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Q59YH3 (CG11_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G1/S-specific cyclin CCN1
Gene names
Name:CCN1
Synonyms:CLN1
ORF Names:CaO19.10719, CaO19.3207
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length693 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. Through binding to CDC28 controls the phosphorylation of CDC11 and SEC2 upon induction of filamentous growth. Ref.3 Ref.5 Ref.8 Ref.9

Subunit structure

Interacts with CDC28. The CDC28-CCN1 complex associates with septin CDC11 upon hyphal induction. Ref.5

Induction

Expression peaks at G1/S. CCN1 is stabilized during germ tube formation. Ref.4 Ref.6 Ref.7

Sequence similarities

Belongs to the cyclin family.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Molecular functionCyclin
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG1/S transition of mitotic cell cycle

Inferred from mutant phenotype Ref.3. Source: CGD

G2/M transition of mitotic cell cycle

Inferred from genetic interaction PubMed 8654974. Source: CGD

cell budding

Inferred from mutant phenotype PubMed 15643064. Source: CGD

cellular response to drug

Inferred from mutant phenotype PubMed 17604452. Source: CGD

cellular response to neutral pH

Inferred from mutant phenotype Ref.3PubMed 15071502. Source: CGD

development of symbiont in host

Inferred from mutant phenotype PubMed 15071502. Source: CGD

filamentous growth

Inferred from mutant phenotype Ref.3PubMed 15071502PubMed 15643065Ref.4. Source: CGD

filamentous growth of a population of unicellular organisms

Inferred from mutant phenotype PubMed 15071502PubMed 15643065. Source: CGD

filamentous growth of a population of unicellular organisms in response to biotic stimulus

Inferred from mutant phenotype Ref.3PubMed 15071502. Source: CGD

filamentous growth of a population of unicellular organisms in response to neutral pH

Inferred from mutant phenotype Ref.3PubMed 15071502. Source: CGD

hyphal growth

Inferred from mutant phenotype PubMed 15643064PubMed 15643065Ref.5. Source: CGD

maintenance of cell polarity

Inferred from mutant phenotype Ref.3. Source: CGD

mitosis

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of filamentous growth of a population of unicellular organisms

Inferred from mutant phenotype PubMed 15643065. Source: CGD

positive regulation of filamentous growth of a population of unicellular organisms

Inferred from mutant phenotype PubMed 15071502. Source: CGD

positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus

Inferred from mutant phenotype Ref.3PubMed 15071502. Source: CGD

positive regulation of filamentous growth of a population of unicellular organisms in response to neutral pH

Inferred from mutant phenotype Ref.3PubMed 15071502. Source: CGD

regulation of cell cycle

Inferred from mutant phenotype Ref.3PubMed 15643065. Source: CGD

regulation of cyclin-dependent protein serine/threonine kinase activity

Inferred from mutant phenotype Ref.4Ref.5. Source: CGD

regulation of mitotic cell cycle

Inferred from direct assay PubMed 20639412. Source: CGD

single-species biofilm formation on inanimate substrate

Inferred from mutant phenotype PubMed 23637598. Source: CGD

   Cellular_componentintracellular

Inferred from direct assay PubMed 17172437. Source: CGD

nucleus

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity

Inferred from direct assay PubMed 20639412PubMed 8654974. Source: CGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 693693G1/S-specific cyclin CCN1
PRO_0000413034

Sequences

Sequence LengthMass (Da)Tools
Q59YH3 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: C04EA6E2C98A66D1

FASTA69378,332
        10         20         30         40         50         60 
MTSLQQQRVK YGPPHHIKRR PYHPILESLE FQTNQHLIQE YSLDIVNTLS QLESLTLVNP 

        70         80         90        100        110        120 
AMIDLQPEIQ WFMRPFLLDF LIELHSSFKL QPTTLFLCLN IIDRYCAKRI VFKRHYQLVG 

       130        140        150        160        170        180 
CTALWIASKY EDKKSRVPTL KELTIMCRNA YDEEMFVQME MHILSTLDWS IGHPTLEDCL 

       190        200        210        220        230        240 
QLAIDSNNLS NNTTNDIENK SVRPNRKSSI SSAVTAVARF LCELSLYDKY FLSVPPSLIA 

       250        260        270        280        290        300 
ITANLLSCSM LQIPHASITL KNLIEQEIIN PQQKKQKKAF SSNSSRTTTA SYTHQNQSDV 

