKLSK NNTTANSTTG TPQPSDGQPI 150
    MGDDEMDLEN LNVQGLKRPG EEFSREDEIK KLRTSGSMTQ NHSEVARVRN 200
    LSTIILGEHI IEPWYFSPYP IELTEEDEIY ICDFTLSYFG SKKQFERFRS 250
    KCSMKHPPGN EIYRDSKVSF WEIDGRKQRT WCRNLCLLSK LFLDHKTLYY 300
    DVDPFLFYIM TIKSDQGHHV VGYFSKEKES ADGYNVACIL TLPCYQKRGF 350
    GKLLIQFSYM LTKVERKVGS PEKPLSDLGL LSYRAYWTDT LVKLLVERNS 400
    PALFRKNNSQ LEYDEAENGK DSSATPTPGP GSNASQSSIL ASAAASRSGL 450
    NSSPIFSNEI TIEDISSITC MTTTDILHTL TTLQMLRYYK GQHIIVLTDQ 500
    IMELYEKLVK KVKEKKKHEL NPKLLHWTPP SFTANQLRFG W 541
    Length:541
    Mass (Da):61,922
    Last modified:April 26, 2005 - v1
    Checksum:i699B10696D755DE9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000051 Genomic DNA. Translation: EAK98737.1.
    AACQ01000050 Genomic DNA. Translation: EAK98837.1.
    RefSeqiXP_717694.1. XM_712601.1.
    XP_717788.1. XM_712695.1.

    Genome annotation databases

    GeneIDi3640518.
    3640628.
    KEGGical:CaO19.12871.
    cal:CaO19.5416.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000051 Genomic DNA. Translation: EAK98737.1 .
    AACQ01000050 Genomic DNA. Translation: EAK98837.1 .
    RefSeqi XP_717694.1. XM_712601.1.
    XP_717788.1. XM_712695.1.

    3D structure databases

    ProteinModelPortali Q5A7Q2.
    SMRi Q5A7Q2. Positions 196-530.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 1223612. 1 interaction.
    STRINGi 5476.CAL0005186.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3640518.
    3640628.
    KEGGi cal:CaO19.12871.
    cal:CaO19.5416.

    Organism-specific databases

    CGDi CAL0005186. orf19.5416.

    Phylogenomic databases

    eggNOGi COG5027.
    KOi K11304.
    OrthoDBi EOG7RFTRR.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR002717. MOZ_SAS.
    IPR025995. Tudor-knot.
    [Graphical view ]
    Pfami PF01853. MOZ_SAS. 1 hit.
    PF11717. Tudor-knot. 1 hit.
    [Graphical view ]
    SMARTi SM00298. CHROMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54160. SSF54160. 1 hit.
    SSF55729. SSF55729. 2 hits.
    PROSITEi PS51726. MYST_HAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiESA1_CANAL
    AccessioniPrimary (citable) accession number: Q5A7Q2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3