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Protein

Extracellular signal-regulated kinase 1

Gene

CEK1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei100 – 1001ATPPROSITE-ProRule annotation
Active sitei195 – 1951Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi77 – 859ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cellular response to drug Source: CGD
  • cellular response to starvation Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms Source: CGD
  • filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  • fungal-type cell wall biogenesis Source: CGD
  • fungal-type cell wall organization Source: CGD
  • mitotic nuclear division Source: UniProtKB-KW
  • parasexual conjugation with cellular fusion Source: CGD
  • pathogenesis Source: CGD
  • positive regulation of filamentous growth of a population of unicellular organisms Source: CGD
  • positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • positive regulation of filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular signal-regulated kinase 1 (EC:2.7.11.24)
Short name:
ERK1
Alternative name(s):
MAP kinase 1
Short name:
MAPK 1
Gene namesi
Name:CEK1
Synonyms:ERK1
ORF Names:CaO19.10404, CaO19.2886
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005224. CEK1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Extracellular signal-regulated kinase 1PRO_0000186325Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei231 – 2311PhosphothreonineBy similarity
Modified residuei233 – 2331PhosphotyrosineBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-231 and Tyr-233, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5A1D3.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
STE5P329172EBI-8783371,EBI-18373From a different organism.

Protein-protein interaction databases

BioGridi1225883. 5 interactions.
IntActiQ5A1D3. 2 interactions.
STRINGi5476.CAL0005224.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 376306Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi231 – 2333TXY

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 5349Ala/Gln-richAdd
BLAST

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ5A1D3.
KOiK04371.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5A1D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIDQHHQLQ QQHQQQMLQQ QAQAQAQAQA QAQQQQQQQQ QAAAAAAAAN
60 70 80 90 100
AAATTSSSSP RQVSFNVSDH YQILEIVGEG AYGIVCSAIH KPSQQKVAIK
110 120 130 140 150
KIEPFERSML CLRTLRELKL LKHFNHENII SILAIQRPIN YESFNEIYLI
160 170 180 190 200
QELMETDLHR VIRTQNLSDD HIQYFIYQTL RALKAMHSAN VLHRDLKPSN
210 220 230 240 250
LLLNSNCDLK ICDFGLARSI ASQEDNYGFM TEYVATRWYR APEIMLTFQE
260 270 280 290 300
YTTAIDVWSV GCILAEMLSG RPLFPGRDYH NQLWLIMEVL GTPNMEDYYN
310 320 330 340 350
IKSKRAREYI RSLPFCKKIP FSELFANTNN NTSTSTSNTG GRTNINPLAL
360 370 380 390 400
DLLEKLLIFN PAKRITVEDA LKHPYLQLYH DPNDEPISDK IPEDFFDFDK
410 420
MKDQLTIEDL KKLLYEEIMK PL
Length:422
Mass (Da):48,623
Last modified:October 19, 2011 - v2
Checksum:i471BE4423FDAAAD5
GO

Sequence cautioni

The sequence EAK96519.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAK96578.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti32 – 354Missing in strain: ATCC 60193 / S-24; in allele 237 B.
Natural varianti33 – 331Q → QA in strain: R-2617; in allele 249 D.
Natural varianti34 – 352QQ → AQAQA in strain: R-2805; in allele 255 A.
Natural varianti34 – 341Q → A in strain: R-2617, R-2624, R-2777 and R-2805; in allele 246 D, 249 E, 249 C and 246 E.
Natural varianti38 – 436Missing in strain: ATCC 36232; in allele 225 A.
Natural varianti38 – 414Missing in strain: R-2621; in allele 237 A.
Natural varianti41 – 411Q → QQ in strain: R-2621; in allele 249 B.
Natural varianti41 – 411Missing in strain: R-2540; in allele 243 A.
Natural varianti52 – 521A → T in strain: R-2617; in allele 246 D.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000084 Genomic DNA. Translation: EAK96519.1. Different initiation.
AACQ01000083 Genomic DNA. Translation: EAK96578.1. Different initiation.
U95784 Genomic DNA. Translation: AAB88588.1.
U95785 Genomic DNA. Translation: AAB88589.1.
U95786 Genomic DNA. Translation: AAB88590.1.
U95787 Genomic DNA. Translation: AAB88591.1.
U95788 Genomic DNA. Translation: AAB88592.1.
U95789 Genomic DNA. Translation: AAB88593.1.
U95790 Genomic DNA. Translation: AAB88594.1.
U95791 Genomic DNA. Translation: AAB88595.1.
U95792 Genomic DNA. Translation: AAB88596.1.
U95793 Genomic DNA. Translation: AAB88597.1.
U95794 Genomic DNA. Translation: AAB88598.1.
U95795 Genomic DNA. Translation: AAB88599.1.
U95796 Genomic DNA. Translation: AAB88600.1.
U95797 Genomic DNA. Translation: AAB88601.1.
U95798 Genomic DNA. Translation: AAB88602.1.
RefSeqiXP_715542.1. XM_710449.1.
XP_715598.1. XM_710505.1.

Genome annotation databases

GeneIDi3642743.
3642789.
KEGGical:CaO19.10404.
cal:CaO19.2886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000084 Genomic DNA. Translation: EAK96519.1. Different initiation.
AACQ01000083 Genomic DNA. Translation: EAK96578.1. Different initiation.
U95784 Genomic DNA. Translation: AAB88588.1.
U95785 Genomic DNA. Translation: AAB88589.1.
U95786 Genomic DNA. Translation: AAB88590.1.
U95787 Genomic DNA. Translation: AAB88591.1.
U95788 Genomic DNA. Translation: AAB88592.1.
U95789 Genomic DNA. Translation: AAB88593.1.
U95790 Genomic DNA. Translation: AAB88594.1.
U95791 Genomic DNA. Translation: AAB88595.1.
U95792 Genomic DNA. Translation: AAB88596.1.
U95793 Genomic DNA. Translation: AAB88597.1.
U95794 Genomic DNA. Translation: AAB88598.1.
U95795 Genomic DNA. Translation: AAB88599.1.
U95796 Genomic DNA. Translation: AAB88600.1.
U95797 Genomic DNA. Translation: AAB88601.1.
U95798 Genomic DNA. Translation: AAB88602.1.
RefSeqiXP_715542.1. XM_710449.1.
XP_715598.1. XM_710505.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1225883. 5 interactions.
IntActiQ5A1D3. 2 interactions.
STRINGi5476.CAL0005224.

Proteomic databases

PRIDEiQ5A1D3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3642743.
3642789.
KEGGical:CaO19.10404.
cal:CaO19.2886.

Organism-specific databases

CGDiCAL0005224. CEK1.

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ5A1D3.
KOiK04371.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Sequence analysis of a compound coding-region microsatellite in Candida albicans resolves homoplasies and provides a high-resolution tool for genotyping."
    Metzgar D., Field D., Haubrich R., Wills C.
    FEMS Immunol. Med. Microbiol. 20:103-109(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-58.
    Strain: ATCC 36232, ATCC 60193 / S-24, R-2436, R-2535, R-2540, R-2607, R-2617, R-2621, R-2624, R-2777 and R-2805.

Entry informationi

Entry nameiERK1_CANAL
AccessioniPrimary (citable) accession number: Q5A1D3
Secondary accession number(s): O13435
, P28869, P87079, P87080, P87081, P87082, P87083, P87084, P87085, P87086, P87322, Q6LC13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 1, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.