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Q5A4J4

- PBN1_CANAL

UniProt

Q5A4J4 - PBN1_CANAL

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Protein

Protein PBN1

Gene

PBN1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14 (By similarity).By similarity

Pathwayi

GO - Biological processi

  1. GPI anchor biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PBN1
Gene namesi
Name:PBN1
ORF Names:CaO19.10951, CaO19.3447
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0067292. orf19.10951.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Protein PBN1PRO_0000246301Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi366 – 3661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0004996.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 459459LumenalSequence AnalysisAdd
BLAST
Topological domaini481 – 4899CytoplasmicSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei460 – 48021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGX family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG86258.
InParanoidiQ5A4J4.
OrthoDBiEOG783N68.

Family and domain databases

InterProiIPR013233. PIG-X/PBN1.
[Graphical view]
PfamiPF08320. PIG-X. 1 hit.
[Graphical view]
SMARTiSM00780. PIG-X. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5A4J4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRQRTTIYNP YSSHDGIITN LNRTNFQLSS IPNHLFTIEN KYTITITTTQ
60 70 80 90 100
PNKSSLYSAI KELRIQTKFN NNESGIPIFS FHYKPGLNIY AVPQSNVDKL
110 120 130 140 150
EFWQQVEQLI MELLGIKLSS QQWIANVNSF YYHDIQPQPL LNLNLNLNLK
160 170 180 190 200
EGWKFNLHPK SNYDYIYNQD KIIIRELLTN VSEIEFNLES GIYKEIGLFL
210 220 230 240 250
IDDKISTNDD LNLSGIRVIL DEDSNTNNKE ESIHKTMFHI KPRHRSFDDS
260 270 280 290 300
TTITTTKIIP QGLHPILSTE LNTTTIVMPT DFDVEECKFY YYLNLNKSLI
310 320 330 340 350
FDQFQNIPIG SQLIINNGNK NLELPEYKIN QWGNELLFEF EFDNDNDIPH
360 370 380 390 400
HINLTVHSRY QLPQNNHSHS HSQISNVLNS LPNIFMGCNV KEGNLLDKSP
410 420 430 440 450
FDTKRDVKIG GNYEIYFTED TVFYHLQNSD NSDNSGSSTL LEINIPHGKT
460 470 480
TFDRVNNITS LGLLIGVLMI LYAISIRVFM STTSKTKRD
Length:489
Mass (Da):56,565
Last modified:April 26, 2005 - v1
Checksum:i12B00A79A0BC4EEC
GO

Sequence cautioni

The sequence EAK97766.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461I → T in allele CaO19.3447.
Natural varianti84 – 841K → E in allele CaO19.3447.
Natural varianti141 – 1466Missing in allele CaO19.3447.
Natural varianti203 – 2031D → E in allele CaO19.3447.
Natural varianti278 – 2781M → I in allele CaO19.3447.
Natural varianti386 – 3861M → I in allele CaO19.3447.
Natural varianti433 – 4331D → G in allele CaO19.3447.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000064 Genomic DNA. Translation: EAK97766.1. Sequence problems.
AACQ01000065 Genomic DNA. Translation: EAK97703.1.
RefSeqiXP_716695.1. XM_711602.1.
XP_716754.1. XM_711661.1.

Genome annotation databases

GeneIDi3641607.
3641704.
KEGGical:CaO19.10951.
cal:CaO19.3447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000064 Genomic DNA. Translation: EAK97766.1 . Sequence problems.
AACQ01000065 Genomic DNA. Translation: EAK97703.1 .
RefSeqi XP_716695.1. XM_711602.1.
XP_716754.1. XM_711661.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0004996.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3641607.
3641704.
KEGGi cal:CaO19.10951.
cal:CaO19.3447.

Organism-specific databases

CGDi CAL0067292. orf19.10951.

Phylogenomic databases

eggNOGi NOG86258.
InParanoidi Q5A4J4.
OrthoDBi EOG783N68.

Enzyme and pathway databases

UniPathwayi UPA00196 .

Family and domain databases

InterProi IPR013233. PIG-X/PBN1.
[Graphical view ]
Pfami PF08320. PIG-X. 1 hit.
[Graphical view ]
SMARTi SM00780. PIG-X. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiPBN1_CANAL
AccessioniPrimary (citable) accession number: Q5A4J4
Secondary accession number(s): Q5A4Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3