       310        320        330        340        350        360 
RHSSFDEDID LDSGDEGDDD EDYIDEFYET NNYDDTNATT FDESISKSTT VNDENQPPQI 

       370        380        390        400        410        420 
HTPFLSGLDE DSILSIKKIC LMLIIQLSKV TEVLSKKYEN LGVIQVINNF HSNYKFIIQS 

       430        440        450        460        470        480 
IYENQELLLN TINDSTNNNE IDYKLIQSSE ILLQFPKFDE YLTEDEDENV STDDEANSQP 

       490        500        510        520        530        540 
QGYDGSGSDG NNQLFTPKSP NAFSSNSSLT LNNHPQSMVP VTPPSATSQY SLFSNKNNRT 

       550        560        570        580        590        600 
HESTSGLNST CNTPTHISIS SFAPPQPPPG SILKPKLTSI NSTNSLKIKK LTSNSNSSNI 

       610        620        630        640        650        660 
NIHHGHHNTK QEKRYSHISI GSNSSSKYDG FSPIKSISTN GSLITNNGSL ITNNGSFTNI 

       670        680        690 
VNNTNSSSPL MNQQQQQQVT QSSLYQHHHQ YHQ 

« Hide

References

« Hide 'large scale' references
[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"Molecular cloning and analysis of CDC28 and cyclin homologues from the human fungal pathogen Candida albicans."
Sherlock G., Bahman A.M., Mahal A., Shieh J.C., Ferreira M., Rosamond J.
Mol. Gen. Genet. 245:716-723(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]"A G1 cyclin is necessary for maintenance of filamentous growth in Candida albicans."
Loeb J.D., Sepulveda-Becerra M., Hazan I., Liu H.
Mol. Cell. Biol. 19:4019-4027(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"The mitotic cyclins Clb2p and Clb4p affect morphogenesis in Candida albicans."
Bensen E.S., Clemente-Blanco A., Finley K.R., Correa-Bordes J., Berman J.
Mol. Biol. Cell 16:3387-3400(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[5]"Cyclin-dependent kinases control septin phosphorylation in Candida albicans hyphal development."
Sinha I., Wang Y.M., Philp R., Li C.R., Yap W.H., Wang Y.
Dev. Cell 13:421-432(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CDC28, FUNCTION.
[6]"cAMP regulates vegetative growth and cell cycle in Candida albicans."
Singh A., Sharma S., Khuller G.K.
Mol. Cell. Biochem. 304:331-341(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[7]"Hyphal chain formation in Candida albicans: Cdc28-Hgc1 phosphorylation of Efg1 represses cell separation genes."
Wang A., Raniga P.P., Lane S., Lu Y., Liu H.
Mol. Cell. Biol. 29:4406-4416(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[8]"Hyphal growth in Candida albicans requires the phosphorylation of Sec2 by the Cdc28-Ccn1/Hgc1 kinase."
Bishop A., Lane R., Beniston R., Chapa-y-Lazo B., Smythe C., Sudbery P.
EMBO J. 29:2930-2942(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION OF THE CDC28-CCN1 COMPLEX.
[9]"A versatile overexpression strategy in the pathogenic yeast Candida albicans: identification of regulators of morphogenesis and fitness."
Chauvel M., Nesseir A., Cabral V., Znaidi S., Goyard S., Bachellier-Bassi S., Firon A., Legrand M., Diogo D., Naulleau C., Rossignol T., d'Enfert C.
PLoS ONE 7:E45912-E45912(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000100 Genomic DNA. Translation: EAK95573.1.
AACQ01000097 Genomic DNA. Translation: EAK95712.1.
RefSeqXP_714623.1. XM_709530.1.
XP_714756.1. XM_709663.1.

3D structure databases

ProteinModelPortalQ59YH3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0003199.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3643627.
3643735.
KEGGcal:CaO19.10719.
cal:CaO19.3207.

Organism-specific databases

CGDCAL0003199. CCN1.

Phylogenomic databases

OrthoDBEOG7FNCJX.

Family and domain databases

Gene3D1.10.472.10. 2 hits.
InterProIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR014399. Cyclin_CLN/Puc1.
IPR006671. Cyclin_N.
[Graphical view]
PfamPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFPIRSF001770. Cyclin_CLN. 1 hit.
SMARTSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
PROSITEPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCG11_CANAL
AccessionPrimary (citable) accession number: Q59YH3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names