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Protein

Histone acetyltransferase ESA1

Gene

ESA1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei338Important for catalytic activityBy similarity1
Active sitei372Proton donor/acceptorBy similarity1
Binding sitei376Acetyl-CoABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri229 – 254C2HC MYST-type; degeneratePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

  • H4 histone acetyltransferase activity Source: CGD

GO - Biological processi

  • filamentous growth of a population of unicellular organisms Source: CGD
  • histone H4 acetylation Source: CGD
  • regulation of transcription from RNA polymerase II promoter Source: CGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase ESA1 (EC:2.3.1.48By similarity)
Gene namesi
Name:ESA1
ORF Names:CaO19.12871, CaO19.5416
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000179231. ESA1.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

  • NuA4 histone acetyltransferase complex Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515531 – 541Histone acetyltransferase ESA1Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei296N6-acetyllysine; by autocatalysisBy similarity1

Post-translational modificationi

Autoacetylation at Lys-296 is required for proper function.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ5A7Q2.

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex.By similarity

Protein-protein interaction databases

BioGridi1223612. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ5A7Q2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini196 – 529MYST-type HATPROSITE-ProRule annotationAdd BLAST334

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni337 – 341Acetyl-CoA bindingBy similarity5
Regioni346 – 352Acetyl-CoA bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi279 – 300ESA1-RPD3 motifBy similarityAdd BLAST22

Domaini

The ESA1-RPD3 motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity.By similarity

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated
Contains 1 C2HC MYST-type zinc finger.PROSITE-ProRule annotation
Contains 1 MYST-type HAT (histone acetyltransferase) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri229 – 254C2HC MYST-type; degeneratePROSITE-ProRule annotationAdd BLAST26

Phylogenomic databases

InParanoidiQ5A7Q2.
KOiK11304.
OrthoDBiEOG092C043Q.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000953. Chromo/shadow_dom.
IPR016197. Chromodomain-like.
IPR002717. HAT_MYST-type.
IPR025995. Tudor-knot.
[Graphical view]
PfamiPF01853. MOZ_SAS. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
SSF55729. SSF55729. 2 hits.
PROSITEiPS51726. MYST_HAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5A7Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVAEIKKEK GSSLSPEPSS PIQILSTEPD ANTDIKQEKF TPKDILPGCK
60 70 80 90 100
VHVSKDGEFR LAEILQEHIK KGRKVFYVHY QDFNKRLDEW IELDRIDFTR
110 120 130 140 150
SLILPEIKAD TKENKSKKKS KSKGQTKLSK NNTTANSTTG TPQPSDGQPI
160 170 180 190 200
MGDDEMDLEN LNVQGLKRPG EEFSREDEIK KLRTSGSMTQ NHSEVARVRN
210 220 230 240 250
LSTIILGEHI IEPWYFSPYP IELTEEDEIY ICDFTLSYFG SKKQFERFRS
260 270 280 290 300
KCSMKHPPGN EIYRDSKVSF WEIDGRKQRT WCRNLCLLSK LFLDHKTLYY
310 320 330 340 350
DVDPFLFYIM TIKSDQGHHV VGYFSKEKES ADGYNVACIL TLPCYQKRGF
360 370 380 390 400
GKLLIQFSYM LTKVERKVGS PEKPLSDLGL LSYRAYWTDT LVKLLVERNS
410 420 430 440 450
PALFRKNNSQ LEYDEAENGK DSSATPTPGP GSNASQSSIL ASAAASRSGL
460 470 480 490 500
NSSPIFSNEI TIEDISSITC MTTTDILHTL TTLQMLRYYK GQHIIVLTDQ
510 520 530 540
IMELYEKLVK KVKEKKKHEL NPKLLHWTPP SFTANQLRFG W
Length:541
Mass (Da):61,922
Last modified:April 26, 2005 - v1
Checksum:i699B10696D755DE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000051 Genomic DNA. Translation: EAK98737.1.
AACQ01000050 Genomic DNA. Translation: EAK98837.1.
RefSeqiXP_717694.1. XM_712601.1.
XP_717788.1. XM_712695.1.

Genome annotation databases

EnsemblFungiiEAK98737; EAK98737; CaO19.12871.
EAK98837; EAK98837; CaO19.5416.
GeneIDi3640518.
3640628.
KEGGical:CaO19.12871.
cal:CaO19.5416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000051 Genomic DNA. Translation: EAK98737.1.
AACQ01000050 Genomic DNA. Translation: EAK98837.1.
RefSeqiXP_717694.1. XM_712601.1.
XP_717788.1. XM_712695.1.

3D structure databases

ProteinModelPortaliQ5A7Q2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1223612. 1 interactor.

Proteomic databases

PRIDEiQ5A7Q2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK98737; EAK98737; CaO19.12871.
EAK98837; EAK98837; CaO19.5416.
GeneIDi3640518.
3640628.
KEGGical:CaO19.12871.
cal:CaO19.5416.

Organism-specific databases

CGDiCAL0000179231. ESA1.

Phylogenomic databases

InParanoidiQ5A7Q2.
KOiK11304.
OrthoDBiEOG092C043Q.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000953. Chromo/shadow_dom.
IPR016197. Chromodomain-like.
IPR002717. HAT_MYST-type.
IPR025995. Tudor-knot.
[Graphical view]
PfamiPF01853. MOZ_SAS. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
SSF55729. SSF55729. 2 hits.
PROSITEiPS51726. MYST_HAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiESA1_CANAL
AccessioniPrimary (citable) accession number: Q5A7Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: April 26, 2005
Last modified: October 5, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.