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Q5A7M3

- KMO_CANAL

UniProt

Q5A7M3 - KMO_CANAL

Protein

Kynurenine 3-monooxygenase

Gene

BNA4

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.UniRule annotation

    Catalytic activityi

    L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
    2. kynurenine 3-monooxygenase activity Source: CGD

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: CGD
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. cellular response to starvation Source: CGD
    4. filamentous growth Source: CGD
    5. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
    6. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
    7. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    8. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00328.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kynurenine 3-monooxygenaseUniRule annotation (EC:1.14.13.9UniRule annotation)
    Alternative name(s):
    Biosynthesis of nicotinic acid protein 4UniRule annotation
    Kynurenine 3-hydroxylaseUniRule annotation
    Gene namesi
    Name:BNA4UniRule annotation
    ORF Names:CaO19.12898, CaO19.5443
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0005260. orf19.5443.

    Subcellular locationi

    Mitochondrion outer membrane UniRule annotation

    GO - Cellular componenti

    1. mitochondrial outer membrane Source: UniProtKB-SubCell
    2. plasma membrane Source: CGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 456456Kynurenine 3-monooxygenasePRO_0000361924Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0005260.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5A7M3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aromatic-ring hydroxylase family. KMO subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0654.
    KOiK00486.
    OrthoDBiEOG7QVMC6.

    Family and domain databases

    HAMAPiMF_01971. Kynurenine_monooxygenase.
    InterProiIPR027545. Kynurenine_monooxygenase.
    IPR002938. mOase_FAD-bd.
    IPR003042. Rng_hydrolase-like.
    [Graphical view]
    PfamiPF01494. FAD_binding_3. 1 hit.
    [Graphical view]
    PRINTSiPR00420. RNGMNOXGNASE.

    Sequencei

    Sequence statusi: Complete.

    Q5A7M3-1 [UniParc]FASTAAdd to Basket

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    MSEEESQKTI GIVGAGLVGC LAALAFAKKG YDVTLFEYRP DPRTVDSSKR    50
    NLRSINLAVS SRGIRALQYV DPAMADRILE HVIPMKGRMI HDITGTKQES 100
    QVYGLNGESI NSIDRSFLNN CLLDELDKSN VKILFKHKLV KLDTSNACRM 150
    TFIDGHNDAK TSTFDFVVGC DGAHSQFRYH LQKTMRMDYS QKYIDMQYLE 200
    LYIPPSEDAN NKFSIDANHL HIWPRHNFML IALANKDGSF TSTFFSPWSV 250
    IEGISSSQEF VEFFRHNFPD AVGLIGEDAL SSAFKSNPRG SLMQVSCYPY 300
    SNGKGIILGD AAHSMVPFYG QGMNCGFEDV RILMELIDTN NGDIEEAFKQ 350
    YSAARKNDLD AICKLALDNY YEMSSKVVDI GYLIKKKLDY TLGKIFKNKW 400
    LPLYTMISFR DDIPYAKAIE IEKRQNRIMN NVGLGVLGTA AVYGLVKLGQ 450
    YWNRRQ 456
    Length:456
    Mass (Da):51,534
    Last modified:April 26, 2005 - v1
    Checksum:i4374754457385ED4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000050 Genomic DNA. Translation: EAK98864.1.
    AACQ01000051 Genomic DNA. Translation: EAK98764.1.
    RefSeqiXP_717721.1. XM_712628.1.
    XP_717815.1. XM_712722.1.

    Genome annotation databases

    GeneIDi3640528.
    3640686.
    KEGGical:CaO19.12898.
    cal:CaO19.5443.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000050 Genomic DNA. Translation: EAK98864.1 .
    AACQ01000051 Genomic DNA. Translation: EAK98764.1 .
    RefSeqi XP_717721.1. XM_712628.1.
    XP_717815.1. XM_712722.1.

    3D structure databases

    ProteinModelPortali Q5A7M3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0005260.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3640528.
    3640686.
    KEGGi cal:CaO19.12898.
    cal:CaO19.5443.

    Organism-specific databases

    CGDi CAL0005260. orf19.5443.

    Phylogenomic databases

    eggNOGi COG0654.
    KOi K00486.
    OrthoDBi EOG7QVMC6.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00328 .

    Family and domain databases

    HAMAPi MF_01971. Kynurenine_monooxygenase.
    InterProi IPR027545. Kynurenine_monooxygenase.
    IPR002938. mOase_FAD-bd.
    IPR003042. Rng_hydrolase-like.
    [Graphical view ]
    Pfami PF01494. FAD_binding_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00420. RNGMNOXGNASE.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiKMO_CANAL
    AccessioniPrimary (citable) accession number: Q5A7M3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3