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Protein

GPI mannosyltransferase 4

Gene

SMP3

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi (By similarity).By similarity

Miscellaneous

May be used as a target for the development of some new fungicide, due the fact the presence of a fourth mannose in GPI-anchor proteins is essential for viability in fungi but not in mammals.

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

  • alpha-1,2-mannosyltransferase activity Source: CGD

GO - Biological processi

  • fungal-type cell wall biogenesis Source: CGD
  • GPI anchor biosynthetic process Source: CGD

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI mannosyltransferase 4 (EC:2.4.1.-)
Alternative name(s):
CaSMP3
GPI mannosyltransferase IV
Short name:
GPI-MT-IV
Gene namesi
Name:SMP3
Ordered Locus Names:CAALFM_C203070CA
ORF Names:CaO19.13214, CaO19.5792
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 2

Organism-specific databases

CGDiCAL0000175734. SMP3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei332 – 348HelicalSequence analysisAdd BLAST17
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002462741 – 498GPI mannosyltransferase 4Add BLAST498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi408N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi473N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5A0L9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ5A0L9.
KOiK08098.
OrthoDBiEOG092C4MQ4.

Family and domain databases

InterProiView protein in InterPro
IPR005599. GPI_mannosylTrfase.
PANTHERiPTHR22760. PTHR22760. 1 hit.
PfamiView protein in Pfam
PF03901. Glyco_transf_22. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5A0L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKINFNWRT FYLLTIVFRF VFTLSDSYIH PDEHFQSLEV LTNRILNYST
60 70 80 90 100
NIPWEFQDDP ARSLAPLYFI YGPLLYFIKF FKLNLTALQI WYIARLQISI
110 120 130 140 150
LSWIITDFCL YWMLPSKPER IKAIFFTSTS YITLVYQNHL FSNSIETLLL
160 170 180 190 200
LVTILLIDDL RYVQESKDQD VQNLNKNKNL FYTGVLISLG IFNRITFPAF
210 220 230 240 250
LILPGWFVMK YVLKHYVSGL YLVMGFFSTT ALLILVDTIL FGNINNVVAE
260 270 280 290 300
PFNVSSYIIA PLNNLLYNAR YENLAQHGIH PYYTHILVNM PQILGPGLIF
310 320 330 340 350
FVSKSYTKTT PFLTVISGLL FLSVIPHQEL RFLIPLLPLA CCSFDFTLKW
360 370 380 390 400
VQPWMLYTWY IFNIFMSILM GKLHQGGVVP VLDHIKSEAS VQVWWRTYTP
410 420 430 440 450
PSWILGSNST ETTHLGEKLN DNKFINIVDC MGADSKEVQQ ILQTISTNKP
460 470 480 490
VYLITPIASF KHFDESRFSP VWNYTFHLDL DHLDFADIQP GLGVYQLL
Length:498
Mass (Da):57,971
Last modified:March 15, 2017 - v2
Checksum:i98A3C4952410BCE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017624 Genomic DNA. Translation: AOW27344.1.
RefSeqiXP_715333.2. XM_710240.2.

Genome annotation databases

EnsemblFungiiEAK96239; EAK96239; CaO19.13214.
EAK96306; EAK96306; CaO19.5792.
GeneIDi3642980.
KEGGical:CAALFM_C203070CA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017624 Genomic DNA. Translation: AOW27344.1.
RefSeqiXP_715333.2. XM_710240.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5A0L9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK96239; EAK96239; CaO19.13214.
EAK96306; EAK96306; CaO19.5792.
GeneIDi3642980.
KEGGical:CAALFM_C203070CA.

Organism-specific databases

CGDiCAL0000175734. SMP3.

Phylogenomic databases

InParanoidiQ5A0L9.
KOiK08098.
OrthoDBiEOG092C4MQ4.

Enzyme and pathway databases

UniPathwayiUPA00196.

Family and domain databases

InterProiView protein in InterPro
IPR005599. GPI_mannosylTrfase.
PANTHERiPTHR22760. PTHR22760. 1 hit.
PfamiView protein in Pfam
PF03901. Glyco_transf_22. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSMP3_CANAL
AccessioniPrimary (citable) accession number: Q5A0L9
Secondary accession number(s): A0A1D8PGU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 15, 2017
Last modified: May 10, 2017
This is version 75 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.