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Q5A216

- NDC80_CANAL

UniProt

Q5A216 - NDC80_CANAL

Protein

Probable kinetochore protein NDC80

Gene

NDC80

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.By similarity

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable kinetochore protein NDC80
    Gene namesi
    Name:NDC80
    ORF Names:CaO19.10345, CaO19.2827
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0005087. orf19.2827.

    Subcellular locationi

    Nucleus By similarity. Chromosomecentromerekinetochore By similarity
    Note: Associated with kinetochores.By similarity

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Centromere, Chromosome, Kinetochore, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 788788Probable kinetochore protein NDC80PRO_0000246634Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0005087.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5A216.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili346 – 788443Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi25 – 3814Poly-AsnAdd
    BLAST
    Compositional biasi81 – 899Poly-Gln
    Compositional biasi174 – 1829Poly-Gln
    Compositional biasi193 – 1964Poly-Gln
    Compositional biasi355 – 3639Poly-Gln
    Compositional biasi367 – 3748Poly-Gly
    Compositional biasi551 – 5544Poly-Tyr
    Compositional biasi555 – 56814Poly-GlnAdd
    BLAST
    Compositional biasi569 – 57911Poly-GluAdd
    BLAST
    Compositional biasi775 – 7828Poly-Gln

    Sequence similaritiesi

    Belongs to the NDC80/HEC1 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5185.
    KOiK11547.
    OrthoDBiEOG7034SB.

    Family and domain databases

    InterProiIPR005550. Kinetochore_Ndc80.
    [Graphical view]
    PANTHERiPTHR10643. PTHR10643. 1 hit.
    PfamiPF03801. Ndc80_HEC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5A216-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQTSNPIYG LRRNNGFAGG SNPSNNNNNN SNNNHNGNRI SLGSATRTSS    50
    IISNNLPFRQ SLLHGNYDNA INNTPSTSSL QKQSQQQQQS SQTSQTKRRS 100
    TLLSTPATTT KRRQSMMGNN LHQQHQYGST ALRHSTQPSS SMNSQFNQAL 150
    QHVSPYYNPT SYSSQTPSSQ PSSQQYQQQQ QQANIPSSAS SSQQQQSMDP 200
    RPLKDKKYQE LIQKEIIRYL IDYKFEIKTN IALTENILKS PTQKNFNAIF 250
    KFLYNQLDPN YMFIKSSIEQ EIVTLLKLLN YPYMHTITRS HFSAVGGNNW 300
    PTFLGILYWL VELNLSLSTL NDDDFLADDD FDKIFIEYIW KSYSLFINDE 350
    EEEEQQQQQQ QQQANNGGSG GGGGDKFYND MKIKFDQLQE KLNQELNNVE 400
    QQHENLLNKY HELNNQLKIR DDALKKTVAL EEDYMKLKSY NQNVEKMMPE 450
    WNKKLEQLSN EVISYEEQMN KLQDEKKSIE MDLQQRGISI DKVNELYIKR 500
    DQLSKSIEII SNKIDDLKEK LSGRSFDLEK NFDNLENLTN QYNEITNKFN 550
    YYYYQQIQQN QQQDQQQQEE EEEEEEEEEH QLIPQFGLKL DENIKTTNER 600
    RQFTRDEIFL NINVKQERQN LLNFRNELDH QILNDRSQAM KFNEKCDIEQ 650
    DKIKDQQSII EELKIQDSLM KRKSDDLKQT IFQIQNEFNS QIESLDQQIR 700
    ETKSNIQSDI LQLERKLRDV NLNKSLIQEQ LIGKRQKIDE DVINLTSFIL 750
    KFKTNIQEKL INIADIVQDQ LKKEQQQQQQ QQASQQLE 788
    Length:788
    Mass (Da):92,449
    Last modified:April 26, 2005 - v1
    Checksum:iE5D57F6E75AEB828
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000080 Genomic DNA. Translation: EAK96744.1.
    AACQ01000079 Genomic DNA. Translation: EAK96795.1.
    RefSeqiXP_715758.1. XM_710665.1.
    XP_715808.1. XM_710715.1.

    Genome annotation databases

    GeneIDi3642548.
    3642573.
    KEGGical:CaO19.10345.
    cal:CaO19.2827.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000080 Genomic DNA. Translation: EAK96744.1 .
    AACQ01000079 Genomic DNA. Translation: EAK96795.1 .
    RefSeqi XP_715758.1. XM_710665.1.
    XP_715808.1. XM_710715.1.

    3D structure databases

    ProteinModelPortali Q5A216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0005087.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3642548.
    3642573.
    KEGGi cal:CaO19.10345.
    cal:CaO19.2827.

    Organism-specific databases

    CGDi CAL0005087. orf19.2827.

    Phylogenomic databases

    eggNOGi COG5185.
    KOi K11547.
    OrthoDBi EOG7034SB.

    Family and domain databases

    InterProi IPR005550. Kinetochore_Ndc80.
    [Graphical view ]
    PANTHERi PTHR10643. PTHR10643. 1 hit.
    Pfami PF03801. Ndc80_HEC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiNDC80_CANAL
    AccessioniPrimary (citable) accession number: Q5A216
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3