Q59X11 (ATG2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Autophagy-related protein 2

Gene names

Name:	ATG2
Synonyms:	SPO72
ORF Names:	CaO19.4119, CaO19.11601

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	1856 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes completion and peroxisome degradation By similarity.
Subcellular location	Prevacuolar compartment By similarity.
Sequence similarities	Belongs to the ATG2 family.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	late endosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1856	1856	Autophagy-related protein 2		PRO_0000215827
Regions
	Compositional bias	271 – 278	8	Poly-Asp
	Compositional bias	505 – 535	31	Ser-rich
	Compositional bias	1018 – 1027	10	Poly-Ser
	Compositional bias	1733 – 1743	11	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	Q59X11 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: A725366378CE9619	FASTA	1,856	207,366
	10 20 30 40 50 60 MIPQWIPQNI QKRLLLYVLQ QLSLFSEIDL PNLEEVSLNN IILKDVALDP EKVGKLPGCN 70 80 90 100 110 120 LRYGQIGSLE LTTISGISGV NIDVNDAEIV ISPDFDIDEN MTNQVAFSLA QSTANLANTI 130 140 150 160 170 180 MLNTNDGSDM NETSDPTSED DDEDDIDDKI TKPIPPKRRT SSVTGNKTTA LGGVMQKAVE 190 200 210 220 230 240 IALSRLSIKV NSLKIKIVSD LTDLQMEVDS VSINSTNGTR TVSIKGVKLR TLKPNVNPGE 250 260 270 280 290 300 GFQSGHAPQK KQQGSDNDSP TDANKHGSEN DNDDDDDDYG NESLMDSMVF SHEEASSIYM 310 320 330 340 350 360 SATSRSFEKS AASGIPGEVD NKATDKEDYS EDPPIIFYMD DCTIEFDGLS TISNLEIEVG 370 380 390 400 410 420 NINLAFTPLT PTLVSIFQGV AKSLKIKYYQ QKKKTKSRSA QRNEKFPQYT NDNDEIPEDQ 430 440 450 460 470 480 SESDDASHEP FFNRFKVNSF VISATSALSE NGLFANKNGI NIIFFNINIK QKNELLLYGG 490 500 510 520 530 540 VETFKIIRFE DDNTYEIFHF DKPQSAPSSA PSYSGSNDVA GTSSSSSSST GSATSKADIR 550 560 570 580 590 600 FEVFKKSEES DDLEVTVLMA KSAHFNFDLQ SLLILSNFAK AVSSIYDEYG LLKSVIDKLD 610 620 630 640 650 660 TRDKKWSGGT NNSKMSSKSE FILQTATIFV NFIISDDCQL QLIVFPIKFN LLQEQLTISK 670 680 690 700 710 720 ILLNCTNGDT QVEGVIILTD VSLITKNQEF RAYFQSTNTT TSANTHPLPR KTTMNSKLSV 730 740 750 760 770 780 IVQKFSSNVS MDKLKFIGEK LKNFSNEFIE RSPTQSNSLE NSFLNEPVER QRLESSLHMN 790 800 810 820 830 840 SSLFSTRRPG RRLGLGFNNS PSVFLGSTRV TLASFQVCFK EATFNITDVF PKFGNFSVQM 850 860 870 880 890 900 SDISFYKLKN DILGHILSVS VQRKKGDLVE NLIHQYQDLS PNSLEFPLLS IKCKLGDKTT 910 920 930 940 950 960 KIEITARNLV LEYYTNWLLL MDKEESIIDA VEEEIIEKVT PSQHSSSQNK LDIRYSMYDC 970 980 990 1000 1010 1020 MVGLTPGRLS CKSYLIIGKG DSDISFGVDQ FYVKCSFRNI SMVLIDDTKN ILPFSEPSTS 1030 1040 1050 1060 1070 1080 SSSSSSSATR QTPYVYIQPL DYYSKLGYIH LGLINVAHVG ITFNTDIEAL KDRNEKLGIK 1090 1100 1110 1120 1130 1140 DSLTFVDLKT NLDECQFNLC ADTANTLIQL VNDLKLPLNF RDEDKMKVDF ADGINVMQGI 1150 1160 1170 1180 1190 1200 DQNIFKGLTE TLTELNLNGT ENGSTSESSS QEASSLMFEE GHFDRGNRSL YDNSHVDPLH 1210 1220 1230 1240 1250 1260 ININLSKVKI YLHDGYDWKD TRKAIRGAVK NFETAQTAKT VAKEKEKKRK VEFETRDIEV 1270 1280 1290 1300 1310 1320 QEDVFQETLF QSIHVVAPRN QNARDMATSI NLDLQNDKDG ESRDVSTANS GKSYKNLKLR 1330 1340 1350 1360 1370 1380 RSAKHKLLFD LKSIEVGVNV YSTRDPRRDK TDENMKYELL NFIELRVGTV DIYDNVSTST 1390 1400 1410 1420 1430 1440 WNKFLSYMNI LGDREIGTSM VKVSILNVRP DPAMVSGEAI MNVSVLPLRL HIDQDALDFL 1450 1460 1470 1480 1490 1500 VRFFEFKDER FELPPDEMVY IQKFEISSIK LKLDYKPKKV DYAGLRSGKA GEFANFFTLD 1510 1520 1530 1540 1550 1560 GSTLTLPKVK LFGIPGAPKI GIGLGRAWLP VFQSTQVIGI ISGVSPLRSV VNIGGGFKDL 1570 1580 1590 1600 1610 1620 VAIPISEYKK DGRLWRSIQK GTVSFAKTTG YEILNLGVKL ASGTQVLLEQ GEEMLGGEGS 1630 1640 1650 1660 1670 1680 SVRSPNLGGS DNRRNSNASD ELPVEVAKPK SQNNLLVSSQ ILNKASTKIE THSYDTKKLY 1690 1700 1710 1720 1730 1740 SNIELDDEDM DDNRINGINK ELLSKSIFLL APAEEKLAKL QPHTKGNHEG LTEEEEDEDE 1750 1760 1770 1780 1790 1800 DEEYQLYAYE DEEELQEKLV SLYSNQPETI EQGLKSAYKS LGTNFKLTKK QLLKLRRELA 1810 1820 1830 1840 1850 ETDTIQDSMV TVLKNSPIIL MRPLIGSTEA VSKLLMGVGN QIDGKKLVEK KDKYPT

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000107 Genomic DNA. Translation: EAK95217.1. AACQ01000110 Genomic DNA. Translation: EAK95064.1.
RefSeq	XP_714151.1. XM_709058.1. XP_714289.1. XM_709196.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q59X11.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3644072. 3644229.
KEGG	cal:CaO19.11601. cal:CaO19.4119.
Organism-specific databases
CGD	CAL0005597. SPO72.
Phylogenomic databases
PhylomeDB	Q59X11.
Family and domain databases
InterPro	IPR015412. Autophagy-rel_C. [Graphical view]
Pfam	PF09333. ATG_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG2_CANAL

Accession

Primary (citable) accession number: Q59X11

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program