Reviewed, UniProtKB/Swiss-Prot Q59ZV4 (BNA7_CANAL)

Names and originHide

Protein names

Recommended name:
Probable kynurenine formamidase
EC=3.5.1.9

Alternative name(s):
Probable N-formylkynurenine formamidase
Biosynthesis of nicotinic acid protein 7

Gene names

Name:	BNA7
ORF Names:	CaO19.7237

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributesHide

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)Hide

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the conversion of tryptophan to nicotinic acid, NAD(H) and NADP(H) By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the BNA7 family.

OntologiesHide

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	tryptophan catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arylformamidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)Hide

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Probable kynurenine formamidase		PRO_0000361881
Sites
	Active site	37	1	Potential
	Active site	104	1	Potential

SequencesHide

	Sequence		Length	Mass (Da)
	Q59ZV4-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 4E1B92AE06554649	FASTA	267	30,609
	10 20 30 40 50 60 MEDISEEQEF KYGEHSLQKI KVFKYSSTNA STYIYIHGGA WRDPSNTFDE MRPVLGIPNA 70 80 90 100 110 120 NLIGINYRLS PEIKHPEHLI DILRALRFVK QNFDVSQITL LGHSVGATMI LQLLHYRQII 130 140 150 160 170 180 RDGLKHTHKD DLSSLDNLFA YVNDNVLLSQ VIFLDGIYDV VELLKEYPDY ASFVDDAFVS 190 200 210 220 230 240 NKHFADSTQL SSANESLDLP FSLVSKDTKF LIYQSLEDDL LSMKQTHLLI DYLSSKNQGF 250 260 TLHVGNWGKH EEIFGKYREI VFSGNVP

ReferencesHide

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-referencesHide

Sequence databases
EMBL GenBank DDBJ	AACQ01000092 Genomic DNA. Translation: EAK95999.1.
RefSeq	XP_715037.1.
3D structure databases
SMR	Q59ZV4. Positions 18-257.
ModBase	Search...
Genome annotation databases
GeneID	3643309.
KEGG	cal:CaO19.7237.
Organism-specific databases
CGD	CAL0003841. orf19.7237.
Phylogenomic databases
OMA	ERILMNE.
OrthoDB	EOG9VT7D9.
PhylomeDB	Q59ZV4.
Family and domain databases
InterPro	IPR013094. AB_hydrolase_3. [Graphical view]
Pfam	PF07859. Abhydrolase_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry informationHide

Entry name

BNA7_CANAL

Accession

Primary (citable) accession number: Q59ZV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	April 26, 2005
Last modified:	July 13, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)