Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5A692

- TRMB_CANAL

UniProt

Q5A692 - TRMB_CANAL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

TRM8

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei122 – 1221S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei219 – 2191S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Active sitei222 – 2221UniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
  2. tRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
Transfer RNA methyltransferase 8UniRule annotation
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:TRM8UniRule annotation
ORF Names:CaO19.11279, CaO19.3798
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001314. orf19.3798.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325tRNA (guanine-N(7)-)-methyltransferasePRO_0000370591Add
BLAST

Interactioni

Subunit structurei

Forms a complex with TRM82.UniRule annotation

Protein-protein interaction databases

STRINGi5476.CAL0001314.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni145 – 1462S-adenosyl-L-methionine bindingUniRule annotation
Regioni199 – 2002S-adenosyl-L-methionine bindingUniRule annotation
Regioni297 – 2993S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
InParanoidiQ5A692.
KOiK03439.
OrthoDBiEOG708W9T.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5A692-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEATDKQEQ VSAETPLERD LKSKQQSIAA TKRKQYRDDK SQIRKQARFE
60 70 80 90 100
VSTTPEPEQS DSSATTATIT ELPKKRYYRQ RAHSNPFSDH RLEYPKSPES
110 120 130 140 150
MDWSNLYPKQ YDISKVEIAD IGCGYGGLMI KLGPQFPKSL ILGLEIRVQV
160 170 180 190 200
TQYVEDRIIA LRKNQEIING KKKKESGGGT GDGDDNDYSY QNIAVLRGNA
210 220 230 240 250
MKFLPNFFVK GQLSKMFFCF PDPHFKQRKH KARIITNTLL SEYAYVLREG
260 270 280 290 300
GVVYTITDVE DLHNWMVKHL DEHPLFERLS KEWEDQDKCV EIMYNATEEG
310 320
QKVTRNKGSK WVACYKRLPS PDDCE
Length:325
Mass (Da):37,537
Last modified:May 5, 2009 - v2
Checksum:iAF55D2784BB9FAA9
GO

Sequence cautioni

The sequence EAK98229.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence EAK98306.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000057 Genomic DNA. Translation: EAK98229.1. Different initiation.
AACQ01000056 Genomic DNA. Translation: EAK98306.1. Different initiation.
RefSeqiXP_717203.1. XM_712110.1.
XP_717279.1. XM_712186.1.

Genome annotation databases

GeneIDi3641083.
3641112.
KEGGical:CaO19.11279.
cal:CaO19.3798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000057 Genomic DNA. Translation: EAK98229.1 . Different initiation.
AACQ01000056 Genomic DNA. Translation: EAK98306.1 . Different initiation.
RefSeqi XP_717203.1. XM_712110.1.
XP_717279.1. XM_712186.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0001314.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3641083.
3641112.
KEGGi cal:CaO19.11279.
cal:CaO19.3798.

Organism-specific databases

CGDi CAL0001314. orf19.3798.

Phylogenomic databases

eggNOGi COG0220.
InParanoidi Q5A692.
KOi K03439.
OrthoDBi EOG708W9T.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiTRMB_CANAL
AccessioniPrimary (citable) accession number: Q5A692
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3