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Q5A368 (NTE1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase NTE1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:NTE1
ORF Names:CaO19.13754, CaO19.6396
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length1386 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13861386Lysophospholipase NTE1
PRO_0000295314

Regions

Topological domain1 – 1919Cytoplasmic By similarity
Transmembrane20 – 4021Helical; Potential
Topological domain41 – 6525Lumenal By similarity
Transmembrane66 – 8621Helical; Potential
Topological domain87 – 13861300Cytoplasmic By similarity
Domain1081 – 1245165Patatin
Nucleotide binding577 – 701125cNMP 1
Nucleotide binding697 – 821125cNMP 2
Motif1112 – 11165GXSXG

Sites

Active site11141 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5A368 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 30459D16F3477170

FASTA1,386155,704
        10         20         30         40         50         60 
MGPEFEDSIP LVHSDNRTTT IYSVYIIISD IFSFVQWLLF KVLNLIIIDS PAFVLRLLSK 

        70         80         90        100        110        120 
NFEINLHLSS ILATLIGVSV VTYLVIRYKF LTGYSHSNDQ KEGAGKKGIH PASSKVFVGK 

       130        140        150        160        170        180 
SKQDKKPSNY LDEFLLAIKV FGYLDKAVFH ELTKSMTTQK LSHEEILCLD ESLGFSIVVE 

       190        200        210        220        230        240 
GVAQVYTKKS KENSSKYKQR YFEEIEEERD EFLILGDKQY QLLNEVKSGA PLSSLFSTLD 

       250        260        270        280        290        300 
LFRPRNKNEE MALTPNDEDG NSVVALNMDY LSKSEPATDS KLSNSDDDEN GQDYPEIIVR 

       310        320        330        340        350        360 
PKKSHNNGTI TIAIIPHTAF ERVQSKYPKA TSHIVTMVLT RLYKVTMSTV QNYLGLTSEI 

       370        380        390        400        410        420 
LKSEIKLNEE NATSLPRYFV DGLLERLNKK EEAEAEAENL PKKLKHHHRN QLQRTTSRYV 

       430        440        450        460        470        480 
SLDSKVKSNH PGDLLSSVPI SRSEFQKKVL PKSSTTSLSD GDNKRMNFTD EMEETEENSL 

       490        500        510        520        530        540 
RVAIIENIFK MVGIEETNGI VERTGYFQSL SSSTSSSIVG LDSLNQSIMS GATTPTTKRS 

       550        560        570        580        590        600 
HPVFNNQGSL MNTINLAELR KPSTAENSTL PKLSGKKRLL SDMNIKDAFA KSLEIKYIGP 

       610        620        630        640        650        660 
DSTIVSQNSA ITGLYYVIDG SLEIYNRSAD VSAPNRYIYT VESGGIAGYL TSVVGFRSMV 

       670        680        690        700        710        720 
TIKTPKKTGA VVAYIPKNDY NKLLDKYYFL QLPVALKLKN LLSKQILTID YALEWCHIPA 

       730        740        750        760        770        780 
GEVLCSQGDL ANGFHVVLSG RFRVVRSTNK NTEKEDVEVL GEYGHGESIG EVEVLTASRR 

       790        800        810        820        830        840 
SNTLIAVRDS ETARIPRSLF EMLSNENPSI MVSVSRLVAS KVLASQYQPR ERNFITSTTS 

       850        860        870        880        890        900 
QESFTSANYK TITILPTVSG LPVRQFAEKL VQALRQIGRN VIALDQASIL THLGRHAFDE 

       910        920        930        940        950        960 
SLARLKLSGY FAYLEEEYET IVYICDTPVQ SNWTSTCISQ GDCILLLADA EDDSTTIGEY 

       970        980        990       1000       1010       1020 
EQLLVKLKTT ARTDLCLLHQ DKVVRAGSTS PWLKNRIWVQ GHHHIQMKFE QGANVLPHKK 

      1030       1040       1050       1060       1070       1080 
SFISDLAAKL SQNKAIKSTF EATKQHIKWY VKENDQSKVL KIYKDDFMRL ARILSNEAVG 

      1090       1100       1110       1120       1130       1140 
LVLGGGGSRG ISHVGVVTSL ERHGIPVDII GGTSIGSFVG GLYAKEYNIV SIYAMAKKFS 

      1150       1160       1170       1180       1190       1200 
KRISSVWRML FDLTYPVTSY ITGYEFNRGI WKVFGFAEIE DFWIKYFCNS ANITNSTMDI 

      1210       1220       1230       1240       1250       1260 
HEKGYAWRFI RASMSLAGLL PPIAFNGCML LDGGYLDNLP VNEMKKRGVK HIIAVDVGSV 

      1270       1280       1290       1300       1310       1320 
DDRTPMNYGD TLSGFWVLLN RWNPFSSHPN IPTMMDIQMR LTYVSSVNAL EEAKRTPGVY 

      1330       1340       1350       1360       1370       1380 
YLRPPIDPYA TLDFGKFDEI YKVGLKYADD LFADWKSKGK FPRIAGLVEK KKDGEEKKIL 


YRRNSI 

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References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000073 Genomic DNA. Translation: EAK97150.1.
AACQ01000072 Genomic DNA. Translation: EAK97237.1.
RefSeqXP_716153.1. XM_711060.1.
XP_716236.1. XM_711143.1.

3D structure databases

ProteinModelPortalQ5A368.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0001431.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3642076.
3642210.
KEGGcal:CaO19.13754.
cal:CaO19.6396.

Organism-specific databases

CGDCAL0001431. orf19.6396.

Phylogenomic databases

eggNOGCOG0664.
KOK14676.
OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 4 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 2 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_CANAL
AccessionPrimary (citable) accession number: Q5A368
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: April 26, 2005
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names