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Q5A4H9

- SSN8_CANAL

UniProt

Q5A4H9 - SSN8_CANAL

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Protein

RNA polymerase II holoenzyme cyclin-like subunit

Gene

SSN8

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: InterPro

GO - Biological processi

  1. fungal-type cell wall organization Source: CGD
  2. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Cyclin, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II holoenzyme cyclin-like subunit
Gene namesi
Name:SSN8
ORF Names:CaO19.7355
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0004675. SSN8.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. mediator complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434RNA polymerase II holoenzyme cyclin-like subunitPRO_0000314270Add
BLAST

Interactioni

Subunit structurei

Component of the SRB8-11 complex, a regulatory module of the Mediator complex.By similarity

Protein-protein interaction databases

BioGridi1224812. 2 interactions.
STRINGi5476.CAL0004675.

Structurei

3D structure databases

ProteinModelPortaliQ5A4H9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 155133Cyclin N-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated
Contains 1 cyclin N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG5333.
InParanoidiQ5A4H9.
KOiK15161.
OrthoDBiEOG744TM6.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR028367. Cyclin-like_Ssn8.
IPR015429. Cyclin_C/H/T/L.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10026. PTHR10026. 1 hit.
PTHR10026:SF7. PTHR10026:SF7. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 3 hits.

Sequencei

Sequence statusi: Complete.

Q5A4H9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSADYWNSSQ RNQWQLTRFS LLEARRRVLL LERKMIQNGL IKDYPNIIYD
60 70 80 90 100
YNMRIYLHNL LIKLGRRLNI RQIALATAEI YLTRFLTRVS LKEINVYLLI
110 120 130 140 150
TTCIYVACKI EECPQHIRLI LSEARNIWPE YIPHDVTKLA EFEFYLIEEM
160 170 180 190 200
DSYLLLHHPY KSLMQINEFL SNNYNVFGFK LTVEELQNAW SLINDSYITD
210 220 230 240 250
LHLLLPPHTI AVAAIYITVV LKKNLSRVRQ GNNNDNNINI NTMHISTGSS
260 270 280 290 300
TNPININNNN NTNTSNNNGT TSTTTTTTAQ ETQVLGQDDN TEMNIDDLMN
310 320 330 340 350
LTKSSNNSQD KSDDKMDIDN PLQSQVNLSQ IQNQTQHQHQ ESTHNNTSST
360 370 380 390 400
NTGRNGINGQ ISQSNQELNN FDLDILDEDT IKINKFMNFL EHSHINLDEV
410 420 430
VEAVQDMMNM YVLWNRYNEQ GVKKALQVML LNRI
Length:434
Mass (Da):50,364
Last modified:April 26, 2005 - v1
Checksum:i3F5B3640BE525EE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000066 Genomic DNA. Translation: EAK97601.1.
RefSeqiXP_716596.1. XM_711503.1.

Genome annotation databases

GeneIDi3641718.
KEGGical:CaO19.7355.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000066 Genomic DNA. Translation: EAK97601.1 .
RefSeqi XP_716596.1. XM_711503.1.

3D structure databases

ProteinModelPortali Q5A4H9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1224812. 2 interactions.
STRINGi 5476.CAL0004675.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3641718.
KEGGi cal:CaO19.7355.

Organism-specific databases

CGDi CAL0004675. SSN8.

Phylogenomic databases

eggNOGi COG5333.
InParanoidi Q5A4H9.
KOi K15161.
OrthoDBi EOG744TM6.

Family and domain databases

Gene3Di 1.10.472.10. 1 hit.
InterProi IPR013763. Cyclin-like.
IPR028367. Cyclin-like_Ssn8.
IPR015429. Cyclin_C/H/T/L.
IPR006671. Cyclin_N.
[Graphical view ]
PANTHERi PTHR10026. PTHR10026. 1 hit.
PTHR10026:SF7. PTHR10026:SF7. 1 hit.
Pfami PF00134. Cyclin_N. 1 hit.
[Graphical view ]
SMARTi SM00385. CYCLIN. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 3 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiSSN8_CANAL
AccessioniPrimary (citable) accession number: Q5A4H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3