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Q5A368

- NTE1_CANAL

UniProt

Q5A368 - NTE1_CANAL

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Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1114 – 11141By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi577 – 701125cNMP 1Add
BLAST
Nucleotide bindingi697 – 821125cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. pathogenesis Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:CaO19.13754, CaO19.6396
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001431. orf19.6396.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13861386Lysophospholipase NTE1PRO_0000295314Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0001431.

Structurei

3D structure databases

ProteinModelPortaliQ5A368.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicBy similarityAdd
BLAST
Topological domaini41 – 6525LumenalBy similarityAdd
BLAST
Topological domaini87 – 13861300CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Transmembranei66 – 8621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1081 – 1245165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1112 – 11165GXSXG

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
InParanoidiQ5A368.
KOiK14676.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 4 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5A368-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPEFEDSIP LVHSDNRTTT IYSVYIIISD IFSFVQWLLF KVLNLIIIDS
60 70 80 90 100
PAFVLRLLSK NFEINLHLSS ILATLIGVSV VTYLVIRYKF LTGYSHSNDQ
110 120 130 140 150
KEGAGKKGIH PASSKVFVGK SKQDKKPSNY LDEFLLAIKV FGYLDKAVFH
160 170 180 190 200
ELTKSMTTQK LSHEEILCLD ESLGFSIVVE GVAQVYTKKS KENSSKYKQR
210 220 230 240 250
YFEEIEEERD EFLILGDKQY QLLNEVKSGA PLSSLFSTLD LFRPRNKNEE
260 270 280 290 300
MALTPNDEDG NSVVALNMDY LSKSEPATDS KLSNSDDDEN GQDYPEIIVR
310 320 330 340 350
PKKSHNNGTI TIAIIPHTAF ERVQSKYPKA TSHIVTMVLT RLYKVTMSTV
360 370 380 390 400
QNYLGLTSEI LKSEIKLNEE NATSLPRYFV DGLLERLNKK EEAEAEAENL
410 420 430 440 450
PKKLKHHHRN QLQRTTSRYV SLDSKVKSNH PGDLLSSVPI SRSEFQKKVL
460 470 480 490 500
PKSSTTSLSD GDNKRMNFTD EMEETEENSL RVAIIENIFK MVGIEETNGI
510 520 530 540 550
VERTGYFQSL SSSTSSSIVG LDSLNQSIMS GATTPTTKRS HPVFNNQGSL
560 570 580 590 600
MNTINLAELR KPSTAENSTL PKLSGKKRLL SDMNIKDAFA KSLEIKYIGP
610 620 630 640 650
DSTIVSQNSA ITGLYYVIDG SLEIYNRSAD VSAPNRYIYT VESGGIAGYL
660 670 680 690 700
TSVVGFRSMV TIKTPKKTGA VVAYIPKNDY NKLLDKYYFL QLPVALKLKN
710 720 730 740 750
LLSKQILTID YALEWCHIPA GEVLCSQGDL ANGFHVVLSG RFRVVRSTNK
760 770 780 790 800
NTEKEDVEVL GEYGHGESIG EVEVLTASRR SNTLIAVRDS ETARIPRSLF
810 820 830 840 850
EMLSNENPSI MVSVSRLVAS KVLASQYQPR ERNFITSTTS QESFTSANYK
860 870 880 890 900
TITILPTVSG LPVRQFAEKL VQALRQIGRN VIALDQASIL THLGRHAFDE
910 920 930 940 950
SLARLKLSGY FAYLEEEYET IVYICDTPVQ SNWTSTCISQ GDCILLLADA
960 970 980 990 1000
EDDSTTIGEY EQLLVKLKTT ARTDLCLLHQ DKVVRAGSTS PWLKNRIWVQ
1010 1020 1030 1040 1050
GHHHIQMKFE QGANVLPHKK SFISDLAAKL SQNKAIKSTF EATKQHIKWY
1060 1070 1080 1090 1100
VKENDQSKVL KIYKDDFMRL ARILSNEAVG LVLGGGGSRG ISHVGVVTSL
1110 1120 1130 1140 1150
ERHGIPVDII GGTSIGSFVG GLYAKEYNIV SIYAMAKKFS KRISSVWRML
1160 1170 1180 1190 1200
FDLTYPVTSY ITGYEFNRGI WKVFGFAEIE DFWIKYFCNS ANITNSTMDI
1210 1220 1230 1240 1250
HEKGYAWRFI RASMSLAGLL PPIAFNGCML LDGGYLDNLP VNEMKKRGVK
1260 1270 1280 1290 1300
HIIAVDVGSV DDRTPMNYGD TLSGFWVLLN RWNPFSSHPN IPTMMDIQMR
1310 1320 1330 1340 1350
LTYVSSVNAL EEAKRTPGVY YLRPPIDPYA TLDFGKFDEI YKVGLKYADD
1360 1370 1380
LFADWKSKGK FPRIAGLVEK KKDGEEKKIL YRRNSI
Length:1,386
Mass (Da):155,704
Last modified:April 26, 2005 - v1
Checksum:i30459D16F3477170
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000073 Genomic DNA. Translation: EAK97150.1.
AACQ01000072 Genomic DNA. Translation: EAK97237.1.
RefSeqiXP_716153.1. XM_711060.1.
XP_716236.1. XM_711143.1.

Genome annotation databases

GeneIDi3642076.
3642210.
KEGGical:CaO19.13754.
cal:CaO19.6396.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000073 Genomic DNA. Translation: EAK97150.1 .
AACQ01000072 Genomic DNA. Translation: EAK97237.1 .
RefSeqi XP_716153.1. XM_711060.1.
XP_716236.1. XM_711143.1.

3D structure databases

ProteinModelPortali Q5A368.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0001431.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3642076.
3642210.
KEGGi cal:CaO19.13754.
cal:CaO19.6396.

Organism-specific databases

CGDi CAL0001431. orf19.6396.

Phylogenomic databases

eggNOGi COG0664.
InParanoidi Q5A368.
KOi K14676.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 4 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 2 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiNTE1_CANAL
AccessioniPrimary (citable) accession number: Q5A368
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3