Q5A5S7 (ATG27_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Autophagy-related protein 27

Gene names

Name:	ATG27
ORF Names:	CaO19.5322, CaO19.12782

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Regulates the cytoplasm to vacuole transport (Cvt) vesicle formation By similarity.
Subcellular location	Cytoplasmic vesicle membrane; Single-pass type I membrane protein By similarity. Golgi apparatus membrane; Single-pass type I membrane protein By similarity. Mitochondrion membrane; Single-pass membrane protein By similarity. Note: Cycles among the pre-autophagosomal structure (PAS), mitochondria and Golgi By similarity.
Sequence similarities	Belongs to the ATG27 family.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasmic vesicle Golgi apparatus Membrane Mitochondrion
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 252	237	Autophagy-related protein 27		PRO_0000001775
Regions
	Topological domain	16 – 176	161	Lumenal Potential
	Transmembrane	177 – 197	21	Helical; Potential
	Topological domain	198 – 252	55	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	49	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5A5S7 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 6BBA16F1A4FF4133	FASTA	252	28,278
	10 20 30 40 50 60 MILASLLTFA TAALAFDCSD KELERYNFES IKGVHSYTTL KNTPPSQTNV TWNVGICQPI 70 80 90 100 110 120 SAIKDCPANS DICGVTSILR KDEKPVVSEV VSFKSDLQKA YESSDNGIKV IYKGANWGDV 130 140 150 160 170 180 LVNAELNFQC DKDSQNNEFT LDQWDGTNLK LSMKTKAACI TSKEDKKKEK HDNGESWGWF 190 200 210 220 230 240 TWIFIFLVLF LSIYIIGGAW FQYNKGNAID FQSALKEVVE NFIELLKGLP SFGKEIIEKF 250 TGRSNRGEYS AV

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000058 Genomic DNA. Translation: EAK98150.1. AACQ01000059 Genomic DNA. Translation: EAK98069.1.
RefSeq	XP_717046.1. XM_711953.1. XP_717125.1. XM_712032.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5A5S7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3641196. 3641264.
KEGG	cal:CaO19.12782. cal:CaO19.5322.
Organism-specific databases
CGD	CAL0004278. orf19.5322.
Phylogenomic databases
PhylomeDB	Q5A5S7.
Family and domain databases
InterPro	IPR018939. Autophagy-rel_prot_27. IPR009011. Man6P_isomerase_rcpt-bd. [Graphical view]
Pfam	PF09451. ATG27. 1 hit. [Graphical view]
SUPFAM	SSF50911. Man6php_recept. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ATG27_CANAL

Accession

Primary (citable) accession number: Q5A5S7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program