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Q5A692

- TRMB_CANAL

UniProt

Q5A692 - TRMB_CANAL

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

TRM8

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei122 – 1221S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Binding sitei219 – 2191S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Active sitei222 – 2221UniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
    2. tRNA binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine, tRNA-binding

    Enzyme and pathway databases

    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    Transfer RNA methyltransferase 8UniRule annotation
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:TRM8UniRule annotation
    ORF Names:CaO19.11279, CaO19.3798
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0001314. orf19.3798.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325tRNA (guanine-N(7)-)-methyltransferasePRO_0000370591Add
    BLAST

    Interactioni

    Subunit structurei

    Forms a complex with TRM82.UniRule annotation

    Protein-protein interaction databases

    STRINGi5476.CAL0001314.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni145 – 1462S-adenosyl-L-methionine bindingUniRule annotation
    Regioni199 – 2002S-adenosyl-L-methionine bindingUniRule annotation
    Regioni297 – 2993S-adenosyl-L-methionine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    KOiK03439.
    OrthoDBiEOG708W9T.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR025763. Trm8_euk.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 2 hits.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5A692-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEATDKQEQ VSAETPLERD LKSKQQSIAA TKRKQYRDDK SQIRKQARFE    50
    VSTTPEPEQS DSSATTATIT ELPKKRYYRQ RAHSNPFSDH RLEYPKSPES 100
    MDWSNLYPKQ YDISKVEIAD IGCGYGGLMI KLGPQFPKSL ILGLEIRVQV 150
    TQYVEDRIIA LRKNQEIING KKKKESGGGT GDGDDNDYSY QNIAVLRGNA 200
    MKFLPNFFVK GQLSKMFFCF PDPHFKQRKH KARIITNTLL SEYAYVLREG 250
    GVVYTITDVE DLHNWMVKHL DEHPLFERLS KEWEDQDKCV EIMYNATEEG 300
    QKVTRNKGSK WVACYKRLPS PDDCE 325
    Length:325
    Mass (Da):37,537
    Last modified:May 5, 2009 - v2
    Checksum:iAF55D2784BB9FAA9
    GO

    Sequence cautioni

    The sequence EAK98229.1 differs from that shown. Reason: Erroneous initiation.
    The sequence EAK98306.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000057 Genomic DNA. Translation: EAK98229.1. Different initiation.
    AACQ01000056 Genomic DNA. Translation: EAK98306.1. Different initiation.
    RefSeqiXP_717203.1. XM_712110.1.
    XP_717279.1. XM_712186.1.

    Genome annotation databases

    GeneIDi3641083.
    3641112.
    KEGGical:CaO19.11279.
    cal:CaO19.3798.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000057 Genomic DNA. Translation: EAK98229.1 . Different initiation.
    AACQ01000056 Genomic DNA. Translation: EAK98306.1 . Different initiation.
    RefSeqi XP_717203.1. XM_712110.1.
    XP_717279.1. XM_712186.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0001314.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3641083.
    3641112.
    KEGGi cal:CaO19.11279.
    cal:CaO19.3798.

    Organism-specific databases

    CGDi CAL0001314. orf19.3798.

    Phylogenomic databases

    eggNOGi COG0220.
    KOi K03439.
    OrthoDBi EOG708W9T.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR025763. Trm8_euk.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 2 hits.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiTRMB_CANAL
    AccessioniPrimary (citable) accession number: Q5A692
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3