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Q5A1D5

- SPT16_CANAL

UniProt

Q5A1D5 - SPT16_CANAL

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Protein

FACT complex subunit SPT16

Gene

SPT16

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II By similarity.By similarity

GO - Biological processi

  1. DNA repair Source: UniProtKB-KW
  2. DNA replication Source: UniProtKB-KW
  3. regulation of DNA-templated transcription, elongation Source: CGD
  4. transcription elongation from RNA polymerase II promoter Source: CGD
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, DNA replication, Transcription, Transcription regulation

Protein family/group databases

MEROPSiM24.974.

Names & Taxonomyi

Protein namesi
Recommended name:
FACT complex subunit SPT16
Alternative name(s):
CaCDC68
Cell division control protein 68
Facilitates chromatin transcription complex subunit SPT16
Gene namesi
Name:SPT16
Synonyms:CDC68
ORF Names:CaO19.10402, CaO19.2884
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005222. CDC68.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. transcription elongation factor complex Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10601060FACT complex subunit SPT16PRO_0000245181Add
BLAST

Interactioni

Subunit structurei

Forms a stable heterodimer with POB3. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex By similarity.By similarity

Protein-protein interaction databases

STRINGi5476.CAL0005222.

Structurei

3D structure databases

ProteinModelPortaliQ5A1D5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili508 – 53225Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi140 – 15617Asn-richAdd
BLAST
Compositional biasi982 – 9854Poly-Glu
Compositional biasi987 – 104458Asp-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the peptidase M24 family. SPT16 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5406.
InParanoidiQ5A1D5.
OrthoDBiEOG7SFJ58.

Family and domain databases

Gene3Di3.40.350.10. 1 hit.
3.90.230.10. 1 hit.
InterProiIPR029149. Creatin/AminoP/Spt16_NTD.
IPR013719. DUF1747.
IPR029148. FACT-Spt16_Nlobe.
IPR013953. FACT_Spt16p.
IPR000994. Pept_M24_structural-domain.
[Graphical view]
PfamiPF14826. FACT-Spt16_Nlob. 1 hit.
PF00557. Peptidase_M24. 1 hit.
PF08512. Rtt106. 1 hit.
PF08644. SPT16. 1 hit.
[Graphical view]
SUPFAMiSSF55920. SSF55920. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5A1D5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEVNIDAGL FYKRLSIFQK QLTANNIPQA LIIVGARSDD NTYKKSTVLQ
60 70 80 90 100
NWLLGYEFIH TAIYITDKKC IFITSEGKSK HLKHLTNQKP DLVELWIRTK
110 120 130 140 150
DVEHNKQLFI KLLETMTKLD SKYGKILKDK YDGKFIDEWN QILNDDNNNN
160 170 180 190 200
NNNTTNDHAL SAVDLAVTVS QALAVKDSEE FNNTKIASNA SVVMMDTFVN
210 220 230 240 250
DMMIIVDDEK KITNSQLTDQ IEDKIENNKW YLKTKLGKNL LQSIKDFDPE
260 270 280 290 300
YLEYCYSPII QSGGDYDLKP SAVSTDKPLI GEGVILSSIG LRYKSYCSNI
310 320 330 340 350
ARTFLIDPTS EMETNYDFLL QLQKYIVDNL LKDGVPANKV YQDTIDYIKK
360 370 380 390 400
ERPDLVNHFT KNCGWLLGME FRDSTFILNA KTTDRKLTTG QIISLTIGFN
410 420 430 440 450
NLSNDKNDKN DKNDNKTNHQ KNKQTYALLL TDTIKITDDS SILLTNYSKD
460 470 480 490 500
RAAISFSFND DNETQKENNN NNNKRPGLSQ TSNTTGLKLE STENTAILKS
510 520 530 540 550
KLRHENTNAD DANSEKLRQE IQIKLHEKRL QEGLARFSKA DATDADDFKP
560 570 580 590 600
IFKKYESYVR ESQIPNSVND LKIHIDYKNQ TIILPISGRP VPFHINSYKS
610 620 630 640 650
GSQNEEGDFT YLRLNFNSPG AGGNVTKKQE LPYEDSPDNS FLRSITIRSR
660 670 680 690 700
DRQRMVDVYK AIQDLKKDSV KREQEKKQMA DVITQANLIE LKGSRVKKLN
710 720 730 740 750
NVFIRPTPDT KKIGGVLQIH ENGLRYQSQP QSQSNFKNDQ RVDVLFSNIK
760 770 780 790 800
HLFFQPCKDE LIVLIHCHLK NPIMIGKRKT FDVQFYREAS DMAFDETGGR
810 820 830 840 850
KRKYRYGDED ELQQEQEERR RKALLDKEFK GFAELIADSS HGMVDLDIPF
860 870 880 890 900
RELGFQGVPF RSSVLCVPTR DCLVQLIDPP YLVVTLEEIE IAHLERVQFG
910 920 930 940 950
LKNFDLVFVF KDFNKPVVHI NTIPVELLED VKSWLTDVDI PISEGQMNLN
960 970 980 990 1000
WVQIMKTVLA DPYQFFIDGG WAFLTGQGES DEEEESDEES DFRVSDEDPQ
1010 1020 1030 1040 1050
DEDEESDDYA SEEESDDYSG SDDDGSGGGD DDDDDDSESG EDWDALERKA
1060
AKADRNSGFD
Length:1,060
Mass (Da):121,378
Last modified:April 26, 2005 - v1
Checksum:iC12A14005E6B3E25
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1494Missing in AAG48574. (PubMed:12420162)Curated
Sequence conflicti338 – 3381N → S in AAG48574. (PubMed:12420162)Curated
Sequence conflicti404 – 4063Missing in AAG48574. (PubMed:12420162)Curated
Sequence conflicti730 – 7301P → PQS in AAG48574. (PubMed:12420162)Curated
Sequence conflicti1030 – 10323Missing in AAG48574. (PubMed:12420162)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF253047 Genomic DNA. Translation: AAG48574.1.
AACQ01000084 Genomic DNA. Translation: EAK96517.1.
AACQ01000083 Genomic DNA. Translation: EAK96576.1.
RefSeqiXP_715540.1. XM_710447.1.
XP_715596.1. XM_710503.1.

