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Q5A368

- NTE1_CANAL

UniProt

Q5A368 - NTE1_CANAL

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Protein

Lysophospholipase NTE1

Gene
NTE1, CaO19.13754, CaO19.6396
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1114 – 11141 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi577 – 701125cNMP 1Add
BLAST
Nucleotide bindingi697 – 821125cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. pathogenesis Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:CaO19.13754, CaO19.6396
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001431. orf19.6396.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919Cytoplasmic By similarityAdd
BLAST
Transmembranei20 – 4021Helical; Reviewed predictionAdd
BLAST
Topological domaini41 – 6525Lumenal By similarityAdd
BLAST
Transmembranei66 – 8621Helical; Reviewed predictionAdd
BLAST
Topological domaini87 – 13861300Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13861386Lysophospholipase NTE1PRO_0000295314Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0001431.

Structurei

3D structure databases

ProteinModelPortaliQ5A368.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1081 – 1245165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1112 – 11165GXSXG

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
KOiK14676.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 4 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5A368-1 [UniParc]FASTAAdd to Basket

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MGPEFEDSIP LVHSDNRTTT IYSVYIIISD IFSFVQWLLF KVLNLIIIDS     50
PAFVLRLLSK NFEINLHLSS ILATLIGVSV VTYLVIRYKF LTGYSHSNDQ 100
KEGAGKKGIH PASSKVFVGK SKQDKKPSNY LDEFLLAIKV FGYLDKAVFH 150
ELTKSMTTQK LSHEEILCLD ESLGFSIVVE GVAQVYTKKS KENSSKYKQR 200
YFEEIEEERD EFLILGDKQY QLLNEVKSGA PLSSLFSTLD LFRPRNKNEE 250
MALTPNDEDG NSVVALNMDY LSKSEPATDS KLSNSDDDEN GQDYPEIIVR 300
PKKSHNNGTI TIAIIPHTAF ERVQSKYPKA TSHIVTMVLT RLYKVTMSTV 350
QNYLGLTSEI LKSEIKLNEE NATSLPRYFV DGLLERLNKK EEAEAEAENL 400
PKKLKHHHRN QLQRTTSRYV SLDSKVKSNH PGDLLSSVPI SRSEFQKKVL 450
PKSSTTSLSD GDNKRMNFTD EMEETEENSL RVAIIENIFK MVGIEETNGI 500
VERTGYFQSL SSSTSSSIVG LDSLNQSIMS GATTPTTKRS HPVFNNQGSL 550
MNTINLAELR KPSTAENSTL PKLSGKKRLL SDMNIKDAFA KSLEIKYIGP 600
DSTIVSQNSA ITGLYYVIDG SLEIYNRSAD VSAPNRYIYT VESGGIAGYL 650
TSVVGFRSMV TIKTPKKTGA VVAYIPKNDY NKLLDKYYFL QLPVALKLKN 700
LLSKQILTID YALEWCHIPA GEVLCSQGDL ANGFHVVLSG RFRVVRSTNK 750
NTEKEDVEVL GEYGHGESIG EVEVLTASRR SNTLIAVRDS ETARIPRSLF 800
EMLSNENPSI MVSVSRLVAS KVLASQYQPR ERNFITSTTS QESFTSANYK 850
TITILPTVSG LPVRQFAEKL VQALRQIGRN VIALDQASIL THLGRHAFDE 900
SLARLKLSGY FAYLEEEYET IVYICDTPVQ SNWTSTCISQ GDCILLLADA 950
EDDSTTIGEY EQLLVKLKTT ARTDLCLLHQ DKVVRAGSTS PWLKNRIWVQ 1000
GHHHIQMKFE QGANVLPHKK SFISDLAAKL SQNKAIKSTF EATKQHIKWY 1050
VKENDQSKVL KIYKDDFMRL ARILSNEAVG LVLGGGGSRG ISHVGVVTSL 1100
ERHGIPVDII GGTSIGSFVG GLYAKEYNIV SIYAMAKKFS KRISSVWRML 1150
FDLTYPVTSY ITGYEFNRGI WKVFGFAEIE DFWIKYFCNS ANITNSTMDI 1200
HEKGYAWRFI RASMSLAGLL PPIAFNGCML LDGGYLDNLP VNEMKKRGVK 1250
HIIAVDVGSV DDRTPMNYGD TLSGFWVLLN RWNPFSSHPN IPTMMDIQMR 1300
LTYVSSVNAL EEAKRTPGVY YLRPPIDPYA TLDFGKFDEI YKVGLKYADD 1350
LFADWKSKGK FPRIAGLVEK KKDGEEKKIL YRRNSI 1386
Length:1,386
Mass (Da):155,704
Last modified:April 26, 2005 - v1
Checksum:i30459D16F3477170
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000073 Genomic DNA. Translation: EAK97150.1.
AACQ01000072 Genomic DNA. Translation: EAK97237.1.
RefSeqiXP_716153.1. XM_711060.1.
XP_716236.1. XM_711143.1.

Genome annotation databases

GeneIDi3642076.
3642210.
KEGGical:CaO19.13754.
cal:CaO19.6396.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000073 Genomic DNA. Translation: EAK97150.1 .
AACQ01000072 Genomic DNA. Translation: EAK97237.1 .
RefSeqi XP_716153.1. XM_711060.1.
XP_716236.1. XM_711143.1.

3D structure databases

ProteinModelPortali Q5A368.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0001431.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3642076.
3642210.
KEGGi cal:CaO19.13754.
cal:CaO19.6396.

Organism-specific databases

CGDi CAL0001431. orf19.6396.

Phylogenomic databases

eggNOGi COG0664.
KOi K14676.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 4 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 2 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiNTE1_CANAL
AccessioniPrimary (citable) accession number: Q5A368
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: April 26, 2005
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi