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Q5A0M4 (EF2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Elongation factor 2

Short name=EF-2
Gene names
Name:EFT2
ORF Names:CaO19.13210, CaO19.5788
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length842 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome By similarity.

Subcellular location

Cytoplasm Ref.3.

Miscellaneous

Has antigenic properties.

Sequence similarities

Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.

Sequence caution

The sequence EAK96235.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence EAK96302.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 842842Elongation factor 2
PRO_0000091015

Regions

Nucleotide binding26 – 338GTP By similarity
Nucleotide binding104 – 1085GTP By similarity
Nucleotide binding158 – 1614GTP By similarity

Amino acid modifications

Modified residue6991Diphthamide By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5A0M4 [UniParc].

Last modified October 19, 2011. Version 2.
Checksum: 5C8C740109A23189

FASTA84293,354
        10         20         30         40         50         60 
MVAFTIEQIR GLMDKVTNVR NMSVIAHVDH GKSTLSDSLV QKAGIISAAK AGDARFMDTR 

        70         80         90        100        110        120 
KDEQERGITI KSTAISLYAS MTDEDVKDIK QKTDGNSFLV NLIDSPGHVD FSSEVTAALR 

       130        140        150        160        170        180 
VTDGALVVVD TVEGVCVQTE TVLRQALGER IKPVVVINKV DRALLELQTT KEDLYQTFAR 

       190        200        210        220        230        240 
TVESVNVIIS TYCDPVLGDV QVYPQKGTVA FASGLHGWAF TVRQFANKYS KKFGVDKEKM 

       250        260        270        280        290        300 
MERLWGDSYF NPKTKKWTNK DKDADGKPLE RAFNMFILDP IFRLFAAIMN FKKDEIPVLL 

       310        320        330        340        350        360 
EKLEIQLKGD EKDLEGKALL KVVMRKFLPA ADALLEMIVL HLPSPVTAQA YRAETLYEGP 

       370        380        390        400        410        420 
SDDPFCTAIR NCDPNADLML YVSKMVPTSD KGRFYAFGRV FAGTVKSGQK VRIQGPNYQV 

       430        440        450        460        470        480 
GKKEDLFLKS IQRTVLMMGR SVEQIDDCPA GNIIGLVGID QFLLKSGTIT TNEAAHNMKV 

       490        500        510        520        530        540 
MKFSVSPVVQ VAVEVKNAND LPKLVEGLKR LSKSDPCVLT YMSESGEHIV AGTGELHLEI 

       550        560        570        580        590        600 
CLQDLENDHA GVPLRISPPV VSYRETVEGE SSMVALSKSP NKHNRIYVKA QPIDEEVSLD 

       610        620        630        640        650        660 
IENGVINPRD DFKARARILA DKHGWDVVDA RKIWCFGPDG NGPNLVVDQT KAVQYLNEIK 

       670        680        690        700        710        720 
DSVVAAFQWA TKEGPIFGEN CRSVRVNILD VTLHADAIHR GGGQIIPTMR RVTYASMLLA 

       730        740        750        760        770        780 
EPAIQEPVFL VEIQCPENAI GGIYSVLNKK RGQVISEEQR PGTPLFTVKA YLPVNESFGF 

       790        800        810        820        830        840 
TGELRQATGG QAFPQLIFDH WQVMSGDVTD ENSKPGAIVK EKRVRAGLKP EVPEYTEYYD 


KL 

« Hide

References

« Hide 'large scale' references
[1]Capa L., Mendoza A., Serramia M.J., Garcia-Bustos J.F.
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 10261 / CBS 2718 / NBRC 1061.
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[3]"Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 559-564; 581-585 AND 675-682, SUBCELLULAR LOCATION, ANTIGENICITY.
Strain: SC5314 / ATCC MYA-2876.
Tissue: Protoplast.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y09664 Genomic DNA. Translation: CAA70857.2.
AACQ01000088 Genomic DNA. Translation: EAK96235.1. Sequence problems.
AACQ01000087 Genomic DNA. Translation: EAK96302.1. Sequence problems.
RefSeqXP_715264.1. XM_710171.1.
XP_715329.1. XM_710236.1.

3D structure databases

ProteinModelPortalQ5A0M4.
SMRQ5A0M4. Positions 1-842.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5A0M4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3642998.
3643055.
KEGGcal:CaO19.13210.
cal:CaO19.5788.

Organism-specific databases

CGDCAL0001544. EFT2.
CAL0064595. EFT2.

Phylogenomic databases

KOK03234.
OrthoDBEOG7966SQ.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
InterProIPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SMARTSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEF2_CANAL
AccessionPrimary (citable) accession number: Q5A0M4
Secondary accession number(s): O13430, Q9P4S4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 16, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names