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Protein

Histone-lysine N-methyltransferase, H3 lysine-36 specific

Gene

SET2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.43)
Alternative name(s):
SET domain-containing protein 2
Gene namesi
Name:SET2
Ordered Locus Names:CAALFM_C210250CA
ORF Names:CaO19.1755, CaO19.9324
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 2

Organism-specific databases

CGDiCAL0000174178 SET2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002697821 – 844Histone-lysine N-methyltransferase, H3 lysine-36 specificAdd BLAST844

Proteomic databases

PRIDEiQ59XV0

Structurei

3D structure databases

ProteinModelPortaliQ59XV0
SMRiQ59XV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 140AWSPROSITE-ProRule annotationAdd BLAST57
Domaini142 – 259SETPROSITE-ProRule annotationAdd BLAST118
Domaini266 – 282Post-SETPROSITE-ProRule annotationAdd BLAST17
Domaini558 – 592WWPROSITE-ProRule annotationAdd BLAST35

Domaini

The AWS and SET domains are necessary for transcription repression.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ59XV0
KOiK11423
OMAiCYVDKWV
OrthoDBiEOG092C3T9B

Family and domain databases

CDDicd00201 WW, 1 hit
Gene3Di1.10.1740.100, 1 hit
InterProiView protein in InterPro
IPR006560 AWS_dom
IPR025788 Hist-Lys_N-MeTrfase_SET2_fun
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR013257 SRI
IPR038190 SRI_sf
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00856 SET, 1 hit
PF08236 SRI, 1 hit
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00570 AWS, 1 hit
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51215 AWS, 1 hit
PS50868 POST_SET, 1 hit
PS51568 SAM_MT43_SET2_1, 1 hit
PS50280 SET, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q59XV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNNFQESS NNTSSPSKRS TPMLFLDAEN KTQEALTTFE LLNACTYQNK
60 70 80 90 100
YVGSANVTTT ATTSTKTSNS TSTKSHQQQH RRKLEYMTCD CEEEWDSELQ
110 120 130 140 150
MNLACGPDSN CINRITCVEC VNRNCLCGDD CQNQRFQNRQ YSKVKVIQTE
160 170 180 190 200
LKGYGLIAEQ DIEENQFIYE YIGEVIDEIS FRQRMIEYDL RHLKHFYFMM
210 220 230 240 250
LSNDSFIDAT EKGSLGRFIN HSCNPNAFVD KWHVGDRLRM GIFAKRKISR
260 270 280 290 300
GEEITFDYNV DRYGAQSQPC YCGEPNCIKF MGGKTQTDAA LLLPQMIAEA
310 320 330 340 350
LGVTPRQEKA WLKENKSIRN QQQNDESNIN EEFVNSIEIE PIENQDGVTK
360 370 380 390 400
VMSALMKTQH PLIIKKLIER IFLSNDQDDI NVMFVRFHGY KTISTILQDL
410 420 430 440 450
LVAKNSGKES ETTDNNDIDN STGDDDQDKD ELIIKILKIL VSWPAVTKNK
460 470 480 490 500
IASANLEEVV KDIQTNNENS NNNDEINQLC TSLLDRWSKL EMAYRIPKQE
510 520 530 540 550
SVPTNNAAAA ATTTATATGT TTSASPFERI SSHTPEVGGT NTPSSTSQQQ
560 570 580 590 600
QQQNSRDAGL PENWRSAFDK NTGGYYYYNL VTKETTWERP LGSLPLGPKP
610 620 630 640 650
PSGPGLKGRI NKYNEIDLAK REELRIQKEK EMKFIEMQNR DRKLKELIEM
660 670 680 690 700
SKKSMNNIGG SSGTTITAAT INGLSDNGGN NNGNITGIYG DDKHSKHHHH
710 720 730 740 750
HHDKHLKNGP RNTSTSSSSG NNVEKIWKRI FAKYIPNIIK KYESEIGRDN
760 770 780 790 800
VKGCAKELVN ILTQSEIKHG NSLPSSSSSN GYSMELSDKK LKKIKEYSHG
810 820 830 840
YMDKFLIKFN NSKKHKSTMG SKGSDNHKRK HNGDGDNGVK RSKV
Length:844
Mass (Da):95,327
Last modified:April 26, 2005 - v1
Checksum:i0E913A5CA46BA55F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017624 Genomic DNA Translation: AOW28002.1
RefSeqiXP_714401.1, XM_709308.1

Genome annotation databases

EnsemblFungiiAOW28002; AOW28002; CAALFM_C210250CA
GeneIDi3643923
KEGGical:CAALFM_C210250CA

Similar proteinsi

Entry informationi

Entry nameiSET2_CANAL
AccessioniPrimary (citable) accession number: Q59XV0
Secondary accession number(s): A0A1D8PIP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health