Protein PBN1 - Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

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Q5A4J4 (PBN1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 45. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein PBN1

Gene names

Name:	PBN1
ORF Names:	CaO19.10951, CaO19.3447

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida ›

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14 By similarity.
Pathway	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type III membrane protein By similarity.
Sequence similarities	Belongs to the PIGX family.
Sequence caution	The sequence EAK97766.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	GPI-anchor biosynthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	GPI anchor biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

489

Protein PBN1

PRO_0000246301

Regions

Topological domain

459

Lumenal Potential

Transmembrane

21

Helical; Potential

Topological domain

9

Cytoplasmic Potential

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

1

I → T in allele CaO19.3447.

Natural variant

1

K → E in allele CaO19.3447.

Natural variant

6

Missing in allele CaO19.3447.

Natural variant

1

D → E in allele CaO19.3447.

Natural variant

1

M → I in allele CaO19.3447.

Natural variant

1

M → I in allele CaO19.3447.

Natural variant

1

D → G in allele CaO19.3447.

Sequences

Sequence

Length

Mass (Da)

Tools

Q5A4J4 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 12B00A79A0BC4EEC
Show »

489

56,565

        10         20         30         40         50         60 
MRQRTTIYNP YSSHDGIITN LNRTNFQLSS IPNHLFTIEN KYTITITTTQ PNKSSLYSAI 

        70         80         90        100        110        120 
KELRIQTKFN NNESGIPIFS FHYKPGLNIY AVPQSNVDKL EFWQQVEQLI MELLGIKLSS 

       130        140        150        160        170        180 
QQWIANVNSF YYHDIQPQPL LNLNLNLNLK EGWKFNLHPK SNYDYIYNQD KIIIRELLTN 

       190        200        210        220        230        240 
VSEIEFNLES GIYKEIGLFL IDDKISTNDD LNLSGIRVIL DEDSNTNNKE ESIHKTMFHI 

       250        260        270        280        290        300 
KPRHRSFDDS TTITTTKIIP QGLHPILSTE LNTTTIVMPT DFDVEECKFY YYLNLNKSLI 

       310        320        330        340        350        360 
FDQFQNIPIG SQLIINNGNK NLELPEYKIN QWGNELLFEF EFDNDNDIPH HINLTVHSRY 

       370        380        390        400        410        420 
QLPQNNHSHS HSQISNVLNS LPNIFMGCNV KEGNLLDKSP FDTKRDVKIG GNYEIYFTED 

       430        440        450        460        470        480 
TVFYHLQNSD NSDNSGSSTL LEINIPHGKT TFDRVNNITS LGLLIGVLMI LYAISIRVFM 


STTSKTKRD

References

[1]

"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000064 Genomic DNA. Translation: EAK97766.1. Sequence problems. AACQ01000065 Genomic DNA. Translation: EAK97703.1.
RefSeq	XP_716695.1. XM_711602.1. XP_716754.1. XM_711661.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0004996.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3641607. 3641704.
KEGG	cal:CaO19.10951. cal:CaO19.3447.
Organism-specific databases
CGD	CAL0067292. orf19.10951.
Phylogenomic databases
eggNOG	NOG86258.
Enzyme and pathway databases
UniPathway	UPA00196.
Family and domain databases
InterPro	IPR013233. PIG-X/PBN1. [Graphical view]
Pfam	PF08320. PIG-X. 1 hit. [Graphical view]
SMART	SM00780. PIG-X. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PBN1_CANAL

Accession

Primary (citable) accession number: Q5A4J4
Secondary accession number(s): Q5A4Q8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Candida albicans

Candida albicans: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents