Reviewed, UniProtKB/Swiss-Prot Q5A7M3 (KMO_CANAL)

Names and origin

Protein names

Recommended name:
    Kynurenine 3-monooxygenase
    EC=1.14.13.9
Alternative name(s):
    Kynurenine 3-hydroxylase
    Biosynthesis of nicotinic acid protein 4

Gene names

Name:	BNA4
ORF Names:	CaO19.5443, CaO19.12898

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	456 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Mitochondrion
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	kynurenine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 456	456	Kynurenine 3-monooxygenase		PRO_0000361924

Sequences

	Sequence		Length	Mass (Da)
	Q5A7M3-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 4374754457385ED4	FASTA	456	51,534
	10 20 30 40 50 60 MSEEESQKTI GIVGAGLVGC LAALAFAKKG YDVTLFEYRP DPRTVDSSKR NLRSINLAVS 70 80 90 100 110 120 SRGIRALQYV DPAMADRILE HVIPMKGRMI HDITGTKQES QVYGLNGESI NSIDRSFLNN 130 140 150 160 170 180 CLLDELDKSN VKILFKHKLV KLDTSNACRM TFIDGHNDAK TSTFDFVVGC DGAHSQFRYH 190 200 210 220 230 240 LQKTMRMDYS QKYIDMQYLE LYIPPSEDAN NKFSIDANHL HIWPRHNFML IALANKDGSF 250 260 270 280 290 300 TSTFFSPWSV IEGISSSQEF VEFFRHNFPD AVGLIGEDAL SSAFKSNPRG SLMQVSCYPY 310 320 330 340 350 360 SNGKGIILGD AAHSMVPFYG QGMNCGFEDV RILMELIDTN NGDIEEAFKQ YSAARKNDLD 370 380 390 400 410 420 AICKLALDNY YEMSSKVVDI GYLIKKKLDY TLGKIFKNKW LPLYTMISFR DDIPYAKAIE 430 440 450 IEKRQNRIMN NVGLGVLGTA AVYGLVKLGQ YWNRRQ

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000050 Genomic DNA. Translation: EAK98864.1. AACQ01000051 Genomic DNA. Translation: EAK98764.1.
RefSeq	XP_717721.1. XP_717815.1.
3D structure databases
SMR	Q5A7M3. Positions 7-369.
ModBase	Search...
Genome annotation databases
GeneID	3640528. 3640686.
KEGG	cal:CaO19.12898. cal:CaO19.5443.
Organism-specific databases
CGD	CAL0005260. orf19.5443.
Phylogenomic databases
OrthoDB	EOG9C2JSV.
PhylomeDB	Q5A7M3.
Family and domain databases
InterPro	IPR002938. mOase_FAD_bd. IPR003042. Rng_hydrolase-like. [Graphical view]
Pfam	PF01494. FAD_binding_3. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...

Entry information

Entry name

KMO_CANAL

Accession

Primary (citable) accession number: Q5A7M3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	April 26, 2005
Last modified:	January 19, 2010
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)