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Q5A360 (SIL1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleotide exchange factor SIL1
Gene names
Name:SIL1
ORF Names:CaO19.13761, CaO19.6403
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 By similarity.

Subunit structure

Interacts with KAR2 By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the SIL1 family.

Ontologies

Keywords
   Biological processProtein transport
Translocation
Transport
   Cellular componentEndoplasmic reticulum
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 414396Nucleotide exchange factor SIL1
PRO_0000223360

Regions

Motif411 – 4144Prevents secretion from ER Potential

Amino acid modifications

Glycosylation171N-linked (GlcNAc...) Potential
Glycosylation3521N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5A360 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: E907BBD67BBC2E3C

FASTA41447,067
        10         20         30         40         50         60 
MKFSVLVLLA SYLVGVNSSI VDTSEELICP DPENPLDCYP KLFVPTNEWQ TIKPGQDIPP 

        70         80         90        100        110        120 
GLHVRLNIDT LEKEAKLMSA DEKDEPVQEV VVGGELQDHS REAITENLQK LHESKHPEVK 

       130        140        150        160        170        180 
QEHAHRTKVS QGDLSNFDAA CSEIESFKPH ESDVERLHLA LDTLEELSHD IEFGVKLTSD 

       190        200        210        220        230        240 
KAIFQSLVNI ANGASDPKIT EKVYRVMGSS LRNNPEAISN ILTNFDKSYV DNLFEQLANE 

       250        260        270        280        290        300 
NDVLQKRILG IIQALVQNSH FVRQYFSFDH SSGLNDLIAI FPKLGPNSKS RASNILEDLQ 

       310        320        330        340        350        360 
LFPVTNDRRS LEDQDPESQV SKFIQNSFVG NKLDEKNFKS YFDQLVNLHQ SNKSLRPSGD 

       370        380        390        400        410 
FLNWLAEEVE SRKENKKRDD YSQEDKDFDE YMLRARHEVF GNPMGLRKAI ADEL 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000073 Genomic DNA. Translation: EAK97157.1.
AACQ01000072 Genomic DNA. Translation: EAK97244.1.
RefSeqXP_716159.1. XM_711066.1.
XP_716242.1. XM_711149.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid1225176. 1 interaction.
STRING5476.CAL0002104.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3642082.
3642216.
KEGGcal:CaO19.13761.
cal:CaO19.6403.

Organism-specific databases

CGDCAL0002104. orf19.6403.

Phylogenomic databases

eggNOGNOG284817.
KOK14001.
OrthoDBEOG7V1G2Q.

Family and domain databases

InterProIPR016024. ARM-type_fold.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSIL1_CANAL
AccessionPrimary (citable) accession number: Q5A360
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: April 26, 2005
Last modified: February 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names