Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Exonuclease V, mitochondrial

Gene

DEM1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively (By similarity).By similarity

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi164Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi586Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi589Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi595Iron-sulfur (4Fe-4S)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding, Exonuclease, Hydrolase, Nuclease
Ligand4Fe-4S, Iron, Iron-sulfur, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Exonuclease V, mitochondrial (EC:3.1.-.-)
Short name:
Exo V
Alternative name(s):
Defects in morphology protein 1
Gene namesi
Name:DEM1
Synonyms:EXO5
Ordered Locus Names:CAALFM_CR03490WA
ORF Names:CaO19.11870, CaO19.4392
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome R

Organism-specific databases

CGDiCAL0000179448. DEM1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 21MitochondrionSequence analysisAdd BLAST21
ChainiPRO_000028532122 – 628Exonuclease V, mitochondrialAdd BLAST607

Proteomic databases

PRIDEiQ59ZZ6.

Interactioni

Subunit structurei

Monomer.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the EXO5 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

InParanoidiQ59ZZ6.
KOiK17815.
OrthoDBiEOG092C160Q.

Family and domain databases

InterProiView protein in InterPro
IPR019190. EXOV.
PfamiView protein in Pfam
PF09810. Exo5. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59ZZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFWHFKKF YFTSCYSMQR MRGKIFKNEP LVPMNVTSEH EQVQSISKEE
60 70 80 90 100
SRSLSSNDLN LSADSELQLE SEPEIESEQL KNHEDVYEII RSMVLAADTT
110 120 130 140 150
LPRLSNNSLT GIYNHWKLNP NDDLPLYNPT KYTPYEFHSQ YNQDRSYIIT
160 170 180 190 200
PRLSVTKLLV SSWCELRSFY QVYSGSVRLP STKAMTQGTK LHSKLEAEVH
210 220 230 240 250
PEIDTTEIEQ FLISNAMSLR ELQTTVPAEE ETVVIDLGEV EQLAVDWAEM
260 270 280 290 300
LIERLFSLIM GAEAREILLH GYLNLKNRSF VTNKDEIRES SSVLVSGIVD
310 320 330 340 350
YIKLQNVTNP SDGTLFDDIH GFVDSAFDQV DNVPLVDLSQ FLPEAKQILQ
360 370 380 390 400
NYDFRLTFTD VKTRSARQIP RQESVLEAAK FQTFYYRHFF HLLSRDSRFT
410 420 430 440 450
YFSLIENAER RGHDVDKPLS ILTTISLLRK HYHIFFKDFV KLANGEPIGF
460 470 480 490 500
SPFDDSAKSI PYDFVSMFQS SDEFSLANPN HNHFLEQISA IDGIEYDSIL
510 520 530 540 550
SPLLKVWKTP PTLRYLAARA SQLFNVFNEN IGDITSVEYR YNKTSELLSE
560 570 580 590 600
KVYDYNFSEF QAEVESASKF WNGEREVIPT EDLSRCSYCE FQSKCMVAGG
610 620
KTTEAVEKKT IGPKIRQFLN ECESSSKG
Length:628
Mass (Da):72,427
Last modified:March 15, 2017 - v2
Checksum:i49AA7D8685397AE1
GO

Sequence cautioni

The sequence AOW31087 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017630 Genomic DNA. Translation: AOW31087.1. Different initiation.
RefSeqiXP_715168.2. XM_710075.2.

Genome annotation databases

GeneIDi3643200.
KEGGical:CAALFM_CR03490WA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017630 Genomic DNA. Translation: AOW31087.1. Different initiation.
RefSeqiXP_715168.2. XM_710075.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ59ZZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3643200.
KEGGical:CAALFM_CR03490WA.

Organism-specific databases

CGDiCAL0000179448. DEM1.

Phylogenomic databases

InParanoidiQ59ZZ6.
KOiK17815.
OrthoDBiEOG092C160Q.

Miscellaneous databases

PROiPR:Q59ZZ6.

Family and domain databases

InterProiView protein in InterPro
IPR019190. EXOV.
PfamiView protein in Pfam
PF09810. Exo5. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEXO5_CANAL
AccessioniPrimary (citable) accession number: Q59ZZ6
Secondary accession number(s): A0A1D8PSI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 15, 2017
Last modified: June 7, 2017
This is version 56 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.