Q59XY9 (OCA1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative tyrosine-protein phosphatase OCA1
EC=3.1.3.48

Gene names

Name:	OCA1
ORF Names:	CaO19.1762, CaO19.9331

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Putative tyrosine-protein phosphatase required for protection against superoxide stress By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Traceable author statement PubMed 18708562. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Putative tyrosine-protein phosphatase OCA1		PRO_0000333389
Sites
	Active site	203	1	Phosphocysteine intermediate By similarity
Natural variations
	Natural variant	94	1	S → L in allele CaO19.9331.

Sequences

	Sequence		Length	Mass (Da)
	Q59XY9 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 35F73D09C9B03D6E	FASTA	269	30,733
	10 20 30 40 50 60 MASITSNPQI LINNDSSTNK APTTNERQLR RINHPPNLRI VPPLNFCPVE NQLYRSGQPS 70 80 90 100 110 120 IINQSFLNQL NLKTIIWLSS EEPTDEFLEY CNDSSINIEY LGMINEFNSE PATATTTDKQ 130 140 150 160 170 180 SQSQSQSQSE EQKSQSQSQS QENQHHQFEQ SDNNLLQDPS HLISSTIAKI NNNNPWDSLN 190 200 210 220 230 240 ENTIKHALDL IVDKTNYPIL ICCGMGRHRT GTVIGCLRRL QHWNLNSVSE EYRRFTGSRG 250 260 GRILVELLIE SFNIDLVNIN WELAPDWLK

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000104 Genomic DNA. Translation: EAK95340.1. AACQ01000105 Genomic DNA. Translation: EAK95299.1.
RefSeq	XP_714367.1. XM_709274.1. XP_714407.1. XM_709314.1.
3D structure databases
ProteinModelPortal	Q59XY9.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0000898.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3643929. 3643991.
KEGG	cal:CaO19.1762. cal:CaO19.9331.
Organism-specific databases
CGD	CAL0000898. orf19.1762.
Phylogenomic databases
eggNOG	COG2365.
Family and domain databases
InterPro	IPR004861. Tyr_Pase_SIW14-like. [Graphical view]
Pfam	PF03162. Y_phosphatase2. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. False negative. PS50056. TYR_PHOSPHATASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OCA1_CANAL

Accession

Primary (citable) accession number: Q59XY9
Secondary accession number(s): Q59XU3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program