Q59XV0 (SET2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific
EC=2.1.1.43

Alternative name(s):
SET domain-containing protein 2

Gene names

Name:	SET2
ORF Names:	CaO19.1755, CaO19.9324

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	844 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression By similarity.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subcellular location	Nucleus By similarity. Chromosome By similarity.
Domain	The AWS and SET domains are necessary for transcription repression By similarity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. SET2 subfamily. Contains 1 AWS domain. Contains 1 post-SET domain. Contains 1 SET domain. Contains 1 WW domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Chromosome Nucleus
Molecular function	Methyltransferase Repressor Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA-dependent transcription, elongation Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone methyltransferase activity (H3-K36 specific) Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 844	844	Histone-lysine N-methyltransferase, H3 lysine-36 specific		PRO_0000269782
Regions
	Domain	84 – 140	57	AWS
	Domain	141 – 263	123	SET
	Domain	266 – 282	17	Post-SET
	Domain	558 – 592	35	WW

Sequences

	Sequence		Length	Mass (Da)
	Q59XV0 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 0E913A5CA46BA55F	FASTA	844	95,327
	10 20 30 40 50 60 MSNNNFQESS NNTSSPSKRS TPMLFLDAEN KTQEALTTFE LLNACTYQNK YVGSANVTTT 70 80 90 100 110 120 ATTSTKTSNS TSTKSHQQQH RRKLEYMTCD CEEEWDSELQ MNLACGPDSN CINRITCVEC 130 140 150 160 170 180 VNRNCLCGDD CQNQRFQNRQ YSKVKVIQTE LKGYGLIAEQ DIEENQFIYE YIGEVIDEIS 190 200 210 220 230 240 FRQRMIEYDL RHLKHFYFMM LSNDSFIDAT EKGSLGRFIN HSCNPNAFVD KWHVGDRLRM 250 260 270 280 290 300 GIFAKRKISR GEEITFDYNV DRYGAQSQPC YCGEPNCIKF MGGKTQTDAA LLLPQMIAEA 310 320 330 340 350 360 LGVTPRQEKA WLKENKSIRN QQQNDESNIN EEFVNSIEIE PIENQDGVTK VMSALMKTQH 370 380 390 400 410 420 PLIIKKLIER IFLSNDQDDI NVMFVRFHGY KTISTILQDL LVAKNSGKES ETTDNNDIDN 430 440 450 460 470 480 STGDDDQDKD ELIIKILKIL VSWPAVTKNK IASANLEEVV KDIQTNNENS NNNDEINQLC 490 500 510 520 530 540 TSLLDRWSKL EMAYRIPKQE SVPTNNAAAA ATTTATATGT TTSASPFERI SSHTPEVGGT 550 560 570 580 590 600 NTPSSTSQQQ QQQNSRDAGL PENWRSAFDK NTGGYYYYNL VTKETTWERP LGSLPLGPKP 610 620 630 640 650 660 PSGPGLKGRI NKYNEIDLAK REELRIQKEK EMKFIEMQNR DRKLKELIEM SKKSMNNIGG 670 680 690 700 710 720 SSGTTITAAT INGLSDNGGN NNGNITGIYG DDKHSKHHHH HHDKHLKNGP RNTSTSSSSG 730 740 750 760 770 780 NNVEKIWKRI FAKYIPNIIK KYESEIGRDN VKGCAKELVN ILTQSEIKHG NSLPSSSSSN 790 800 810 820 830 840 GYSMELSDKK LKKIKEYSHG YMDKFLIKFN NSKKHKSTMG SKGSDNHKRK HNGDGDNGVK RSKV

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000104 Genomic DNA. Translation: EAK95333.1. AACQ01000105 Genomic DNA. Translation: EAK95292.1.
RefSeq	XP_714361.1. XM_709268.1. XP_714401.1. XM_709308.1.
3D structure databases
ProteinModelPortal	Q59XV0.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0000871.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3643923. 3643985.
KEGG	cal:CaO19.1755. cal:CaO19.9324.
Organism-specific databases
CGD	CAL0000871. orf19.1755.
Phylogenomic databases
eggNOG	COG2940.
KO	K11423.
Family and domain databases
InterPro	IPR006560. AWS. IPR025788. Hist-Lys_N-MeTrfase_SET2_fun. IPR003616. Post-SET_dom. IPR001214. SET_dom. IPR013257. SRI. IPR001202. WW_dom. [Graphical view]
Pfam	PF00856. SET. 1 hit. PF08236. SRI. 1 hit. PF00397. WW. 1 hit. [Graphical view]
SMART	SM00570. AWS. 1 hit. SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. SM00456. WW. 1 hit. [Graphical view]
SUPFAM	SSF51045. WW_Rsp5_WWP. 1 hit.
PROSITE	PS51215. AWS. 1 hit. PS50868. POST_SET. 1 hit. PS50280. SET. 1 hit. PS01159. WW_DOMAIN_1. 1 hit. PS50020. WW_DOMAIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SET2_CANAL

Accession

Primary (citable) accession number: Q59XV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	April 26, 2005
Last modified:	May 29, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program