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Protein

RNA exonuclease 4

Gene

REX4

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity).By similarity

GO - Molecular functioni

  1. exonuclease activity Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro

GO - Biological processi

  1. rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA exonuclease 4 (EC:3.1.-.-)
Gene namesi
Name:REX4
ORF Names:CaO19.12687, CaO19.5220
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003518. orf19.5220.

Subcellular locationi

  1. Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285RNA exonuclease 4PRO_0000131692Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0003518.

Structurei

3D structure databases

ProteinModelPortaliQ5A3Q0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini116 – 267152ExonucleaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi47 – 8842Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the REXO4 family.Curated
Contains 1 exonuclease domain.Curated

Phylogenomic databases

eggNOGiCOG0847.
InParanoidiQ5A3Q0.
KOiK18327.
OrthoDBiEOG751NQ2.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR006055. Exonuclease.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5A3Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLSQNWKK LSSKIQDKPK NGSVKKPTLK GKISKKVKAS ISEKLSTTNN
60 70 80 90 100
TTTTTTTTTS TTDVVPIASS TKPTATPLEY TLWTQNHTIN VSHIPKTPKP
110 120 130 140 150
LPLSRNDSRK LDPGKYVAID CEFVGIGKDG EESALARISI INYYGVVLLD
160 170 180 190 200
TYVRPQERVT DWRTWVSGIQ SYHMQDAIDF KTAQLKTMEL INNKILVGHA
210 220 230 240 250
VNNDLDILFL SHPKSMIRDT CKFPKFREIA GGKSPSLKKL IKHFIQVDIQ
260 270 280
IGQHSSVEDA RATMLLFRLF KREIEQSMRN RNKRQ
Length:285
Mass (Da):32,210
Last modified:April 26, 2005 - v1
Checksum:iB861D7C31107CD6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000070 Genomic DNA. Translation: EAK97357.1.
AACQ01000071 Genomic DNA. Translation: EAK97293.1.
RefSeqiXP_716289.1. XM_711196.1.
XP_716353.1. XM_711260.1.

Genome annotation databases

GeneIDi3641941.
3642012.
KEGGical:CaO19.12687.
cal:CaO19.5220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000070 Genomic DNA. Translation: EAK97357.1.
AACQ01000071 Genomic DNA. Translation: EAK97293.1.
RefSeqiXP_716289.1. XM_711196.1.
XP_716353.1. XM_711260.1.

3D structure databases

ProteinModelPortaliQ5A3Q0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0003518.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3641941.
3642012.
KEGGical:CaO19.12687.
cal:CaO19.5220.

Organism-specific databases

CGDiCAL0003518. orf19.5220.

Phylogenomic databases

eggNOGiCOG0847.
InParanoidiQ5A3Q0.
KOiK18327.
OrthoDBiEOG751NQ2.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR006055. Exonuclease.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiREXO4_CANAL
AccessioniPrimary (citable) accession number: Q5A3Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: April 26, 2005
Last modified: January 7, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.