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Q59YK4

- PALH_CANAL

UniProt

Q59YK4 - PALH_CANAL

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Protein

pH-response regulator protein palH/RIM21

Gene

RIM21

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.By similarity

GO - Biological processi

  1. cellular response to alkaline pH Source: CGD
  2. cellular response to lithium ion Source: CGD
  3. cellular response to neutral pH Source: CGD
  4. cellular response to pH Source: CGD
  5. filamentous growth Source: CGD
  6. filamentous growth of a population of unicellular organisms in response to neutral pH Source: CGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
pH-response regulator protein palH/RIM21
Gene namesi
Name:RIM21
ORF Names:CaO19.10686, CaO19.3176
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0002399. RIM21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9696ExtracellularSequence AnalysisAdd
BLAST
Transmembranei97 – 11721HelicalSequence AnalysisAdd
BLAST
Topological domaini118 – 13013CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence AnalysisAdd
BLAST
Topological domaini152 – 17221ExtracellularSequence AnalysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Topological domaini194 – 20411CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence AnalysisAdd
BLAST
Topological domaini226 – 24116ExtracellularSequence AnalysisAdd
BLAST
Transmembranei242 – 26221HelicalSequence AnalysisAdd
BLAST
Topological domaini263 – 27311CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei274 – 29421HelicalSequence AnalysisAdd
BLAST
Topological domaini295 – 2984ExtracellularSequence Analysis
Transmembranei299 – 31921HelicalSequence AnalysisAdd
BLAST
Topological domaini320 – 529210CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529pH-response regulator protein palH/RIM21PRO_0000058197Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0002399.

Family & Domainsi

Sequence similaritiesi

Belongs to the palH/RIM21 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45763.
InParanoidiQ59YK4.
OrthoDBiEOG7KSXKQ.

Family and domain databases

InterProiIPR014844. PalH.
[Graphical view]
PfamiPF08733. PalH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59YK4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYWKNAWWVG TVYSSCEPIE LPEGMLISKQ YETYPITTVS KAIYKQMCYR
60 70 80 90 100
NCIPVLNTNV GFVIDTFAKP LPIVSQSWRE FTKDSLRGSF AYSVVSIIYA
110 120 130 140 150
IAVSAVIIWF LTIFVLTNYT IKPSWLLKTS TILSTVYILV VVIKSILILH
160 170 180 190 200
GQQRDGYLHG AKLLSELNDY NPIQIIDLIV VLLLQINQVQ IIMRIFQRQK
210 220 230 240 250
DKRMALLIGI VATLASQVIW AIAQFYTPAD ANEASDILPA FIYLVRIAMA
260 270 280 290 300
LCYAAIITVF FISKIQIILA NKKIWLLTLL TFILIYSPVA FFVADVSNAF
310 320 330 340 350
VYELSEIFSV VNYVIGVVIP WEWCNKFNLI MKAKEKEGVL GRRFYEDELY
360 370 380 390 400
ELDRFELFVE EQMPEDEDNG DTHSDSPGNE LNGGAHHNSQ EQSDRLIGSN
410 420 430 440 450
SPTNKPHNGN NTDPTSRFRQ LLTNTKDAFL TLTDNIIAAG FAIPRSVSVS
460 470 480 490 500
TQSLTGRYRN NSTARTEYTK EVVPDFSPEM FLQPEGSSHI TETLSEQNAA
510 520
PSTTNSNHRR RNVYVYSRKE VILDVSSDE
Length:529
Mass (Da):60,057
Last modified:April 26, 2005 - v1
Checksum:iC6D88774DE73C239
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti263 – 2631S → T in allele CaO19.10686.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000100 Genomic DNA. Translation: EAK95542.1.
AACQ01000097 Genomic DNA. Translation: EAK95679.1.
RefSeqiXP_714594.1. XM_709501.1.
XP_714725.1. XM_709632.1.

Genome annotation databases

GeneIDi3643616.
3643739.
KEGGical:CaO19.10686.
cal:CaO19.3176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000100 Genomic DNA. Translation: EAK95542.1 .
AACQ01000097 Genomic DNA. Translation: EAK95679.1 .
RefSeqi XP_714594.1. XM_709501.1.
XP_714725.1. XM_709632.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0002399.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3643616.
3643739.
KEGGi cal:CaO19.10686.
cal:CaO19.3176.

Organism-specific databases

CGDi CAL0002399. RIM21.

Phylogenomic databases

eggNOGi NOG45763.
InParanoidi Q59YK4.
OrthoDBi EOG7KSXKQ.

Family and domain databases

InterProi IPR014844. PalH.
[Graphical view ]
Pfami PF08733. PalH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiPALH_CANAL
AccessioniPrimary (citable) accession number: Q59YK4
Secondary accession number(s): Q59YZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3