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Q5A368

- NTE1_CANAL

UniProt

Q5A368 - NTE1_CANAL

Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1114 – 11141By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi577 – 701125cNMP 1Add
    BLAST
    Nucleotide bindingi697 – 821125cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. pathogenesis Source: CGD

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase NTE1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:NTE1
    ORF Names:CaO19.13754, CaO19.6396
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0001431. orf19.6396.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13861386Lysophospholipase NTE1PRO_0000295314Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0001431.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5A368.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919CytoplasmicBy similarityAdd
    BLAST
    Topological domaini41 – 6525LumenalBy similarityAdd
    BLAST
    Topological domaini87 – 13861300CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei66 – 8621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1081 – 1245165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1112 – 11165GXSXG

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    KOiK14676.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 4 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 2 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5A368-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPEFEDSIP LVHSDNRTTT IYSVYIIISD IFSFVQWLLF KVLNLIIIDS     50
    PAFVLRLLSK NFEINLHLSS ILATLIGVSV VTYLVIRYKF LTGYSHSNDQ 100
    KEGAGKKGIH PASSKVFVGK SKQDKKPSNY LDEFLLAIKV FGYLDKAVFH 150
    ELTKSMTTQK LSHEEILCLD ESLGFSIVVE GVAQVYTKKS KENSSKYKQR 200
    YFEEIEEERD EFLILGDKQY QLLNEVKSGA PLSSLFSTLD LFRPRNKNEE 250
    MALTPNDEDG NSVVALNMDY LSKSEPATDS KLSNSDDDEN GQDYPEIIVR 300
    PKKSHNNGTI TIAIIPHTAF ERVQSKYPKA TSHIVTMVLT RLYKVTMSTV 350
    QNYLGLTSEI LKSEIKLNEE NATSLPRYFV DGLLERLNKK EEAEAEAENL 400
    PKKLKHHHRN QLQRTTSRYV SLDSKVKSNH PGDLLSSVPI SRSEFQKKVL 450
    PKSSTTSLSD GDNKRMNFTD EMEETEENSL RVAIIENIFK MVGIEETNGI 500
    VERTGYFQSL SSSTSSSIVG LDSLNQSIMS GATTPTTKRS HPVFNNQGSL 550
    MNTINLAELR KPSTAENSTL PKLSGKKRLL SDMNIKDAFA KSLEIKYIGP 600
    DSTIVSQNSA ITGLYYVIDG SLEIYNRSAD VSAPNRYIYT VESGGIAGYL 650
    TSVVGFRSMV TIKTPKKTGA VVAYIPKNDY NKLLDKYYFL QLPVALKLKN 700
    LLSKQILTID YALEWCHIPA GEVLCSQGDL ANGFHVVLSG RFRVVRSTNK 750
    NTEKEDVEVL GEYGHGESIG EVEVLTASRR SNTLIAVRDS ETARIPRSLF 800
    EMLSNENPSI MVSVSRLVAS KVLASQYQPR ERNFITSTTS QESFTSANYK 850
    TITILPTVSG LPVRQFAEKL VQALRQIGRN VIALDQASIL THLGRHAFDE 900
    SLARLKLSGY FAYLEEEYET IVYICDTPVQ SNWTSTCISQ GDCILLLADA 950
    EDDSTTIGEY EQLLVKLKTT ARTDLCLLHQ DKVVRAGSTS PWLKNRIWVQ 1000
    GHHHIQMKFE QGANVLPHKK SFISDLAAKL SQNKAIKSTF EATKQHIKWY 1050
    VKENDQSKVL KIYKDDFMRL ARILSNEAVG LVLGGGGSRG ISHVGVVTSL 1100
    ERHGIPVDII GGTSIGSFVG GLYAKEYNIV SIYAMAKKFS KRISSVWRML 1150
    FDLTYPVTSY ITGYEFNRGI WKVFGFAEIE DFWIKYFCNS ANITNSTMDI 1200
    HEKGYAWRFI RASMSLAGLL PPIAFNGCML LDGGYLDNLP VNEMKKRGVK 1250
    HIIAVDVGSV DDRTPMNYGD TLSGFWVLLN RWNPFSSHPN IPTMMDIQMR 1300
    LTYVSSVNAL EEAKRTPGVY YLRPPIDPYA TLDFGKFDEI YKVGLKYADD 1350
    LFADWKSKGK FPRIAGLVEK KKDGEEKKIL YRRNSI 1386
    Length:1,386
    Mass (Da):155,704
    Last modified:April 26, 2005 - v1
    Checksum:i30459D16F3477170
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000073 Genomic DNA. Translation: EAK97150.1.
    AACQ01000072 Genomic DNA. Translation: EAK97237.1.
    RefSeqiXP_716153.1. XM_711060.1.
    XP_716236.1. XM_711143.1.

    Genome annotation databases

    GeneIDi3642076.
    3642210.
    KEGGical:CaO19.13754.
    cal:CaO19.6396.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000073 Genomic DNA. Translation: EAK97150.1 .
    AACQ01000072 Genomic DNA. Translation: EAK97237.1 .
    RefSeqi XP_716153.1. XM_711060.1.
    XP_716236.1. XM_711143.1.

    3D structure databases

    ProteinModelPortali Q5A368.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0001431.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3642076.
    3642210.
    KEGGi cal:CaO19.13754.
    cal:CaO19.6396.

    Organism-specific databases

    CGDi CAL0001431. orf19.6396.

    Phylogenomic databases

    eggNOGi COG0664.
    KOi K14676.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 4 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 2 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiNTE1_CANAL
    AccessioniPrimary (citable) accession number: Q5A368
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3