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Q5A360

- SIL1_CANAL

UniProt

Q5A360 - SIL1_CANAL

Protein

Nucleotide exchange factor SIL1

Gene

SIL1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 By similarity.By similarity

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleotide exchange factor SIL1
    Gene namesi
    Name:SIL1
    ORF Names:CaO19.13761, CaO19.6403
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0002104. orf19.6403.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 414396Nucleotide exchange factor SIL1PRO_0000223360Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with KAR2.By similarity

    Protein-protein interaction databases

    BioGridi1225176. 1 interaction.
    STRINGi5476.CAL0002104.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi411 – 4144Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the SIL1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284817.
    KOiK14001.
    OrthoDBiEOG7V1G2Q.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5A360-1 [UniParc]FASTAAdd to Basket

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    MKFSVLVLLA SYLVGVNSSI VDTSEELICP DPENPLDCYP KLFVPTNEWQ    50
    TIKPGQDIPP GLHVRLNIDT LEKEAKLMSA DEKDEPVQEV VVGGELQDHS 100
    REAITENLQK LHESKHPEVK QEHAHRTKVS QGDLSNFDAA CSEIESFKPH 150
    ESDVERLHLA LDTLEELSHD IEFGVKLTSD KAIFQSLVNI ANGASDPKIT 200
    EKVYRVMGSS LRNNPEAISN ILTNFDKSYV DNLFEQLANE NDVLQKRILG 250
    IIQALVQNSH FVRQYFSFDH SSGLNDLIAI FPKLGPNSKS RASNILEDLQ 300
    LFPVTNDRRS LEDQDPESQV SKFIQNSFVG NKLDEKNFKS YFDQLVNLHQ 350
    SNKSLRPSGD FLNWLAEEVE SRKENKKRDD YSQEDKDFDE YMLRARHEVF 400
    GNPMGLRKAI ADEL 414
    Length:414
    Mass (Da):47,067
    Last modified:April 26, 2005 - v1
    Checksum:iE907BBD67BBC2E3C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000073 Genomic DNA. Translation: EAK97157.1.
    AACQ01000072 Genomic DNA. Translation: EAK97244.1.
    RefSeqiXP_716159.1. XM_711066.1.
    XP_716242.1. XM_711149.1.

    Genome annotation databases

    GeneIDi3642082.
    3642216.
    KEGGical:CaO19.13761.
    cal:CaO19.6403.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000073 Genomic DNA. Translation: EAK97157.1 .
    AACQ01000072 Genomic DNA. Translation: EAK97244.1 .
    RefSeqi XP_716159.1. XM_711066.1.
    XP_716242.1. XM_711149.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 1225176. 1 interaction.
    STRINGi 5476.CAL0002104.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3642082.
    3642216.
    KEGGi cal:CaO19.13761.
    cal:CaO19.6403.

    Organism-specific databases

    CGDi CAL0002104. orf19.6403.

    Phylogenomic databases

    eggNOGi NOG284817.
    KOi K14001.
    OrthoDBi EOG7V1G2Q.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiSIL1_CANAL
    AccessioniPrimary (citable) accession number: Q5A360
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3