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Q5A0L9

- SMP3_CANAL

UniProt

Q5A0L9 - SMP3_CANAL

Protein

GPI mannosyltransferase 4

Gene

SMP3

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi By similarity.By similarity

    Pathwayi

    GO - Molecular functioni

    1. alpha-1,2-mannosyltransferase activity Source: CGD

    GO - Biological processi

    1. fungal-type cell wall biogenesis Source: CGD
    2. GPI anchor biosynthetic process Source: CGD
    3. mannosylation Source: GOC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    GPI-anchor biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00196.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GPI mannosyltransferase 4 (EC:2.4.1.-)
    Alternative name(s):
    CaSMP3
    GPI mannosyltransferase IV
    Short name:
    GPI-MT-IV
    Gene namesi
    Name:SMP3
    ORF Names:CaO19.13214, CaO19.5792
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0001551. SMP3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: CGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 498498GPI mannosyltransferase 4PRO_0000246274Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi408 – 4081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi473 – 4731N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0001551.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei96 – 11621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei247 – 26721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei282 – 30221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei310 – 33021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei332 – 34817HelicalSequence AnalysisAdd
    BLAST
    Transmembranei350 – 37021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG310998.
    KOiK08098.
    OrthoDBiEOG7XPZFT.

    Family and domain databases

    InterProiIPR005599. GPI_mannosylTrfase.
    [Graphical view]
    PANTHERiPTHR22760. PTHR22760. 1 hit.
    PfamiPF03901. Glyco_transf_22. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5A0L9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKINFNWRT FYLLTIVFRF VFTLSDSYIH PDEHFQSLEV LTNRILNYST    50
    NIPWEFQDDP ARSLAPLYFI YGPLLYFIKF FKLNLTALQI WYIARLQISI 100
    LSWIITDFCL YWMLPSKPER IKAIFFTSTS YITLVYQNHL FSNSIETLLL 150
    LVTILLIDDL RYVQESKDQD VQNLNKNKNL FYTGVLISLG IFNRITFPAF 200
    LILPGWFVMK YVLKHYVSGL YLVMGFFSTT ALLILVDTIL FGNINNVVAE 250
    PFNISSYIIA PLNNLLYNAR YENLAQHGIH PYYTHILVNM PQILGPGLIF 300
    FVSKSYTKTT PFLTVISGLL FLSVIPHQEL RFLIPLLPLA CCSFDFTLKW 350
    VQPWMLYTWY IFNIFMSILM GKLHQGGVVP VLDHIKSEAS VQVWWRTYTP 400
    PSWILGSNST ETTHLGEKLN DNKFINIVDC MGADSKEVQQ ILQTISTNKP 450
    VYLITPIASF KHFDESRFSP VWNYTFHLDL DHLDFADIQP GLGVYQLL 498
    Length:498
    Mass (Da):57,985
    Last modified:April 26, 2005 - v1
    Checksum:i8533C495219CCD22
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000088 Genomic DNA. Translation: EAK96239.1.
    AACQ01000087 Genomic DNA. Translation: EAK96306.1.
    RefSeqiXP_715268.1. XM_710175.1.
    XP_715333.1. XM_710240.1.

    Genome annotation databases

    GeneIDi3642980.
    3643037.
    KEGGical:CaO19.13214.
    cal:CaO19.5792.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000088 Genomic DNA. Translation: EAK96239.1 .
    AACQ01000087 Genomic DNA. Translation: EAK96306.1 .
    RefSeqi XP_715268.1. XM_710175.1.
    XP_715333.1. XM_710240.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0001551.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3642980.
    3643037.
    KEGGi cal:CaO19.13214.
    cal:CaO19.5792.

    Organism-specific databases

    CGDi CAL0001551. SMP3.

    Phylogenomic databases

    eggNOGi NOG310998.
    KOi K08098.
    OrthoDBi EOG7XPZFT.

    Enzyme and pathway databases

    UniPathwayi UPA00196 .

    Family and domain databases

    InterProi IPR005599. GPI_mannosylTrfase.
    [Graphical view ]
    PANTHERi PTHR22760. PTHR22760. 1 hit.
    Pfami PF03901. Glyco_transf_22. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. "Deficiencies in the essential Smp3 mannosyltransferase block glycosylphosphatidylinositol assembly and lead to defects in growth and cell wall biogenesis in Candida albicans."
      Grimme S.J., Colussi P.A., Taron C.H., Orlean P.
      Microbiology 150:3115-3128(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiSMP3_CANAL
    AccessioniPrimary (citable) accession number: Q5A0L9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    May be used as a target for the development of some new fungicide, due the fact the presence of a fourth mannose in GPI-anchor proteins is essential for viability in fungi but not in mammals.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3