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Q5A360

- SIL1_CANAL

UniProt

Q5A360 - SIL1_CANAL

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Protein

Nucleotide exchange factor SIL1

Gene

SIL1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 (By similarity).By similarity

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleotide exchange factor SIL1
Gene namesi
Name:SIL1
ORF Names:CaO19.13761, CaO19.6403
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0002104. orf19.6403.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 414396Nucleotide exchange factor SIL1PRO_0000223360Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with KAR2.By similarity

Protein-protein interaction databases

BioGridi1225176. 1 interaction.
STRINGi5476.CAL0002104.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi411 – 4144Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the SIL1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG284817.
InParanoidiQ5A360.
KOiK14001.
OrthoDBiEOG7V1G2Q.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5A360-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MKFSVLVLLA SYLVGVNSSI VDTSEELICP DPENPLDCYP KLFVPTNEWQ
60 70 80 90 100
TIKPGQDIPP GLHVRLNIDT LEKEAKLMSA DEKDEPVQEV VVGGELQDHS
110 120 130 140 150
REAITENLQK LHESKHPEVK QEHAHRTKVS QGDLSNFDAA CSEIESFKPH
160 170 180 190 200
ESDVERLHLA LDTLEELSHD IEFGVKLTSD KAIFQSLVNI ANGASDPKIT
210 220 230 240 250
EKVYRVMGSS LRNNPEAISN ILTNFDKSYV DNLFEQLANE NDVLQKRILG
260 270 280 290 300
IIQALVQNSH FVRQYFSFDH SSGLNDLIAI FPKLGPNSKS RASNILEDLQ
310 320 330 340 350
LFPVTNDRRS LEDQDPESQV SKFIQNSFVG NKLDEKNFKS YFDQLVNLHQ
360 370 380 390 400
SNKSLRPSGD FLNWLAEEVE SRKENKKRDD YSQEDKDFDE YMLRARHEVF
410
GNPMGLRKAI ADEL
Length:414
Mass (Da):47,067
Last modified:April 26, 2005 - v1
Checksum:iE907BBD67BBC2E3C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000073 Genomic DNA. Translation: EAK97157.1.
AACQ01000072 Genomic DNA. Translation: EAK97244.1.
RefSeqiXP_716159.1. XM_711066.1.
XP_716242.1. XM_711149.1.

Genome annotation databases

GeneIDi3642082.
3642216.
KEGGical:CaO19.13761.
cal:CaO19.6403.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000073 Genomic DNA. Translation: EAK97157.1 .
AACQ01000072 Genomic DNA. Translation: EAK97244.1 .
RefSeqi XP_716159.1. XM_711066.1.
XP_716242.1. XM_711149.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1225176. 1 interaction.
STRINGi 5476.CAL0002104.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3642082.
3642216.
KEGGi cal:CaO19.13761.
cal:CaO19.6403.

Organism-specific databases

CGDi CAL0002104. orf19.6403.

Phylogenomic databases

eggNOGi NOG284817.
InParanoidi Q5A360.
KOi K14001.
OrthoDBi EOG7V1G2Q.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiSIL1_CANAL
AccessioniPrimary (citable) accession number: Q5A360
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3