SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q59XV0

- SET2_CANAL

UniProt

Q59XV0 - SET2_CANAL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Histone-lysine N-methyltransferase, H3 lysine-36 specific
Gene
SET2, CaO19.1755, CaO19.9324
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. histone methyltransferase activity (H3-K36 specific) Source: InterPro

GO - Biological processi

  1. DNA-templated transcription, elongation Source: InterPro
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.43)
Alternative name(s):
SET domain-containing protein 2
Gene namesi
Name:SET2
ORF Names:CaO19.1755, CaO19.9324
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000871. orf19.1755.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 844844Histone-lysine N-methyltransferase, H3 lysine-36 specific
PRO_0000269782Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0000871.

Structurei

3D structure databases

ProteinModelPortaliQ59XV0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 14057AWS
Add
BLAST
Domaini142 – 259118SET
Add
BLAST
Domaini266 – 28217Post-SET
Add
BLAST
Domaini558 – 59235WW
Add
BLAST

Domaini

The AWS and SET domains are necessary for transcription repression By similarity.

Sequence similaritiesi

Contains 1 AWS domain.
Contains 1 post-SET domain.
Contains 1 SET domain.
Contains 1 WW domain.

Phylogenomic databases

eggNOGiCOG2940.
KOiK11423.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59XV0-1 [UniParc]FASTAAdd to Basket

« Hide

MSNNNFQESS NNTSSPSKRS TPMLFLDAEN KTQEALTTFE LLNACTYQNK    50
YVGSANVTTT ATTSTKTSNS TSTKSHQQQH RRKLEYMTCD CEEEWDSELQ 100
MNLACGPDSN CINRITCVEC VNRNCLCGDD CQNQRFQNRQ YSKVKVIQTE 150
LKGYGLIAEQ DIEENQFIYE YIGEVIDEIS FRQRMIEYDL RHLKHFYFMM 200
LSNDSFIDAT EKGSLGRFIN HSCNPNAFVD KWHVGDRLRM GIFAKRKISR 250
GEEITFDYNV DRYGAQSQPC YCGEPNCIKF MGGKTQTDAA LLLPQMIAEA 300
LGVTPRQEKA WLKENKSIRN QQQNDESNIN EEFVNSIEIE PIENQDGVTK 350
VMSALMKTQH PLIIKKLIER IFLSNDQDDI NVMFVRFHGY KTISTILQDL 400
LVAKNSGKES ETTDNNDIDN STGDDDQDKD ELIIKILKIL VSWPAVTKNK 450
IASANLEEVV KDIQTNNENS NNNDEINQLC TSLLDRWSKL EMAYRIPKQE 500
SVPTNNAAAA ATTTATATGT TTSASPFERI SSHTPEVGGT NTPSSTSQQQ 550
QQQNSRDAGL PENWRSAFDK NTGGYYYYNL VTKETTWERP LGSLPLGPKP 600
PSGPGLKGRI NKYNEIDLAK REELRIQKEK EMKFIEMQNR DRKLKELIEM 650
SKKSMNNIGG SSGTTITAAT INGLSDNGGN NNGNITGIYG DDKHSKHHHH 700
HHDKHLKNGP RNTSTSSSSG NNVEKIWKRI FAKYIPNIIK KYESEIGRDN 750
VKGCAKELVN ILTQSEIKHG NSLPSSSSSN GYSMELSDKK LKKIKEYSHG 800
YMDKFLIKFN NSKKHKSTMG SKGSDNHKRK HNGDGDNGVK RSKV 844
Length:844
Mass (Da):95,327
Last modified:April 26, 2005 - v1
Checksum:i0E913A5CA46BA55F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000104 Genomic DNA. Translation: EAK95333.1.
AACQ01000105 Genomic DNA. Translation: EAK95292.1.
RefSeqiXP_714361.1. XM_709268.1.
XP_714401.1. XM_709308.1.

Genome annotation databases

GeneIDi3643923.
3643985.
KEGGical:CaO19.1755.
cal:CaO19.9324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000104 Genomic DNA. Translation: EAK95333.1 .
AACQ01000105 Genomic DNA. Translation: EAK95292.1 .
RefSeqi XP_714361.1. XM_709268.1.
XP_714401.1. XM_709308.1.

3D structure databases

ProteinModelPortali Q59XV0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0000871.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3643923.
3643985.
KEGGi cal:CaO19.1755.
cal:CaO19.9324.

Organism-specific databases

CGDi CAL0000871. orf19.1755.

Phylogenomic databases

eggNOGi COG2940.
KOi K11423.
OrthoDBi EOG7P8PH3.

Family and domain databases

InterProi IPR006560. AWS.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR001202. WW_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
PF00397. WW. 1 hit.
[Graphical view ]
SMARTi SM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
[Graphical view ]
SUPFAMi SSF51045. SSF51045. 1 hit.
PROSITEi PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiSET2_CANAL
AccessioniPrimary (citable) accession number: Q59XV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi