Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G1/S-specific cyclin CCN1

Gene

CCN1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. Through binding to CDC28 controls the phosphorylation of CDC11 and SEC2 upon induction of filamentous growth.4 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin CCN1
Gene namesi
Name:CCN1
Synonyms:CLN1
ORF Names:CaO19.10719, CaO19.3207
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003199. CCN1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693G1/S-specific cyclin CCN1PRO_0000413034Add
BLAST

Expressioni

Inductioni

Expression peaks at G1/S. CCN1 is stabilized during germ tube formation.3 Publications

Interactioni

Subunit structurei

Interacts with CDC28. The CDC28-CCN1 complex associates with septin CDC11 upon hyphal induction.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ59YH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

InParanoidiQ59YH3.
OrthoDBiEOG7FNCJX.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR014399. Cyclin_CLN.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001770. Cyclin_CLN. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59YH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSLQQQRVK YGPPHHIKRR PYHPILESLE FQTNQHLIQE YSLDIVNTLS
60 70 80 90 100
QLESLTLVNP AMIDLQPEIQ WFMRPFLLDF LIELHSSFKL QPTTLFLCLN
110 120 130 140 150
IIDRYCAKRI VFKRHYQLVG CTALWIASKY EDKKSRVPTL KELTIMCRNA
160 170 180 190 200
YDEEMFVQME MHILSTLDWS IGHPTLEDCL QLAIDSNNLS NNTTNDIENK
210 220 230 240 250
SVRPNRKSSI SSAVTAVARF LCELSLYDKY FLSVPPSLIA ITANLLSCSM
260 270 280 290 300
LQIPHASITL KNLIEQEIIN PQQKKQKKAF SSNSSRTTTA SYTHQNQSDV
310 320 330 340 350
RHSSFDEDID LDSGDEGDDD EDYIDEFYET NNYDDTNATT FDESISKSTT
360 370 380 390 400
VNDENQPPQI HTPFLSGLDE DSILSIKKIC LMLIIQLSKV TEVLSKKYEN
410 420 430 440 450
LGVIQVINNF HSNYKFIIQS IYENQELLLN TINDSTNNNE IDYKLIQSSE
460 470 480 490 500
ILLQFPKFDE YLTEDEDENV STDDEANSQP QGYDGSGSDG NNQLFTPKSP
510 520 530 540 550
NAFSSNSSLT LNNHPQSMVP VTPPSATSQY SLFSNKNNRT HESTSGLNST
560 570 580 590 600
CNTPTHISIS SFAPPQPPPG SILKPKLTSI NSTNSLKIKK LTSNSNSSNI
610 620 630 640 650
NIHHGHHNTK QEKRYSHISI GSNSSSKYDG FSPIKSISTN GSLITNNGSL
660 670 680 690
ITNNGSFTNI VNNTNSSSPL MNQQQQQQVT QSSLYQHHHQ YHQ
Length:693
Mass (Da):78,332
Last modified:April 26, 2005 - v1
Checksum:iC04EA6E2C98A66D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000100 Genomic DNA. Translation: EAK95573.1.
AACQ01000097 Genomic DNA. Translation: EAK95712.1.
RefSeqiXP_714623.1. XM_709530.1.
XP_714756.1. XM_709663.1.

Genome annotation databases

GeneIDi3643627.
3643735.
KEGGical:CaO19.10719.
cal:CaO19.3207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000100 Genomic DNA. Translation: EAK95573.1.
AACQ01000097 Genomic DNA. Translation: EAK95712.1.
RefSeqiXP_714623.1. XM_709530.1.
XP_714756.1. XM_709663.1.

3D structure databases

ProteinModelPortaliQ59YH3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3643627.
3643735.
KEGGical:CaO19.10719.
cal:CaO19.3207.

Organism-specific databases

CGDiCAL0003199. CCN1.

Phylogenomic databases

InParanoidiQ59YH3.
OrthoDBiEOG7FNCJX.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR014399. Cyclin_CLN.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001770. Cyclin_CLN. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Molecular cloning and analysis of CDC28 and cyclin homologues from the human fungal pathogen Candida albicans."
    Sherlock G., Bahman A.M., Mahal A., Shieh J.C., Ferreira M., Rosamond J.
    Mol. Gen. Genet. 245:716-723(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  3. "A G1 cyclin is necessary for maintenance of filamentous growth in Candida albicans."
    Loeb J.D., Sepulveda-Becerra M., Hazan I., Liu H.
    Mol. Cell. Biol. 19:4019-4027(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "The mitotic cyclins Clb2p and Clb4p affect morphogenesis in Candida albicans."
    Bensen E.S., Clemente-Blanco A., Finley K.R., Correa-Bordes J., Berman J.
    Mol. Biol. Cell 16:3387-3400(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. "Cyclin-dependent kinases control septin phosphorylation in Candida albicans hyphal development."
    Sinha I., Wang Y.M., Philp R., Li C.R., Yap W.H., Wang Y.
    Dev. Cell 13:421-432(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDC28, FUNCTION.
  6. "cAMP regulates vegetative growth and cell cycle in Candida albicans."
    Singh A., Sharma S., Khuller G.K.
    Mol. Cell. Biochem. 304:331-341(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  7. "Hyphal chain formation in Candida albicans: Cdc28-Hgc1 phosphorylation of Efg1 represses cell separation genes."
    Wang A., Raniga P.P., Lane S., Lu Y., Liu H.
    Mol. Cell. Biol. 29:4406-4416(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  8. "Hyphal growth in Candida albicans requires the phosphorylation of Sec2 by the Cdc28-Ccn1/Hgc1 kinase."
    Bishop A., Lane R., Beniston R., Chapa-y-Lazo B., Smythe C., Sudbery P.
    EMBO J. 29:2930-2942(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE CDC28-CCN1 COMPLEX.
  9. "A versatile overexpression strategy in the pathogenic yeast Candida albicans: identification of regulators of morphogenesis and fitness."
    Chauvel M., Nesseir A., Cabral V., Znaidi S., Goyard S., Bachellier-Bassi S., Firon A., Legrand M., Diogo D., Naulleau C., Rossignol T., d'Enfert C.
    PLoS ONE 7:E45912-E45912(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCG11_CANAL
AccessioniPrimary (citable) accession number: Q59YH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: April 26, 2005
Last modified: June 24, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.