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Q5A7M3

- KMO_CANAL

UniProt

Q5A7M3 - KMO_CANAL

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Protein

Kynurenine 3-monooxygenase

Gene

BNA4

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.UniRule annotation

Catalytic activityi

L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  2. kynurenine 3-monooxygenase activity Source: CGD

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: CGD
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. cellular response to starvation Source: CGD
  4. filamentous growth Source: CGD
  5. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  6. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  7. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  8. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

UniPathwayiUPA00253; UER00328.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine 3-monooxygenaseUniRule annotation (EC:1.14.13.9UniRule annotation)
Alternative name(s):
Biosynthesis of nicotinic acid protein 4UniRule annotation
Kynurenine 3-hydroxylaseUniRule annotation
Gene namesi
Name:BNA4UniRule annotation
ORF Names:CaO19.12898, CaO19.5443
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005260. orf19.5443.

Subcellular locationi

Mitochondrion outer membrane UniRule annotation

GO - Cellular componenti

  1. mitochondrial outer membrane Source: UniProtKB-KW
  2. plasma membrane Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Kynurenine 3-monooxygenasePRO_0000361924Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0005260.

Structurei

3D structure databases

ProteinModelPortaliQ5A7M3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0654.
InParanoidiQ5A7M3.
KOiK00486.
OrthoDBiEOG7QVMC6.

Family and domain databases

HAMAPiMF_01971. Kynurenine_monooxygenase.
InterProiIPR027545. Kynurenine_monooxygenase.
IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSiPR00420. RNGMNOXGNASE.

Sequencei

Sequence statusi: Complete.

Q5A7M3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEEESQKTI GIVGAGLVGC LAALAFAKKG YDVTLFEYRP DPRTVDSSKR
60 70 80 90 100
NLRSINLAVS SRGIRALQYV DPAMADRILE HVIPMKGRMI HDITGTKQES
110 120 130 140 150
QVYGLNGESI NSIDRSFLNN CLLDELDKSN VKILFKHKLV KLDTSNACRM
160 170 180 190 200
TFIDGHNDAK TSTFDFVVGC DGAHSQFRYH LQKTMRMDYS QKYIDMQYLE
210 220 230 240 250
LYIPPSEDAN NKFSIDANHL HIWPRHNFML IALANKDGSF TSTFFSPWSV
260 270 280 290 300
IEGISSSQEF VEFFRHNFPD AVGLIGEDAL SSAFKSNPRG SLMQVSCYPY
310 320 330 340 350
SNGKGIILGD AAHSMVPFYG QGMNCGFEDV RILMELIDTN NGDIEEAFKQ
360 370 380 390 400
YSAARKNDLD AICKLALDNY YEMSSKVVDI GYLIKKKLDY TLGKIFKNKW
410 420 430 440 450
LPLYTMISFR DDIPYAKAIE IEKRQNRIMN NVGLGVLGTA AVYGLVKLGQ

YWNRRQ
Length:456
Mass (Da):51,534
Last modified:April 26, 2005 - v1
Checksum:i4374754457385ED4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000050 Genomic DNA. Translation: EAK98864.1.
AACQ01000051 Genomic DNA. Translation: EAK98764.1.
RefSeqiXP_717721.1. XM_712628.1.
XP_717815.1. XM_712722.1.

Genome annotation databases

GeneIDi3640528.
3640686.
KEGGical:CaO19.12898.
cal:CaO19.5443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000050 Genomic DNA. Translation: EAK98864.1 .
AACQ01000051 Genomic DNA. Translation: EAK98764.1 .
RefSeqi XP_717721.1. XM_712628.1.
XP_717815.1. XM_712722.1.

3D structure databases

ProteinModelPortali Q5A7M3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0005260.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3640528.
3640686.
KEGGi cal:CaO19.12898.
cal:CaO19.5443.

Organism-specific databases

CGDi CAL0005260. orf19.5443.

Phylogenomic databases

eggNOGi COG0654.
InParanoidi Q5A7M3.
KOi K00486.
OrthoDBi EOG7QVMC6.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00328 .

Family and domain databases

HAMAPi MF_01971. Kynurenine_monooxygenase.
InterProi IPR027545. Kynurenine_monooxygenase.
IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view ]
Pfami PF01494. FAD_binding_3. 1 hit.
[Graphical view ]
PRINTSi PR00420. RNGMNOXGNASE.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiKMO_CANAL
AccessioniPrimary (citable) accession number: Q5A7M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: April 26, 2005
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3