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Q5A692

- TRMB_CANAL

UniProt

Q5A692 - TRMB_CANAL

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
TRM8, CaO19.11279, CaO19.3798
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei122 – 1221S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei219 – 2191S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Active sitei222 – 2221 By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
  2. tRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
Transfer RNA methyltransferase 8
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:TRM8
ORF Names:CaO19.11279, CaO19.3798
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001314. orf19.3798.

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000370591Add
BLAST

Interactioni

Subunit structurei

Forms a complex with TRM82 By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi5476.CAL0001314.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni145 – 1462S-adenosyl-L-methionine binding By similarity
Regioni199 – 2002S-adenosyl-L-methionine binding By similarity
Regioni297 – 2993S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
KOiK03439.
OrthoDBiEOG708W9T.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5A692-1 [UniParc]FASTAAdd to Basket

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MSEATDKQEQ VSAETPLERD LKSKQQSIAA TKRKQYRDDK SQIRKQARFE    50
VSTTPEPEQS DSSATTATIT ELPKKRYYRQ RAHSNPFSDH RLEYPKSPES 100
MDWSNLYPKQ YDISKVEIAD IGCGYGGLMI KLGPQFPKSL ILGLEIRVQV 150
TQYVEDRIIA LRKNQEIING KKKKESGGGT GDGDDNDYSY QNIAVLRGNA 200
MKFLPNFFVK GQLSKMFFCF PDPHFKQRKH KARIITNTLL SEYAYVLREG 250
GVVYTITDVE DLHNWMVKHL DEHPLFERLS KEWEDQDKCV EIMYNATEEG 300
QKVTRNKGSK WVACYKRLPS PDDCE 325
Length:325
Mass (Da):37,537
Last modified:May 5, 2009 - v2
Checksum:iAF55D2784BB9FAA9
GO

Sequence cautioni

The sequence EAK98229.1 differs from that shown. Reason: Erroneous initiation.
The sequence EAK98306.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000057 Genomic DNA. Translation: EAK98229.1. Different initiation.
AACQ01000056 Genomic DNA. Translation: EAK98306.1. Different initiation.
RefSeqiXP_717203.1. XM_712110.1.
XP_717279.1. XM_712186.1.

Genome annotation databases

GeneIDi3641083.
3641112.
KEGGical:CaO19.11279.
cal:CaO19.3798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000057 Genomic DNA. Translation: EAK98229.1 . Different initiation.
AACQ01000056 Genomic DNA. Translation: EAK98306.1 . Different initiation.
RefSeqi XP_717203.1. XM_712110.1.
XP_717279.1. XM_712186.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0001314.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3641083.
3641112.
KEGGi cal:CaO19.11279.
cal:CaO19.3798.

Organism-specific databases

CGDi CAL0001314. orf19.3798.

Phylogenomic databases

eggNOGi COG0220.
KOi K03439.
OrthoDBi EOG708W9T.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiTRMB_CANAL
AccessioniPrimary (citable) accession number: Q5A692
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: June 11, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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