ID   CG11_CANAL              Reviewed;         693 AA.
AC   Q59YH3; A0A1D8PN87;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   27-MAR-2024, entry version 136.
DE   RecName: Full=G1/S-specific cyclin CCN1;
GN   Name=CCN1; Synonyms=CLN1; OrderedLocusNames=CAALFM_C501680CA;
GN   ORFNames=CaO19.10719, CaO19.3207;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=7830719; DOI=10.1007/bf00297278;
RA   Sherlock G., Bahman A.M., Mahal A., Shieh J.C., Ferreira M., Rosamond J.;
RT   "Molecular cloning and analysis of CDC28 and cyclin homologues from the
RT   human fungal pathogen Candida albicans.";
RL   Mol. Gen. Genet. 245:716-723(1994).
RN   [5]
RP   FUNCTION.
RX   PubMed=10330142; DOI=10.1128/mcb.19.6.4019;
RA   Loeb J.D., Sepulveda-Becerra M., Hazan I., Liu H.;
RT   "A G1 cyclin is necessary for maintenance of filamentous growth in Candida
RT   albicans.";
RL   Mol. Cell. Biol. 19:4019-4027(1999).
RN   [6]
RP   INDUCTION.
RX   PubMed=15888543; DOI=10.1091/mbc.e04-12-1081;
RA   Bensen E.S., Clemente-Blanco A., Finley K.R., Correa-Bordes J., Berman J.;
RT   "The mitotic cyclins Clb2p and Clb4p affect morphogenesis in Candida
RT   albicans.";
RL   Mol. Biol. Cell 16:3387-3400(2005).
RN   [7]
RP   INTERACTION WITH CDC28, AND FUNCTION.
RX   PubMed=17765684; DOI=10.1016/j.devcel.2007.06.011;
RA   Sinha I., Wang Y.M., Philp R., Li C.R., Yap W.H., Wang Y.;
RT   "Cyclin-dependent kinases control septin phosphorylation in Candida
RT   albicans hyphal development.";
RL   Dev. Cell 13:421-432(2007).
RN   [8]
RP   INDUCTION.
RX   PubMed=17557192; DOI=10.1007/s11010-007-9516-4;
RA   Singh A., Sharma S., Khuller G.K.;
RT   "cAMP regulates vegetative growth and cell cycle in Candida albicans.";
RL   Mol. Cell. Biochem. 304:331-341(2007).
RN   [9]
RP   INDUCTION.
RX   PubMed=19528234; DOI=10.1128/mcb.01502-08;
RA   Wang A., Raniga P.P., Lane S., Lu Y., Liu H.;
RT   "Hyphal chain formation in Candida albicans: Cdc28-Hgc1 phosphorylation of
RT   Efg1 represses cell separation genes.";
RL   Mol. Cell. Biol. 29:4406-4416(2009).
RN   [10]
RP   FUNCTION OF THE CDC28-CCN1 COMPLEX.
RX   PubMed=20639857; DOI=10.1038/emboj.2010.158;
RA   Bishop A., Lane R., Beniston R., Chapa-y-Lazo B., Smythe C., Sudbery P.;
RT   "Hyphal growth in Candida albicans requires the phosphorylation of Sec2 by
RT   the Cdc28-Ccn1/Hgc1 kinase.";
RL   EMBO J. 29:2930-2942(2010).
RN   [11]
RP   FUNCTION.
RX   PubMed=23049891; DOI=10.1371/journal.pone.0045912;
RA   Chauvel M., Nesseir A., Cabral V., Znaidi S., Goyard S.,
RA   Bachellier-Bassi S., Firon A., Legrand M., Diogo D., Naulleau C.,
RA   Rossignol T., d'Enfert C.;
RT   "A versatile overexpression strategy in the pathogenic yeast Candida
RT   albicans: identification of regulators of morphogenesis and fitness.";
RL   PLoS ONE 7:E45912-E45912(2012).
CC   -!- FUNCTION: G1/S-specific cyclin essential for the control of the cell
CC       cycle at the G1/S (start) transition and for maintenance of filamentous
CC       growth. Through binding to CDC28 controls the phosphorylation of CDC11
CC       and SEC2 upon induction of filamentous growth.
CC       {ECO:0000269|PubMed:10330142, ECO:0000269|PubMed:17765684,
CC       ECO:0000269|PubMed:20639857, ECO:0000269|PubMed:23049891}.
CC   -!- SUBUNIT: Interacts with CDC28. The CDC28-CCN1 complex associates with
CC       septin CDC11 upon hyphal induction. {ECO:0000269|PubMed:17765684}.
CC   -!- INDUCTION: Expression peaks at G1/S. CCN1 is stabilized during germ
CC       tube formation. {ECO:0000269|PubMed:15888543,
CC       ECO:0000269|PubMed:17557192, ECO:0000269|PubMed:19528234}.
CC   -!- SIMILARITY: Belongs to the cyclin family. {ECO:0000305}.
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DR   EMBL; CP017627; AOW29599.1; -; Genomic_DNA.
