Q5A7M3 (KMO_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine 3-monooxygenase
EC=1.14.13.9

Alternative name(s):
Biosynthesis of nicotinic acid protein 4
Kynurenine 3-hydroxylase

Gene names

Name:	BNA4
ORF Names:	CaO19.12898, CaO19.5443

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	456 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity. HAMAP-Rule MF_03018
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O. HAMAP-Rule MF_03018
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3. HAMAP-Rule MF_03018
Subcellular location	Mitochondrion outer membrane By similarity HAMAP-Rule MF_03018.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Membrane Mitochondrion Mitochondrion outer membrane
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to biotic stimulus Inferred from mutant phenotype PubMed 12773383. Source: CGD cellular response to starvation Inferred from mutant phenotype PubMed 12773383. Source: CGD de novo NAD biosynthetic process from tryptophan Inferred from sequence alignment PubMed 17425674. Source: CGD filamentous growth of a population of unicellular organisms in response to biotic stimulus Inferred from mutant phenotype PubMed 12773383. Source: CGD filamentous growth of a population of unicellular organisms in response to starvation Inferred from mutant phenotype PubMed 12773383. Source: CGD
Cellular_component	mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from direct assay PubMed 19824013. Source: CGD
Molecular_function	kynurenine 3-monooxygenase activity Inferred from sequence alignment PubMed 17425674. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 456	456	Kynurenine 3-monooxygenase HAMAP-Rule MF_03018		PRO_0000361924

Sequences

	Sequence		Length	Mass (Da)
	Q5A7M3 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 4374754457385ED4	FASTA	456	51,534
	10 20 30 40 50 60 MSEEESQKTI GIVGAGLVGC LAALAFAKKG YDVTLFEYRP DPRTVDSSKR NLRSINLAVS 70 80 90 100 110 120 SRGIRALQYV DPAMADRILE HVIPMKGRMI HDITGTKQES QVYGLNGESI NSIDRSFLNN 130 140 150 160 170 180 CLLDELDKSN VKILFKHKLV KLDTSNACRM TFIDGHNDAK TSTFDFVVGC DGAHSQFRYH 190 200 210 220 230 240 LQKTMRMDYS QKYIDMQYLE LYIPPSEDAN NKFSIDANHL HIWPRHNFML IALANKDGSF 250 260 270 280 290 300 TSTFFSPWSV IEGISSSQEF VEFFRHNFPD AVGLIGEDAL SSAFKSNPRG SLMQVSCYPY 310 320 330 340 350 360 SNGKGIILGD AAHSMVPFYG QGMNCGFEDV RILMELIDTN NGDIEEAFKQ YSAARKNDLD 370 380 390 400 410 420 AICKLALDNY YEMSSKVVDI GYLIKKKLDY TLGKIFKNKW LPLYTMISFR DDIPYAKAIE 430 440 450 IEKRQNRIMN NVGLGVLGTA AVYGLVKLGQ YWNRRQ

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000050 Genomic DNA. Translation: EAK98864.1. AACQ01000051 Genomic DNA. Translation: EAK98764.1.
RefSeq	XP_717721.1. XM_712628.1. XP_717815.1. XM_712722.1.
3D structure databases
ProteinModelPortal	Q5A7M3.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0005260.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3640528. 3640686.
KEGG	cal:CaO19.12898. cal:CaO19.5443.
Organism-specific databases
CGD	CAL0005260. orf19.5443.
Phylogenomic databases
eggNOG	COG0654.
KO	K00486.
Enzyme and pathway databases
UniPathway	UPA00253; UER00328.
Family and domain databases
HAMAP	MF_01971. Kynurenine_monooxygenase.
InterPro	IPR002938. mOase_FAD-bd. IPR003042. Rng_hydrolase-like. [Graphical view]
Pfam	PF01494. FAD_binding_3. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...

Entry information

Entry name

KMO_CANAL

Accession

Primary (citable) accession number: Q5A7M3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program