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Q5A0M4

- EF2_CANAL

UniProt

Q5A0M4 - EF2_CANAL

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Protein

Elongation factor 2

Gene

EFT2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 338GTPBy similarity
Nucleotide bindingi104 – 1085GTPBy similarity
Nucleotide bindingi158 – 1614GTPBy similarity

GO - Molecular functioni

  1. drug binding Source: CGD
  2. GTPase activity Source: CGD
  3. GTP binding Source: UniProtKB-KW
  4. translation elongation factor activity Source: CGD

GO - Biological processi

  1. cellular response to drug Source: CGD
  2. GTP catabolic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 2
Short name:
EF-2
Gene namesi
Name:EFT2
ORF Names:CaO19.13210, CaO19.5788
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001544. EFT2.
CAL0064595. EFT2.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cell surface Source: CGD
  2. cytoplasm Source: UniProtKB-KW
  3. membrane Source: CGD
  4. plasma membrane Source: CGD
  5. yeast-form cell wall Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 842842Elongation factor 2PRO_0000091015Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei699 – 6991DiphthamideBy similarity

Proteomic databases

PRIDEiQ5A0M4.

Structurei

3D structure databases

ProteinModelPortaliQ5A0M4.
SMRiQ5A0M4. Positions 1-842.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 346330tr-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.PROSITE-ProRule annotation
Contains 1 tr-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ5A0M4.
KOiK03234.
OrthoDBiEOG7966SQ.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5A0M4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAFTIEQIR GLMDKVTNVR NMSVIAHVDH GKSTLSDSLV QKAGIISAAK
60 70 80 90 100
AGDARFMDTR KDEQERGITI KSTAISLYAS MTDEDVKDIK QKTDGNSFLV
110 120 130 140 150
NLIDSPGHVD FSSEVTAALR VTDGALVVVD TVEGVCVQTE TVLRQALGER
160 170 180 190 200
IKPVVVINKV DRALLELQTT KEDLYQTFAR TVESVNVIIS TYCDPVLGDV
210 220 230 240 250
QVYPQKGTVA FASGLHGWAF TVRQFANKYS KKFGVDKEKM MERLWGDSYF
260 270 280 290 300
NPKTKKWTNK DKDADGKPLE RAFNMFILDP IFRLFAAIMN FKKDEIPVLL
310 320 330 340 350
EKLEIQLKGD EKDLEGKALL KVVMRKFLPA ADALLEMIVL HLPSPVTAQA
360 370 380 390 400
YRAETLYEGP SDDPFCTAIR NCDPNADLML YVSKMVPTSD KGRFYAFGRV
410 420 430 440 450
FAGTVKSGQK VRIQGPNYQV GKKEDLFLKS IQRTVLMMGR SVEQIDDCPA
460 470 480 490 500
GNIIGLVGID QFLLKSGTIT TNEAAHNMKV MKFSVSPVVQ VAVEVKNAND
510 520 530 540 550
LPKLVEGLKR LSKSDPCVLT YMSESGEHIV AGTGELHLEI CLQDLENDHA
560 570 580 590 600
GVPLRISPPV VSYRETVEGE SSMVALSKSP NKHNRIYVKA QPIDEEVSLD
610 620 630 640 650
IENGVINPRD DFKARARILA DKHGWDVVDA RKIWCFGPDG NGPNLVVDQT
660 670 680 690 700
KAVQYLNEIK DSVVAAFQWA TKEGPIFGEN CRSVRVNILD VTLHADAIHR
710 720 730 740 750
GGGQIIPTMR RVTYASMLLA EPAIQEPVFL VEIQCPENAI GGIYSVLNKK
760 770 780 790 800
RGQVISEEQR PGTPLFTVKA YLPVNESFGF TGELRQATGG QAFPQLIFDH
810 820 830 840
WQVMSGDVTD ENSKPGAIVK EKRVRAGLKP EVPEYTEYYD KL
Length:842
Mass (Da):93,354
Last modified:October 19, 2011 - v2
Checksum:i5C8C740109A23189
GO

Sequence cautioni

The sequence EAK96235.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAK96302.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09664 Genomic DNA. Translation: CAA70857.2.
AACQ01000088 Genomic DNA. Translation: EAK96235.1. Sequence problems.
AACQ01000087 Genomic DNA. Translation: EAK96302.1. Sequence problems.
RefSeqiXP_715264.1. XM_710171.1.
XP_715329.1. XM_710236.1.

Genome annotation databases

GeneIDi3642998.
3643055.
KEGGical:CaO19.13210.
cal:CaO19.5788.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09664 Genomic DNA. Translation: CAA70857.2 .
AACQ01000088 Genomic DNA. Translation: EAK96235.1 . Sequence problems.
AACQ01000087 Genomic DNA. Translation: EAK96302.1 . Sequence problems.
RefSeqi XP_715264.1. XM_710171.1.
XP_715329.1. XM_710236.1.

3D structure databases

ProteinModelPortali Q5A0M4.
SMRi Q5A0M4. Positions 1-842.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5A0M4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3642998.
3643055.
KEGGi cal:CaO19.13210.
cal:CaO19.5788.

Organism-specific databases

CGDi CAL0001544. EFT2.
CAL0064595. EFT2.

Phylogenomic databases

InParanoidi Q5A0M4.
KOi K03234.
OrthoDBi EOG7966SQ.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
Pfami PF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SMARTi SM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view ]
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Capa L., Mendoza A., Serramia M.J., Garcia-Bustos J.F.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10261 / CBS 2718 / NBRC 1061.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  3. "Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies."
    Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C.
    Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 559-564; 581-585 AND 675-682, SUBCELLULAR LOCATION, ANTIGENICITY.
    Strain: SC5314 / ATCC MYA-2876.
    Tissue: Protoplast.

Entry informationi

Entry nameiEF2_CANAL
AccessioniPrimary (citable) accession number: Q5A0M4
Secondary accession number(s): O13430, Q9P4S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 19, 2011
Last modified: October 29, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Has antigenic properties.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3