Reviewed, UniProtKB/Swiss-Prot Q5A013 (NNT1_CANAL)

Names and origin

Protein names

Recommended name:
    Putative nicotinamide N-methyltransferase
    EC=2.1.1.1

Gene names

Name:	NNT1
ORF Names:	CaO19.4375, CaO19.11853

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Putative nicotinamide N-methyltransferase involved in rDNA silencing and in lifespan determination By similarity.
Catalytic activity	S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NNT1 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinamide N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Putative nicotinamide N-methyltransferase		PRO_0000096891

Sequences

	Sequence		Length	Mass (Da)
	Q5A013-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 4C1EAFD9320AD296	FASTA	262	30,430
	10 20 30 40 50 60 MSEDEISIEG DLFEEPEGFL PERPSSHFST YKRKIPNAEP QEITMKLVGH NPLYGHLLWN 70 80 90 100 110 120 AGIYTADYLD KHSDTLVQGK KILELGAASA LPSLVCSLNH AKEVIVTDYP DPDLLSHMEY 130 140 150 160 170 180 SFNDLKEKTK YELSPWKVKG YIWGHDLGEL LFDEPGRKLA EEEKFDLIIL SDLVFNHSEH 190 200 210 220 230 240 HKLLDTCRQS LKRNGGKCLV VFSPHRPYLL QDDLSFFETA KQYQFKTEKI EMVTWKPMFE 250 260 EDEETADIRA RVYAFFLIPE WE

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000090 Genomic DNA. Translation: EAK96118.1. AACQ01000091 Genomic DNA. Translation: EAK96066.1.
RefSeq	XP_715100.1. XP_715151.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3643178. 3643242.
KEGG	cal:CaO19.11853. cal:CaO19.4375.
Organism-specific databases
CGD	CAL0001114. orf19.4375.
Phylogenomic databases
OMA	VVFSPHR.
Enzyme and pathway databases
BRENDA	2.1.1.1. 1124.
Family and domain databases
InterPro	IPR019410. Methyltransferase-16_put. [Graphical view]
Pfam	PF10294. Methyltransf_16. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NNT1_CANAL

Accession

Primary (citable) accession number: Q5A013

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	April 26, 2005
Last modified:	November 3, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)