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Protein
Submitted name:

Dihydrofolate reductase

Gene

DFR1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • dihydrofolate reductase activity Source: CGD
  • drug binding Source: CGD
  • NADP binding Source: InterPro

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Dihydrofolate reductaseImported
Gene namesi
Name:DFR1Imported
Ordered Locus Names:orf19.5142Imported
ORF Names:CAALFM_C703130CAImported
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)Imported
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 7

Organism-specific databases

CGDiCAL0000177250. DFR1.

Structurei

3D structure databases

ProteinModelPortaliQ5A5E0.
SMRiQ5A5E0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dihydrofolate reductase family.UniRule annotation

Phylogenomic databases

KOiK00287.
OrthoDBiEOG092C4LJX.

Family and domain databases

CDDicd00209. DHFR. 1 hit.
Gene3Di3.40.430.10. 1 hit.
InterProiView protein in InterPro
IPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
PfamiView protein in Pfam
PF00186. DHFR_1. 1 hit.
PRINTSiPR00070. DHFR.
SUPFAMiSSF53597. SSF53597. 1 hit.
PROSITEiView protein in PROSITE
PS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5A5E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPNVAIIV AALKPALGIG YKGKMPWRLR KEIRYFKDVT TRTTKPNTRN
60 70 80 90 100
AVIMGRKTWE SIPQKFRPLP DRLNIILSRS YENEIIDDNI IHASSIESSL
110 120 130 140 150
NLVSDVERVF IIGGAEIYNE LINNSLVSHL LITEIEHPSP ESIEMDTFLK
160 170 180 190
FPLESWTKQP KSELQKFVGD TVLEDDIKEG DFTYNYTLWT RK
Length:192
Mass (Da):22,139
Last modified:April 26, 2005 - v1
Checksum:i28E3B406B0AA0021
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017629 Genomic DNA. Translation: AOW30658.1.
RefSeqiXP_716965.1. XM_711872.2.

Genome annotation databases

EnsemblFungiiKHC71984; KHC71984; W5Q_05343.
KHC79841; KHC79841; I503_05307.
GeneIDi3641348.
KEGGical:CAALFM_C703130CA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017629 Genomic DNA. Translation: AOW30658.1.
RefSeqiXP_716965.1. XM_711872.2.

3D structure databases

ProteinModelPortaliQ5A5E0.
SMRiQ5A5E0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiKHC71984; KHC71984; W5Q_05343.
KHC79841; KHC79841; I503_05307.
GeneIDi3641348.
KEGGical:CAALFM_C703130CA.

Organism-specific databases

CGDiCAL0000177250. DFR1.

Phylogenomic databases

KOiK00287.
OrthoDBiEOG092C4LJX.

Family and domain databases

CDDicd00209. DHFR. 1 hit.
Gene3Di3.40.430.10. 1 hit.
InterProiView protein in InterPro
IPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
PfamiView protein in Pfam
PF00186. DHFR_1. 1 hit.
PRINTSiPR00070. DHFR.
SUPFAMiSSF53597. SSF53597. 1 hit.
PROSITEiView protein in PROSITE
PS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5A5E0_CANAL
AccessioniPrimary (citable) accession number: Q5A5E0
Secondary accession number(s): Q3MP43
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: June 7, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.