Q59ZZ6 (EXO5_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Exonuclease V, mitochondrial
Short name=Exo V
EC=3.1.-.-

Alternative name(s):
Defects in morphology protein 1

Gene names

Name:	DEM1
Synonyms:	EXO5
ORF Names:	CaO19.11870, CaO19.4392

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	628 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively By similarity.
Cofactor	Magnesium By similarity. Binds 1 4Fe-4S cluster By similarity.
Subunit structure	Monomer By similarity.
Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the EXO5 family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	4Fe-4S DNA-binding Iron Iron-sulfur Magnesium Metal-binding
Molecular function	Exonuclease Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: UniProtKB-KW exonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 21	21	Mitochondrion Potential
	Chain	22 – 628	607	Exonuclease V, mitochondrial		PRO_0000285321
Sites
	Metal binding	164	1	Iron-sulfur (4Fe-4S) By similarity
	Metal binding	586	1	Iron-sulfur (4Fe-4S) By similarity
	Metal binding	589	1	Iron-sulfur (4Fe-4S) By similarity
	Metal binding	595	1	Iron-sulfur (4Fe-4S) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q59ZZ6 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: E631E79B50E96211	FASTA	628	72,500
	10 20 30 40 50 60 MSRFWHFKKF YFTSCYSMQR MRGKIFKNEP LVPMDVTSEH EQVQSISKEE SRSLSSNDLN 70 80 90 100 110 120 LSADSELQLE SEPEIESEQL KNHEDVYEII RSMVLAADTT LPRLSNNSLT GIYNHWKLNP 130 140 150 160 170 180 NDDLPLYNPT KYTPYEFHSQ YNQDRSYIIT PRLSVTKLLV SSWCELRSFY QVYSGSVRLP 190 200 210 220 230 240 STKAMTQGTK LHSKLEAEIH PEIDTTEIEQ FLISNAMSLR ELQTTVPAEE ETVVIDLGEV 250 260 270 280 290 300 EQLAVDWAEM LIERLFSLIM GAEAREILLH GYLNLKNRSF VTNKDEIRES SSVLVSGIVD 310 320 330 340 350 360 YIKLQNVTNP SDGTLFDDIH GFVDSAFDQV DNVPLVDLSQ FLPEAKQILQ NYDFRLTFTD 370 380 390 400 410 420 VKTRSARQIP RQESVLEAAK FQTFYYRHFF HLLSRDSRFT YFSLIENAER RGHDVDKPLS 430 440 450 460 470 480 ILTTISLLRK HYHIFFKDFV KLANGEPIGF SPFDDSAKSI PYDFVSMFQS SDEFSLANPN 490 500 510 520 530 540 HNHFLEQISE IDGIEYDSIL SPLLKVWKTP PTLRYLAARA SQLFNVFNEN IGDITSVEYR 550 560 570 580 590 600 YNKTSELLSE KVYDYNFSEF QAEVESASKF WNGEREVIPT EDLSRCSYCE FQSKCMVAGG 610 620 KTTEAVEKKT IGPKIRQFLN ECESSSKG

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000090 Genomic DNA. Translation: EAK96135.1. AACQ01000091 Genomic DNA. Translation: EAK96083.1.
RefSeq	XP_715117.1. XM_710024.1. XP_715168.1. XM_710075.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3643200. 3643259.
KEGG	cal:CaO19.11870. cal:CaO19.4392.
Organism-specific databases
CGD	CAL0001175. DEM1.
Phylogenomic databases
eggNOG	NOG328932.
Family and domain databases
InterPro	IPR019190. EXOV. [Graphical view]
Pfam	PF09810. Morph_protein1. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EXO5_CANAL

Accession

Primary (citable) accession number: Q59ZZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	April 26, 2005
Last modified:	May 1, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program