Q5A3Q0 (REXO4_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA exonuclease 4
EC=3.1.-.-

Gene names

Name:	REX4
ORF Names:	CaO19.12687, CaO19.5220

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the REXO4 family. Contains 1 exonuclease domain.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Nucleus
Molecular function	Exonuclease Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC rRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	exonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 285	285	RNA exonuclease 4		PRO_0000131692
Regions
	Domain	116 – 267	152	Exonuclease
	Compositional bias	47 – 88	42	Thr-rich

Sequences

	Sequence		Length	Mass (Da)
	Q5A3Q0 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: B861D7C31107CD6F	FASTA	285	32,210
	10 20 30 40 50 60 MAKLSQNWKK LSSKIQDKPK NGSVKKPTLK GKISKKVKAS ISEKLSTTNN TTTTTTTTTS 70 80 90 100 110 120 TTDVVPIASS TKPTATPLEY TLWTQNHTIN VSHIPKTPKP LPLSRNDSRK LDPGKYVAID 130 140 150 160 170 180 CEFVGIGKDG EESALARISI INYYGVVLLD TYVRPQERVT DWRTWVSGIQ SYHMQDAIDF 190 200 210 220 230 240 KTAQLKTMEL INNKILVGHA VNNDLDILFL SHPKSMIRDT CKFPKFREIA GGKSPSLKKL 250 260 270 280 IKHFIQVDIQ IGQHSSVEDA RATMLLFRLF KREIEQSMRN RNKRQ

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000070 Genomic DNA. Translation: EAK97357.1. AACQ01000071 Genomic DNA. Translation: EAK97293.1.
RefSeq	XP_716289.1. XM_711196.1. XP_716353.1. XM_711260.1.
3D structure databases
ProteinModelPortal	Q5A3Q0.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0003518.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3641941. 3642012.
KEGG	cal:CaO19.12687. cal:CaO19.5220.
Organism-specific databases
CGD	CAL0003518. orf19.5220.
Phylogenomic databases
eggNOG	COG0847.
KO	K01175.
Family and domain databases
InterPro	IPR006055. Exonuclease. IPR013520. Exonuclease_RNaseT/DNA_pol3. IPR012337. RNaseH-like_dom. [Graphical view]
Pfam	PF00929. RNase_T. 1 hit. [Graphical view]
SMART	SM00479. EXOIII. 1 hit. [Graphical view]
SUPFAM	SSF53098. RNaseH_fold. 1 hit.
ProtoNet	Search...

Entry information

Entry name

REXO4_CANAL

Accession

Primary (citable) accession number: Q5A3Q0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program