Q59YK4 (PALH_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
pH-response regulator protein palH/RIM21

Gene names

Name:	RIM21
ORF Names:	CaO19.10686, CaO19.3176

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the palH/RIM21 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to alkalinity Inferred from mutant phenotype PubMed 19230847PubMed 22427429. Source: CGD cellular response to lithium ion Inferred from mutant phenotype PubMed 19230847. Source: CGD cellular response to neutral pH Inferred from mutant phenotype PubMed 19230847. Source: CGD filamentous growth of a population of unicellular organisms in response to neutral pH Inferred from mutant phenotype PubMed 19230847. Source: CGD
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 529	529	pH-response regulator protein palH/RIM21		PRO_0000058197
Regions
	Topological domain	1 – 96	96	Extracellular Potential
	Transmembrane	97 – 117	21	Helical; Potential
	Topological domain	118 – 130	13	Cytoplasmic Potential
	Transmembrane	131 – 151	21	Helical; Potential
	Topological domain	152 – 172	21	Extracellular Potential
	Transmembrane	173 – 193	21	Helical; Potential
	Topological domain	194 – 204	11	Cytoplasmic Potential
	Transmembrane	205 – 225	21	Helical; Potential
	Topological domain	226 – 241	16	Extracellular Potential
	Transmembrane	242 – 262	21	Helical; Potential
	Topological domain	263 – 273	11	Cytoplasmic Potential
	Transmembrane	274 – 294	21	Helical; Potential
	Topological domain	295 – 298	4	Extracellular Potential
	Transmembrane	299 – 319	21	Helical; Potential
	Topological domain	320 – 529	210	Cytoplasmic Potential
Natural variations
	Natural variant	263	1	S → T in allele CaO19.10686.

Sequences

	Sequence		Length	Mass (Da)
	Q59YK4 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: C6D88774DE73C239	FASTA	529	60,057
	10 20 30 40 50 60 MYWKNAWWVG TVYSSCEPIE LPEGMLISKQ YETYPITTVS KAIYKQMCYR NCIPVLNTNV 70 80 90 100 110 120 GFVIDTFAKP LPIVSQSWRE FTKDSLRGSF AYSVVSIIYA IAVSAVIIWF LTIFVLTNYT 130 140 150 160 170 180 IKPSWLLKTS TILSTVYILV VVIKSILILH GQQRDGYLHG AKLLSELNDY NPIQIIDLIV 190 200 210 220 230 240 VLLLQINQVQ IIMRIFQRQK DKRMALLIGI VATLASQVIW AIAQFYTPAD ANEASDILPA 250 260 270 280 290 300 FIYLVRIAMA LCYAAIITVF FISKIQIILA NKKIWLLTLL TFILIYSPVA FFVADVSNAF 310 320 330 340 350 360 VYELSEIFSV VNYVIGVVIP WEWCNKFNLI MKAKEKEGVL GRRFYEDELY ELDRFELFVE 370 380 390 400 410 420 EQMPEDEDNG DTHSDSPGNE LNGGAHHNSQ EQSDRLIGSN SPTNKPHNGN NTDPTSRFRQ 430 440 450 460 470 480 LLTNTKDAFL TLTDNIIAAG FAIPRSVSVS TQSLTGRYRN NSTARTEYTK EVVPDFSPEM 490 500 510 520 FLQPEGSSHI TETLSEQNAA PSTTNSNHRR RNVYVYSRKE VILDVSSDE

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000100 Genomic DNA. Translation: EAK95542.1. AACQ01000097 Genomic DNA. Translation: EAK95679.1.
RefSeq	XP_714594.1. XM_709501.1. XP_714725.1. XM_709632.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0002399.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3643616. 3643739.
KEGG	cal:CaO19.10686. cal:CaO19.3176.
Organism-specific databases
CGD	CAL0002399. RIM21.
Phylogenomic databases
eggNOG	NOG45763.
Family and domain databases
InterPro	IPR014844. PalH. [Graphical view]
Pfam	PF08733. PalH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PALH_CANAL

Accession

Primary (citable) accession number: Q59YK4
Secondary accession number(s): Q59YZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program