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Protein

G2/mitotic-specific cyclin-4

Gene

CLB4

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

2/mitotic-specific cyclin essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Degradation is necessary for the cell to exit from mitosis. Plays a role in morphogenesis by negatively regulating polarized growth. Through binding to CDC28 regulates cytokinesis, partly by phosphorylation of the actomyosin ring component IQG1.1 Publication

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: CGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • filamentous growth Source: CGD
  • mitotic nuclear division Source: UniProtKB-KW
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: CGD
  • regulation of G1/S transition of mitotic cell cycle Source: EnsemblFungi
  • regulation of mitotic cell cycle Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-4
Gene namesi
Name:CLB4
Synonyms:CYB2
ORF Names:CaO19.7186
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000175354. CLB4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486G2/mitotic-specific cyclin-4PRO_0000424605Add
BLAST

Expressioni

Inductioni

Expressed from S phase through G2 and M phases and is degraded at the end of mitosis. Expression is down-regulated by the anti-fungal agent plagiochin E (PLE).2 Publications

Interactioni

Subunit structurei

Interacts with IQG1.1 Publication

Protein-protein interaction databases

IntActiQ5A0A9. 1 interaction.
MINTiMINT-7295609.

Structurei

3D structure databases

ProteinModelPortaliQ5A0A9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini234 – 359126Cyclin N-terminalAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili122 – 18463Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi74 – 785Poly-Ser
Compositional biasi109 – 1124Poly-Asp

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated
Contains 1 cyclin N-terminal domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000167672.
InParanoidiQ5A0A9.
KOiK06659.
OrthoDBiEOG7FNCJX.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5A0A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSYKSSITD ENELTKQRLR AKSIANLSSN HTTAGQPSTS SQHREALTDL
60 70 80 90 100
TSQENKNHPR VKLTQTNTNH HRNSSSSSNK IQIYQQIEQK KTDIHQFKKP
110 120 130 140 150
RLEKVLLNDD DDETDDEFDD EEDKENRYHD LELNEDDSKH QLISEAFETI
160 170 180 190 200
DDRGISEGEN DTAQEARERL EEETQSHTQD MRSIYGVHVP MQPMWNNAII
210 220 230 240 250
NELKYVIQKY SRNTLDENDE DTYDTTMVAE YSPEIFNYLH ELENKFTPDP
260 270 280 290 300
NYMDFQDDLK WEMRAVLIDW VVQVHARFNL FSETLYLTVN YIDRFLSKRR
310 320 330 340 350
VSLSRFQLVG AVALFIAAKY EEINCPTVQE IAYMADNAYS IDEFLKAERF
360 370 380 390 400
MIDVLEFDLG WPGPMSFLRR ISKADDYDYE TRTLAKYFLE ITIMDSKFVA
410 420 430 440 450
SPPSWLAAGA HYISRILLGR GEWTELHVFY SGYTEKQLQP LADVLLENCR
460 470 480
HAEINHKAIF EKYKERRYRK SSLFVQEYFR HIMSQS
Length:486
Mass (Da):57,249
Last modified:April 26, 2005 - v1
Checksum:i1743090E4312FFA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000089 Genomic DNA. Translation: EAK96204.1.
RefSeqiXP_715235.1. XM_710142.1.
XP_888999.1. XM_883906.1.

Genome annotation databases

EnsemblFungiiEAK96204; EAK96204; CaO19.7186.
GeneIDi3643102.
3704065.
KEGGical:CaO19.7186.
cal:CaO19_7186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000089 Genomic DNA. Translation: EAK96204.1.
RefSeqiXP_715235.1. XM_710142.1.
XP_888999.1. XM_883906.1.

3D structure databases

ProteinModelPortaliQ5A0A9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5A0A9. 1 interaction.
MINTiMINT-7295609.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK96204; EAK96204; CaO19.7186.
GeneIDi3643102.
3704065.
KEGGical:CaO19.7186.
cal:CaO19_7186.

Organism-specific databases

CGDiCAL0000175354. CLB4.

Phylogenomic databases

HOGENOMiHOG000167672.
InParanoidiQ5A0A9.
KOiK06659.
OrthoDBiEOG7FNCJX.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "The mitotic cyclins Clb2p and Clb4p affect morphogenesis in Candida albicans."
    Bensen E.S., Clemente-Blanco A., Finley K.R., Correa-Bordes J., Berman J.
    Mol. Biol. Cell 16:3387-3400(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, FUNCTION.
  3. "The IQGAP Iqg1 is a regulatory target of CDK for cytokinesis in Candida albicans."
    Li C.R., Wang Y.M., Wang Y.
    EMBO J. 27:2998-3010(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IQG1.
  4. "Plagiochin E, an antifungal active macrocyclic bis(bibenzyl), induced apoptosis in Candida albicans through a metacaspase-dependent apoptotic pathway."
    Wu X.Z., Chang W.Q., Cheng A.X., Sun L.M., Lou H.X.
    Biochim. Biophys. Acta 1800:439-447(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiCG24_CANAL
AccessioniPrimary (citable) accession number: Q5A0A9
Secondary accession number(s): Q3MNW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 11, 2013
Last sequence update: April 26, 2005
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.