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Protein

G2/mitotic-specific cyclin-4

Gene

CLB4

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

2/mitotic-specific cyclin essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Degradation is necessary for the cell to exit from mitosis. Plays a role in morphogenesis by negatively regulating polarized growth. Through binding to CDC28 regulates cytokinesis, partly by phosphorylation of the actomyosin ring component IQG1.1 Publication

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: CGD

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • filamentous growth Source: CGD
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: CGD
  • regulation of mitotic cell cycle Source: CGD

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-4
Gene namesi
Name:CLB4
Synonyms:CYB2
Ordered Locus Names:CAALFM_C703940CA
ORF Names:CaO19.7186
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 7

Organism-specific databases

CGDiCAL0000175354 CLB4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004246051 – 486G2/mitotic-specific cyclin-4Add BLAST486

Expressioni

Inductioni

Expressed from S phase through G2 and M phases and is degraded at the end of mitosis. Expression is down-regulated by the anti-fungal agent plagiochin E (PLE).2 Publications

Interactioni

Subunit structurei

Interacts with IQG1.1 Publication

Protein-protein interaction databases

IntActiQ5A0A9, 1 interactor
MINTiQ5A0A9

Structurei

3D structure databases

ProteinModelPortaliQ5A0A9
SMRiQ5A0A9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini234 – 359Cyclin N-terminalAdd BLAST126

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili122 – 184Sequence analysisAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi74 – 78Poly-Ser5
Compositional biasi109 – 112Poly-Asp4

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000167672
InParanoidiQ5A0A9
KOiK06659
OMAiCKTIDFR
OrthoDBiEOG092C2S0G

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

Q5A0A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSYKSSITD ENELTKQRLR AKSIANLSSN HTTAGQPSTS SQHREALTDL
60 70 80 90 100
TSQENKNHPR VKLTQTNTNH HRNSSSSSNK IQIYQQIEQK KTDIHQFKKP
110 120 130 140 150
RLEKVLLNDD DDETDDEFDD EEDKENRYHD LELNEDDSKH QLISEAFETI
160 170 180 190 200
DDRGISEGEN DTAQEARERL EEETQSHTQD MRSIYGVHVP MQPMWNNAII
210 220 230 240 250
NELKYVIQKY SRNTLDENDE DTYDTTMVAE YSPEIFNYLH ELENKFTPDP
260 270 280 290 300
NYMDFQDDLK WEMRAVLIDW VVQVHARFNL FSETLYLTVN YIDRFLSKRR
310 320 330 340 350
VSLSRFQLVG AVALFIAAKY EEINCPTVQE IAYMADNAYS IDEFLKAERF
360 370 380 390 400
MIDVLEFDLG WPGPMSFLRR ISKADDYDYE TRTLAKYFLE ITIMDSKFVA
410 420 430 440 450
SPPSWLAAGA HYISRILLGR GEWTELHVFY SGYTEKQLQP LADVLLENCR
460 470 480
HAEINHKAIF EKYKERRYRK SSLFVQEYFR HIMSQS
Length:486
Mass (Da):57,249
Last modified:April 26, 2005 - v1
Checksum:i1743090E4312FFA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017629 Genomic DNA Translation: AOW30733.1
RefSeqiXP_715235.1, XM_710142.1

Genome annotation databases

EnsemblFungiiAOW30733; AOW30733; CAALFM_C703940CA
GeneIDi3643102
KEGGical:CAALFM_C703940CA

Similar proteinsi

Entry informationi

Entry nameiCG24_CANAL
AccessioniPrimary (citable) accession number: Q5A0A9
Secondary accession number(s): A0A1D8PRH5, Q3MNW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 11, 2013
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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