Q59YH3 (CG11_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G1/S-specific cyclin CCN1

Gene names

Name:	CCN1
Synonyms:	CLN1
ORF Names:	CaO19.10719, CaO19.3207

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	693 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDC2 protein kinase to form MPF.
Sequence similarities	Belongs to the cyclin family.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Molecular function	Cyclin
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G1/S transition of mitotic cell cycle Inferred from mutant phenotype PubMed 10330142. Source: CGD cell division Inferred from electronic annotation. Source: UniProtKB-KW cellular response to biotic stimulus Inferred from mutant phenotype PubMed 10330142. Source: CGD cellular response to drug Inferred from mutant phenotype PubMed 17604452. Source: CGD cellular response to neutral pH Inferred from mutant phenotype PubMed 10330142. Source: CGD filamentous growth of a population of unicellular organisms in response to biotic stimulus Inferred from mutant phenotype PubMed 10330142. Source: CGD filamentous growth of a population of unicellular organisms in response to neutral pH Inferred from mutant phenotype PubMed 10330142. Source: CGD hyphal growth Inferred from mutant phenotype PubMed 17765684. Source: CGD maintenance of cell polarity Inferred from mutant phenotype PubMed 10330142. Source: CGD positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus Inferred from mutant phenotype PubMed 10330142. Source: CGD positive regulation of filamentous growth of a population of unicellular organisms in response to neutral pH Inferred from mutant phenotype PubMed 10330142. Source: CGD regulation of cyclin-dependent protein serine/threonine kinase activity Inferred from mutant phenotype PubMed 17765684. Source: CGD
Cellular_component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity Inferred from genetic interaction PubMed 1409649PubMed 7830719. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 693	693	G1/S-specific cyclin CCN1		PRO_0000413034

Sequences

	Sequence		Length	Mass (Da)
	Q59YH3 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: C04EA6E2C98A66D1	FASTA	693	78,332
	10 20 30 40 50 60 MTSLQQQRVK YGPPHHIKRR PYHPILESLE FQTNQHLIQE YSLDIVNTLS QLESLTLVNP 70 80 90 100 110 120 AMIDLQPEIQ WFMRPFLLDF LIELHSSFKL QPTTLFLCLN IIDRYCAKRI VFKRHYQLVG 130 140 150 160 170 180 CTALWIASKY EDKKSRVPTL KELTIMCRNA YDEEMFVQME MHILSTLDWS IGHPTLEDCL 190 200 210 220 230 240 QLAIDSNNLS NNTTNDIENK SVRPNRKSSI SSAVTAVARF LCELSLYDKY FLSVPPSLIA 250 260 270 280 290 300 ITANLLSCSM LQIPHASITL KNLIEQEIIN PQQKKQKKAF SSNSSRTTTA SYTHQNQSDV 310 320 330 340 350 360 RHSSFDEDID LDSGDEGDDD EDYIDEFYET NNYDDTNATT FDESISKSTT VNDENQPPQI 370 380 390 400 410 420 HTPFLSGLDE DSILSIKKIC LMLIIQLSKV TEVLSKKYEN LGVIQVINNF HSNYKFIIQS 430 440 450 460 470 480 IYENQELLLN TINDSTNNNE IDYKLIQSSE ILLQFPKFDE YLTEDEDENV STDDEANSQP 490 500 510 520 530 540 QGYDGSGSDG NNQLFTPKSP NAFSSNSSLT LNNHPQSMVP VTPPSATSQY SLFSNKNNRT 550 560 570 580 590 600 HESTSGLNST CNTPTHISIS SFAPPQPPPG SILKPKLTSI NSTNSLKIKK LTSNSNSSNI 610 620 630 640 650 660 NIHHGHHNTK QEKRYSHISI GSNSSSKYDG FSPIKSISTN GSLITNNGSL ITNNGSFTNI 670 680 690 VNNTNSSSPL MNQQQQQQVT QSSLYQHHHQ YHQ

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000100 Genomic DNA. Translation: EAK95573.1. AACQ01000097 Genomic DNA. Translation: EAK95712.1.
RefSeq	XP_714623.1. XM_709530.1. XP_714756.1. XM_709663.1.
3D structure databases
ProteinModelPortal	Q59YH3.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0003199.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3643627. 3643735.
KEGG	cal:CaO19.10719. cal:CaO19.3207.
Organism-specific databases
CGD	CAL0003199. CCN1.
Family and domain databases
Gene3D	1.10.472.10. 2 hits.
InterPro	IPR013763. Cyclin-like. IPR004367. Cyclin_C-dom. IPR014399. Cyclin_CLN/Puc1. IPR006671. Cyclin_N. [Graphical view]
Pfam	PF02984. Cyclin_C. 1 hit. PF00134. Cyclin_N. 1 hit. [Graphical view]
PIRSF	PIRSF001770. Cyclin_CLN. 1 hit.
SMART	SM00385. CYCLIN. 1 hit. [Graphical view]
SUPFAM	SSF47954. Cyclin_like. 2 hits.
PROSITE	PS00292. CYCLINS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CG11_CANAL

Accession

Primary (citable) accession number: Q59YH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2011
Last sequence update:	April 26, 2005
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program