Q5A216 (NDC80_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable kinetochore protein NDC80

Gene names

Name:	NDC80
ORF Names:	CaO19.10345, CaO19.2827

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	788 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity By similarity.
Subunit structure	Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25 By similarity.
Subcellular location	Nucleus By similarity. Chromosome › centromere › kinetochore By similarity. Note: Associated with kinetochores By similarity.
Sequence similarities	Belongs to the NDC80/HEC1 family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Centromere Chromosome Kinetochore Nucleus
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	condensed chromosome kinetochore Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 788	788	Probable kinetochore protein NDC80		PRO_0000246634
Regions
	Coiled coil	346 – 788	443	Potential
	Compositional bias	25 – 38	14	Poly-Asn
	Compositional bias	81 – 89	9	Poly-Gln
	Compositional bias	174 – 182	9	Poly-Gln
	Compositional bias	193 – 196	4	Poly-Gln
	Compositional bias	355 – 363	9	Poly-Gln
	Compositional bias	367 – 374	8	Poly-Gly
	Compositional bias	551 – 554	4	Poly-Tyr
	Compositional bias	555 – 568	14	Poly-Gln
	Compositional bias	569 – 579	11	Poly-Glu
	Compositional bias	775 – 782	8	Poly-Gln

Sequences

	Sequence		Length	Mass (Da)
	Q5A216 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: E5D57F6E75AEB828	FASTA	788	92,449
	10 20 30 40 50 60 MSQTSNPIYG LRRNNGFAGG SNPSNNNNNN SNNNHNGNRI SLGSATRTSS IISNNLPFRQ 70 80 90 100 110 120 SLLHGNYDNA INNTPSTSSL QKQSQQQQQS SQTSQTKRRS TLLSTPATTT KRRQSMMGNN 130 140 150 160 170 180 LHQQHQYGST ALRHSTQPSS SMNSQFNQAL QHVSPYYNPT SYSSQTPSSQ PSSQQYQQQQ 190 200 210 220 230 240 QQANIPSSAS SSQQQQSMDP RPLKDKKYQE LIQKEIIRYL IDYKFEIKTN IALTENILKS 250 260 270 280 290 300 PTQKNFNAIF KFLYNQLDPN YMFIKSSIEQ EIVTLLKLLN YPYMHTITRS HFSAVGGNNW 310 320 330 340 350 360 PTFLGILYWL VELNLSLSTL NDDDFLADDD FDKIFIEYIW KSYSLFINDE EEEEQQQQQQ 370 380 390 400 410 420 QQQANNGGSG GGGGDKFYND MKIKFDQLQE KLNQELNNVE QQHENLLNKY HELNNQLKIR 430 440 450 460 470 480 DDALKKTVAL EEDYMKLKSY NQNVEKMMPE WNKKLEQLSN EVISYEEQMN KLQDEKKSIE 490 500 510 520 530 540 MDLQQRGISI DKVNELYIKR DQLSKSIEII SNKIDDLKEK LSGRSFDLEK NFDNLENLTN 550 560 570 580 590 600 QYNEITNKFN YYYYQQIQQN QQQDQQQQEE EEEEEEEEEH QLIPQFGLKL DENIKTTNER 610 620 630 640 650 660 RQFTRDEIFL NINVKQERQN LLNFRNELDH QILNDRSQAM KFNEKCDIEQ DKIKDQQSII 670 680 690 700 710 720 EELKIQDSLM KRKSDDLKQT IFQIQNEFNS QIESLDQQIR ETKSNIQSDI LQLERKLRDV 730 740 750 760 770 780 NLNKSLIQEQ LIGKRQKIDE DVINLTSFIL KFKTNIQEKL INIADIVQDQ LKKEQQQQQQ QQASQQLE

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000080 Genomic DNA. Translation: EAK96744.1. AACQ01000079 Genomic DNA. Translation: EAK96795.1.
RefSeq	XP_715758.1. XM_710665.1. XP_715808.1. XM_710715.1.
3D structure databases
ProteinModelPortal	Q5A216.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3642548. 3642573.
KEGG	cal:CaO19.10345. cal:CaO19.2827.
Organism-specific databases
CGD	CAL0005087. orf19.2827.
Phylogenomic databases
eggNOG	COG5185.
KO	K11547.
Family and domain databases
InterPro	IPR005550. Kinetochore_Ndc80. [Graphical view]
PANTHER	PTHR10643. PTHR10643. 1 hit.
Pfam	PF03801. Ndc80_HEC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDC80_CANAL

Accession

Primary (citable) accession number: Q5A216

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	April 26, 2005
Last modified:	October 3, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program