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Q59XV0

- SET2_CANAL

UniProt

Q59XV0 - SET2_CANAL

Protein

Histone-lysine N-methyltransferase, H3 lysine-36 specific

Gene

SET2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

    GO - Molecular functioni

    1. histone methyltransferase activity (H3-K36 specific) Source: InterPro

    GO - Biological processi

    1. DNA-templated transcription, elongation Source: InterPro
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.43)
    Alternative name(s):
    SET domain-containing protein 2
    Gene namesi
    Name:SET2
    ORF Names:CaO19.1755, CaO19.9324
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0000871. orf19.1755.

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 844844Histone-lysine N-methyltransferase, H3 lysine-36 specificPRO_0000269782Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0000871.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59XV0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini84 – 14057AWSPROSITE-ProRule annotationAdd
    BLAST
    Domaini142 – 259118SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini266 – 28217Post-SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini558 – 59235WWPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The AWS and SET domains are necessary for transcription repression.By similarity

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
    Contains 1 AWS domain.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation
    Contains 1 WW domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2940.
    KOiK11423.
    OrthoDBiEOG7P8PH3.

    Family and domain databases

    InterProiIPR006560. AWS.
    IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
    IPR003616. Post-SET_dom.
    IPR001214. SET_dom.
    IPR013257. SRI.
    IPR001202. WW_dom.
    [Graphical view]
    PfamiPF00856. SET. 1 hit.
    PF08236. SRI. 1 hit.
    PF00397. WW. 1 hit.
    [Graphical view]
    SMARTiSM00570. AWS. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    SM00456. WW. 1 hit.
    [Graphical view]
    SUPFAMiSSF51045. SSF51045. 1 hit.
    PROSITEiPS51215. AWS. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS51568. SAM_MT43_SET2_1. 1 hit.
    PS50280. SET. 1 hit.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59XV0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNNNFQESS NNTSSPSKRS TPMLFLDAEN KTQEALTTFE LLNACTYQNK    50
    YVGSANVTTT ATTSTKTSNS TSTKSHQQQH RRKLEYMTCD CEEEWDSELQ 100
    MNLACGPDSN CINRITCVEC VNRNCLCGDD CQNQRFQNRQ YSKVKVIQTE 150
    LKGYGLIAEQ DIEENQFIYE YIGEVIDEIS FRQRMIEYDL RHLKHFYFMM 200
    LSNDSFIDAT EKGSLGRFIN HSCNPNAFVD KWHVGDRLRM GIFAKRKISR 250
    GEEITFDYNV DRYGAQSQPC YCGEPNCIKF MGGKTQTDAA LLLPQMIAEA 300
    LGVTPRQEKA WLKENKSIRN QQQNDESNIN EEFVNSIEIE PIENQDGVTK 350
    VMSALMKTQH PLIIKKLIER IFLSNDQDDI NVMFVRFHGY KTISTILQDL 400
    LVAKNSGKES ETTDNNDIDN STGDDDQDKD ELIIKILKIL VSWPAVTKNK 450
    IASANLEEVV KDIQTNNENS NNNDEINQLC TSLLDRWSKL EMAYRIPKQE 500
    SVPTNNAAAA ATTTATATGT TTSASPFERI SSHTPEVGGT NTPSSTSQQQ 550
    QQQNSRDAGL PENWRSAFDK NTGGYYYYNL VTKETTWERP LGSLPLGPKP 600
    PSGPGLKGRI NKYNEIDLAK REELRIQKEK EMKFIEMQNR DRKLKELIEM 650
    SKKSMNNIGG SSGTTITAAT INGLSDNGGN NNGNITGIYG DDKHSKHHHH 700
    HHDKHLKNGP RNTSTSSSSG NNVEKIWKRI FAKYIPNIIK KYESEIGRDN 750
    VKGCAKELVN ILTQSEIKHG NSLPSSSSSN GYSMELSDKK LKKIKEYSHG 800
    YMDKFLIKFN NSKKHKSTMG SKGSDNHKRK HNGDGDNGVK RSKV 844
    Length:844
    Mass (Da):95,327
    Last modified:April 26, 2005 - v1
    Checksum:i0E913A5CA46BA55F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000104 Genomic DNA. Translation: EAK95333.1.
    AACQ01000105 Genomic DNA. Translation: EAK95292.1.
    RefSeqiXP_714361.1. XM_709268.1.
    XP_714401.1. XM_709308.1.

    Genome annotation databases

    GeneIDi3643923.
    3643985.
    KEGGical:CaO19.1755.
    cal:CaO19.9324.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000104 Genomic DNA. Translation: EAK95333.1 .
    AACQ01000105 Genomic DNA. Translation: EAK95292.1 .
    RefSeqi XP_714361.1. XM_709268.1.
    XP_714401.1. XM_709308.1.

    3D structure databases

    ProteinModelPortali Q59XV0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0000871.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3643923.
    3643985.
    KEGGi cal:CaO19.1755.
    cal:CaO19.9324.

    Organism-specific databases

    CGDi CAL0000871. orf19.1755.

    Phylogenomic databases

    eggNOGi COG2940.
    KOi K11423.
    OrthoDBi EOG7P8PH3.

    Family and domain databases

    InterProi IPR006560. AWS.
    IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
    IPR003616. Post-SET_dom.
    IPR001214. SET_dom.
    IPR013257. SRI.
    IPR001202. WW_dom.
    [Graphical view ]
    Pfami PF00856. SET. 1 hit.
    PF08236. SRI. 1 hit.
    PF00397. WW. 1 hit.
    [Graphical view ]
    SMARTi SM00570. AWS. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    SM00456. WW. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51045. SSF51045. 1 hit.
    PROSITEi PS51215. AWS. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS51568. SAM_MT43_SET2_1. 1 hit.
    PS50280. SET. 1 hit.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiSET2_CANAL
    AccessioniPrimary (citable) accession number: Q59XV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3