Genome annotation databases

GeneIDi3642741.
3642787.
KEGGical:CaO19.10402.
cal:CaO19.2884.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF253047 Genomic DNA. Translation: AAG48574.1 .
AACQ01000084 Genomic DNA. Translation: EAK96517.1 .
AACQ01000083 Genomic DNA. Translation: EAK96576.1 .
RefSeqi XP_715540.1. XM_710447.1.
XP_715596.1. XM_710503.1.

3D structure databases

ProteinModelPortali Q5A1D5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0005222.

Protein family/group databases

MEROPSi M24.974.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3642741.
3642787.
KEGGi cal:CaO19.10402.
cal:CaO19.2884.

Organism-specific databases

CGDi CAL0005222. CDC68.

Phylogenomic databases

eggNOGi COG5406.
InParanoidi Q5A1D5.
OrthoDBi EOG7SFJ58.

Family and domain databases

Gene3Di 3.40.350.10. 1 hit.
3.90.230.10. 1 hit.
InterProi IPR029149. Creatin/AminoP/Spt16_NTD.
IPR013719. DUF1747.
IPR029148. FACT-Spt16_Nlobe.
IPR013953. FACT_Spt16p.
IPR000994. Pept_M24_structural-domain.
[Graphical view ]
Pfami PF14826. FACT-Spt16_Nlob. 1 hit.
PF00557. Peptidase_M24. 1 hit.
PF08512. Rtt106. 1 hit.
PF08644. SPT16. 1 hit.
[Graphical view ]
SUPFAMi SSF55920. SSF55920. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 1006.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiSPT16_CANAL
AccessioniPrimary (citable) accession number: Q5A1D5
Secondary accession number(s): Q9HF08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting that it may lack peptidase activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3