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Protein

RNA polymerase II holoenzyme cyclin-like subunit

Gene

SSN8

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • fungal-type cell wall organization Source: CGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Cyclin, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II holoenzyme cyclin-like subunit
Gene namesi
Name:SSN8
Ordered Locus Names:CAALFM_C305740CA
ORF Names:CaO19.7355
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 3

Organism-specific databases

CGDiCAL0000180084 SSN8
EuPathDBiFungiDB:C3_05740C_A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003142701 – 434RNA polymerase II holoenzyme cyclin-like subunitAdd BLAST434

Interactioni

Subunit structurei

Component of the SRB8-11 complex, a regulatory module of the Mediator complex.By similarity

Protein-protein interaction databases

BioGridi1224812, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ5A4H9
SMRiQ5A4H9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 155Cyclin N-terminalAdd BLAST133

Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated

Phylogenomic databases

InParanoidiQ5A4H9
KOiK15161
OMAiFWASSHY
OrthoDBiEOG092C2LUP

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
IPR028367 CyclinC/Ssn8
PANTHERiPTHR10026:SF7 PTHR10026:SF7, 1 hit
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 3 hits

Sequencei

Sequence statusi: Complete.

Q5A4H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADYWNSSQ RNQWQLTRFS LLEARRRVLL LERKMIQNGL IKDYPNIIYD
60 70 80 90 100
YNMRIYLHNL LIKLGRRLNI RQIALATAEI YLTRFLTRVS LKEINVYLLI
110 120 130 140 150
TTCIYVACKI EECPQHIRLI LSEARNIWPE YIPHDVTKLA EFEFYLIEEM
160 170 180 190 200
DSYLLLHHPY KSLMQINEFL SNNYNVFGFK LTVEELQNAW SLINDSYITD
210 220 230 240 250
LHLLLPPHTI AVAAIYITVV LKKNLSRVRQ GNNNDNNINI NTMHISTGSS
260 270 280 290 300
TNPININNNN NTNTSNNNGT TSTTTTTTAQ ETQVLGQDDN TEMNIDDLMN
310 320 330 340 350
LTKSSNNSQD KSDDKMDIDN PLQSQVNLSQ IQNQTQHQHQ ESTHNNTSST
360 370 380 390 400
NTGRNGINGQ ISQSNQELNN FDLDILDEDT IKINKFMNFL EHSHINLDEV
410 420 430
VEAVQDMMNM YVLWNRYNEQ GVKKALQVML LNRI
Length:434
Mass (Da):50,364
Last modified:April 26, 2005 - v1
Checksum:i3F5B3640BE525EE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017625 Genomic DNA Translation: AOW28583.1
RefSeqiXP_716596.1, XM_711503.1

Genome annotation databases

EnsemblFungiiAOW28583; AOW28583; CAALFM_C305740CA
GeneIDi3641718
KEGGical:CAALFM_C305740CA

Similar proteinsi

Entry informationi

Entry nameiSSN8_CANAL
AccessioniPrimary (citable) accession number: Q5A4H9
Secondary accession number(s): A0A1D8PKE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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