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Q59XV0

- SET2_CANAL

UniProt

Q59XV0 - SET2_CANAL

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Protein

Histone-lysine N-methyltransferase, H3 lysine-36 specific

Gene

SET2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

  1. histone methyltransferase activity (H3-K36 specific) Source: InterPro

GO - Biological processi

  1. DNA-templated transcription, elongation Source: InterPro
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.43)
Alternative name(s):
SET domain-containing protein 2
Gene namesi
Name:SET2
ORF Names:CaO19.1755, CaO19.9324
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000871. orf19.1755.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 844844Histone-lysine N-methyltransferase, H3 lysine-36 specificPRO_0000269782Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0000871.

Structurei

3D structure databases

ProteinModelPortaliQ59XV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 14057AWSPROSITE-ProRule annotationAdd
BLAST
Domaini142 – 259118SETPROSITE-ProRule annotationAdd
BLAST
Domaini266 – 28217Post-SETPROSITE-ProRule annotationAdd
BLAST
Domaini558 – 59235WWPROSITE-ProRule annotationAdd
BLAST

Domaini

The AWS and SET domains are necessary for transcription repression.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
Contains 1 AWS domain.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation
Contains 1 WW domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2940.
InParanoidiQ59XV0.
KOiK11423.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59XV0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNNNFQESS NNTSSPSKRS TPMLFLDAEN KTQEALTTFE LLNACTYQNK
60 70 80 90 100
YVGSANVTTT ATTSTKTSNS TSTKSHQQQH RRKLEYMTCD CEEEWDSELQ
110 120 130 140 150
MNLACGPDSN CINRITCVEC VNRNCLCGDD CQNQRFQNRQ YSKVKVIQTE
160 170 180 190 200
LKGYGLIAEQ DIEENQFIYE YIGEVIDEIS FRQRMIEYDL RHLKHFYFMM
210 220 230 240 250
LSNDSFIDAT EKGSLGRFIN HSCNPNAFVD KWHVGDRLRM GIFAKRKISR
260 270 280 290 300
GEEITFDYNV DRYGAQSQPC YCGEPNCIKF MGGKTQTDAA LLLPQMIAEA
310 320 330 340 350
LGVTPRQEKA WLKENKSIRN QQQNDESNIN EEFVNSIEIE PIENQDGVTK
360 370 380 390 400
VMSALMKTQH PLIIKKLIER IFLSNDQDDI NVMFVRFHGY KTISTILQDL
410 420 430 440 450
LVAKNSGKES ETTDNNDIDN STGDDDQDKD ELIIKILKIL VSWPAVTKNK
460 470 480 490 500
IASANLEEVV KDIQTNNENS NNNDEINQLC TSLLDRWSKL EMAYRIPKQE
510 520 530 540 550
SVPTNNAAAA ATTTATATGT TTSASPFERI SSHTPEVGGT NTPSSTSQQQ
560 570 580 590 600
QQQNSRDAGL PENWRSAFDK NTGGYYYYNL VTKETTWERP LGSLPLGPKP
610 620 630 640 650
PSGPGLKGRI NKYNEIDLAK REELRIQKEK EMKFIEMQNR DRKLKELIEM
660 670 680 690 700
SKKSMNNIGG SSGTTITAAT INGLSDNGGN NNGNITGIYG DDKHSKHHHH
710 720 730 740 750
HHDKHLKNGP RNTSTSSSSG NNVEKIWKRI FAKYIPNIIK KYESEIGRDN
760 770 780 790 800
VKGCAKELVN ILTQSEIKHG NSLPSSSSSN GYSMELSDKK LKKIKEYSHG
810 820 830 840
YMDKFLIKFN NSKKHKSTMG SKGSDNHKRK HNGDGDNGVK RSKV
Length:844
Mass (Da):95,327
Last modified:April 26, 2005 - v1
Checksum:i0E913A5CA46BA55F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000104 Genomic DNA. Translation: EAK95333.1.
AACQ01000105 Genomic DNA. Translation: EAK95292.1.
RefSeqiXP_714361.1. XM_709268.1.
XP_714401.1. XM_709308.1.

Genome annotation databases

GeneIDi3643923.
3643985.
KEGGical:CaO19.1755.
cal:CaO19.9324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000104 Genomic DNA. Translation: EAK95333.1 .
AACQ01000105 Genomic DNA. Translation: EAK95292.1 .
RefSeqi XP_714361.1. XM_709268.1.
XP_714401.1. XM_709308.1.

3D structure databases

ProteinModelPortali Q59XV0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0000871.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3643923.
3643985.
KEGGi cal:CaO19.1755.
cal:CaO19.9324.

Organism-specific databases

CGDi CAL0000871. orf19.1755.

Phylogenomic databases

eggNOGi COG2940.
InParanoidi Q59XV0.
KOi K11423.
OrthoDBi EOG7P8PH3.

Family and domain databases

InterProi IPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR001202. WW_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
PF00397. WW. 1 hit.
[Graphical view ]
SMARTi SM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
[Graphical view ]
SUPFAMi SSF51045. SSF51045. 1 hit.
PROSITEi PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiSET2_CANAL
AccessioniPrimary (citable) accession number: Q59XV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3