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Q5A7M3

- KMO_CANAL

UniProt

Q5A7M3 - KMO_CANAL

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Protein

Kynurenine 3-monooxygenase

Gene
BNA4, CaO19.12898, CaO19.5443
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.UniRule annotation

Catalytic activityi

L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  2. kynurenine 3-monooxygenase activity Source: CGD

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: CGD
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. cellular response to starvation Source: CGD
  4. filamentous growth Source: CGD
  5. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  6. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  7. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  8. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

UniPathwayiUPA00253; UER00328.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine 3-monooxygenase (EC:1.14.13.9)
Alternative name(s):
Biosynthesis of nicotinic acid protein 4
Kynurenine 3-hydroxylase
Gene namesi
Name:BNA4
ORF Names:CaO19.12898, CaO19.5443
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005260. orf19.5443.

Subcellular locationi

Mitochondrion outer membrane By similarity UniRule annotation

GO - Cellular componenti

  1. mitochondrial outer membrane Source: UniProtKB-SubCell
  2. plasma membrane Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Kynurenine 3-monooxygenaseUniRule annotationPRO_0000361924Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0005260.

Structurei

3D structure databases

ProteinModelPortaliQ5A7M3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0654.
KOiK00486.
OrthoDBiEOG7QVMC6.

Family and domain databases

HAMAPiMF_01971. Kynurenine_monooxygenase.
InterProiIPR027545. Kynurenine_monooxygenase.
IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSiPR00420. RNGMNOXGNASE.

Sequencei

Sequence statusi: Complete.

Q5A7M3-1 [UniParc]FASTAAdd to Basket

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MSEEESQKTI GIVGAGLVGC LAALAFAKKG YDVTLFEYRP DPRTVDSSKR    50
NLRSINLAVS SRGIRALQYV DPAMADRILE HVIPMKGRMI HDITGTKQES 100
QVYGLNGESI NSIDRSFLNN CLLDELDKSN VKILFKHKLV KLDTSNACRM 150
TFIDGHNDAK TSTFDFVVGC DGAHSQFRYH LQKTMRMDYS QKYIDMQYLE 200
LYIPPSEDAN NKFSIDANHL HIWPRHNFML IALANKDGSF TSTFFSPWSV 250
IEGISSSQEF VEFFRHNFPD AVGLIGEDAL SSAFKSNPRG SLMQVSCYPY 300
SNGKGIILGD AAHSMVPFYG QGMNCGFEDV RILMELIDTN NGDIEEAFKQ 350
YSAARKNDLD AICKLALDNY YEMSSKVVDI GYLIKKKLDY TLGKIFKNKW 400
LPLYTMISFR DDIPYAKAIE IEKRQNRIMN NVGLGVLGTA AVYGLVKLGQ 450
YWNRRQ 456
Length:456
Mass (Da):51,534
Last modified:April 26, 2005 - v1
Checksum:i4374754457385ED4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000050 Genomic DNA. Translation: EAK98864.1.
AACQ01000051 Genomic DNA. Translation: EAK98764.1.
RefSeqiXP_717721.1. XM_712628.1.
XP_717815.1. XM_712722.1.

Genome annotation databases

GeneIDi3640528.
3640686.
KEGGical:CaO19.12898.
cal:CaO19.5443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000050 Genomic DNA. Translation: EAK98864.1 .
AACQ01000051 Genomic DNA. Translation: EAK98764.1 .
RefSeqi XP_717721.1. XM_712628.1.
XP_717815.1. XM_712722.1.

3D structure databases

ProteinModelPortali Q5A7M3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0005260.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3640528.
3640686.
KEGGi cal:CaO19.12898.
cal:CaO19.5443.

Organism-specific databases

CGDi CAL0005260. orf19.5443.

Phylogenomic databases

eggNOGi COG0654.
KOi K00486.
OrthoDBi EOG7QVMC6.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00328 .

Family and domain databases

HAMAPi MF_01971. Kynurenine_monooxygenase.
InterProi IPR027545. Kynurenine_monooxygenase.
IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view ]
Pfami PF01494. FAD_binding_3. 1 hit.
[Graphical view ]
PRINTSi PR00420. RNGMNOXGNASE.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiKMO_CANAL
AccessioniPrimary (citable) accession number: Q5A7M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: April 26, 2005
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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