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Q59ZZ6

- EXO5_CANAL

UniProt

Q59ZZ6 - EXO5_CANAL

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Protein

Exonuclease V, mitochondrial

Gene

DEM1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively (By similarity).By similarity

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi164 – 1641Iron-sulfur (4Fe-4S)By similarity
Metal bindingi586 – 5861Iron-sulfur (4Fe-4S)By similarity
Metal bindingi589 – 5891Iron-sulfur (4Fe-4S)By similarity
Metal bindingi595 – 5951Iron-sulfur (4Fe-4S)By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. single-stranded DNA 5'-3' exodeoxyribonuclease activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Ligandi

4Fe-4S, DNA-binding, Iron, Iron-sulfur, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Exonuclease V, mitochondrial (EC:3.1.-.-)
Short name:
Exo V
Alternative name(s):
Defects in morphology protein 1
Gene namesi
Name:DEM1
Synonyms:EXO5
ORF Names:CaO19.11870, CaO19.4392
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001175. DEM1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121MitochondrionSequence AnalysisAdd
BLAST
Chaini22 – 628607Exonuclease V, mitochondrialPRO_0000285321Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the EXO5 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG328932.
InParanoidiQ59ZZ6.
KOiK17815.
OrthoDBiEOG7B5X4N.

Family and domain databases

InterProiIPR019190. EXOV.
[Graphical view]
PfamiPF09810. Exo5. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59ZZ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRFWHFKKF YFTSCYSMQR MRGKIFKNEP LVPMDVTSEH EQVQSISKEE
60 70 80 90 100
SRSLSSNDLN LSADSELQLE SEPEIESEQL KNHEDVYEII RSMVLAADTT
110 120 130 140 150
LPRLSNNSLT GIYNHWKLNP NDDLPLYNPT KYTPYEFHSQ YNQDRSYIIT
160 170 180 190 200
PRLSVTKLLV SSWCELRSFY QVYSGSVRLP STKAMTQGTK LHSKLEAEIH
210 220 230 240 250
PEIDTTEIEQ FLISNAMSLR ELQTTVPAEE ETVVIDLGEV EQLAVDWAEM
260 270 280 290 300
LIERLFSLIM GAEAREILLH GYLNLKNRSF VTNKDEIRES SSVLVSGIVD
310 320 330 340 350
YIKLQNVTNP SDGTLFDDIH GFVDSAFDQV DNVPLVDLSQ FLPEAKQILQ
360 370 380 390 400
NYDFRLTFTD VKTRSARQIP RQESVLEAAK FQTFYYRHFF HLLSRDSRFT
410 420 430 440 450
YFSLIENAER RGHDVDKPLS ILTTISLLRK HYHIFFKDFV KLANGEPIGF
460 470 480 490 500
SPFDDSAKSI PYDFVSMFQS SDEFSLANPN HNHFLEQISE IDGIEYDSIL
510 520 530 540 550
SPLLKVWKTP PTLRYLAARA SQLFNVFNEN IGDITSVEYR YNKTSELLSE
560 570 580 590 600
KVYDYNFSEF QAEVESASKF WNGEREVIPT EDLSRCSYCE FQSKCMVAGG
610 620
KTTEAVEKKT IGPKIRQFLN ECESSSKG
Length:628
Mass (Da):72,500
Last modified:April 26, 2005 - v1
Checksum:iE631E79B50E96211
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000090 Genomic DNA. Translation: EAK96135.1.
AACQ01000091 Genomic DNA. Translation: EAK96083.1.
RefSeqiXP_715117.1. XM_710024.1.
XP_715168.1. XM_710075.1.

Genome annotation databases

GeneIDi3643200.
3643259.
KEGGical:CaO19.11870.
cal:CaO19.4392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000090 Genomic DNA. Translation: EAK96135.1 .
AACQ01000091 Genomic DNA. Translation: EAK96083.1 .
RefSeqi XP_715117.1. XM_710024.1.
XP_715168.1. XM_710075.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3643200.
3643259.
KEGGi cal:CaO19.11870.
cal:CaO19.4392.

Organism-specific databases

CGDi CAL0001175. DEM1.

Phylogenomic databases

eggNOGi NOG328932.
InParanoidi Q59ZZ6.
KOi K17815.
OrthoDBi EOG7B5X4N.

Family and domain databases

InterProi IPR019190. EXOV.
[Graphical view ]
Pfami PF09810. Exo5. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiEXO5_CANAL
AccessioniPrimary (citable) accession number: Q59ZZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: April 26, 2005
Last modified: November 26, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3