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Q5A4J4 (PBN1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein PBN1
Gene names
Name:PBN1
ORF Names:CaO19.10951, CaO19.3447
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14 By similarity.

Pathway

Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type III membrane protein By similarity.

Sequence similarities

Belongs to the PIGX family.

Sequence caution

The sequence EAK97766.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processGPI-anchor biosynthesis
   Cellular componentEndoplasmic reticulum
Membrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processGPI anchor biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489Protein PBN1
PRO_0000246301

Regions

Topological domain1 – 459459Lumenal Potential
Transmembrane460 – 48021Helical; Potential
Topological domain481 – 4899Cytoplasmic Potential

Amino acid modifications

Glycosylation221N-linked (GlcNAc...) Potential
Glycosylation521N-linked (GlcNAc...) Potential
Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation1801N-linked (GlcNAc...) Potential
Glycosylation2121N-linked (GlcNAc...) Potential
Glycosylation2721N-linked (GlcNAc...) Potential
Glycosylation2961N-linked (GlcNAc...) Potential
Glycosylation3531N-linked (GlcNAc...) Potential
Glycosylation3661N-linked (GlcNAc...) Potential
Glycosylation4571N-linked (GlcNAc...) Potential

Natural variations

Natural variant461I → T in allele CaO19.3447.
Natural variant841K → E in allele CaO19.3447.
Natural variant141 – 1466Missing in allele CaO19.3447.
Natural variant2031D → E in allele CaO19.3447.
Natural variant2781M → I in allele CaO19.3447.
Natural variant3861M → I in allele CaO19.3447.
Natural variant4331D → G in allele CaO19.3447.

Sequences

Sequence LengthMass (Da)Tools
Q5A4J4 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 12B00A79A0BC4EEC

FASTA48956,565
        10         20         30         40         50         60 
MRQRTTIYNP YSSHDGIITN LNRTNFQLSS IPNHLFTIEN KYTITITTTQ PNKSSLYSAI 

        70         80         90        100        110        120 
KELRIQTKFN NNESGIPIFS FHYKPGLNIY AVPQSNVDKL EFWQQVEQLI MELLGIKLSS 

       130        140        150        160        170        180 
QQWIANVNSF YYHDIQPQPL LNLNLNLNLK EGWKFNLHPK SNYDYIYNQD KIIIRELLTN 

       190        200        210        220        230        240 
VSEIEFNLES GIYKEIGLFL IDDKISTNDD LNLSGIRVIL DEDSNTNNKE ESIHKTMFHI 

       250        260        270        280        290        300 
KPRHRSFDDS TTITTTKIIP QGLHPILSTE LNTTTIVMPT DFDVEECKFY YYLNLNKSLI 

       310        320        330        340        350        360 
FDQFQNIPIG SQLIINNGNK NLELPEYKIN QWGNELLFEF EFDNDNDIPH HINLTVHSRY 

       370        380        390        400        410        420 
QLPQNNHSHS HSQISNVLNS LPNIFMGCNV KEGNLLDKSP FDTKRDVKIG GNYEIYFTED 

       430        440        450        460        470        480 
TVFYHLQNSD NSDNSGSSTL LEINIPHGKT TFDRVNNITS LGLLIGVLMI LYAISIRVFM 


STTSKTKRD 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000064 Genomic DNA. Translation: EAK97766.1. Sequence problems.
AACQ01000065 Genomic DNA. Translation: EAK97703.1.
RefSeqXP_716695.1. XM_711602.1.
XP_716754.1. XM_711661.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0004996.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3641607.
3641704.
KEGGcal:CaO19.10951.
cal:CaO19.3447.

Organism-specific databases

CGDCAL0067292. orf19.10951.

Phylogenomic databases

eggNOGNOG86258.
OrthoDBEOG783N68.

Enzyme and pathway databases

UniPathwayUPA00196.

Family and domain databases

InterProIPR013233. PIG-X/PBN1.
[Graphical view]
PfamPF08320. PIG-X. 1 hit.
[Graphical view]
SMARTSM00780. PIG-X. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePBN1_CANAL
AccessionPrimary (citable) accession number: Q5A4J4
Secondary accession number(s): Q5A4Q8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: April 26, 2005
Last modified: February 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Candida albicans

Candida albicans: entries and gene names