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Q5A216 (NDC80_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable kinetochore protein NDC80
Gene names
Name:NDC80
ORF Names:CaO19.10345, CaO19.2827
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length788 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity By similarity.

Subunit structure

Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25 By similarity.

Subcellular location

Nucleus By similarity. Chromosomecentromerekinetochore By similarity. Note: Associated with kinetochores By similarity.

Sequence similarities

Belongs to the NDC80/HEC1 family.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Cellular componentCentromere
Chromosome
Kinetochore
Nucleus
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmitotic nuclear division

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcondensed chromosome kinetochore

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 788788Probable kinetochore protein NDC80
PRO_0000246634

Regions

Coiled coil346 – 788443 Potential
Compositional bias25 – 3814Poly-Asn
Compositional bias81 – 899Poly-Gln
Compositional bias174 – 1829Poly-Gln
Compositional bias193 – 1964Poly-Gln
Compositional bias355 – 3639Poly-Gln
Compositional bias367 – 3748Poly-Gly
Compositional bias551 – 5544Poly-Tyr
Compositional bias555 – 56814Poly-Gln
Compositional bias569 – 57911Poly-Glu
Compositional bias775 – 7828Poly-Gln

Sequences

Sequence LengthMass (Da)Tools
Q5A216 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: E5D57F6E75AEB828

FASTA78892,449
        10         20         30         40         50         60 
MSQTSNPIYG LRRNNGFAGG SNPSNNNNNN SNNNHNGNRI SLGSATRTSS IISNNLPFRQ 

        70         80         90        100        110        120 
SLLHGNYDNA INNTPSTSSL QKQSQQQQQS SQTSQTKRRS TLLSTPATTT KRRQSMMGNN 

       130        140        150        160        170        180 
LHQQHQYGST ALRHSTQPSS SMNSQFNQAL QHVSPYYNPT SYSSQTPSSQ PSSQQYQQQQ 

       190        200        210        220        230        240 
QQANIPSSAS SSQQQQSMDP RPLKDKKYQE LIQKEIIRYL IDYKFEIKTN IALTENILKS 

       250        260        270        280        290        300 
PTQKNFNAIF KFLYNQLDPN YMFIKSSIEQ EIVTLLKLLN YPYMHTITRS HFSAVGGNNW 

       310        320        330        340        350        360 
PTFLGILYWL VELNLSLSTL NDDDFLADDD FDKIFIEYIW KSYSLFINDE EEEEQQQQQQ 

       370        380        390        400        410        420 
QQQANNGGSG GGGGDKFYND MKIKFDQLQE KLNQELNNVE QQHENLLNKY HELNNQLKIR 

       430        440        450        460        470        480 
DDALKKTVAL EEDYMKLKSY NQNVEKMMPE WNKKLEQLSN EVISYEEQMN KLQDEKKSIE 

       490        500        510        520        530        540 
MDLQQRGISI DKVNELYIKR DQLSKSIEII SNKIDDLKEK LSGRSFDLEK NFDNLENLTN 

       550        560        570        580        590        600 
QYNEITNKFN YYYYQQIQQN QQQDQQQQEE EEEEEEEEEH QLIPQFGLKL DENIKTTNER 

       610        620        630        640        650        660 
RQFTRDEIFL NINVKQERQN LLNFRNELDH QILNDRSQAM KFNEKCDIEQ DKIKDQQSII 

       670        680        690        700        710        720 
EELKIQDSLM KRKSDDLKQT IFQIQNEFNS QIESLDQQIR ETKSNIQSDI LQLERKLRDV 

       730        740        750        760        770        780 
NLNKSLIQEQ LIGKRQKIDE DVINLTSFIL KFKTNIQEKL INIADIVQDQ LKKEQQQQQQ 


QQASQQLE 

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References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000080 Genomic DNA. Translation: EAK96744.1.
AACQ01000079 Genomic DNA. Translation: EAK96795.1.
RefSeqXP_715758.1. XM_710665.1.
XP_715808.1. XM_710715.1.

3D structure databases

ProteinModelPortalQ5A216.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0005087.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3642548.
3642573.
KEGGcal:CaO19.10345.
cal:CaO19.2827.

Organism-specific databases

CGDCAL0005087. orf19.2827.

Phylogenomic databases

eggNOGCOG5185.
KOK11547.
OrthoDBEOG7034SB.

Family and domain databases

InterProIPR005550. Kinetochore_Ndc80.
[Graphical view]
PANTHERPTHR10643. PTHR10643. 1 hit.
PfamPF03801. Ndc80_HEC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDC80_CANAL
AccessionPrimary (citable) accession number: Q5A216
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: April 26, 2005
Last modified: March 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names