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Q59YH3

- CG11_CANAL

UniProt

Q59YH3 - CG11_CANAL

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Protein

G1/S-specific cyclin CCN1

Gene

CCN1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. Through binding to CDC28 controls the phosphorylation of CDC11 and SEC2 upon induction of filamentous growth.4 Publications

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: CGD

GO - Biological processi

  1. cell budding Source: CGD
  2. cellular response to drug Source: CGD
  3. cellular response to neutral pH Source: CGD
  4. development of symbiont in host Source: CGD
  5. filamentous growth Source: CGD
  6. filamentous growth of a population of unicellular organisms Source: CGD
  7. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  8. filamentous growth of a population of unicellular organisms in response to neutral pH Source: CGD
  9. G1/S transition of mitotic cell cycle Source: CGD
  10. G2/M transition of mitotic cell cycle Source: CGD
  11. hyphal growth Source: CGD
  12. maintenance of cell polarity Source: CGD
  13. mitotic nuclear division Source: UniProtKB-KW
  14. negative regulation of filamentous growth of a population of unicellular organisms Source: CGD
  15. positive regulation of filamentous growth of a population of unicellular organisms Source: CGD
  16. positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  17. positive regulation of filamentous growth of a population of unicellular organisms in response to neutral pH Source: CGD
  18. regulation of cell cycle Source: CGD
  19. regulation of cyclin-dependent protein serine/threonine kinase activity Source: CGD
  20. regulation of mitotic cell cycle Source: CGD
  21. single-species biofilm formation on inanimate substrate Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin CCN1
Gene namesi
Name:CCN1
Synonyms:CLN1
ORF Names:CaO19.10719, CaO19.3207
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003199. CCN1.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: CGD
  2. nucleus Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693G1/S-specific cyclin CCN1PRO_0000413034Add
BLAST

Expressioni

Inductioni

Expression peaks at G1/S. CCN1 is stabilized during germ tube formation.3 Publications

Interactioni

Subunit structurei

Interacts with CDC28. The CDC28-CCN1 complex associates with septin CDC11 upon hyphal induction.1 Publication

Protein-protein interaction databases

STRINGi5476.CAL0003199.

Structurei

3D structure databases

ProteinModelPortaliQ59YH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

InParanoidiQ59YH3.
OrthoDBiEOG7FNCJX.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR014399. Cyclin_CLN/Puc1.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001770. Cyclin_CLN. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59YH3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSLQQQRVK YGPPHHIKRR PYHPILESLE FQTNQHLIQE YSLDIVNTLS
60 70 80 90 100
QLESLTLVNP AMIDLQPEIQ WFMRPFLLDF LIELHSSFKL QPTTLFLCLN
110 120 130 140 150
IIDRYCAKRI VFKRHYQLVG CTALWIASKY EDKKSRVPTL KELTIMCRNA
160 170 180 190 200
YDEEMFVQME MHILSTLDWS IGHPTLEDCL QLAIDSNNLS NNTTNDIENK
210 220 230 240 250
SVRPNRKSSI SSAVTAVARF LCELSLYDKY FLSVPPSLIA ITANLLSCSM
260 270 280 290 300
LQIPHASITL KNLIEQEIIN PQQKKQKKAF SSNSSRTTTA SYTHQNQSDV
310 320 330 340 350
RHSSFDEDID LDSGDEGDDD EDYIDEFYET NNYDDTNATT FDESISKSTT
360 370 380 390 400
VNDENQPPQI HTPFLSGLDE DSILSIKKIC LMLIIQLSKV TEVLSKKYEN
410 420 430 440 450
LGVIQVINNF HSNYKFIIQS IYENQELLLN TINDSTNNNE IDYKLIQSSE
460 470 480 490 500
ILLQFPKFDE YLTEDEDENV STDDEANSQP QGYDGSGSDG NNQLFTPKSP
510 520 530 540 550
NAFSSNSSLT LNNHPQSMVP VTPPSATSQY SLFSNKNNRT HESTSGLNST
560 570 580 590 600
CNTPTHISIS SFAPPQPPPG SILKPKLTSI NSTNSLKIKK LTSNSNSSNI
610 620 630 640 650
NIHHGHHNTK QEKRYSHISI GSNSSSKYDG FSPIKSISTN GSLITNNGSL
660 670 680 690
ITNNGSFTNI VNNTNSSSPL MNQQQQQQVT QSSLYQHHHQ YHQ
Length:693
Mass (Da):78,332
Last modified:April 26, 2005 - v1
Checksum:iC04EA6E2C98A66D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000100 Genomic DNA. Translation: EAK95573.1.
AACQ01000097 Genomic DNA. Translation: EAK95712.1.
RefSeqiXP_714623.1. XM_709530.1.
XP_714756.1. XM_709663.1.

