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Protein

Protein PBN1

Gene

PBN1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14 (By similarity).By similarity

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PBN1
Gene namesi
Name:PBN1
ORF Names:CaO19.10951, CaO19.3447
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 459LumenalSequence analysisAdd BLAST459
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Topological domaini481 – 489CytoplasmicSequence analysis9

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002463011 – 489Protein PBN1Add BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22N-linked (GlcNAc...)Sequence analysis1
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi180N-linked (GlcNAc...)Sequence analysis1
Glycosylationi212N-linked (GlcNAc...)Sequence analysis1
Glycosylationi272N-linked (GlcNAc...)Sequence analysis1
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Glycosylationi353N-linked (GlcNAc...)Sequence analysis1
Glycosylationi366N-linked (GlcNAc...)Sequence analysis1
Glycosylationi457N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5A4J4.

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGX family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ5A4J4.
OrthoDBiEOG092C4TF1.

Family and domain databases

InterProiIPR013233. PIG-X/PBN1.
[Graphical view]
PfamiPF08320. PIG-X. 1 hit.
[Graphical view]
SMARTiSM00780. PIG-X. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5A4J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQRTTIYNP YSSHDGIITN LNRTNFQLSS IPNHLFTIEN KYTITITTTQ
60 70 80 90 100
PNKSSLYSAI KELRIQTKFN NNESGIPIFS FHYKPGLNIY AVPQSNVDKL
110 120 130 140 150
EFWQQVEQLI MELLGIKLSS QQWIANVNSF YYHDIQPQPL LNLNLNLNLK
160 170 180 190 200
EGWKFNLHPK SNYDYIYNQD KIIIRELLTN VSEIEFNLES GIYKEIGLFL
210 220 230 240 250
IDDKISTNDD LNLSGIRVIL DEDSNTNNKE ESIHKTMFHI KPRHRSFDDS
260 270 280 290 300
TTITTTKIIP QGLHPILSTE LNTTTIVMPT DFDVEECKFY YYLNLNKSLI
310 320 330 340 350
FDQFQNIPIG SQLIINNGNK NLELPEYKIN QWGNELLFEF EFDNDNDIPH
360 370 380 390 400
HINLTVHSRY QLPQNNHSHS HSQISNVLNS LPNIFMGCNV KEGNLLDKSP
410 420 430 440 450
FDTKRDVKIG GNYEIYFTED TVFYHLQNSD NSDNSGSSTL LEINIPHGKT
460 470 480
TFDRVNNITS LGLLIGVLMI LYAISIRVFM STTSKTKRD
Length:489
Mass (Da):56,565
Last modified:April 26, 2005 - v1
Checksum:i12B00A79A0BC4EEC
GO

Sequence cautioni

The sequence EAK97766 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti46I → T in allele CaO19.3447. 1
Natural varianti84K → E in allele CaO19.3447. 1
Natural varianti141 – 146Missing in allele CaO19.3447. 6
Natural varianti203D → E in allele CaO19.3447. 1
Natural varianti278M → I in allele CaO19.3447. 1
Natural varianti386M → I in allele CaO19.3447. 1
Natural varianti433D → G in allele CaO19.3447. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000064 Genomic DNA. Translation: EAK97766.1. Sequence problems.
AACQ01000065 Genomic DNA. Translation: EAK97703.1.
RefSeqiXP_716695.1. XM_711602.1.
XP_716754.1. XM_711661.1.

Genome annotation databases

EnsemblFungiiEAK97703; EAK97703; CaO19.10951.
EAK97766; EAK97766; CaO19.3447.
GeneIDi3641607.
3641704.
KEGGical:CaO19.10951.
cal:CaO19.3447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000064 Genomic DNA. Translation: EAK97766.1. Sequence problems.
AACQ01000065 Genomic DNA. Translation: EAK97703.1.
RefSeqiXP_716695.1. XM_711602.1.
XP_716754.1. XM_711661.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5A4J4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK97703; EAK97703; CaO19.10951.
EAK97766; EAK97766; CaO19.3447.
GeneIDi3641607.
3641704.
KEGGical:CaO19.10951.
cal:CaO19.3447.

Phylogenomic databases

InParanoidiQ5A4J4.
OrthoDBiEOG092C4TF1.

Enzyme and pathway databases

UniPathwayiUPA00196.

Family and domain databases

InterProiIPR013233. PIG-X/PBN1.
[Graphical view]
PfamiPF08320. PIG-X. 1 hit.
[Graphical view]
SMARTiSM00780. PIG-X. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPBN1_CANAL
AccessioniPrimary (citable) accession number: Q5A4J4
Secondary accession number(s): Q5A4Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: April 26, 2005
Last modified: October 5, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.