Q59X94 (CCPR2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative heme-binding peroxidase
EC=1.11.1.-

Gene names

Name:	CCP2
ORF Names:	CaO19.584, CaO19.8216

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per subunit By similarity.
Sequence similarities	Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.

Ontologies

Keywords
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	Putative heme-binding peroxidase		PRO_0000055584
Sites
	Active site	61	1	Proton acceptor By similarity
	Active site	201	1	Tryptophan radical intermediate By similarity
	Metal binding	185	1	Iron (heme axial ligand) By similarity
	Site	57	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q59X94 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 50EC570C6615D744	FASTA	291	32,918
	10 20 30 40 50 60 MIRSYIRNII LAILSPLLTT PPPLILPPPY EKIIQEITTV LSINNYDDGS LAPIILRLAW 70 80 90 100 110 120 HCCATYDVTT NTGGSNGATM RFVPEITDEG NYGLDIARAA LEPIKQRYPA ISYADLWTLA 130 140 150 160 170 180 GKVAIEYMGG PTIIWKSGRV DYTNDRCTPS NGLLPFADKD ANHIRKTFTR LGYNDQQTVA 190 200 210 220 230 240 LIGAHGVGRC HKRFSGWEGK WTRTPKTFSN QFYVVLLNET WSQGEVPETG KTQYFNADKS 250 260 270 280 290 LIMLNTDMEL IRDKSYLHWV EIYAKDEPKF FHDFSSAFAK LLELGIKRET L

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000109 Genomic DNA. Translation: EAK95087.1. AACQ01000108 Genomic DNA. Translation: EAK95134.1.
RefSeq	XP_714170.1. XM_709077.1. XP_714211.1. XM_709118.1.
3D structure databases
ProteinModelPortal	Q59X94.
ModBase	Search...
Protein family/group databases
PeroxiBase	2345. CalCcP01.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3644127. 3644156.
KEGG	cal:CaO19.584. cal:CaO19.8216.
Organism-specific databases
CGD	CAL0000335. orf19.584.
Phylogenomic databases
PhylomeDB	Q59X94.
Family and domain databases
InterPro	IPR002207. Asc_peroxidase. IPR010255. Haem_peroxidase. IPR002016. Haem_peroxidase_pln/fun/bac. IPR019794. Peroxidases_AS. [Graphical view]
Pfam	PF00141. peroxidase. 1 hit. [Graphical view]
PRINTS	PR00459. ASPEROXIDASE. PR00458. PEROXIDASE.
SUPFAM	SSF48113. Peroxidase_super. 1 hit.
PROSITE	PS00435. PEROXIDASE_1. False negative. PS00436. PEROXIDASE_2. 1 hit. PS50873. PEROXIDASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCPR2_CANAL

Accession

Primary (citable) accession number: Q59X94

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program