Genome annotation databases

GeneIDi3643627.
3643735.
KEGGical:CaO19.10719.
cal:CaO19.3207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000100 Genomic DNA. Translation: EAK95573.1 .
AACQ01000097 Genomic DNA. Translation: EAK95712.1 .
RefSeqi XP_714623.1. XM_709530.1.
XP_714756.1. XM_709663.1.

3D structure databases

ProteinModelPortali Q59YH3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0003199.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3643627.
3643735.
KEGGi cal:CaO19.10719.
cal:CaO19.3207.

Organism-specific databases

CGDi CAL0003199. CCN1.

Phylogenomic databases

InParanoidi Q59YH3.
OrthoDBi EOG7FNCJX.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR014399. Cyclin_CLN/Puc1.
IPR006671. Cyclin_N.
[Graphical view ]
Pfami PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001770. Cyclin_CLN. 1 hit.
SMARTi SM00385. CYCLIN. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00292. CYCLINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Molecular cloning and analysis of CDC28 and cyclin homologues from the human fungal pathogen Candida albicans."
    Sherlock G., Bahman A.M., Mahal A., Shieh J.C., Ferreira M., Rosamond J.
    Mol. Gen. Genet. 245:716-723(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  3. "A G1 cyclin is necessary for maintenance of filamentous growth in Candida albicans."
    Loeb J.D., Sepulveda-Becerra M., Hazan I., Liu H.
    Mol. Cell. Biol. 19:4019-4027(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "The mitotic cyclins Clb2p and Clb4p affect morphogenesis in Candida albicans."
    Bensen E.S., Clemente-Blanco A., Finley K.R., Correa-Bordes J., Berman J.
    Mol. Biol. Cell 16:3387-3400(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. "Cyclin-dependent kinases control septin phosphorylation in Candida albicans hyphal development."
    Sinha I., Wang Y.M., Philp R., Li C.R., Yap W.H., Wang Y.
    Dev. Cell 13:421-432(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDC28, FUNCTION.
  6. "cAMP regulates vegetative growth and cell cycle in Candida albicans."
    Singh A., Sharma S., Khuller G.K.
    Mol. Cell. Biochem. 304:331-341(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  7. "Hyphal chain formation in Candida albicans: Cdc28-Hgc1 phosphorylation of Efg1 represses cell separation genes."
    Wang A., Raniga P.P., Lane S., Lu Y., Liu H.
    Mol. Cell. Biol. 29:4406-4416(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  8. "Hyphal growth in Candida albicans requires the phosphorylation of Sec2 by the Cdc28-Ccn1/Hgc1 kinase."
    Bishop A., Lane R., Beniston R., Chapa-y-Lazo B., Smythe C., Sudbery P.
    EMBO J. 29:2930-2942(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE CDC28-CCN1 COMPLEX.
  9. "A versatile overexpression strategy in the pathogenic yeast Candida albicans: identification of regulators of morphogenesis and fitness."
    Chauvel M., Nesseir A., Cabral V., Znaidi S., Goyard S., Bachellier-Bassi S., Firon A., Legrand M., Diogo D., Naulleau C., Rossignol T., d'Enfert C.
    PLoS ONE 7:E45912-E45912(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCG11_CANAL
AccessioniPrimary (citable) accession number: Q59YH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3