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Q59ZZ6

- EXO5_CANAL

UniProt

Q59ZZ6 - EXO5_CANAL

Protein

Exonuclease V, mitochondrial

Gene

DEM1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively By similarity.By similarity

    Cofactori

    Magnesium.By similarity
    Binds 1 4Fe-4S cluster.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi164 – 1641Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi586 – 5861Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi589 – 5891Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi595 – 5951Iron-sulfur (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. single-stranded DNA 5'-3' exodeoxyribonuclease activity Source: InterPro

    Keywords - Molecular functioni

    Exonuclease, Hydrolase, Nuclease

    Keywords - Ligandi

    4Fe-4S, DNA-binding, Iron, Iron-sulfur, Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exonuclease V, mitochondrial (EC:3.1.-.-)
    Short name:
    Exo V
    Alternative name(s):
    Defects in morphology protein 1
    Gene namesi
    Name:DEM1
    Synonyms:EXO5
    ORF Names:CaO19.11870, CaO19.4392
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0001175. DEM1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2121MitochondrionSequence AnalysisAdd
    BLAST
    Chaini22 – 628607Exonuclease V, mitochondrialPRO_0000285321Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the EXO5 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG328932.
    KOiK17815.
    OrthoDBiEOG7B5X4N.

    Family and domain databases

    InterProiIPR019190. EXOV.
    [Graphical view]
    PfamiPF09810. Exo5. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q59ZZ6-1 [UniParc]FASTAAdd to Basket

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    MSRFWHFKKF YFTSCYSMQR MRGKIFKNEP LVPMDVTSEH EQVQSISKEE    50
    SRSLSSNDLN LSADSELQLE SEPEIESEQL KNHEDVYEII RSMVLAADTT 100
    LPRLSNNSLT GIYNHWKLNP NDDLPLYNPT KYTPYEFHSQ YNQDRSYIIT 150
    PRLSVTKLLV SSWCELRSFY QVYSGSVRLP STKAMTQGTK LHSKLEAEIH 200
    PEIDTTEIEQ FLISNAMSLR ELQTTVPAEE ETVVIDLGEV EQLAVDWAEM 250
    LIERLFSLIM GAEAREILLH GYLNLKNRSF VTNKDEIRES SSVLVSGIVD 300
    YIKLQNVTNP SDGTLFDDIH GFVDSAFDQV DNVPLVDLSQ FLPEAKQILQ 350
    NYDFRLTFTD VKTRSARQIP RQESVLEAAK FQTFYYRHFF HLLSRDSRFT 400
    YFSLIENAER RGHDVDKPLS ILTTISLLRK HYHIFFKDFV KLANGEPIGF 450
    SPFDDSAKSI PYDFVSMFQS SDEFSLANPN HNHFLEQISE IDGIEYDSIL 500
    SPLLKVWKTP PTLRYLAARA SQLFNVFNEN IGDITSVEYR YNKTSELLSE 550
    KVYDYNFSEF QAEVESASKF WNGEREVIPT EDLSRCSYCE FQSKCMVAGG 600
    KTTEAVEKKT IGPKIRQFLN ECESSSKG 628
    Length:628
    Mass (Da):72,500
    Last modified:April 26, 2005 - v1
    Checksum:iE631E79B50E96211
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000090 Genomic DNA. Translation: EAK96135.1.
    AACQ01000091 Genomic DNA. Translation: EAK96083.1.
    RefSeqiXP_715117.1. XM_710024.1.
    XP_715168.1. XM_710075.1.

    Genome annotation databases

    GeneIDi3643200.
    3643259.
    KEGGical:CaO19.11870.
    cal:CaO19.4392.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000090 Genomic DNA. Translation: EAK96135.1 .
    AACQ01000091 Genomic DNA. Translation: EAK96083.1 .
    RefSeqi XP_715117.1. XM_710024.1.
    XP_715168.1. XM_710075.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3643200.
    3643259.
    KEGGi cal:CaO19.11870.
    cal:CaO19.4392.

    Organism-specific databases

    CGDi CAL0001175. DEM1.

    Phylogenomic databases

    eggNOGi NOG328932.
    KOi K17815.
    OrthoDBi EOG7B5X4N.

    Family and domain databases

    InterProi IPR019190. EXOV.
    [Graphical view ]
    Pfami PF09810. Exo5. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiEXO5_CANAL
    AccessioniPrimary (citable) accession number: Q59ZZ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3