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Protein

Autophagy-related protein 22

Gene

ATG22

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May be required for lysis of autophagic vesicles after delivery to the vacuole.By similarity

GO - Molecular functioni

  1. transporter activity Source: GO_Central

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
  2. ion transmembrane transport Source: GO_Central
  3. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 22
Gene namesi
Name:ATG22
ORF Names:CaO19.552, CaO19.8187
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000232. orf19.552.

Subcellular locationi

  1. Vacuole membrane By similarity; Multi-pass membrane protein By similarity

  2. Note: Vacuole and punctate structures.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei108 – 12821HelicalSequence AnalysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence AnalysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence AnalysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence AnalysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence AnalysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence AnalysisAdd
BLAST
Transmembranei339 – 35921HelicalSequence AnalysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence AnalysisAdd
BLAST
Transmembranei438 – 45821HelicalSequence AnalysisAdd
BLAST
Transmembranei467 – 48721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of fungal-type vacuolar membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Autophagy-related protein 22PRO_0000207619Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG22 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146046.
InParanoidiQ5A6K2.
OrthoDBiEOG7F7WJP.

Family and domain databases

InterProiIPR024671. Atg22-like.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF11700. ATG22. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5A6K2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVNHNHISN TSVNNSEDVL EAQDEISNDN NKNQESIWNK KSIFHTWLLL
60 70 80 90 100
CYSTGPVASM SRTYIPASIQ SIAKNVGKTK MNQPCGTQGN DCYVKFGFMT
110 120 130 140 150
VHHTSYVLYL RAVSTAIEGV VAIFLMGIAD YSNYRKSFLI FSILVYGFLA
160 170 180 190 200
LPFIGLTNND YQTLVLASIL YSLLIIDDSI YQILEGSYIP LFMRADKKNP
210 220 230 240 250
MQRGSVVAVL GLFLGNLGGI TALVIGIIIS YLSGTPESKG YHNFLLAITI
260 270 280 290 300
AGCLTIGLSL FSALYIPNVQ GKQRIDNFLV LPFKRFFNLL KDIQKYPMAF
310 320 330 340 350
LYCISWVIWN VSFNNFMSMF LLLFRSTLGL GNSDAEYTVY TFMSYICSSW
360 370 380 390 400
GSLLWMFLYQ KWNSNIKYWG YSFLSVSLLA NFWGCLGIHK LTPLGYQNRW
410 420 430 440 450
EFWVFEVFYS ATSSAMRSLN RCVYSSLLPE GNEAQYFGLE VTLGIASGWI
460 470 480 490 500
GGLVNAVIQD RTNDDRFPFL PNMFLVVVSL IVYYYVDLQK GKNDVNNGNS
Length:500
Mass (Da):56,532
Last modified:April 26, 2005 - v1
Checksum:i83F4934EBB6958FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000055 Genomic DNA. Translation: EAK98446.1.
AACQ01000054 Genomic DNA. Translation: EAK98543.1.
RefSeqiXP_717415.1. XM_712322.1.
XP_717509.1. XM_712416.1.

Genome annotation databases

GeneIDi3640918.
3640951.
KEGGical:CaO19.552.
cal:CaO19.8187.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000055 Genomic DNA. Translation: EAK98446.1.
AACQ01000054 Genomic DNA. Translation: EAK98543.1.
RefSeqiXP_717415.1. XM_712322.1.
XP_717509.1. XM_712416.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3640918.
3640951.
KEGGical:CaO19.552.
cal:CaO19.8187.

Organism-specific databases

CGDiCAL0000232. orf19.552.

Phylogenomic databases

eggNOGiNOG146046.
InParanoidiQ5A6K2.
OrthoDBiEOG7F7WJP.

Family and domain databases

InterProiIPR024671. Atg22-like.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF11700. ATG22. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiATG22_CANAL
AccessioniPrimary (citable) accession number: Q5A6K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: April 26, 2005
Last modified: February 4, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.