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Protein

Increased recombination centers protein 22-2

Gene

IRC22-2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Is probably involved in a pathway contributing to genomic integrity.

Names & Taxonomyi

Protein namesi
Recommended name:
Increased recombination centers protein 22-2
Gene namesi
Name:IRC22-2
ORF Names:CaO19.1782, CaO19.9348
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000962. orf19.1782.
CAL0062511. orf19.9348.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 161142LumenalSequence AnalysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST
Topological domaini183 – 23957CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 239220Increased recombination centers protein 22-2PRO_0000399071Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0000962.

Family & Domainsi

Sequence similaritiesi

Belongs to the IRC22 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40706.
HOGENOMiHOG000248201.
InParanoidiQ59XW9.
OrthoDBiEOG78M0CV.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59XW9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLSTIFTAF AATIATVAGY ETTGSKQTVD ILIDYIIKET PELSQNDVAN
60 70 80 90 100
WENGDTVTLQ YVVNNNEESE ITVVGVTGQF KNPINNEIVT NLTTGKVGPI
110 120 130 140 150
AVPPGEAIKF DQKINVDLIP ANYELIPHVF IAQDSLIKVI PCRGQLATIV
160 170 180 190 200
DAAVSFFDPR LIFLELVLLI TFAGLIYVGY EIWGKQYFKG VAPVKAKKVS
210 220 230
AAKASSPVAT GPSTISATGY DTNWIPESHL KQKKTKKVN
Length:239
Mass (Da):25,976
Last modified:April 26, 2005 - v1
Checksum:i3028F889FE5FC302
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti210 – 2101T → S in allele CaO19.9348.
Natural varianti215 – 2151I → T in allele CaO19.9348.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000105 Genomic DNA. Translation: EAK95316.1.
AACQ01000104 Genomic DNA. Translation: EAK95360.1.
RefSeqiXP_714384.1. XM_709291.1.
XP_714427.1. XM_709334.1.

Genome annotation databases

GeneIDi3643962.
3643974.
KEGGical:CaO19.1782.
cal:CaO19.9348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000105 Genomic DNA. Translation: EAK95316.1.
AACQ01000104 Genomic DNA. Translation: EAK95360.1.
RefSeqiXP_714384.1. XM_709291.1.
XP_714427.1. XM_709334.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0000962.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3643962.
3643974.
KEGGical:CaO19.1782.
cal:CaO19.9348.

Organism-specific databases

CGDiCAL0000962. orf19.1782.
CAL0062511. orf19.9348.

Phylogenomic databases

eggNOGiNOG40706.
HOGENOMiHOG000248201.
InParanoidiQ59XW9.
OrthoDBiEOG78M0CV.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiIR222_CANAL
AccessioniPrimary (citable) accession number: Q59XW9
Secondary accession number(s): Q59XS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: April 26, 2005
Last modified: January 7, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.