DR   RefSeq; XP_714623.2; XM_709530.2.
DR   AlphaFoldDB; Q59YH3; -.
DR   SMR; Q59YH3; -.
DR   BioGRID; 1226721; 2.
DR   STRING; 237561.Q59YH3; -.
DR   EnsemblFungi; C5_01680C_A-T; C5_01680C_A-T-p1; C5_01680C_A.
DR   GeneID; 3643735; -.
DR   KEGG; cal:CAALFM_C501680CA; -.
DR   CGD; CAL0000199358; CCN1.
DR   VEuPathDB; FungiDB:C5_01680C_A; -.
DR   eggNOG; KOG0653; Eukaryota.
DR   HOGENOM; CLU_029626_0_0_1; -.
DR   InParanoid; Q59YH3; -.
DR   OrthoDB; 5474295at2759; -.
DR   PRO; PR:Q59YH3; -.
DR   Proteomes; UP000000559; Chromosome 5.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005816; C:spindle pole body; IBA:GO_Central.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IGI:CGD.
DR   GO; GO:0004672; F:protein kinase activity; IMP:CGD.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0036244; P:cellular response to neutral pH; IMP:CGD.
DR   GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR   GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR   GO; GO:0036178; P:filamentous growth of a population of unicellular organisms in response to neutral pH; IMP:CGD.
DR   GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:CGD.
DR   GO; GO:0030448; P:hyphal growth; IMP:CGD.
DR   GO; GO:0030011; P:maintenance of cell polarity; IMP:CGD.
DR   GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR   GO; GO:0060258; P:negative regulation of filamentous growth; IMP:CGD.
DR   GO; GO:1900445; P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR   GO; GO:1900442; P:positive regulation of filamentous growth of a population of unicellular organisms in response to neutral pH; IMP:CGD.
DR   GO; GO:0051726; P:regulation of cell cycle; IMP:CGD.
DR   GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IEA:InterPro.
DR   GO; GO:0044010; P:single-species biofilm formation; IGI:CGD.
DR   CDD; cd20537; CYCLIN_CCNO-like_rpt2; 1.
DR   CDD; cd20559; CYCLIN_ScCLN_like; 1.
DR   Gene3D; 1.10.472.10; Cyclin-like; 2.
DR   InterPro; IPR039361; Cyclin.
DR   InterPro; IPR013763; Cyclin-like_dom.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR004367; Cyclin_C-dom.
DR   InterPro; IPR014399; Cyclin_CLN.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR048258; Cyclins_cyclin-box.
DR   PANTHER; PTHR10177; CYCLINS; 1.
DR   PANTHER; PTHR10177:SF523; G1_S-SPECIFIC CYCLIN CLN1-RELATED; 1.
DR   Pfam; PF02984; Cyclin_C; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   PIRSF; PIRSF001770; Cyclin_CLN; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SMART; SM01332; Cyclin_C; 1.
DR   SUPFAM; SSF47954; Cyclin-like; 2.
DR   PROSITE; PS00292; CYCLINS; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Cyclin; Mitosis; Reference proteome.
FT   CHAIN           1..693
FT                   /note="G1/S-specific cyclin CCN1"
FT                   /id="PRO_0000413034"
FT   REGION          273..320
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          465..571
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          595..615
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          662..693
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        273..299
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        474..560
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   693 AA;  78370 MW;  8539900A01AE63DA CRC64;
     MTSLQQQRVK YGPPHHIKRR PYHPILESLE FQTNQHLIQE YSLDIVNTLS QLESLTLVNP
     AMIDLQPEIQ WFMRPFLLDF LIELHSSFKL QPTTLFLCLN IIDRYCAKRI VFKRHYQLVG
     CTALWIASKY EDKKSRVPTL KELTIMCRNA YDEEMFVQME MHILSTLDWS IGHPTLEDCL
     QLAIDSNNLS NNTTNDIENK SVRPNRKSSI SSAVTAVARF LCELSLYDKY FLSVPPSLIA
     ITANLLSCSM LQIPHASITL KNLIEQEIIN PQQKKQKKAL SSNSSRTTTA SYTHQNQSDV
     RHSSFDEDID LDSGDEEDDD EDYIDEFYET NNYDDTNATT FDESISKSTT VNDENQPPQI
     HTPFLSGLDE DSILSIKKIC LMLIIQLSKV TEVLSKKYEN LGVIQVINNF HSNYKFIIQS
     IYENQELLLN TINDSTNNNE IDYKLIQSSE ILLQFPKFDE YLTEDEDENV STDDEANSQP
     QGYDGSGSDG NNQLFTPKSP NAFSSNSSLT LNNHPQSMVP VTPPSATSQY SLFSNKNNRT
     HESTSGLNST CNTPTHISIS SFAPPQPPPG SILKPKLTSI NSTNSLKIKK LTSNSNSSNI
     NIHHGHHNTK QEKRYSHISI GSNSSSKYDG FSPIKSISTN GSLITNNGSL ITNNGSFTNI
     VNNTNSSSPL MNQQQQQQVT QSSLYQHHHQ YHQ
//