Q59XW9 (IR222_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Increased recombination centers protein 22-2

Gene names

Name:	IRC22-2
ORF Names:	CaO19.1782, CaO19.9348

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Is probably involved in a pathway contributing to genomic integrity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Belongs to the IRC22 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Signal Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay PubMed 19824013. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 239	220	Increased recombination centers protein 22-2		PRO_0000399071
Regions
	Topological domain	20 – 161	142	Lumenal Potential
	Transmembrane	162 – 182	21	Helical; Potential
	Topological domain	183 – 239	57	Cytoplasmic Potential
Natural variations
	Natural variant	210	1	T → S in allele CaO19.9348.
	Natural variant	215	1	I → T in allele CaO19.9348.

Sequences

	Sequence		Length	Mass (Da)
	Q59XW9 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 3028F889FE5FC302	FASTA	239	25,976
	10 20 30 40 50 60 MKLSTIFTAF AATIATVAGY ETTGSKQTVD ILIDYIIKET PELSQNDVAN WENGDTVTLQ 70 80 90 100 110 120 YVVNNNEESE ITVVGVTGQF KNPINNEIVT NLTTGKVGPI AVPPGEAIKF DQKINVDLIP 130 140 150 160 170 180 ANYELIPHVF IAQDSLIKVI PCRGQLATIV DAAVSFFDPR LIFLELVLLI TFAGLIYVGY 190 200 210 220 230 EIWGKQYFKG VAPVKAKKVS AAKASSPVAT GPSTISATGY DTNWIPESHL KQKKTKKVN

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000105 Genomic DNA. Translation: EAK95316.1. AACQ01000104 Genomic DNA. Translation: EAK95360.1.
RefSeq	XP_714384.1. XM_709291.1. XP_714427.1. XM_709334.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0000962.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3643962. 3643974.
KEGG	cal:CaO19.1782. cal:CaO19.9348.
Organism-specific databases
CGD	CAL0000962. orf19.1782. CAL0062511. orf19.9348.
Phylogenomic databases
eggNOG	NOG40706.
HOGENOM	HOG000248201.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

IR222_CANAL

Accession

Primary (citable) accession number: Q59XW9
Secondary accession number(s): Q59XS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 5, 2010
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program