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Q5A1D5

- SPT16_CANAL

UniProt

Q5A1D5 - SPT16_CANAL

Protein

FACT complex subunit SPT16

Gene

SPT16

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II By similarity.By similarity

    GO - Biological processi

    1. DNA repair Source: UniProtKB-KW
    2. DNA replication Source: UniProtKB-KW
    3. regulation of DNA-templated transcription, elongation Source: CGD
    4. transcription elongation from RNA polymerase II promoter Source: CGD

    Keywords - Biological processi

    DNA damage, DNA repair, DNA replication, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FACT complex subunit SPT16
    Alternative name(s):
    CaCDC68
    Cell division control protein 68
    Facilitates chromatin transcription complex subunit SPT16
    Gene namesi
    Name:SPT16
    Synonyms:CDC68
    ORF Names:CaO19.10402, CaO19.2884
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0005222. CDC68.

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. transcription elongation factor complex Source: CGD

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10601060FACT complex subunit SPT16PRO_0000245181Add
    BLAST

    Interactioni

    Subunit structurei

    Forms a stable heterodimer with POB3. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex By similarity.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0005222.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5A1D5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili508 – 53225Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi140 – 15617Asn-richAdd
    BLAST
    Compositional biasi982 – 9854Poly-Glu
    Compositional biasi987 – 104458Asp-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase M24 family. SPT16 subfamily.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5406.
    OrthoDBiEOG7SFJ58.

    Family and domain databases

    Gene3Di3.40.350.10. 1 hit.
    3.90.230.10. 1 hit.
    InterProiIPR029149. Creatin/AminoP/Spt16_NTD.
    IPR013719. DUF1747.
    IPR029148. FACT-Spt16_Nlobe.
    IPR013953. FACT_Spt16p.
    IPR000994. Pept_M24_structural-domain.
    [Graphical view]
    PfamiPF14826. FACT-Spt16_Nlob. 1 hit.
    PF00557. Peptidase_M24. 1 hit.
    PF08512. Rtt106. 1 hit.
    PF08644. SPT16. 1 hit.
    [Graphical view]
    SUPFAMiSSF55920. SSF55920. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5A1D5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEVNIDAGL FYKRLSIFQK QLTANNIPQA LIIVGARSDD NTYKKSTVLQ     50
    NWLLGYEFIH TAIYITDKKC IFITSEGKSK HLKHLTNQKP DLVELWIRTK 100
    DVEHNKQLFI KLLETMTKLD SKYGKILKDK YDGKFIDEWN QILNDDNNNN 150
    NNNTTNDHAL SAVDLAVTVS QALAVKDSEE FNNTKIASNA SVVMMDTFVN 200
    DMMIIVDDEK KITNSQLTDQ IEDKIENNKW YLKTKLGKNL LQSIKDFDPE 250
    YLEYCYSPII QSGGDYDLKP SAVSTDKPLI GEGVILSSIG LRYKSYCSNI 300
    ARTFLIDPTS EMETNYDFLL QLQKYIVDNL LKDGVPANKV YQDTIDYIKK 350
    ERPDLVNHFT KNCGWLLGME FRDSTFILNA KTTDRKLTTG QIISLTIGFN 400
    NLSNDKNDKN DKNDNKTNHQ KNKQTYALLL TDTIKITDDS SILLTNYSKD 450
    RAAISFSFND DNETQKENNN NNNKRPGLSQ TSNTTGLKLE STENTAILKS 500
    KLRHENTNAD DANSEKLRQE IQIKLHEKRL QEGLARFSKA DATDADDFKP 550
    IFKKYESYVR ESQIPNSVND LKIHIDYKNQ TIILPISGRP VPFHINSYKS 600
    GSQNEEGDFT YLRLNFNSPG AGGNVTKKQE LPYEDSPDNS FLRSITIRSR 650
    DRQRMVDVYK AIQDLKKDSV KREQEKKQMA DVITQANLIE LKGSRVKKLN 700
    NVFIRPTPDT KKIGGVLQIH ENGLRYQSQP QSQSNFKNDQ RVDVLFSNIK 750
    HLFFQPCKDE LIVLIHCHLK NPIMIGKRKT FDVQFYREAS DMAFDETGGR 800
    KRKYRYGDED ELQQEQEERR RKALLDKEFK GFAELIADSS HGMVDLDIPF 850
    RELGFQGVPF RSSVLCVPTR DCLVQLIDPP YLVVTLEEIE IAHLERVQFG 900
    LKNFDLVFVF KDFNKPVVHI NTIPVELLED VKSWLTDVDI PISEGQMNLN 950
    WVQIMKTVLA DPYQFFIDGG WAFLTGQGES DEEEESDEES DFRVSDEDPQ 1000
    DEDEESDDYA SEEESDDYSG SDDDGSGGGD DDDDDDSESG EDWDALERKA 1050
    AKADRNSGFD 1060
    Length:1,060
    Mass (Da):121,378
    Last modified:April 26, 2005 - v1
    Checksum:iC12A14005E6B3E25
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti146 – 1494Missing in AAG48574. (PubMed:12420162)Curated
    Sequence conflicti338 – 3381N → S in AAG48574. (PubMed:12420162)Curated
    Sequence conflicti404 – 4063Missing in AAG48574. (PubMed:12420162)Curated
    Sequence conflicti730 – 7301P → PQS in AAG48574. (PubMed:12420162)Curated
    Sequence conflicti1030 – 10323Missing in AAG48574. (PubMed:12420162)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF253047 Genomic DNA. Translation: AAG48574.1.
    AACQ01000084 Genomic DNA. Translation: EAK96517.1.
    AACQ01000083 Genomic DNA. Translation: EAK96576.1.
    RefSeqiXP_715540.1. XM_710447.1.
    XP_715596.1. XM_710503.1.

    Genome annotation databases

    GeneIDi3642741.
    3642787.
    KEGGical:CaO19.10402.
    cal:CaO19.2884.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF253047 Genomic DNA. Translation: AAG48574.1 .
    AACQ01000084 Genomic DNA. Translation: EAK96517.1 .
    AACQ01000083 Genomic DNA. Translation: EAK96576.1 .
    RefSeqi XP_715540.1. XM_710447.1.
    XP_715596.1. XM_710503.1.

    3D structure databases

    ProteinModelPortali Q5A1D5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0005222.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3642741.
    3642787.
    KEGGi cal:CaO19.10402.
    cal:CaO19.2884.

    Organism-specific databases

    CGDi CAL0005222. CDC68.

    Phylogenomic databases

    eggNOGi COG5406.
    OrthoDBi EOG7SFJ58.

    Family and domain databases

    Gene3Di 3.40.350.10. 1 hit.
    3.90.230.10. 1 hit.
    InterProi IPR029149. Creatin/AminoP/Spt16_NTD.
    IPR013719. DUF1747.
    IPR029148. FACT-Spt16_Nlobe.
    IPR013953. FACT_Spt16p.
    IPR000994. Pept_M24_structural-domain.
    [Graphical view ]
    Pfami PF14826. FACT-Spt16_Nlob. 1 hit.
    PF00557. Peptidase_M24. 1 hit.
    PF08512. Rtt106. 1 hit.
    PF08644. SPT16. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55920. SSF55920. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 1006.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiSPT16_CANAL
    AccessioniPrimary (citable) accession number: Q5A1D5
    Secondary accession number(s): Q9HF08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Caution

    Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting that it may lack peptidase activity.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3