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Q59YH3

- CG11_CANAL

UniProt

Q59YH3 - CG11_CANAL

Protein

G1/S-specific cyclin CCN1

Gene

CCN1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. Through binding to CDC28 controls the phosphorylation of CDC11 and SEC2 upon induction of filamentous growth.4 Publications

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: CGD

    GO - Biological processi

    1. cell budding Source: CGD
    2. cellular response to drug Source: CGD
    3. cellular response to neutral pH Source: CGD
    4. development of symbiont in host Source: CGD
    5. filamentous growth Source: CGD
    6. filamentous growth of a population of unicellular organisms Source: CGD
    7. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
    8. filamentous growth of a population of unicellular organisms in response to neutral pH Source: CGD
    9. G1/S transition of mitotic cell cycle Source: CGD
    10. G2/M transition of mitotic cell cycle Source: CGD
    11. hyphal growth Source: CGD
    12. maintenance of cell polarity Source: CGD
    13. mitotic nuclear division Source: UniProtKB-KW
    14. negative regulation of filamentous growth of a population of unicellular organisms Source: CGD
    15. positive regulation of filamentous growth of a population of unicellular organisms Source: CGD
    16. positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
    17. positive regulation of filamentous growth of a population of unicellular organisms in response to neutral pH Source: CGD
    18. regulation of cell cycle Source: CGD
    19. regulation of cyclin-dependent protein serine/threonine kinase activity Source: CGD
    20. regulation of mitotic cell cycle Source: CGD
    21. single-species biofilm formation on inanimate substrate Source: CGD

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G1/S-specific cyclin CCN1
    Gene namesi
    Name:CCN1
    Synonyms:CLN1
    ORF Names:CaO19.10719, CaO19.3207
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0003199. CCN1.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: CGD
    2. nucleus Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 693693G1/S-specific cyclin CCN1PRO_0000413034Add
    BLAST

    Expressioni

    Inductioni

    Expression peaks at G1/S. CCN1 is stabilized during germ tube formation.3 Publications

    Interactioni

    Subunit structurei

    Interacts with CDC28. The CDC28-CCN1 complex associates with septin CDC11 upon hyphal induction.1 Publication

    Protein-protein interaction databases

    STRINGi5476.CAL0003199.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59YH3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cyclin family.Curated

    Phylogenomic databases

    OrthoDBiEOG7FNCJX.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR004367. Cyclin_C-dom.
    IPR014399. Cyclin_CLN/Puc1.
    IPR006671. Cyclin_N.
    [Graphical view]
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001770. Cyclin_CLN. 1 hit.
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59YH3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSLQQQRVK YGPPHHIKRR PYHPILESLE FQTNQHLIQE YSLDIVNTLS    50
    QLESLTLVNP AMIDLQPEIQ WFMRPFLLDF LIELHSSFKL QPTTLFLCLN 100
    IIDRYCAKRI VFKRHYQLVG CTALWIASKY EDKKSRVPTL KELTIMCRNA 150
    YDEEMFVQME MHILSTLDWS IGHPTLEDCL QLAIDSNNLS NNTTNDIENK 200
    SVRPNRKSSI SSAVTAVARF LCELSLYDKY FLSVPPSLIA ITANLLSCSM 250
    LQIPHASITL KNLIEQEIIN PQQKKQKKAF SSNSSRTTTA SYTHQNQSDV 300
    RHSSFDEDID LDSGDEGDDD EDYIDEFYET NNYDDTNATT FDESISKSTT 350
    VNDENQPPQI HTPFLSGLDE DSILSIKKIC LMLIIQLSKV TEVLSKKYEN 400
    LGVIQVINNF HSNYKFIIQS IYENQELLLN TINDSTNNNE IDYKLIQSSE 450
    ILLQFPKFDE YLTEDEDENV STDDEANSQP QGYDGSGSDG NNQLFTPKSP 500
    NAFSSNSSLT LNNHPQSMVP VTPPSATSQY SLFSNKNNRT HESTSGLNST 550
    CNTPTHISIS SFAPPQPPPG SILKPKLTSI NSTNSLKIKK LTSNSNSSNI 600
    NIHHGHHNTK QEKRYSHISI GSNSSSKYDG FSPIKSISTN GSLITNNGSL 650
    ITNNGSFTNI VNNTNSSSPL MNQQQQQQVT QSSLYQHHHQ YHQ 693
    Length:693
    Mass (Da):78,332
    Last modified:April 26, 2005 - v1
    Checksum:iC04EA6E2C98A66D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000100 Genomic DNA. Translation: EAK95573.1.
    AACQ01000097 Genomic DNA. Translation: EAK95712.1.
    RefSeqiXP_714623.1. XM_709530.1.
    XP_714756.1. XM_709663.1.

