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Protein

Kynurenine 3-monooxygenase

Gene

BNA4

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.UniRule annotation

Catalytic activityi

L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

GO - Molecular functioni

GO - Biological processi

  • 'de novo' NAD biosynthetic process from tryptophan Source: CGD
  • anthranilate metabolic process Source: UniProtKB-HAMAP
  • cellular response to starvation Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  • kynurenine metabolic process Source: GO_Central
  • NAD metabolic process Source: GO_Central
  • quinolinate biosynthetic process Source: UniProtKB-HAMAP
  • secondary metabolite biosynthetic process Source: GO_Central
  • tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

UniPathwayiUPA00253; UER00328.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine 3-monooxygenaseUniRule annotation (EC:1.14.13.9UniRule annotation)
Alternative name(s):
Biosynthesis of nicotinic acid protein 4UniRule annotation
Kynurenine 3-hydroxylaseUniRule annotation
Gene namesi
Name:BNA4UniRule annotation
ORF Names:CaO19.12898, CaO19.5443
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005260. orf19.5443.

Subcellular locationi

  • Mitochondrion outer membrane UniRule annotation

GO - Cellular componenti

  • mitochondrial outer membrane Source: UniProtKB-SubCell
  • mitochondrion Source: GO_Central
  • plasma membrane Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Kynurenine 3-monooxygenasePRO_0000361924Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0005260.

Structurei

3D structure databases

ProteinModelPortaliQ5A7M3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0654.
InParanoidiQ5A7M3.
KOiK00486.
OrthoDBiEOG7QVMC6.

Family and domain databases

HAMAPiMF_01971. Kynurenine_monooxygenase.
InterProiIPR027545. Kynurenine_monooxygenase.
IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSiPR00420. RNGMNOXGNASE.

Sequencei

Sequence statusi: Complete.

Q5A7M3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEESQKTI GIVGAGLVGC LAALAFAKKG YDVTLFEYRP DPRTVDSSKR
60 70 80 90 100
NLRSINLAVS SRGIRALQYV DPAMADRILE HVIPMKGRMI HDITGTKQES
110 120 130 140 150
QVYGLNGESI NSIDRSFLNN CLLDELDKSN VKILFKHKLV KLDTSNACRM
160 170 180 190 200
TFIDGHNDAK TSTFDFVVGC DGAHSQFRYH LQKTMRMDYS QKYIDMQYLE
210 220 230 240 250
LYIPPSEDAN NKFSIDANHL HIWPRHNFML IALANKDGSF TSTFFSPWSV
260 270 280 290 300
IEGISSSQEF VEFFRHNFPD AVGLIGEDAL SSAFKSNPRG SLMQVSCYPY
310 320 330 340 350
SNGKGIILGD AAHSMVPFYG QGMNCGFEDV RILMELIDTN NGDIEEAFKQ
360 370 380 390 400
YSAARKNDLD AICKLALDNY YEMSSKVVDI GYLIKKKLDY TLGKIFKNKW
410 420 430 440 450
LPLYTMISFR DDIPYAKAIE IEKRQNRIMN NVGLGVLGTA AVYGLVKLGQ

YWNRRQ
Length:456
Mass (Da):51,534
Last modified:April 26, 2005 - v1
Checksum:i4374754457385ED4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000050 Genomic DNA. Translation: EAK98864.1.
AACQ01000051 Genomic DNA. Translation: EAK98764.1.
RefSeqiXP_717721.1. XM_712628.1.
XP_717815.1. XM_712722.1.

Genome annotation databases

GeneIDi3640528.
3640686.
KEGGical:CaO19.12898.
cal:CaO19.5443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000050 Genomic DNA. Translation: EAK98864.1.
AACQ01000051 Genomic DNA. Translation: EAK98764.1.
RefSeqiXP_717721.1. XM_712628.1.
XP_717815.1. XM_712722.1.

3D structure databases

ProteinModelPortaliQ5A7M3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0005260.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3640528.
3640686.
KEGGical:CaO19.12898.
cal:CaO19.5443.

Organism-specific databases

CGDiCAL0005260. orf19.5443.

Phylogenomic databases

eggNOGiCOG0654.
InParanoidiQ5A7M3.
KOiK00486.
OrthoDBiEOG7QVMC6.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00328.

Family and domain databases

HAMAPiMF_01971. Kynurenine_monooxygenase.
InterProiIPR027545. Kynurenine_monooxygenase.
IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSiPR00420. RNGMNOXGNASE.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiKMO_CANAL
AccessioniPrimary (citable) accession number: Q5A7M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: April 26, 2005
Last modified: February 4, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.