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Protein

GPI mannosyltransferase 4

Gene

SMP3

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi (By similarity).By similarity

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI mannosyltransferase 4 (EC:2.4.1.-)
Alternative name(s):
CaSMP3
GPI mannosyltransferase IV
Short name:
GPI-MT-IV
Gene namesi
Name:SMP3
ORF Names:CaO19.13214, CaO19.5792
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei332 – 348HelicalSequence analysisAdd BLAST17
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002462741 – 498GPI mannosyltransferase 4Add BLAST498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...)Sequence analysis1
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Glycosylationi408N-linked (GlcNAc...)Sequence analysis1
Glycosylationi473N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5A0L9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ5A0L9.
KOiK08098.
OrthoDBiEOG092C4MQ4.

Family and domain databases

InterProiIPR005599. GPI_mannosylTrfase.
[Graphical view]
PANTHERiPTHR22760. PTHR22760. 1 hit.
PfamiPF03901. Glyco_transf_22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5A0L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKINFNWRT FYLLTIVFRF VFTLSDSYIH PDEHFQSLEV LTNRILNYST
60 70 80 90 100
NIPWEFQDDP ARSLAPLYFI YGPLLYFIKF FKLNLTALQI WYIARLQISI
110 120 130 140 150
LSWIITDFCL YWMLPSKPER IKAIFFTSTS YITLVYQNHL FSNSIETLLL
160 170 180 190 200
LVTILLIDDL RYVQESKDQD VQNLNKNKNL FYTGVLISLG IFNRITFPAF
210 220 230 240 250
LILPGWFVMK YVLKHYVSGL YLVMGFFSTT ALLILVDTIL FGNINNVVAE
260 270 280 290 300
PFNISSYIIA PLNNLLYNAR YENLAQHGIH PYYTHILVNM PQILGPGLIF
310 320 330 340 350
FVSKSYTKTT PFLTVISGLL FLSVIPHQEL RFLIPLLPLA CCSFDFTLKW
360 370 380 390 400
VQPWMLYTWY IFNIFMSILM GKLHQGGVVP VLDHIKSEAS VQVWWRTYTP
410 420 430 440 450
PSWILGSNST ETTHLGEKLN DNKFINIVDC MGADSKEVQQ ILQTISTNKP
460 470 480 490
VYLITPIASF KHFDESRFSP VWNYTFHLDL DHLDFADIQP GLGVYQLL
Length:498
Mass (Da):57,985
Last modified:April 26, 2005 - v1
Checksum:i8533C495219CCD22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000088 Genomic DNA. Translation: EAK96239.1.
AACQ01000087 Genomic DNA. Translation: EAK96306.1.
RefSeqiXP_715268.1. XM_710175.1.
XP_715333.1. XM_710240.1.

Genome annotation databases

EnsemblFungiiEAK96239; EAK96239; CaO19.13214.
EAK96306; EAK96306; CaO19.5792.
GeneIDi3642980.
3643037.
KEGGical:CaO19.13214.
cal:CaO19.5792.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000088 Genomic DNA. Translation: EAK96239.1.
AACQ01000087 Genomic DNA. Translation: EAK96306.1.
RefSeqiXP_715268.1. XM_710175.1.
XP_715333.1. XM_710240.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5A0L9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK96239; EAK96239; CaO19.13214.
EAK96306; EAK96306; CaO19.5792.
GeneIDi3642980.
3643037.
KEGGical:CaO19.13214.
cal:CaO19.5792.

Phylogenomic databases

InParanoidiQ5A0L9.
KOiK08098.
OrthoDBiEOG092C4MQ4.

Enzyme and pathway databases

UniPathwayiUPA00196.

Family and domain databases

InterProiIPR005599. GPI_mannosylTrfase.
[Graphical view]
PANTHERiPTHR22760. PTHR22760. 1 hit.
PfamiPF03901. Glyco_transf_22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMP3_CANAL
AccessioniPrimary (citable) accession number: Q5A0L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: April 26, 2005
Last modified: October 5, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

May be used as a target for the development of some new fungicide, due the fact the presence of a fourth mannose in GPI-anchor proteins is essential for viability in fungi but not in mammals.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.