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Q59YK4 (PALH_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
pH-response regulator protein palH/RIM21
Gene names
Name:RIM21
ORF Names:CaO19.10686, CaO19.3176
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the palH/RIM21 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 529529pH-response regulator protein palH/RIM21
PRO_0000058197

Regions

Topological domain1 – 9696Extracellular Potential
Transmembrane97 – 11721Helical; Potential
Topological domain118 – 13013Cytoplasmic Potential
Transmembrane131 – 15121Helical; Potential
Topological domain152 – 17221Extracellular Potential
Transmembrane173 – 19321Helical; Potential
Topological domain194 – 20411Cytoplasmic Potential
Transmembrane205 – 22521Helical; Potential
Topological domain226 – 24116Extracellular Potential
Transmembrane242 – 26221Helical; Potential
Topological domain263 – 27311Cytoplasmic Potential
Transmembrane274 – 29421Helical; Potential
Topological domain295 – 2984Extracellular Potential
Transmembrane299 – 31921Helical; Potential
Topological domain320 – 529210Cytoplasmic Potential

Natural variations

Natural variant2631S → T in allele CaO19.10686.

Sequences

Sequence LengthMass (Da)Tools
Q59YK4 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: C6D88774DE73C239

FASTA52960,057
        10         20         30         40         50         60 
MYWKNAWWVG TVYSSCEPIE LPEGMLISKQ YETYPITTVS KAIYKQMCYR NCIPVLNTNV 

        70         80         90        100        110        120 
GFVIDTFAKP LPIVSQSWRE FTKDSLRGSF AYSVVSIIYA IAVSAVIIWF LTIFVLTNYT 

       130        140        150        160        170        180 
IKPSWLLKTS TILSTVYILV VVIKSILILH GQQRDGYLHG AKLLSELNDY NPIQIIDLIV 

       190        200        210        220        230        240 
VLLLQINQVQ IIMRIFQRQK DKRMALLIGI VATLASQVIW AIAQFYTPAD ANEASDILPA 

       250        260        270        280        290        300 
FIYLVRIAMA LCYAAIITVF FISKIQIILA NKKIWLLTLL TFILIYSPVA FFVADVSNAF 

       310        320        330        340        350        360 
VYELSEIFSV VNYVIGVVIP WEWCNKFNLI MKAKEKEGVL GRRFYEDELY ELDRFELFVE 

       370        380        390        400        410        420 
EQMPEDEDNG DTHSDSPGNE LNGGAHHNSQ EQSDRLIGSN SPTNKPHNGN NTDPTSRFRQ 

       430        440        450        460        470        480 
LLTNTKDAFL TLTDNIIAAG FAIPRSVSVS TQSLTGRYRN NSTARTEYTK EVVPDFSPEM 

       490        500        510        520 
FLQPEGSSHI TETLSEQNAA PSTTNSNHRR RNVYVYSRKE VILDVSSDE 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000100 Genomic DNA. Translation: EAK95542.1.
AACQ01000097 Genomic DNA. Translation: EAK95679.1.
RefSeqXP_714594.1. XM_709501.1.
XP_714725.1. XM_709632.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0002399.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3643616.
3643739.
KEGGcal:CaO19.10686.
cal:CaO19.3176.

Organism-specific databases

CGDCAL0002399. RIM21.

Phylogenomic databases

eggNOGNOG45763.
OrthoDBEOG7KSXKQ.

Family and domain databases

InterProIPR014844. PalH.
[Graphical view]
PfamPF08733. PalH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePALH_CANAL
AccessionPrimary (citable) accession number: Q59YK4
Secondary accession number(s): Q59YZ2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names