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Q59XV0 (SET2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific

EC=2.1.1.43
Alternative name(s):
SET domain-containing protein 2
Gene names
Name:SET2
ORF Names:CaO19.1755, CaO19.9324
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length844 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus By similarity. Chromosome By similarity.

Domain

The AWS and SET domains are necessary for transcription repression By similarity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.

Contains 1 AWS domain.

Contains 1 post-SET domain.

Contains 1 SET domain.

Contains 1 WW domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 844844Histone-lysine N-methyltransferase, H3 lysine-36 specific
PRO_0000269782

Regions

Domain84 – 14057AWS
Domain142 – 259118SET
Domain266 – 28217Post-SET
Domain558 – 59235WW

Sequences

Sequence LengthMass (Da)Tools
Q59XV0 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 0E913A5CA46BA55F

FASTA84495,327
        10         20         30         40         50         60 
MSNNNFQESS NNTSSPSKRS TPMLFLDAEN KTQEALTTFE LLNACTYQNK YVGSANVTTT 

        70         80         90        100        110        120 
ATTSTKTSNS TSTKSHQQQH RRKLEYMTCD CEEEWDSELQ MNLACGPDSN CINRITCVEC 

       130        140        150        160        170        180 
VNRNCLCGDD CQNQRFQNRQ YSKVKVIQTE LKGYGLIAEQ DIEENQFIYE YIGEVIDEIS 

       190        200        210        220        230        240 
FRQRMIEYDL RHLKHFYFMM LSNDSFIDAT EKGSLGRFIN HSCNPNAFVD KWHVGDRLRM 

       250        260        270        280        290        300 
GIFAKRKISR GEEITFDYNV DRYGAQSQPC YCGEPNCIKF MGGKTQTDAA LLLPQMIAEA 

       310        320        330        340        350        360 
LGVTPRQEKA WLKENKSIRN QQQNDESNIN EEFVNSIEIE PIENQDGVTK VMSALMKTQH 

       370        380        390        400        410        420 
PLIIKKLIER IFLSNDQDDI NVMFVRFHGY KTISTILQDL LVAKNSGKES ETTDNNDIDN 

       430        440        450        460        470        480 
STGDDDQDKD ELIIKILKIL VSWPAVTKNK IASANLEEVV KDIQTNNENS NNNDEINQLC 

       490        500        510        520        530        540 
TSLLDRWSKL EMAYRIPKQE SVPTNNAAAA ATTTATATGT TTSASPFERI SSHTPEVGGT 

       550        560        570        580        590        600 
NTPSSTSQQQ QQQNSRDAGL PENWRSAFDK NTGGYYYYNL VTKETTWERP LGSLPLGPKP 

       610        620        630        640        650        660 
PSGPGLKGRI NKYNEIDLAK REELRIQKEK EMKFIEMQNR DRKLKELIEM SKKSMNNIGG 

       670        680        690        700        710        720 
SSGTTITAAT INGLSDNGGN NNGNITGIYG DDKHSKHHHH HHDKHLKNGP RNTSTSSSSG 

       730        740        750        760        770        780 
NNVEKIWKRI FAKYIPNIIK KYESEIGRDN VKGCAKELVN ILTQSEIKHG NSLPSSSSSN 

       790        800        810        820        830        840 
GYSMELSDKK LKKIKEYSHG YMDKFLIKFN NSKKHKSTMG SKGSDNHKRK HNGDGDNGVK 


RSKV 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000104 Genomic DNA. Translation: EAK95333.1.
AACQ01000105 Genomic DNA. Translation: EAK95292.1.
RefSeqXP_714361.1. XM_709268.1.
XP_714401.1. XM_709308.1.

3D structure databases

ProteinModelPortalQ59XV0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0000871.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3643923.
3643985.
KEGGcal:CaO19.1755.
cal:CaO19.9324.

Organism-specific databases

CGDCAL0000871. orf19.1755.

Phylogenomic databases

eggNOGCOG2940.
KOK11423.
OrthoDBEOG7P8PH3.

Family and domain databases

InterProIPR006560. AWS.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR001202. WW_dom.
[Graphical view]
PfamPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMSSF51045. SSF51045. 1 hit.
PROSITEPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSET2_CANAL
AccessionPrimary (citable) accession number: Q59XV0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names