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Q5A3Q0

- REXO4_CANAL

UniProt

Q5A3Q0 - REXO4_CANAL

Protein

RNA exonuclease 4

Gene

REX4

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs By similarity.By similarity

    GO - Molecular functioni

    1. exonuclease activity Source: UniProtKB-KW
    2. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. rRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Exonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    rRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA exonuclease 4 (EC:3.1.-.-)
    Gene namesi
    Name:REX4
    ORF Names:CaO19.12687, CaO19.5220
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0003518. orf19.5220.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 285285RNA exonuclease 4PRO_0000131692Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0003518.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5A3Q0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini116 – 267152ExonucleaseAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi47 – 8842Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the REXO4 family.Curated
    Contains 1 exonuclease domain.Curated

    Phylogenomic databases

    eggNOGiCOG0847.
    KOiK18327.
    OrthoDBiEOG751NQ2.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    InterProiIPR006055. Exonuclease.
    IPR013520. Exonuclease_RNaseT/DNA_pol3.
    IPR012337. RNaseH-like_dom.
    [Graphical view]
    PfamiPF00929. RNase_T. 1 hit.
    [Graphical view]
    SMARTiSM00479. EXOIII. 1 hit.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5A3Q0-1 [UniParc]FASTAAdd to Basket

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    MAKLSQNWKK LSSKIQDKPK NGSVKKPTLK GKISKKVKAS ISEKLSTTNN    50
    TTTTTTTTTS TTDVVPIASS TKPTATPLEY TLWTQNHTIN VSHIPKTPKP 100
    LPLSRNDSRK LDPGKYVAID CEFVGIGKDG EESALARISI INYYGVVLLD 150
    TYVRPQERVT DWRTWVSGIQ SYHMQDAIDF KTAQLKTMEL INNKILVGHA 200
    VNNDLDILFL SHPKSMIRDT CKFPKFREIA GGKSPSLKKL IKHFIQVDIQ 250
    IGQHSSVEDA RATMLLFRLF KREIEQSMRN RNKRQ 285
    Length:285
    Mass (Da):32,210
    Last modified:April 26, 2005 - v1
    Checksum:iB861D7C31107CD6F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000070 Genomic DNA. Translation: EAK97357.1.
    AACQ01000071 Genomic DNA. Translation: EAK97293.1.
    RefSeqiXP_716289.1. XM_711196.1.
    XP_716353.1. XM_711260.1.

    Genome annotation databases

    GeneIDi3641941.
    3642012.
    KEGGical:CaO19.12687.
    cal:CaO19.5220.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000070 Genomic DNA. Translation: EAK97357.1 .
    AACQ01000071 Genomic DNA. Translation: EAK97293.1 .
    RefSeqi XP_716289.1. XM_711196.1.
    XP_716353.1. XM_711260.1.

    3D structure databases

    ProteinModelPortali Q5A3Q0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0003518.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3641941.
    3642012.
    KEGGi cal:CaO19.12687.
    cal:CaO19.5220.

    Organism-specific databases

    CGDi CAL0003518. orf19.5220.

    Phylogenomic databases

    eggNOGi COG0847.
    KOi K18327.
    OrthoDBi EOG751NQ2.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    InterProi IPR006055. Exonuclease.
    IPR013520. Exonuclease_RNaseT/DNA_pol3.
    IPR012337. RNaseH-like_dom.
    [Graphical view ]
    Pfami PF00929. RNase_T. 1 hit.
    [Graphical view ]
    SMARTi SM00479. EXOIII. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53098. SSF53098. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiREXO4_CANAL
    AccessioniPrimary (citable) accession number: Q5A3Q0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3