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Q5A0L9

- SMP3_CANAL

UniProt

Q5A0L9 - SMP3_CANAL

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Protein

GPI mannosyltransferase 4

Gene

SMP3

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi (By similarity).By similarity

Pathwayi

GO - Molecular functioni

  1. alpha-1,2-mannosyltransferase activity Source: CGD

GO - Biological processi

  1. fungal-type cell wall biogenesis Source: CGD
  2. GPI anchor biosynthetic process Source: CGD
  3. mannosylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI mannosyltransferase 4 (EC:2.4.1.-)
Alternative name(s):
CaSMP3
GPI mannosyltransferase IV
Short name:
GPI-MT-IV
Gene namesi
Name:SMP3
ORF Names:CaO19.13214, CaO19.5792
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001551. SMP3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Transmembranei63 – 8321HelicalSequence AnalysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence AnalysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence AnalysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence AnalysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence AnalysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence AnalysisAdd
BLAST
Transmembranei282 – 30221HelicalSequence AnalysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence AnalysisAdd
BLAST
Transmembranei332 – 34817HelicalSequence AnalysisAdd
BLAST
Transmembranei350 – 37021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498GPI mannosyltransferase 4PRO_0000246274Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi408 – 4081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi473 – 4731N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0001551.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG310998.
InParanoidiQ5A0L9.
KOiK08098.
OrthoDBiEOG7XPZFT.

Family and domain databases

InterProiIPR005599. GPI_mannosylTrfase.
[Graphical view]
PANTHERiPTHR22760. PTHR22760. 1 hit.
PfamiPF03901. Glyco_transf_22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5A0L9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKINFNWRT FYLLTIVFRF VFTLSDSYIH PDEHFQSLEV LTNRILNYST
60 70 80 90 100
NIPWEFQDDP ARSLAPLYFI YGPLLYFIKF FKLNLTALQI WYIARLQISI
110 120 130 140 150
LSWIITDFCL YWMLPSKPER IKAIFFTSTS YITLVYQNHL FSNSIETLLL
160 170 180 190 200
LVTILLIDDL RYVQESKDQD VQNLNKNKNL FYTGVLISLG IFNRITFPAF
210 220 230 240 250
LILPGWFVMK YVLKHYVSGL YLVMGFFSTT ALLILVDTIL FGNINNVVAE
260 270 280 290 300
PFNISSYIIA PLNNLLYNAR YENLAQHGIH PYYTHILVNM PQILGPGLIF
310 320 330 340 350
FVSKSYTKTT PFLTVISGLL FLSVIPHQEL RFLIPLLPLA CCSFDFTLKW
360 370 380 390 400
VQPWMLYTWY IFNIFMSILM GKLHQGGVVP VLDHIKSEAS VQVWWRTYTP
410 420 430 440 450
PSWILGSNST ETTHLGEKLN DNKFINIVDC MGADSKEVQQ ILQTISTNKP
460 470 480 490
VYLITPIASF KHFDESRFSP VWNYTFHLDL DHLDFADIQP GLGVYQLL
Length:498
Mass (Da):57,985
Last modified:April 26, 2005 - v1
Checksum:i8533C495219CCD22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000088 Genomic DNA. Translation: EAK96239.1.
AACQ01000087 Genomic DNA. Translation: EAK96306.1.
RefSeqiXP_715268.1. XM_710175.1.
XP_715333.1. XM_710240.1.

Genome annotation databases

GeneIDi3642980.
3643037.
KEGGical:CaO19.13214.
cal:CaO19.5792.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000088 Genomic DNA. Translation: EAK96239.1 .
AACQ01000087 Genomic DNA. Translation: EAK96306.1 .
RefSeqi XP_715268.1. XM_710175.1.
XP_715333.1. XM_710240.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0001551.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3642980.
3643037.
KEGGi cal:CaO19.13214.
cal:CaO19.5792.

Organism-specific databases

CGDi CAL0001551. SMP3.

Phylogenomic databases

eggNOGi NOG310998.
InParanoidi Q5A0L9.
KOi K08098.
OrthoDBi EOG7XPZFT.

Enzyme and pathway databases

UniPathwayi UPA00196 .

Family and domain databases

InterProi IPR005599. GPI_mannosylTrfase.
[Graphical view ]
PANTHERi PTHR22760. PTHR22760. 1 hit.
Pfami PF03901. Glyco_transf_22. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Deficiencies in the essential Smp3 mannosyltransferase block glycosylphosphatidylinositol assembly and lead to defects in growth and cell wall biogenesis in Candida albicans."
    Grimme S.J., Colussi P.A., Taron C.H., Orlean P.
    Microbiology 150:3115-3128(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiSMP3_CANAL
AccessioniPrimary (citable) accession number: Q5A0L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

May be used as a target for the development of some new fungicide, due the fact the presence of a fourth mannose in GPI-anchor proteins is essential for viability in fungi but not in mammals.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3