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Protein

RNA exonuclease 4

Gene

REX4

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease
Biological processrRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA exonuclease 4 (EC:3.1.-.-)
Gene namesi
Name:REX4
Ordered Locus Names:CAALFM_C112440WA
ORF Names:CaO19.12687, CaO19.5220
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000191259. orf19.5220.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001316921 – 285RNA exonuclease 4Add BLAST285

Proteomic databases

PRIDEiQ5A3Q0.

Structurei

3D structure databases

ProteinModelPortaliQ5A3Q0.
SMRiQ5A3Q0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 267ExonucleaseAdd BLAST152

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi47 – 88Thr-richAdd BLAST42

Sequence similaritiesi

Belongs to the REXO4 family.Curated

Phylogenomic databases

InParanoidiQ5A3Q0.
KOiK18327.
OrthoDBiEOG092C2R0D.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiView protein in InterPro
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR034920. Rex4.
IPR012337. RNaseH-like_dom.
PANTHERiPTHR12801:SF97. PTHR12801:SF97. 1 hit.
PfamiView protein in Pfam
PF00929. RNase_T. 1 hit.
SMARTiView protein in SMART
SM00479. EXOIII. 1 hit.
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5A3Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLSQNWKK LSSKIQDKPK NGSVKKPTLK GKISKKVKAS ISEKLSTTNN
60 70 80 90 100
TTTTTTTTTS TTDVVPIASS TKPTATPLEY TLWTQNHTIN VSHIPKTPKP
110 120 130 140 150
LPLSRNDSRK LDPGKYVAID CEFVGIGKDG EESALARISI INYYGVVLLD
160 170 180 190 200
TYVRPQERVT DWRTWVSGIQ SYHMQDAIDF KTAQLKTMEL INNKILVGHA
210 220 230 240 250
VNNDLDILFL SHPKSMIRDT CKFPKFREIA GGKSPSLKKL IKHFIQVDIQ
260 270 280
IGQHSSVEDA RATMLLFRLF KREIEQSMRN RNKRQ
Length:285
Mass (Da):32,210
Last modified:April 26, 2005 - v1
Checksum:iB861D7C31107CD6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA. Translation: AOW26861.1.
RefSeqiXP_716289.1. XM_711196.2.

Genome annotation databases

GeneIDi3642012.
KEGGical:CAALFM_C112440WA.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiREXO4_CANAL
AccessioniPrimary (citable) accession number: Q5A3Q0
Secondary accession number(s): A0A1D8PFD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: April 26, 2005
Last modified: June 7, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families