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Protein

pH-response regulator protein palH/RIM21

Gene

RIM21

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.By similarity

GO - Biological processi

  • cellular response to alkaline pH Source: CGD
  • cellular response to lithium ion Source: CGD
  • cellular response to neutral pH Source: CGD
  • cellular response to pH Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms in response to neutral pH Source: CGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
pH-response regulator protein palH/RIM21
Gene namesi
Name:RIM21
ORF Names:CaO19.10686, CaO19.3176
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000199829. RIM21.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 96ExtracellularSequence analysisAdd BLAST96
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Topological domaini118 – 130CytoplasmicSequence analysisAdd BLAST13
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 172ExtracellularSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 204CytoplasmicSequence analysisAdd BLAST11
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Topological domaini226 – 241ExtracellularSequence analysisAdd BLAST16
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 273CytoplasmicSequence analysisAdd BLAST11
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 298ExtracellularSequence analysis4
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 529CytoplasmicSequence analysisAdd BLAST210

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000581971 – 529pH-response regulator protein palH/RIM21Add BLAST529

Proteomic databases

PRIDEiQ59YK4.

Family & Domainsi

Sequence similaritiesi

Belongs to the palH/RIM21 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ59YK4.
OrthoDBiEOG092C27BG.

Family and domain databases

InterProiIPR014844. PalH.
[Graphical view]
PfamiPF08733. PalH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59YK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYWKNAWWVG TVYSSCEPIE LPEGMLISKQ YETYPITTVS KAIYKQMCYR
60 70 80 90 100
NCIPVLNTNV GFVIDTFAKP LPIVSQSWRE FTKDSLRGSF AYSVVSIIYA
110 120 130 140 150
IAVSAVIIWF LTIFVLTNYT IKPSWLLKTS TILSTVYILV VVIKSILILH
160 170 180 190 200
GQQRDGYLHG AKLLSELNDY NPIQIIDLIV VLLLQINQVQ IIMRIFQRQK
210 220 230 240 250
DKRMALLIGI VATLASQVIW AIAQFYTPAD ANEASDILPA FIYLVRIAMA
260 270 280 290 300
LCYAAIITVF FISKIQIILA NKKIWLLTLL TFILIYSPVA FFVADVSNAF
310 320 330 340 350
VYELSEIFSV VNYVIGVVIP WEWCNKFNLI MKAKEKEGVL GRRFYEDELY
360 370 380 390 400
ELDRFELFVE EQMPEDEDNG DTHSDSPGNE LNGGAHHNSQ EQSDRLIGSN
410 420 430 440 450
SPTNKPHNGN NTDPTSRFRQ LLTNTKDAFL TLTDNIIAAG FAIPRSVSVS
460 470 480 490 500
TQSLTGRYRN NSTARTEYTK EVVPDFSPEM FLQPEGSSHI TETLSEQNAA
510 520
PSTTNSNHRR RNVYVYSRKE VILDVSSDE
Length:529
Mass (Da):60,057
Last modified:April 26, 2005 - v1
Checksum:iC6D88774DE73C239
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti263S → T in allele CaO19.10686. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000100 Genomic DNA. Translation: EAK95542.1.
AACQ01000097 Genomic DNA. Translation: EAK95679.1.
RefSeqiXP_714594.1. XM_709501.1.
XP_714725.1. XM_709632.1.

Genome annotation databases

EnsemblFungiiEAK95542; EAK95542; CaO19.3176.
EAK95679; EAK95679; CaO19.10686.
GeneIDi3643616.
3643739.
KEGGical:CaO19.10686.
cal:CaO19.3176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000100 Genomic DNA. Translation: EAK95542.1.
AACQ01000097 Genomic DNA. Translation: EAK95679.1.
RefSeqiXP_714594.1. XM_709501.1.
XP_714725.1. XM_709632.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ59YK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK95542; EAK95542; CaO19.3176.
EAK95679; EAK95679; CaO19.10686.
GeneIDi3643616.
3643739.
KEGGical:CaO19.10686.
cal:CaO19.3176.

Organism-specific databases

CGDiCAL0000199829. RIM21.

Phylogenomic databases

InParanoidiQ59YK4.
OrthoDBiEOG092C27BG.

Family and domain databases

InterProiIPR014844. PalH.
[Graphical view]
PfamiPF08733. PalH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPALH_CANAL
AccessioniPrimary (citable) accession number: Q59YK4
Secondary accession number(s): Q59YZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: April 26, 2005
Last modified: October 5, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.