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Q5A6T5 (STE7_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase STE7 homolog

EC=2.7.12.2
Gene names
Name:HST7
Synonyms:STE7
ORF Names:CaO19.469, CaO19.8100
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length589 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processMAPK cascade

Inferred from genetic interaction PubMed 8544826PubMed 8917571PubMed 8917572PubMed 9596738. Source: CGD

MAPK cascade involved in conjugation with cellular fusion

Inferred from mutant phenotype PubMed 12453220. Source: CGD

activation of MAPK activity

Inferred from mutant phenotype PubMed 15817773. Source: GOC

cellular hyperosmotic response

Inferred from mutant phenotype PubMed 15817773. Source: CGD

cellular response to drug

Inferred from mutant phenotype PubMed 20140194. Source: CGD

cellular response to osmotic stress

Inferred from mutant phenotype PubMed 15817773. Source: CGD

cellular response to starvation

Inferred from mutant phenotype PubMed 8917572PubMed 9259554PubMed 9596738. Source: CGD

chlamydospore formation

Inferred from mutant phenotype PubMed 16002645. Source: CGD

development of symbiont in host

Inferred from mutant phenotype PubMed 10816502PubMed 9259554. Source: CGD

establishment or maintenance of cell polarity

Inferred from mutant phenotype PubMed 9259554. Source: CGD

filamentous growth

Inferred from mutant phenotype PubMed 15817773PubMed 8917572PubMed 9259554PubMed 9596738. Source: CGD

filamentous growth of a population of unicellular organisms

Inferred from mutant phenotype PubMed 11722734PubMed 12581351PubMed 8917571. Source: CGD

filamentous growth of a population of unicellular organisms in response to biotic stimulus

Inferred from mutant phenotype PubMed 9259554. Source: CGD

filamentous growth of a population of unicellular organisms in response to starvation

Inferred from mutant phenotype PubMed 8917571PubMed 8917572PubMed 9259554PubMed 9596738. Source: CGD

fungal-type cell wall organization

Inferred from mutant phenotype PubMed 15817773PubMed 16467475. Source: CGD

parasexual conjugation with cellular fusion

Inferred from mutant phenotype PubMed 12453219. Source: CGD

pathogenesis

Inferred from mutant phenotype PubMed 12381467PubMed 9259554. Source: CGD

positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus

Inferred from mutant phenotype PubMed 9259554. Source: CGD

positive regulation of filamentous growth of a population of unicellular organisms in response to starvation

Inferred from mutant phenotype PubMed 8917572PubMed 9259554PubMed 9596738. Source: CGD

positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 12581351. Source: CGD

protein phosphorylation

Inferred from mutant phenotype PubMed 15817773PubMed 16467475. Source: CGD

regulation of pseudohyphal growth

Inferred from genetic interaction PubMed 12581351. Source: CGD

stress-activated protein kinase signaling cascade

Inferred from mutant phenotype PubMed 15817773. Source: CGD

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

MAP kinase kinase activity

Inferred from mutant phenotype PubMed 15817773. Source: CGD

protein serine/threonine kinase activity

Inferred from genetic interaction PubMed 9259554. Source: CGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 589589Serine/threonine-protein kinase STE7 homolog
PRO_0000413042

Regions

Domain249 – 565317Protein kinase
Nucleotide binding255 – 2639ATP By similarity

Sites

Active site3741Proton acceptor By similarity
Binding site2781ATP By similarity

Amino acid modifications

Modified residue4021Phosphoserine By similarity
Modified residue4081Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5A6T5 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: CC2CAD1BEE25A186

FASTA58965,246
        10         20         30         40         50         60 
MTRTTRIDTQ EATKHKDLPP VPSPLSLSSN PNPECLMESK SLGRKNFKKL SLDASPVKST 

        70         80         90        100        110        120 
SGSLRSSDMM SIKEPTSLRQ KRQRPPPILH LPTASSSATS TPTSNITGSS SASSIQFAQK 

       130        140        150        160        170        180 
SPGSGVIVSQ TLSRPSSAGG IPSSGYSSLN VNQSNRNVDP DNVVSTDMIL NQISNLDLTS 

       190        200        210        220        230        240 
MNHHRQHYQN SHHHLPTTNR KRQTVISSIS PTKSSAASSP LEPQIQSLPA SSQSPIATTS 

       250        260        270        280        290        300 
ALKLNNKDLL TLKQLGSGNS GSVSKILHIP TQKTMAKKII HIDSKSVIQT QIIRELRILH 

       310        320        330        340        350        360 
ECHSPYIIEF YGACLNNNNT IVICMEYCNC GSLDKILPLC ENKQFPTFVL KKLSFAILSG 

       370        380        390        400        410        420 
LTYLYTTHKI IHRDIKPNNV LMTHKGEFKL CDFGVSRELT NSLVMADTFV GTSMYMSPER 

       430        440        450        460        470        480 
IQGLDYGVKS DVWSTGLMLI ELASGVPVWS EDDNNNDDDE DDEDDAYVRQ GSIAAERNGQ 

       490        500        510        520        530        540 
NSPSRSRKNK QKGNGYNSYN GPEGILDLLQ RIVNEDAPTL TNKINPVTKL PYDKYLCQFI 

       550        560        570        580 
DLCLIKDDSV RKTPWQLLED KEHFFKGVEE GVYDKEHKSW AKKIRKCKV 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000055 Genomic DNA. Translation: EAK98363.1.
AACQ01000054 Genomic DNA. Translation: EAK98456.1.
RefSeqXP_717333.1. XM_712240.1.
XP_717423.1. XM_712330.1.

3D structure databases

ProteinModelPortalQ5A6T5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid1224047. 4 interactions.
STRING5476.CAL0005777.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3640873.
3640953.
KEGGcal:CaO19.469.
cal:CaO19.8100.

Organism-specific databases

CGDCAL0005777. HST7.

Phylogenomic databases

KOK11226.
OrthoDBEOG7380F1.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSTE7_CANAL
AccessionPrimary (citable) accession number: Q5A6T5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names