    Genome annotation databases

    GeneIDi3643627.
    3643735.
    KEGGical:CaO19.10719.
    cal:CaO19.3207.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000100 Genomic DNA. Translation: EAK95573.1 .
    AACQ01000097 Genomic DNA. Translation: EAK95712.1 .
    RefSeqi XP_714623.1. XM_709530.1.
    XP_714756.1. XM_709663.1.

    3D structure databases

    ProteinModelPortali Q59YH3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0003199.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3643627.
    3643735.
    KEGGi cal:CaO19.10719.
    cal:CaO19.3207.

    Organism-specific databases

    CGDi CAL0003199. CCN1.

    Phylogenomic databases

    OrthoDBi EOG7FNCJX.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR004367. Cyclin_C-dom.
    IPR014399. Cyclin_CLN/Puc1.
    IPR006671. Cyclin_N.
    [Graphical view ]
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001770. Cyclin_CLN. 1 hit.
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. "Molecular cloning and analysis of CDC28 and cyclin homologues from the human fungal pathogen Candida albicans."
      Sherlock G., Bahman A.M., Mahal A., Shieh J.C., Ferreira M., Rosamond J.
      Mol. Gen. Genet. 245:716-723(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    3. "A G1 cyclin is necessary for maintenance of filamentous growth in Candida albicans."
      Loeb J.D., Sepulveda-Becerra M., Hazan I., Liu H.
      Mol. Cell. Biol. 19:4019-4027(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "The mitotic cyclins Clb2p and Clb4p affect morphogenesis in Candida albicans."
      Bensen E.S., Clemente-Blanco A., Finley K.R., Correa-Bordes J., Berman J.
      Mol. Biol. Cell 16:3387-3400(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    5. "Cyclin-dependent kinases control septin phosphorylation in Candida albicans hyphal development."
      Sinha I., Wang Y.M., Philp R., Li C.R., Yap W.H., Wang Y.
      Dev. Cell 13:421-432(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CDC28, FUNCTION.
    6. "cAMP regulates vegetative growth and cell cycle in Candida albicans."
      Singh A., Sharma S., Khuller G.K.
      Mol. Cell. Biochem. 304:331-341(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    7. "Hyphal chain formation in Candida albicans: Cdc28-Hgc1 phosphorylation of Efg1 represses cell separation genes."
      Wang A., Raniga P.P., Lane S., Lu Y., Liu H.
      Mol. Cell. Biol. 29:4406-4416(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    8. "Hyphal growth in Candida albicans requires the phosphorylation of Sec2 by the Cdc28-Ccn1/Hgc1 kinase."
      Bishop A., Lane R., Beniston R., Chapa-y-Lazo B., Smythe C., Sudbery P.
      EMBO J. 29:2930-2942(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE CDC28-CCN1 COMPLEX.
    9. "A versatile overexpression strategy in the pathogenic yeast Candida albicans: identification of regulators of morphogenesis and fitness."
      Chauvel M., Nesseir A., Cabral V., Znaidi S., Goyard S., Bachellier-Bassi S., Firon A., Legrand M., Diogo D., Naulleau C., Rossignol T., d'Enfert C.
      PLoS ONE 7:E45912-E45912(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCG11_CANAL
    AccessioniPrimary (citable) accession number: Q59YH3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3