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Protein

Acetyl-coenzyme A synthetase

Gene

ACS1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

GO - Molecular functioni

  1. acetate-CoA ligase activity Source: CGD
  2. AMP binding Source: InterPro
  3. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. acetyl-CoA biosynthetic process Source: CGD
  2. acetyl-CoA biosynthetic process from acetate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Gene namesi
Name:ACS1Imported
ORF Names:CaO19.1743Imported, CaO19.9310Imported
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)Imported
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000855. ACS1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: CGD
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0000855.

Structurei

3D structure databases

ProteinModelPortaliQ59XW4.
SMRiQ59XW4. Positions 38-670.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

KOiK01895.
OrthoDBiEOG7M3J82.

Family and domain databases

InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59XW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPESTQQSHL SLDHEKMQQP PKGFTERSKT KPNLPDFETY QKLYKQSIEN
60 70 80 90 100
PNEFFTQQAK ENLDWFKPFD LARFPIDPKD DYKNGDLPAW FINGQLNACY
110 120 130 140 150
NAVDRWAIKN PDKPAIIYEG DEPDQGRIIT YGELLKQVSK LAQALTKLGV
160 170 180 190 200
KKGDSVAVYL PMIPEAIVTL LAIVRIGAMH SVVFAGFSSA SLRDRILDAD
210 220 230 240 250
SRIVITADES KRGGKTIETK KIVDDALKEC PKVRNVIVFK RTGNSHVPFS
260 270 280 290 300
PGRDLWWHDE MAKYGPYFPP VPVNSEDPLF LLYTSGSTGK PKGVQHNTAG
310 320 330 340 350
YLLGAVLTTK YTFDVHEDDI LFTAGDIGWI TGHTYCVYGP LLAGATSVVF
360 370 380 390 400
EGTPAYPNYS RYWEIVDKYK VNQFYVAPTA LRLLKRAGTK YVEKYDLSSL
410 420 430 440 450
RVLGSVGEPI AAEVWHWYND NIGRGQAHIV DTYWQTESGS HLLTPLAGIT
460 470 480 490 500
PTKPGSASLP FFGVDPKILD PTTGEELPDN DVEGVLAIKS AWPSITRGIY
510 520 530 540 550
NDYNRFIDTY LAPYANYYFS GDGAARDRDG FYWILGRVDD VVNVSGHRLS
560 570 580 590 600
TAEIEAALIE HPIVGESAVV GYADELTGQA VAAYVSLKKD KAVGEDVENI
610 620 630 640 650
KKEMILTVRK EIGPFAAPKM ILLVDDLPKT RSGKIMRRIL RKVLAGEEDQ
660 670
LGDISTLSNP GVVQQIIDVV HHAKK
Length:675
Mass (Da):75,140
Last modified:April 26, 2005 - v1
Checksum:i3D54EC14B45F7EF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000105 Genomic DNA. Translation: EAK95278.1.
AACQ01000104 Genomic DNA. Translation: EAK95321.1.
RefSeqiXP_714347.1. XM_709254.1.
XP_714389.1. XM_709296.1.

Genome annotation databases

GeneIDi3643941.
3643993.
KEGGical:CaO19.1743.
cal:CaO19.9310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000105 Genomic DNA. Translation: EAK95278.1.
AACQ01000104 Genomic DNA. Translation: EAK95321.1.
RefSeqiXP_714347.1. XM_709254.1.
XP_714389.1. XM_709296.1.

3D structure databases

ProteinModelPortaliQ59XW4.
SMRiQ59XW4. Positions 38-670.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0000855.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3643941.
3643993.
KEGGical:CaO19.1743.
cal:CaO19.9310.

Organism-specific databases

CGDiCAL0000855. ACS1.

Phylogenomic databases

KOiK01895.
OrthoDBiEOG7M3J82.

Family and domain databases

InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314Imported and SC5314 / ATCC MYA-2876Imported.

Entry informationi

Entry nameiQ59XW4_CANAL
AccessioniPrimary (citable) accession number: Q59XW4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: February 4, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.