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Protein

Transcription factor SKN7

Gene

SKN7

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Transcription factor that is the final receptor of the SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to oxidative stress and probably to changes in the osmolarity of the extracellular environment.

GO - Molecular functioni

GO - Biological processi

  • cellular response to oxidative stress Source: CGD
  • cellular response to starvation Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  • phosphorelay signal transduction system Source: CGD
  • positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • positive regulation of filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processStress response, Transcription, Transcription regulation, Two-component regulatory system

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SKN7
Gene namesi
Name:SKN7
Ordered Locus Names:CAALFM_C500240WA
ORF Names:CaO19.8586, CaO19.971
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 5

Organism-specific databases

CGDiCAL0000174257. SKN7.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Leads to sensitivity to H2O2 in vitro, but only mildly attenuated virulence.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004258011 – 559Transcription factor SKN7Add BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4744-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by the phosphorelay intermediate protein YPD1.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5A4X5.

Structurei

3D structure databases

ProteinModelPortaliQ5A4X5.
SMRiQ5A4X5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini425 – 539Response regulatoryPROSITE-ProRule annotationAdd BLAST115

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili158 – 196Sequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi344 – 351Poly-Pro8
Compositional biasi357 – 364Poly-Pro8

Sequence similaritiesi

Belongs to the SKN7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiQ5A4X5.
KOiK15859.
OrthoDBiEOG092C2G9O.

Family and domain databases

CDDicd00156. REC. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR011006. CheY-like_superfamily.
IPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR014402. Sig_transdc_resp-reg_Skn7.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR10015. PTHR10015. 1 hit.
PTHR10015:SF207. PTHR10015:SF207. 1 hit.
PfamiView protein in Pfam
PF00447. HSF_DNA-bind. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF002595. RR_SKN7. 1 hit.
PRINTSiPR00056. HSFDOMAIN.
SMARTiView protein in SMART
SM00415. HSF. 1 hit.
SM00448. REC. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiView protein in PROSITE
PS00434. HSF_DOMAIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5A4X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLQQPIPP NSTLATTASS NQSGSNDFVK KLFLMLQEDS YKEVVRWTVK
60 70 80 90 100
GDSFVVINTN EFTKDILPKH FKHSNFASFV RQLNKYDFHK VKISNEAKAS
110 120 130 140 150
YPYGEDAWEF KHPEFRINDA EALENIKRKG PTAKKSASNV TIKTEANNNG
160 170 180 190 200
TQPTCNHNYS QLVSATNHLK EQVESLKNDK HSLYQEISVL ERKYKTVVEN
210 220 230 240 250
IVAINTFNER YYRSMNVLIN SIVQNGMKLP PLDFPPPVQL GPDSGIGSNL
260 270 280 290 300
GPISSDTALP SISHHLSSPL PHHQQLLNRT IRPISSPIDG IPLVKLQQQS
310 320 330 340 350
LGQNLQAPIG TPSAVPFSEE ASSSIQAATP APLAQPVAQP INQPPPPPPP
360 370 380 390 400
PATQQQPLPP PPPPATATSQ IPSAPPPPTQ QQVGTSSSSV PTISPKSQGI
410 420 430 440 450
VVSNSASPTT SAQISTTSVP NPKFHVLLVE DDNVCIQLCR KFLVKYGCSV
460 470 480 490 500
TVVTDGLNAI STVEHTKYDL VLMDIVMPNL DGATATSVIR SFDTKTPIIA
510 520 530 540 550
MTGNIEDNDL VTYLQNGMSD ILAKPFTKDD LYAILSKHLL DPKENKQDNE

PTVKKQKLS
Length:559
Mass (Da):61,058
Last modified:April 26, 2005 - v1
Checksum:i90FECE66BC208EBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017627 Genomic DNA. Translation: AOW29470.1.
RefSeqiXP_716809.1. XM_711716.1.

Genome annotation databases

GeneIDi3641563.
KEGGical:CAALFM_C500240WA.

Similar proteinsi

Entry informationi

Entry nameiSKN7_CANAL
AccessioniPrimary (citable) accession number: Q5A4X5
Secondary accession number(s): A0A1D8PMV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 19, 2014
Last sequence update: April 26, 2005
Last modified: August 30, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families