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Q59ZZ6 (EXO5_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Exonuclease V, mitochondrial

Short name=Exo V
EC=3.1.-.-
Alternative name(s):
Defects in morphology protein 1
Gene names
Name:DEM1
Synonyms:EXO5
ORF Names:CaO19.11870, CaO19.4392
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length628 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively By similarity.

Cofactor

Magnesium By similarity.

Binds 1 4Fe-4S cluster By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the EXO5 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2121Mitochondrion Potential
Chain22 – 628607Exonuclease V, mitochondrial
PRO_0000285321

Sites

Metal binding1641Iron-sulfur (4Fe-4S) By similarity
Metal binding5861Iron-sulfur (4Fe-4S) By similarity
Metal binding5891Iron-sulfur (4Fe-4S) By similarity
Metal binding5951Iron-sulfur (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q59ZZ6 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: E631E79B50E96211

FASTA62872,500
        10         20         30         40         50         60 
MSRFWHFKKF YFTSCYSMQR MRGKIFKNEP LVPMDVTSEH EQVQSISKEE SRSLSSNDLN 

        70         80         90        100        110        120 
LSADSELQLE SEPEIESEQL KNHEDVYEII RSMVLAADTT LPRLSNNSLT GIYNHWKLNP 

       130        140        150        160        170        180 
NDDLPLYNPT KYTPYEFHSQ YNQDRSYIIT PRLSVTKLLV SSWCELRSFY QVYSGSVRLP 

       190        200        210        220        230        240 
STKAMTQGTK LHSKLEAEIH PEIDTTEIEQ FLISNAMSLR ELQTTVPAEE ETVVIDLGEV 

       250        260        270        280        290        300 
EQLAVDWAEM LIERLFSLIM GAEAREILLH GYLNLKNRSF VTNKDEIRES SSVLVSGIVD 

       310        320        330        340        350        360 
YIKLQNVTNP SDGTLFDDIH GFVDSAFDQV DNVPLVDLSQ FLPEAKQILQ NYDFRLTFTD 

       370        380        390        400        410        420 
VKTRSARQIP RQESVLEAAK FQTFYYRHFF HLLSRDSRFT YFSLIENAER RGHDVDKPLS 

       430        440        450        460        470        480 
ILTTISLLRK HYHIFFKDFV KLANGEPIGF SPFDDSAKSI PYDFVSMFQS SDEFSLANPN 

       490        500        510        520        530        540 
HNHFLEQISE IDGIEYDSIL SPLLKVWKTP PTLRYLAARA SQLFNVFNEN IGDITSVEYR 

       550        560        570        580        590        600 
YNKTSELLSE KVYDYNFSEF QAEVESASKF WNGEREVIPT EDLSRCSYCE FQSKCMVAGG 

       610        620 
KTTEAVEKKT IGPKIRQFLN ECESSSKG 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000090 Genomic DNA. Translation: EAK96135.1.
AACQ01000091 Genomic DNA. Translation: EAK96083.1.
RefSeqXP_715117.1. XM_710024.1.
XP_715168.1. XM_710075.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3643200.
3643259.
KEGGcal:CaO19.11870.
cal:CaO19.4392.

Organism-specific databases

CGDCAL0001175. DEM1.

Phylogenomic databases

eggNOGNOG328932.
KOK17815.
OrthoDBEOG7B5X4N.

Family and domain databases

InterProIPR019190. EXOV.
[Graphical view]
PfamPF09810. Exo5. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEXO5_CANAL
AccessionPrimary (citable) accession number: Q59ZZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names