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Protein

RNA exonuclease 4

Gene

REX4

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease
Biological processrRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA exonuclease 4 (EC:3.1.-.-)
Gene namesi
Name:REX4
Ordered Locus Names:CAALFM_C112440WA
ORF Names:CaO19.12687, CaO19.5220
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000191259 orf19.5220

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001316921 – 285RNA exonuclease 4Add BLAST285

Proteomic databases

PRIDEiQ5A3Q0

Structurei

3D structure databases

ProteinModelPortaliQ5A3Q0
SMRiQ5A3Q0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 267ExonucleaseAdd BLAST152

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi47 – 88Thr-richAdd BLAST42

Sequence similaritiesi

Belongs to the REXO4 family.Curated

Phylogenomic databases

InParanoidiQ5A3Q0
KOiK18327
OMAiREKVTDW
OrthoDBiEOG092C2R0D

Family and domain databases

CDDicd06144 REX4_like, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR037431 REX4_DEDDh_dom
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF00929 RNase_T, 1 hit
SMARTiView protein in SMART
SM00479 EXOIII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

Sequencei

Sequence statusi: Complete.

Q5A3Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLSQNWKK LSSKIQDKPK NGSVKKPTLK GKISKKVKAS ISEKLSTTNN
60 70 80 90 100
TTTTTTTTTS TTDVVPIASS TKPTATPLEY TLWTQNHTIN VSHIPKTPKP
110 120 130 140 150
LPLSRNDSRK LDPGKYVAID CEFVGIGKDG EESALARISI INYYGVVLLD
160 170 180 190 200
TYVRPQERVT DWRTWVSGIQ SYHMQDAIDF KTAQLKTMEL INNKILVGHA
210 220 230 240 250
VNNDLDILFL SHPKSMIRDT CKFPKFREIA GGKSPSLKKL IKHFIQVDIQ
260 270 280
IGQHSSVEDA RATMLLFRLF KREIEQSMRN RNKRQ
Length:285
Mass (Da):32,210
Last modified:April 26, 2005 - v1
Checksum:iB861D7C31107CD6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA Translation: AOW26861.1
RefSeqiXP_716289.1, XM_711196.2

Genome annotation databases

EnsemblFungiiAOW26861; AOW26861; CAALFM_C112440WA
GeneIDi3642012
KEGGical:CAALFM_C112440WA

Similar proteinsi

Entry informationi

Entry nameiREXO4_CANAL
AccessioniPrimary (citable) accession number: Q5A3Q0
Secondary accession number(s): A0A1D8PFD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health