Q5A4H9 (SSN8_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA polymerase II holoenzyme cyclin-like subunit

Gene names

Name:	SSN8
ORF Names:	CaO19.7355

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.
Subunit structure	Component of the SRB8-11 complex, a regulatory module of the Mediator complex By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the cyclin family. Cyclin C subfamily. Contains 1 cyclin N-terminal domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Activator Cyclin Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fungal-type cell wall organization Inferred from mutant phenotype PubMed 16652171. Source: CGD regulation of cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	RNA polymerase II holoenzyme cyclin-like subunit		PRO_0000314270
Regions
	Domain	23 – 155	133	Cyclin N-terminal

Sequences

	Sequence		Length	Mass (Da)
	Q5A4H9 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 3F5B3640BE525EE9	FASTA	434	50,364
	10 20 30 40 50 60 MSADYWNSSQ RNQWQLTRFS LLEARRRVLL LERKMIQNGL IKDYPNIIYD YNMRIYLHNL 70 80 90 100 110 120 LIKLGRRLNI RQIALATAEI YLTRFLTRVS LKEINVYLLI TTCIYVACKI EECPQHIRLI 130 140 150 160 170 180 LSEARNIWPE YIPHDVTKLA EFEFYLIEEM DSYLLLHHPY KSLMQINEFL SNNYNVFGFK 190 200 210 220 230 240 LTVEELQNAW SLINDSYITD LHLLLPPHTI AVAAIYITVV LKKNLSRVRQ GNNNDNNINI 250 260 270 280 290 300 NTMHISTGSS TNPININNNN NTNTSNNNGT TSTTTTTTAQ ETQVLGQDDN TEMNIDDLMN 310 320 330 340 350 360 LTKSSNNSQD KSDDKMDIDN PLQSQVNLSQ IQNQTQHQHQ ESTHNNTSST NTGRNGINGQ 370 380 390 400 410 420 ISQSNQELNN FDLDILDEDT IKINKFMNFL EHSHINLDEV VEAVQDMMNM YVLWNRYNEQ 430 GVKKALQVML LNRI

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000066 Genomic DNA. Translation: EAK97601.1.
RefSeq	XP_716596.1. XM_711503.1.
3D structure databases
HSSP	HSSP built from PDB template 1ZP2 based on UniProtKB O94503.
ProteinModelPortal	Q5A4H9.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0004675.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3641718.
KEGG	cal:CaO19.7355.
Organism-specific databases
CGD	CAL0004675. SSN8.
Phylogenomic databases
eggNOG	COG5333.
KO	K15161.
Family and domain databases
Gene3D	1.10.472.10. 1 hit.
InterPro	IPR013763. Cyclin-like. IPR015429. Cyclin_C/H/T/L. IPR006671. Cyclin_N. [Graphical view]
PANTHER	PTHR10026. PTHR10026. 1 hit.
Pfam	PF00134. Cyclin_N. 1 hit. [Graphical view]
SMART	SM00385. CYCLIN. 1 hit. [Graphical view]
SUPFAM	SSF47954. Cyclin_like. 2 hits.
PROSITE	PS00292. CYCLINS. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SSN8_CANAL

Accession

Primary (citable) accession number: Q5A4H9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 26, 2005
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program