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Q59W55

- PRM1_CANAL

UniProt

Q59W55 - PRM1_CANAL

Protein

Plasma membrane fusion protein PRM1

Gene

PRM1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.By similarity

    GO - Biological processi

    1. plasma membrane fusion involved in cytogamy Source: InterPro

    Keywords - Biological processi

    Conjugation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plasma membrane fusion protein PRM1
    Gene namesi
    Name:PRM1
    ORF Names:CaO19.669, CaO19.8286
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mating projection tip Source: InterPro
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 623623Plasma membrane fusion protein PRM1PRO_0000337274Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Inductioni

    By pheromones during mating.3 Publications

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0001069.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919ExtracellularBy similarityAdd
    BLAST
    Topological domaini41 – 9252CytoplasmicBy similarityAdd
    BLAST
    Topological domaini114 – 281168ExtracellularBy similarityAdd
    BLAST
    Topological domaini303 – 36563CytoplasmicBy similarityAdd
    BLAST
    Topological domaini387 – 537151ExtracellularBy similarityAdd
    BLAST
    Topological domaini559 – 62365CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei93 – 11321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei282 – 30221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei366 – 38621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei538 – 55821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PRM1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG74887.
    OrthoDBiEOG715QCZ.

    Family and domain databases

    InterProiIPR026777. PRM1.
    [Graphical view]
    PANTHERiPTHR31030. PTHR31030. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q59W55-1 [UniParc]FASTAAdd to Basket

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    MFRNYLNLPE ILTQVYLNKY AILLILILIK LILLETSILD NLNSVLLDNS    50
    ICDNGEIQPV LNTVHYMIVD SLQTLEAAGI VSIILTLKVI KQLALFFIEL 100
    FFGTYICLLN AALKGSTEVA LDASEGVIRA VNATVVSATN DIESALKGLS 150
    SIINDLVTGF NAIKNMFTGS KSDPTQYQNK INITLGDLKS KIMIPSEVLT 200
    KLDNFKNSSL YGLSQLGNGT QTIVSTPFEL AIKKLNTMKS SYNFTTGAPS 250
    PINFREECLK DMSKLKDVQT DLAKLVEKIS KWLFIGLVLA MVGSILYVSY 300
    IQWRHWRRMD KFINETGIDK EVQFRNQYNI YNNFLIYTIV KRMGIDLNER 350
    AIWMLSFMFS KISRNVFFFG IMGVVSVVAQ YILLNSVQSS MNNHIKSFDI 400
    TSNSTSMSAS TIYLRDMNTY IDDTQDKLNQ ELFSGIKEIS VSLNSTIVEF 450
    LDKLNETLSD IFGSTPLAGP INTVVYCTIG RKLEKVEKGL TWMNDNLNIN 500
    IPSISRDIED GLSHMTFLQP QSVLARANKI IDLYRKSILL ELYISLGLLG 550
    VWLFQIFVGS ATLTIRYWNS TRQGNNSYAI SSPHELSEQE KQVYGYPLSH 600
    PLIDGKDLTT SSSFYPTTEE KSK 623
    Length:623
    Mass (Da):70,125
    Last modified:April 26, 2005 - v1
    Checksum:i2508494BACC066FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000117 Genomic DNA. Translation: EAK94700.1.
    AACQ01000116 Genomic DNA. Translation: EAK94741.1.
    RefSeqiXP_713802.1. XM_708709.1.
    XP_713842.1. XM_708749.1.

    Genome annotation databases

    GeneIDi3644488.
    3644549.
    KEGGical:CaO19.669.
    cal:CaO19.8286.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000117 Genomic DNA. Translation: EAK94700.1 .
    AACQ01000116 Genomic DNA. Translation: EAK94741.1 .
    RefSeqi XP_713802.1. XM_708709.1.
    XP_713842.1. XM_708749.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0001069.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3644488.
    3644549.
    KEGGi cal:CaO19.669.
    cal:CaO19.8286.

    Phylogenomic databases

    eggNOGi NOG74887.
    OrthoDBi EOG715QCZ.

    Family and domain databases

    InterProi IPR026777. PRM1.
    [Graphical view ]
    PANTHERi PTHR31030. PTHR31030. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. "Unique aspects of gene expression during Candida albicans mating and possible G(1) dependency."
      Zhao R., Daniels K.J., Lockhart S.R., Yeater K.M., Hoyer L.L., Soll D.R.
      Eukaryot. Cell 4:1175-1190(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    3. "SST2, a regulator of G-protein signaling for the Candida albicans mating response pathway."
      Dignard D., Whiteway M.
      Eukaryot. Cell 5:192-202(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    4. "The role of nutrient regulation and the Gpa2 protein in the mating pheromone response of C. albicans."
      Bennett R.J., Johnson A.D.
      Mol. Microbiol. 62:100-119(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiPRM1_CANAL
    AccessioniPrimary (citable) accession number: Q59W55
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3