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Q5A3Q0 (REXO4_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA exonuclease 4

EC=3.1.-.-
Gene names
Name:REX4
ORF Names:CaO19.12687, CaO19.5220
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the REXO4 family.

Contains 1 exonuclease domain.

Ontologies

Keywords
   Biological processrRNA processing
   Cellular componentNucleus
   Molecular functionExonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processrRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionexonuclease activity

Inferred from electronic annotation. Source: UniProtKB-KW

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285RNA exonuclease 4
PRO_0000131692

Regions

Domain116 – 267152Exonuclease
Compositional bias47 – 8842Thr-rich

Sequences

Sequence LengthMass (Da)Tools
Q5A3Q0 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: B861D7C31107CD6F

FASTA28532,210
        10         20         30         40         50         60 
MAKLSQNWKK LSSKIQDKPK NGSVKKPTLK GKISKKVKAS ISEKLSTTNN TTTTTTTTTS 

        70         80         90        100        110        120 
TTDVVPIASS TKPTATPLEY TLWTQNHTIN VSHIPKTPKP LPLSRNDSRK LDPGKYVAID 

       130        140        150        160        170        180 
CEFVGIGKDG EESALARISI INYYGVVLLD TYVRPQERVT DWRTWVSGIQ SYHMQDAIDF 

       190        200        210        220        230        240 
KTAQLKTMEL INNKILVGHA VNNDLDILFL SHPKSMIRDT CKFPKFREIA GGKSPSLKKL 

       250        260        270        280 
IKHFIQVDIQ IGQHSSVEDA RATMLLFRLF KREIEQSMRN RNKRQ 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000070 Genomic DNA. Translation: EAK97357.1.
AACQ01000071 Genomic DNA. Translation: EAK97293.1.
RefSeqXP_716289.1. XM_711196.1.
XP_716353.1. XM_711260.1.

3D structure databases

ProteinModelPortalQ5A3Q0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0003518.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3641941.
3642012.
KEGGcal:CaO19.12687.
cal:CaO19.5220.

Organism-specific databases

CGDCAL0003518. orf19.5220.

Phylogenomic databases

eggNOGCOG0847.
KOK01175.
OrthoDBEOG751NQ2.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
InterProIPR006055. Exonuclease.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamPF00929. RNase_T. 1 hit.
[Graphical view]
SMARTSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMSSF53098. SSF53098. 1 hit.
ProtoNetSearch...

Entry information

Entry nameREXO4_CANAL
AccessionPrimary (citable) accession number: Q5A3Q0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names