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Protein

Transcription factor SKN7

Gene

SKN7

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Transcription factor that is the final receptor of the SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to oxidative stress and probably to changes in the osmolarity of the extracellular environment.

GO - Molecular functioni

GO - Biological processi

  • cellular response to oxidative stress Source: CGD
  • cellular response to starvation Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  • phosphorelay signal transduction system Source: CGD
  • positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • positive regulation of filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Stress response, Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SKN7
Gene namesi
Name:SKN7
ORF Names:CaO19.8586, CaO19.971
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000174257. SKN7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Leads to sensitivity to H2O2 in vitro, but only mildly attenuated virulence.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Transcription factor SKN7PRO_0000425801Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei474 – 47414-aspartylphosphatePROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by the phosphorelay intermediate protein YPD1.By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5A4X5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini425 – 539115Response regulatoryPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili158 – 19639Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi344 – 3518Poly-Pro
Compositional biasi357 – 3648Poly-Pro

Sequence similaritiesi

Belongs to the SKN7 family.Curated
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiQ5A4X5.
KOiK15859.
OrthoDBiEOG092C2G9O.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR014402. Sig_transdc_resp-reg_Skn7.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10015. PTHR10015. 2 hits.
PfamiPF00447. HSF_DNA-bind. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF002595. RR_SKN7. 1 hit.
PRINTSiPR00056. HSFDOMAIN.
SMARTiSM00415. HSF. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS00434. HSF_DOMAIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5A4X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLQQPIPP NSTLATTASS NQSGSNDFVK KLFLMLQEDS YKEVVRWTVK
60 70 80 90 100
GDSFVVINTN EFTKDILPKH FKHSNFASFV RQLNKYDFHK VKISNEAKAS
110 120 130 140 150
YPYGEDAWEF KHPEFRINDA EALENIKRKG PTAKKSASNV TIKTEANNNG
160 170 180 190 200
TQPTCNHNYS QLVSATNHLK EQVESLKNDK HSLYQEISVL ERKYKTVVEN
210 220 230 240 250
IVAINTFNER YYRSMNVLIN SIVQNGMKLP PLDFPPPVQL GPDSGIGSNL
260 270 280 290 300
GPISSDTALP SISHHLSSPL PHHQQLLNRT IRPISSPIDG IPLVKLQQQS
310 320 330 340 350
LGQNLQAPIG TPSAVPFSEE ASSSIQAATP APLAQPVAQP INQPPPPPPP
360 370 380 390 400
PATQQQPLPP PPPPATATSQ IPSAPPPPTQ QQVGTSSSSV PTISPKSQGI
410 420 430 440 450
VVSNSASPTT SAQISTTSVP NPKFHVLLVE DDNVCIQLCR KFLVKYGCSV
460 470 480 490 500
TVVTDGLNAI STVEHTKYDL VLMDIVMPNL DGATATSVIR SFDTKTPIIA
510 520 530 540 550
MTGNIEDNDL VTYLQNGMSD ILAKPFTKDD LYAILSKHLL DPKENKQDNE

PTVKKQKLS
Length:559
Mass (Da):61,058
Last modified:April 26, 2005 - v1
Checksum:i90FECE66BC208EBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000063 Genomic DNA. Translation: EAK97823.1.
AACQ01000062 Genomic DNA. Translation: EAK97884.1.
RefSeqiXP_716809.1. XM_711716.1.
XP_716869.1. XM_711776.1.

Genome annotation databases

EnsemblFungiiEAK97823; EAK97823; CaO19.971.
EAK97884; EAK97884; CaO19.8586.
GeneIDi3641499.
3641563.
KEGGical:CaO19.8586.
cal:CaO19.971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000063 Genomic DNA. Translation: EAK97823.1.
AACQ01000062 Genomic DNA. Translation: EAK97884.1.
RefSeqiXP_716809.1. XM_711716.1.
XP_716869.1. XM_711776.1.

3D structure databases

ProteinModelPortaliQ5A4X5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK97823; EAK97823; CaO19.971.
EAK97884; EAK97884; CaO19.8586.
GeneIDi3641499.
3641563.
KEGGical:CaO19.8586.
cal:CaO19.971.

Organism-specific databases

CGDiCAL0000174257. SKN7.

Phylogenomic databases

InParanoidiQ5A4X5.
KOiK15859.
OrthoDBiEOG092C2G9O.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR014402. Sig_transdc_resp-reg_Skn7.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10015. PTHR10015. 2 hits.
PfamiPF00447. HSF_DNA-bind. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF002595. RR_SKN7. 1 hit.
PRINTSiPR00056. HSFDOMAIN.
SMARTiSM00415. HSF. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS00434. HSF_DOMAIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSKN7_CANAL
AccessioniPrimary (citable) accession number: Q5A4X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 19, 2014
Last sequence update: April 26, 2005
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.