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Protein

Protein PBN1

Gene

PBN1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14 (By similarity).By similarity

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Biological processi

Keywordsi

Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PBN1
Gene namesi
Name:PBN1
Ordered Locus Names:CAALFM_C601370WA
ORF Names:CaO19.10951, CaO19.3447
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 6

Organism-specific databases

CGDiCAL0000174087. C6_01370W_A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 451LumenalSequence analysisAdd BLAST451
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Topological domaini473 – 481CytoplasmicSequence analysis9

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002463011 – 481Protein PBN1Add BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22N-linked (GlcNAc...)PROSITE-ProRule annotation1
Glycosylationi52N-linked (GlcNAc...)PROSITE-ProRule annotation1
Glycosylationi72N-linked (GlcNAc...)PROSITE-ProRule annotation1
Glycosylationi174N-linked (GlcNAc...)PROSITE-ProRule annotation1
Glycosylationi206N-linked (GlcNAc...)PROSITE-ProRule annotation1
Glycosylationi266N-linked (GlcNAc...)PROSITE-ProRule annotation1
Glycosylationi290N-linked (GlcNAc...)PROSITE-ProRule annotation1
Glycosylationi347N-linked (GlcNAc...)PROSITE-ProRule annotation1
Glycosylationi360N-linked (GlcNAc...)PROSITE-ProRule annotation1
Glycosylationi449N-linked (GlcNAc...)PROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5A4J4.

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGX family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ5A4J4.
OrthoDBiEOG092C4TF1.

Family and domain databases

InterProiView protein in InterPro
IPR013233. PIG-X/PBN1.
PfamiView protein in Pfam
PF08320. PIG-X. 1 hit.
SMARTiView protein in SMART
SM00780. PIG-X. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5A4J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQRTTIYNP YSSHDGIITN LNRTNFQLSS IPNHLFTIEN KYTITTTTTQ
60 70 80 90 100
PNKSSLYSAI KELRIQTKFN NNESGIPIFS FHYEPGLNIY AVPQSNVDKL
110 120 130 140 150
EFWQQVEQLI MELLGIKLSS QQWIANVNSF YYHDIQPQPL LNLKEGWKFN
160 170 180 190 200
LHPKSNYDYI YNQDKIIIRE LLTNVSEIEF NLESGIYKEI GLFLIDEKIS
210 220 230 240 250
TNDDLNLSGI RVILDEDSNT NNKEESIHKT MFHIKPRHRS FDDSTTITTT
260 270 280 290 300
KIIPQGLHPI LSTELNTTTI VIPTDFDVEE CKFYYYLNLN KSLIFDQFQN
310 320 330 340 350
IPIGSQLIIN NGNKNLELPE YKINQWGNEL LFEFEFDNDN DIPHHINLTV
360 370 380 390 400
HSRYQLPQNN HSHSQISNVL NSLPNIFIGC NVKEGNLLDK SPFDTKRDVK
410 420 430 440 450
IGGNYEIYFT EDTVFYHLQN SDNSGNSGSS TLLEINIPHG KTTFDRVNNI
460 470 480
TSLGLLIGVL MILYAISIRV FMSTTSKTKR D
Length:481
Mass (Da):55,568
Last modified:March 15, 2017 - v2
Checksum:iD6651B7327A4E7B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017628 Genomic DNA. Translation: AOW30078.1.

Genome annotation databases

EnsemblFungiiEAK97703; EAK97703; CaO19.10951.
EAK97766; EAK97766; CaO19.3447.
KEGGical:CaO19.10951.
cal:CaO19.3447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017628 Genomic DNA. Translation: AOW30078.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5A4J4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK97703; EAK97703; CaO19.10951.
EAK97766; EAK97766; CaO19.3447.
KEGGical:CaO19.10951.
cal:CaO19.3447.

Organism-specific databases

CGDiCAL0000174087. C6_01370W_A.

Phylogenomic databases

InParanoidiQ5A4J4.
OrthoDBiEOG092C4TF1.

Enzyme and pathway databases

UniPathwayiUPA00196.

Family and domain databases

InterProiView protein in InterPro
IPR013233. PIG-X/PBN1.
PfamiView protein in Pfam
PF08320. PIG-X. 1 hit.
SMARTiView protein in SMART
SM00780. PIG-X. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPBN1_CANAL
AccessioniPrimary (citable) accession number: Q5A4J4
Secondary accession number(s): A0A1D8PPL2, Q5A4Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 15, 2017
Last modified: March 15, 2017
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.