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Q59W55

- PRM1_CANAL

UniProt

Q59W55 - PRM1_CANAL

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Protein

Plasma membrane fusion protein PRM1

Gene
PRM1, CaO19.669, CaO19.8286
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in cell fusion during mating by stabilizing the plasma membrane fusion event By similarity.

GO - Biological processi

  1. plasma membrane fusion involved in cytogamy Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Conjugation

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane fusion protein PRM1
Gene namesi
Name:PRM1
ORF Names:CaO19.669, CaO19.8286
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919Extracellular By similarityAdd
BLAST
Transmembranei20 – 4021Helical; Reviewed predictionAdd
BLAST
Topological domaini41 – 9252Cytoplasmic By similarityAdd
BLAST
Transmembranei93 – 11321Helical; Reviewed predictionAdd
BLAST
Topological domaini114 – 281168Extracellular By similarityAdd
BLAST
Transmembranei282 – 30221Helical; Reviewed predictionAdd
BLAST
Topological domaini303 – 36563Cytoplasmic By similarityAdd
BLAST
Transmembranei366 – 38621Helical; Reviewed predictionAdd
BLAST
Topological domaini387 – 537151Extracellular By similarityAdd
BLAST
Transmembranei538 – 55821Helical; Reviewed predictionAdd
BLAST
Topological domaini559 – 62365Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mating projection tip Source: InterPro
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 623623Plasma membrane fusion protein PRM1PRO_0000337274Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi132 – 1321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi182 – 1821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi207 – 2071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi218 – 2181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi243 – 2431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi403 – 4031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi444 – 4441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi455 – 4551N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Expressioni

Inductioni

By pheromones during mating.3 Publications

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0001069.

Family & Domainsi

Sequence similaritiesi

Belongs to the PRM1 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74887.
OrthoDBiEOG715QCZ.

Family and domain databases

InterProiIPR026777. PRM1.
[Graphical view]
PANTHERiPTHR31030. PTHR31030. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59W55-1 [UniParc]FASTAAdd to Basket

« Hide

MFRNYLNLPE ILTQVYLNKY AILLILILIK LILLETSILD NLNSVLLDNS    50
ICDNGEIQPV LNTVHYMIVD SLQTLEAAGI VSIILTLKVI KQLALFFIEL 100
FFGTYICLLN AALKGSTEVA LDASEGVIRA VNATVVSATN DIESALKGLS 150
SIINDLVTGF NAIKNMFTGS KSDPTQYQNK INITLGDLKS KIMIPSEVLT 200
KLDNFKNSSL YGLSQLGNGT QTIVSTPFEL AIKKLNTMKS SYNFTTGAPS 250
PINFREECLK DMSKLKDVQT DLAKLVEKIS KWLFIGLVLA MVGSILYVSY 300
IQWRHWRRMD KFINETGIDK EVQFRNQYNI YNNFLIYTIV KRMGIDLNER 350
AIWMLSFMFS KISRNVFFFG IMGVVSVVAQ YILLNSVQSS MNNHIKSFDI 400
TSNSTSMSAS TIYLRDMNTY IDDTQDKLNQ ELFSGIKEIS VSLNSTIVEF 450
LDKLNETLSD IFGSTPLAGP INTVVYCTIG RKLEKVEKGL TWMNDNLNIN 500
IPSISRDIED GLSHMTFLQP QSVLARANKI IDLYRKSILL ELYISLGLLG 550
VWLFQIFVGS ATLTIRYWNS TRQGNNSYAI SSPHELSEQE KQVYGYPLSH 600
PLIDGKDLTT SSSFYPTTEE KSK 623
Length:623
Mass (Da):70,125
Last modified:April 26, 2005 - v1
Checksum:i2508494BACC066FE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000117 Genomic DNA. Translation: EAK94700.1.
AACQ01000116 Genomic DNA. Translation: EAK94741.1.
RefSeqiXP_713802.1. XM_708709.1.
XP_713842.1. XM_708749.1.

Genome annotation databases

GeneIDi3644488.
3644549.
KEGGical:CaO19.669.
cal:CaO19.8286.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000117 Genomic DNA. Translation: EAK94700.1 .
AACQ01000116 Genomic DNA. Translation: EAK94741.1 .
RefSeqi XP_713802.1. XM_708709.1.
XP_713842.1. XM_708749.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0001069.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3644488.
3644549.
KEGGi cal:CaO19.669.
cal:CaO19.8286.

Phylogenomic databases

eggNOGi NOG74887.
OrthoDBi EOG715QCZ.

Family and domain databases

InterProi IPR026777. PRM1.
[Graphical view ]
PANTHERi PTHR31030. PTHR31030. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Unique aspects of gene expression during Candida albicans mating and possible G(1) dependency."
    Zhao R., Daniels K.J., Lockhart S.R., Yeater K.M., Hoyer L.L., Soll D.R.
    Eukaryot. Cell 4:1175-1190(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  3. "SST2, a regulator of G-protein signaling for the Candida albicans mating response pathway."
    Dignard D., Whiteway M.
    Eukaryot. Cell 5:192-202(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  4. "The role of nutrient regulation and the Gpa2 protein in the mating pheromone response of C. albicans."
    Bennett R.J., Johnson A.D.
    Mol. Microbiol. 62:100-119(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiPRM1_CANAL
AccessioniPrimary (citable) accession number: Q59W55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 26, 2005
Last modified: March 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi