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Protein

Probable kinetochore protein NDC80

Gene

NDC80

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable kinetochore protein NDC80
Gene namesi
Name:NDC80
ORF Names:CaO19.10345, CaO19.2827
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005087. orf19.2827.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 788788Probable kinetochore protein NDC80PRO_0000246634Add
BLAST

Interactioni

Subunit structurei

Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5A216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili346 – 788443Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 3814Poly-AsnAdd
BLAST
Compositional biasi81 – 899Poly-Gln
Compositional biasi174 – 1829Poly-Gln
Compositional biasi193 – 1964Poly-Gln
Compositional biasi355 – 3639Poly-Gln
Compositional biasi367 – 3748Poly-Gly
Compositional biasi551 – 5544Poly-Tyr
Compositional biasi555 – 56814Poly-GlnAdd
BLAST
Compositional biasi569 – 57911Poly-GluAdd
BLAST
Compositional biasi775 – 7828Poly-Gln

Sequence similaritiesi

Belongs to the NDC80/HEC1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5185.
InParanoidiQ5A216.
KOiK11547.
OrthoDBiEOG7034SB.

Family and domain databases

InterProiIPR005550. Kinetochore_Ndc80.
[Graphical view]
PANTHERiPTHR10643. PTHR10643. 1 hit.
PfamiPF03801. Ndc80_HEC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5A216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTSNPIYG LRRNNGFAGG SNPSNNNNNN SNNNHNGNRI SLGSATRTSS
60 70 80 90 100
IISNNLPFRQ SLLHGNYDNA INNTPSTSSL QKQSQQQQQS SQTSQTKRRS
110 120 130 140 150
TLLSTPATTT KRRQSMMGNN LHQQHQYGST ALRHSTQPSS SMNSQFNQAL
160 170 180 190 200
QHVSPYYNPT SYSSQTPSSQ PSSQQYQQQQ QQANIPSSAS SSQQQQSMDP
210 220 230 240 250
RPLKDKKYQE LIQKEIIRYL IDYKFEIKTN IALTENILKS PTQKNFNAIF
260 270 280 290 300
KFLYNQLDPN YMFIKSSIEQ EIVTLLKLLN YPYMHTITRS HFSAVGGNNW
310 320 330 340 350
PTFLGILYWL VELNLSLSTL NDDDFLADDD FDKIFIEYIW KSYSLFINDE
360 370 380 390 400
EEEEQQQQQQ QQQANNGGSG GGGGDKFYND MKIKFDQLQE KLNQELNNVE
410 420 430 440 450
QQHENLLNKY HELNNQLKIR DDALKKTVAL EEDYMKLKSY NQNVEKMMPE
460 470 480 490 500
WNKKLEQLSN EVISYEEQMN KLQDEKKSIE MDLQQRGISI DKVNELYIKR
510 520 530 540 550
DQLSKSIEII SNKIDDLKEK LSGRSFDLEK NFDNLENLTN QYNEITNKFN
560 570 580 590 600
YYYYQQIQQN QQQDQQQQEE EEEEEEEEEH QLIPQFGLKL DENIKTTNER
610 620 630 640 650
RQFTRDEIFL NINVKQERQN LLNFRNELDH QILNDRSQAM KFNEKCDIEQ
660 670 680 690 700
DKIKDQQSII EELKIQDSLM KRKSDDLKQT IFQIQNEFNS QIESLDQQIR
710 720 730 740 750
ETKSNIQSDI LQLERKLRDV NLNKSLIQEQ LIGKRQKIDE DVINLTSFIL
760 770 780
KFKTNIQEKL INIADIVQDQ LKKEQQQQQQ QQASQQLE
Length:788
Mass (Da):92,449
Last modified:April 26, 2005 - v1
Checksum:iE5D57F6E75AEB828
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000080 Genomic DNA. Translation: EAK96744.1.
AACQ01000079 Genomic DNA. Translation: EAK96795.1.
RefSeqiXP_715758.1. XM_710665.1.
XP_715808.1. XM_710715.1.

Genome annotation databases

GeneIDi3642548.
3642573.
KEGGical:CaO19.10345.
cal:CaO19.2827.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000080 Genomic DNA. Translation: EAK96744.1.
AACQ01000079 Genomic DNA. Translation: EAK96795.1.
RefSeqiXP_715758.1. XM_710665.1.
XP_715808.1. XM_710715.1.

3D structure databases

ProteinModelPortaliQ5A216.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3642548.
3642573.
KEGGical:CaO19.10345.
cal:CaO19.2827.

Organism-specific databases

CGDiCAL0005087. orf19.2827.

Phylogenomic databases

eggNOGiCOG5185.
InParanoidiQ5A216.
KOiK11547.
OrthoDBiEOG7034SB.

Family and domain databases

InterProiIPR005550. Kinetochore_Ndc80.
[Graphical view]
PANTHERiPTHR10643. PTHR10643. 1 hit.
PfamiPF03801. Ndc80_HEC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiNDC80_CANAL
AccessioniPrimary (citable) accession number: Q5A216
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: April 26, 2005
Last modified: June 24, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.