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Q5A4H9 (SSN8_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA polymerase II holoenzyme cyclin-like subunit
Gene names
Name:SSN8
ORF Names:CaO19.7355
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Subunit structure

Component of the SRB8-11 complex, a regulatory module of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the cyclin family. Cyclin C subfamily.

Contains 1 cyclin N-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434RNA polymerase II holoenzyme cyclin-like subunit
PRO_0000314270

Regions

Domain23 – 155133Cyclin N-terminal

Sequences

Sequence LengthMass (Da)Tools
Q5A4H9 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 3F5B3640BE525EE9

FASTA43450,364
        10         20         30         40         50         60 
MSADYWNSSQ RNQWQLTRFS LLEARRRVLL LERKMIQNGL IKDYPNIIYD YNMRIYLHNL 

        70         80         90        100        110        120 
LIKLGRRLNI RQIALATAEI YLTRFLTRVS LKEINVYLLI TTCIYVACKI EECPQHIRLI 

       130        140        150        160        170        180 
LSEARNIWPE YIPHDVTKLA EFEFYLIEEM DSYLLLHHPY KSLMQINEFL SNNYNVFGFK 

       190        200        210        220        230        240 
LTVEELQNAW SLINDSYITD LHLLLPPHTI AVAAIYITVV LKKNLSRVRQ GNNNDNNINI 

       250        260        270        280        290        300 
NTMHISTGSS TNPININNNN NTNTSNNNGT TSTTTTTTAQ ETQVLGQDDN TEMNIDDLMN 

       310        320        330        340        350        360 
LTKSSNNSQD KSDDKMDIDN PLQSQVNLSQ IQNQTQHQHQ ESTHNNTSST NTGRNGINGQ 

       370        380        390        400        410        420 
ISQSNQELNN FDLDILDEDT IKINKFMNFL EHSHINLDEV VEAVQDMMNM YVLWNRYNEQ 

       430 
GVKKALQVML LNRI 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000066 Genomic DNA. Translation: EAK97601.1.
RefSeqXP_716596.1. XM_711503.1.

3D structure databases

ProteinModelPortalQ5A4H9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid1224812. 2 interactions.
STRING5476.CAL0004675.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3641718.
KEGGcal:CaO19.7355.

Organism-specific databases

CGDCAL0004675. SSN8.

Phylogenomic databases

eggNOGCOG5333.
KOK15161.
OrthoDBEOG744TM6.

Family and domain databases

Gene3D1.10.472.10. 1 hit.
InterProIPR013763. Cyclin-like.
IPR028367. Cyclin-like_Ssn8.
IPR015429. Cyclin_C/H/T/L.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERPTHR10026. PTHR10026. 1 hit.
PTHR10026:SF47. PTHR10026:SF47. 1 hit.
PfamPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMSSF47954. SSF47954. 3 hits.
ProtoNetSearch...

Entry information

Entry nameSSN8_CANAL
AccessionPrimary (citable) accession number: Q5A4H9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 26, 2005
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names