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Q59YK4

- PALH_CANAL

UniProt

Q59YK4 - PALH_CANAL

Protein

pH-response regulator protein palH/RIM21

Gene

RIM21

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.By similarity

    GO - Biological processi

    1. cellular response to alkaline pH Source: CGD
    2. cellular response to lithium ion Source: CGD
    3. cellular response to neutral pH Source: CGD
    4. cellular response to pH Source: CGD
    5. filamentous growth Source: CGD
    6. filamentous growth of a population of unicellular organisms in response to neutral pH Source: CGD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    pH-response regulator protein palH/RIM21
    Gene namesi
    Name:RIM21
    ORF Names:CaO19.10686, CaO19.3176
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0002399. RIM21.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 529529pH-response regulator protein palH/RIM21PRO_0000058197Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0002399.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9696ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini118 – 13013CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini152 – 17221ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini194 – 20411CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini226 – 24116ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini263 – 27311CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini295 – 2984ExtracellularSequence Analysis
    Topological domaini320 – 529210CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei97 – 11721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei131 – 15121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei242 – 26221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei274 – 29421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei299 – 31921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the palH/RIM21 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45763.
    OrthoDBiEOG7KSXKQ.

    Family and domain databases

    InterProiIPR014844. PalH.
    [Graphical view]
    PfamiPF08733. PalH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59YK4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYWKNAWWVG TVYSSCEPIE LPEGMLISKQ YETYPITTVS KAIYKQMCYR    50
    NCIPVLNTNV GFVIDTFAKP LPIVSQSWRE FTKDSLRGSF AYSVVSIIYA 100
    IAVSAVIIWF LTIFVLTNYT IKPSWLLKTS TILSTVYILV VVIKSILILH 150
    GQQRDGYLHG AKLLSELNDY NPIQIIDLIV VLLLQINQVQ IIMRIFQRQK 200
    DKRMALLIGI VATLASQVIW AIAQFYTPAD ANEASDILPA FIYLVRIAMA 250
    LCYAAIITVF FISKIQIILA NKKIWLLTLL TFILIYSPVA FFVADVSNAF 300
    VYELSEIFSV VNYVIGVVIP WEWCNKFNLI MKAKEKEGVL GRRFYEDELY 350
    ELDRFELFVE EQMPEDEDNG DTHSDSPGNE LNGGAHHNSQ EQSDRLIGSN 400
    SPTNKPHNGN NTDPTSRFRQ LLTNTKDAFL TLTDNIIAAG FAIPRSVSVS 450
    TQSLTGRYRN NSTARTEYTK EVVPDFSPEM FLQPEGSSHI TETLSEQNAA 500
    PSTTNSNHRR RNVYVYSRKE VILDVSSDE 529
    Length:529
    Mass (Da):60,057
    Last modified:April 26, 2005 - v1
    Checksum:iC6D88774DE73C239
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti263 – 2631S → T in allele CaO19.10686.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000100 Genomic DNA. Translation: EAK95542.1.
    AACQ01000097 Genomic DNA. Translation: EAK95679.1.
    RefSeqiXP_714594.1. XM_709501.1.
    XP_714725.1. XM_709632.1.

    Genome annotation databases

    GeneIDi3643616.
    3643739.
    KEGGical:CaO19.10686.
    cal:CaO19.3176.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000100 Genomic DNA. Translation: EAK95542.1 .
    AACQ01000097 Genomic DNA. Translation: EAK95679.1 .
    RefSeqi XP_714594.1. XM_709501.1.
    XP_714725.1. XM_709632.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0002399.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3643616.
    3643739.
    KEGGi cal:CaO19.10686.
    cal:CaO19.3176.

    Organism-specific databases

    CGDi CAL0002399. RIM21.

    Phylogenomic databases

    eggNOGi NOG45763.
    OrthoDBi EOG7KSXKQ.

    Family and domain databases

    InterProi IPR014844. PalH.
    [Graphical view ]
    Pfami PF08733. PalH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiPALH_CANAL
    AccessioniPrimary (citable) accession number: Q59YK4
    Secondary accession number(s): Q59YZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3