Reviewed, UniProtKB/Swiss-Prot Q5A4Q1 (KAD12_CANAL)

Names and origin

Protein names

Recommended name:
    Adenylate kinase 1-2
      Short name=AK 1 2
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 1 2
    Adenylate kinase cytosolic and mitochondrial 2

Gene names

Name:	ADK1-2
ORF Names:	CaO19.3391, CaO19.10894

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	249 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in cytoplasm and mitochondrion intermembrane space By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 249	249	Adenylate kinase 1-2		PRO_0000365667
Regions
	Nucleotide binding	40 – 48	9	ATP By similarity
	Nucleotide binding	63 – 92	30	AMP By similarity
Sites
	Binding site	64	1	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5A4Q1-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: C4D4BFA4EE9BB1CC	FASTA	249	27,596
	10 20 30 40 50 60 MSIEDLKNTV TKLQERIQEL EKKAGIIPDV PKSVRMVLIG PPGSGKGTQA PNLKEKFCAC 70 80 90 100 110 120 HLATGDMLRA QVAAKTALGV EAKKIMDQGG LVSDEIMVNM IKSELENNQE CSKGFILDGF 130 140 150 160 170 180 PRTIPQAEKL DSMLESRKTP LEKAVELKID DELLVARITG RLVHPASGRS YHKLFNPPKK 190 200 210 220 230 240 DMTDDVTGEP LVQRSDDNED ALKKRLVTYH KQTEPIVAYY QKTGIWSGVD ASQKPTKVWS DILKCLGQN

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000064 Genomic DNA. Translation: EAK97710.1. AACQ01000065 Genomic DNA. Translation: EAK97646.1.
RefSeq	XP_716641.1. XP_716701.1.
3D structure databases
SMR	Q5A4Q1. Positions 32-249.
ModBase	Search...
Genome annotation databases
GeneID	3641596. 3641655.
KEGG	cal:CaO19.10894. cal:CaO19.3391.
Organism-specific databases
CGD	CAL0004216. ADK1.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_Znf_lid. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
ProDom	PD000657. Adenylate_kin. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD12_CANAL

Accession

Primary (citable) accession number: Q5A4Q1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	April 26, 2005
Last modified:	June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)