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Protein

Extracellular signal-regulated kinase 1

Gene

CEK1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99ATPPROSITE-ProRule annotation1
Active sitei194Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi76 – 84ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • cellular response to drug Source: CGD
  • cellular response to starvation Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms Source: CGD
  • filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  • fungal-type cell wall biogenesis Source: CGD
  • fungal-type cell wall organization Source: CGD
  • parasexual conjugation with cellular fusion Source: CGD
  • pathogenesis Source: CGD
  • positive regulation of filamentous growth of a population of unicellular organisms Source: CGD
  • positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • positive regulation of filamentous growth of a population of unicellular organisms in response to starvation Source: CGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular signal-regulated kinase 1 (EC:2.7.11.24)
Short name:
ERK1
Alternative name(s):
MAP kinase 1
Short name:
MAPK 1
Gene namesi
Name:CEK1
Synonyms:ERK1
Ordered Locus Names:CAALFM_C406480CA
ORF Names:CaO19.10404, CaO19.2886
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 4

Organism-specific databases

CGDiCAL0000176774. CEK1.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001863251 – 421Extracellular signal-regulated kinase 1Add BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230PhosphothreonineBy similarity1
Modified residuei232PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-230 and Tyr-232, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5A1D3.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
STE5P329172EBI-8783371,EBI-18373From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).

Protein-protein interaction databases

BioGridi1225837. 6 interactors.
IntActiQ5A1D3. 2 interactors.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 375Protein kinasePROSITE-ProRule annotationAdd BLAST306

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi230 – 232TXY3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 53Ala/Gln-richAdd BLAST49

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ5A1D3.
KOiK04371.
OrthoDBiEOG092C2FL8.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5A1D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIDQHHQLQ QQHQQQMLQQ QAQAQAQAQA QAQQQQQQQQ QAAAAAAAAN
60 70 80 90 100
AAATTSSSPR QVSFNVSDHY QILEIVGEGA YGIVCSAIHK PSQQKVAIKK
110 120 130 140 150
IEPFERSMLC LRTLRELKLL KHFNHENIIS ILAIQRPINY ESFNEIYLIQ
160 170 180 190 200
ELMETDLHRV IRTQNLSDDH IQYFIYQTLR ALKAMHSANV LHRDLKPSNL
210 220 230 240 250
LLNSNCDLKI CDFGLARSIA SQEDNYGFMT EYVATRWYRA PEIMLTFQEY
260 270 280 290 300
TTAIDVWSVG CILAEMLSGR PLFPGRDYHN QLWLIMEVLG TPNMEDYYNI
310 320 330 340 350
KSKRAREYIR SLPFCKKIPF SELFANTNNN TSTSTSNTGG RTNINPLALD
360 370 380 390 400
LLEKLLIFNP AKRITVEDAL KHPYLQLYHD PNDEPISDKI PEDFFDFDKM
410 420
KDQLTIEDLK KLLYEEIMKP L
Length:421
Mass (Da):48,536
Last modified:March 15, 2017 - v3
Checksum:iEC070EC9E6501B52
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti32 – 35Missing in strain: ATCC 60193 / S-24; in allele 237 B. 4
Natural varianti33Q → QA in strain: R-2617; in allele 249 D. 1
Natural varianti34 – 35QQ → AQAQA in strain: R-2805; in allele 255 A. 2
Natural varianti34Q → A in strain: R-2617, R-2624, R-2777 and R-2805; in allele 246 D, 249 E, 249 C and 246 E. 1
Natural varianti38 – 43Missing in strain: ATCC 36232; in allele 225 A. 6
Natural varianti38 – 41Missing in strain: R-2621; in allele 237 A. 4
Natural varianti41Q → QQ in strain: R-2621; in allele 249 B. 1
Natural varianti41Missing in strain: R-2540; in allele 243 A. 1
Natural varianti52A → T in strain: R-2617; in allele 246 D. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017626 Genomic DNA. Translation: AOW29372.1.
U95784 Genomic DNA. Translation: AAB88588.1.
U95785 Genomic DNA. Translation: AAB88589.1.
U95786 Genomic DNA. Translation: AAB88590.1.
U95787 Genomic DNA. Translation: AAB88591.1.
U95788 Genomic DNA. Translation: AAB88592.1.
U95789 Genomic DNA. Translation: AAB88593.1.
U95790 Genomic DNA. Translation: AAB88594.1.
U95791 Genomic DNA. Translation: AAB88595.1.
U95792 Genomic DNA. Translation: AAB88596.1.
U95793 Genomic DNA. Translation: AAB88597.1.
U95794 Genomic DNA. Translation: AAB88598.1.
U95795 Genomic DNA. Translation: AAB88599.1.
U95796 Genomic DNA. Translation: AAB88600.1.
U95797 Genomic DNA. Translation: AAB88601.1.
U95798 Genomic DNA. Translation: AAB88602.1.
RefSeqiXP_715542.2. XM_710449.2.

Genome annotation databases

GeneIDi3642789.
KEGGical:CAALFM_C406480CA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017626 Genomic DNA. Translation: AOW29372.1.
U95784 Genomic DNA. Translation: AAB88588.1.
U95785 Genomic DNA. Translation: AAB88589.1.
U95786 Genomic DNA. Translation: AAB88590.1.
U95787 Genomic DNA. Translation: AAB88591.1.
U95788 Genomic DNA. Translation: AAB88592.1.
U95789 Genomic DNA. Translation: AAB88593.1.
U95790 Genomic DNA. Translation: AAB88594.1.
U95791 Genomic DNA. Translation: AAB88595.1.
U95792 Genomic DNA. Translation: AAB88596.1.
U95793 Genomic DNA. Translation: AAB88597.1.
U95794 Genomic DNA. Translation: AAB88598.1.
U95795 Genomic DNA. Translation: AAB88599.1.
U95796 Genomic DNA. Translation: AAB88600.1.
U95797 Genomic DNA. Translation: AAB88601.1.
U95798 Genomic DNA. Translation: AAB88602.1.
RefSeqiXP_715542.2. XM_710449.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1225837. 6 interactors.
IntActiQ5A1D3. 2 interactors.

Proteomic databases

PRIDEiQ5A1D3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3642789.
KEGGical:CAALFM_C406480CA.

Organism-specific databases

CGDiCAL0000176774. CEK1.

Phylogenomic databases

InParanoidiQ5A1D3.
KOiK04371.
OrthoDBiEOG092C2FL8.

Miscellaneous databases

PROiPR:Q5A1D3.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiERK1_CANAL
AccessioniPrimary (citable) accession number: Q5A1D3
Secondary accession number(s): A0A1D8PMK1
, O13435, P28869, P87079, P87080, P87081, P87082, P87083, P87084, P87085, P87086, P87322, Q6LC13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: March 15, 2017
Last modified: June 7, 2017
This is version 109 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.