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Protein

Nucleotide exchange factor SIL1

Gene

SIL1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleotide exchange factor SIL1
Gene namesi
Name:SIL1
Ordered Locus Names:CAALFM_CR08350WA
ORF Names:CaO19.13761, CaO19.6403
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi

Organism-specific databases

CGDiCAL0000176393 orf19.6403

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000022336019 – 414Nucleotide exchange factor SIL1Add BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi352N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5A360

Interactioni

Subunit structurei

Interacts with KAR2.By similarity

Structurei

3D structure databases

SMRiQ5A360
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi411 – 414Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the SIL1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiQ5A360
KOiK14001
OrthoDBiEOG092C3G73

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR031884 Sil1_fungi
PfamiView protein in Pfam
PF16782 SIL1, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5A360-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFSVLVLLA SYLVGVNSSI VDTSEELICP DPENPLDCYP KLFVPTNEWQ
60 70 80 90 100
TIKPGQDIPP GLHVRLNIDT LEKEAKLMSA DEKDEPVQEV VVGGELQDHS
110 120 130 140 150
REAITENLQK LHESKHPEVK QEHAHRTKVS QGDLSNFDAA CSEIESFKPH
160 170 180 190 200
ESDVERLHLA LDTLEELSHD IEFGVKLTSD KAIFQSLVNI ANGASDPKIT
210 220 230 240 250
EKVYRVMGSS LRNNPEAISN ILTNFDKSYV DNLFEQLANE NDVLQKRILG
260 270 280 290 300
IIQALVQNSH FVRQYFSFDH SSGLNDLIAI FPKLGPNSKS RASNILEDLQ
310 320 330 340 350
LFPVTNDRRS LEDQDPESQV SKFIQNSFVG NKLDEKNFKS YFDQLVNLHQ
360 370 380 390 400
SNKSLRPSGD FLNWLAEEVE SRKENKKRDD YSQEDKDFDE YMLRARHEVF
410
GNPMGLRKAI ADEL
Length:414
Mass (Da):47,067
Last modified:April 26, 2005 - v1
Checksum:iE907BBD67BBC2E3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017630 Genomic DNA Translation: AOW31516.1
RefSeqiXP_716242.1, XM_711149.1

Genome annotation databases

EnsemblFungiiAOW31516; AOW31516; CAALFM_CR08350WA
GeneIDi3642082
KEGGical:CAALFM_CR08350WA

Entry informationi

Entry nameiSIL1_CANAL
AccessioniPrimary (citable) accession number: Q5A360
Secondary accession number(s): A0A1D8PTR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: April 26, 2005
Last modified: April 25, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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