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Q5A0L9 (SMP3_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GPI mannosyltransferase 4

EC=2.4.1.-
Alternative name(s):
CaSMP3
GPI mannosyltransferase IV
Short name=GPI-MT-IV
Gene names
Name:SMP3
ORF Names:CaO19.13214, CaO19.5792
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi By similarity.

Pathway

Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Miscellaneous

May be used as a target for the development of some new fungicide, due the fact the presence of a fourth mannose in GPI-anchor proteins is essential for viability in fungi but not in mammals.

Sequence similarities

Belongs to the glycosyltransferase 22 family. PIGZ subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498GPI mannosyltransferase 4
PRO_0000246274

Regions

Transmembrane11 – 3121Helical; Potential
Transmembrane63 – 8321Helical; Potential
Transmembrane96 – 11621Helical; Potential
Transmembrane140 – 16021Helical; Potential
Transmembrane189 – 20921Helical; Potential
Transmembrane222 – 24221Helical; Potential
Transmembrane247 – 26721Helical; Potential
Transmembrane282 – 30221Helical; Potential
Transmembrane310 – 33021Helical; Potential
Transmembrane332 – 34817Helical; Potential
Transmembrane350 – 37021Helical; Potential

Amino acid modifications

Glycosylation471N-linked (GlcNAc...) Potential
Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation4081N-linked (GlcNAc...) Potential
Glycosylation4731N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5A0L9 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 8533C495219CCD22

FASTA49857,985
        10         20         30         40         50         60 
MIKINFNWRT FYLLTIVFRF VFTLSDSYIH PDEHFQSLEV LTNRILNYST NIPWEFQDDP 

        70         80         90        100        110        120 
ARSLAPLYFI YGPLLYFIKF FKLNLTALQI WYIARLQISI LSWIITDFCL YWMLPSKPER 

       130        140        150        160        170        180 
IKAIFFTSTS YITLVYQNHL FSNSIETLLL LVTILLIDDL RYVQESKDQD VQNLNKNKNL 

       190        200        210        220        230        240 
FYTGVLISLG IFNRITFPAF LILPGWFVMK YVLKHYVSGL YLVMGFFSTT ALLILVDTIL 

       250        260        270        280        290        300 
FGNINNVVAE PFNISSYIIA PLNNLLYNAR YENLAQHGIH PYYTHILVNM PQILGPGLIF 

       310        320        330        340        350        360 
FVSKSYTKTT PFLTVISGLL FLSVIPHQEL RFLIPLLPLA CCSFDFTLKW VQPWMLYTWY 

       370        380        390        400        410        420 
IFNIFMSILM GKLHQGGVVP VLDHIKSEAS VQVWWRTYTP PSWILGSNST ETTHLGEKLN 

       430        440        450        460        470        480 
DNKFINIVDC MGADSKEVQQ ILQTISTNKP VYLITPIASF KHFDESRFSP VWNYTFHLDL 

       490 
DHLDFADIQP GLGVYQLL 

« Hide

References

« Hide 'large scale' references
[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"Deficiencies in the essential Smp3 mannosyltransferase block glycosylphosphatidylinositol assembly and lead to defects in growth and cell wall biogenesis in Candida albicans."
Grimme S.J., Colussi P.A., Taron C.H., Orlean P.
Microbiology 150:3115-3128(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000088 Genomic DNA. Translation: EAK96239.1.
AACQ01000087 Genomic DNA. Translation: EAK96306.1.
RefSeqXP_715268.1. XM_710175.1.
XP_715333.1. XM_710240.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0001551.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3642980.
3643037.
KEGGcal:CaO19.13214.
cal:CaO19.5792.

Organism-specific databases

CGDCAL0001551. SMP3.

Phylogenomic databases

eggNOGNOG310998.
KOK08098.
OrthoDBEOG7XPZFT.

Enzyme and pathway databases

UniPathwayUPA00196.

Family and domain databases

InterProIPR005599. GPI_mannosylTrfase.
[Graphical view]
PANTHERPTHR22760. PTHR22760. 1 hit.
PfamPF03901. Glyco_transf_22. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSMP3_CANAL
AccessionPrimary (citable) accession number: Q5A0L9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Candida albicans

Candida albicans: entries and gene names