Reviewed, UniProtKB/Swiss-Prot Q59ZV4 (BNA7_CANAL)

Names and origin

Protein names

Recommended name:
    Probable kynurenine formamidase
    EC=3.5.1.9
Alternative name(s):
    Probable N-formylkynurenine formamidase
    Biosynthesis of nicotinic acid protein 7

Gene names

Name:	BNA7
ORF Names:	CaO19.7237

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the conversion of tryptophan to nicotinic acid, NAD(H) and NADP(H) By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the BNA7 family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	tryptophan catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arylformamidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Probable kynurenine formamidase		PRO_0000361881
Sites
	Active site	37	1	Potential
	Active site	104	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q59ZV4-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 4E1B92AE06554649	FASTA	267	30,609
	10 20 30 40 50 60 MEDISEEQEF KYGEHSLQKI KVFKYSSTNA STYIYIHGGA WRDPSNTFDE MRPVLGIPNA 70 80 90 100 110 120 NLIGINYRLS PEIKHPEHLI DILRALRFVK QNFDVSQITL LGHSVGATMI LQLLHYRQII 130 140 150 160 170 180 RDGLKHTHKD DLSSLDNLFA YVNDNVLLSQ VIFLDGIYDV VELLKEYPDY ASFVDDAFVS 190 200 210 220 230 240 NKHFADSTQL SSANESLDLP FSLVSKDTKF LIYQSLEDDL LSMKQTHLLI DYLSSKNQGF 250 260 TLHVGNWGKH EEIFGKYREI VFSGNVP

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000092 Genomic DNA. Translation: EAK95999.1.
RefSeq	XP_715037.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3643309.
KEGG	cal:CaO19.7237.
Organism-specific databases
CGD	CAL0003841. orf19.7237.
Phylogenomic databases
OMA	ERILMNE.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

BNA7_CANAL

Accession

Primary (citable) accession number: Q59ZV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	April 26, 2005
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)