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Q59W55

- PRM1_CANAL

UniProt

Q59W55 - PRM1_CANAL

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Protein

Plasma membrane fusion protein PRM1

Gene

PRM1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.By similarity

GO - Biological processi

  1. plasma membrane fusion involved in cytogamy Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Conjugation

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane fusion protein PRM1
Gene namesi
Name:PRM1
ORF Names:CaO19.669, CaO19.8286
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919ExtracellularBy similarityAdd
BLAST
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Topological domaini41 – 9252CytoplasmicBy similarityAdd
BLAST
Transmembranei93 – 11321HelicalSequence AnalysisAdd
BLAST
Topological domaini114 – 281168ExtracellularBy similarityAdd
BLAST
Transmembranei282 – 30221HelicalSequence AnalysisAdd
BLAST
Topological domaini303 – 36563CytoplasmicBy similarityAdd
BLAST
Transmembranei366 – 38621HelicalSequence AnalysisAdd
BLAST
Topological domaini387 – 537151ExtracellularBy similarityAdd
BLAST
Transmembranei538 – 55821HelicalSequence AnalysisAdd
BLAST
Topological domaini559 – 62365CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mating projection tip Source: InterPro
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 623623Plasma membrane fusion protein PRM1PRO_0000337274Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Inductioni

By pheromones during mating.3 Publications

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0001069.

Family & Domainsi

Sequence similaritiesi

Belongs to the PRM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74887.
InParanoidiQ59W55.
OrthoDBiEOG715QCZ.

Family and domain databases

InterProiIPR026777. PRM1.
[Graphical view]
PANTHERiPTHR31030. PTHR31030. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59W55-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFRNYLNLPE ILTQVYLNKY AILLILILIK LILLETSILD NLNSVLLDNS
60 70 80 90 100
ICDNGEIQPV LNTVHYMIVD SLQTLEAAGI VSIILTLKVI KQLALFFIEL
110 120 130 140 150
FFGTYICLLN AALKGSTEVA LDASEGVIRA VNATVVSATN DIESALKGLS
160 170 180 190 200
SIINDLVTGF NAIKNMFTGS KSDPTQYQNK INITLGDLKS KIMIPSEVLT
210 220 230 240 250
KLDNFKNSSL YGLSQLGNGT QTIVSTPFEL AIKKLNTMKS SYNFTTGAPS
260 270 280 290 300
PINFREECLK DMSKLKDVQT DLAKLVEKIS KWLFIGLVLA MVGSILYVSY
310 320 330 340 350
IQWRHWRRMD KFINETGIDK EVQFRNQYNI YNNFLIYTIV KRMGIDLNER
360 370 380 390 400
AIWMLSFMFS KISRNVFFFG IMGVVSVVAQ YILLNSVQSS MNNHIKSFDI
410 420 430 440 450
TSNSTSMSAS TIYLRDMNTY IDDTQDKLNQ ELFSGIKEIS VSLNSTIVEF
460 470 480 490 500
LDKLNETLSD IFGSTPLAGP INTVVYCTIG RKLEKVEKGL TWMNDNLNIN
510 520 530 540 550
IPSISRDIED GLSHMTFLQP QSVLARANKI IDLYRKSILL ELYISLGLLG
560 570 580 590 600
VWLFQIFVGS ATLTIRYWNS TRQGNNSYAI SSPHELSEQE KQVYGYPLSH
610 620
PLIDGKDLTT SSSFYPTTEE KSK
Length:623
Mass (Da):70,125
Last modified:April 26, 2005 - v1
Checksum:i2508494BACC066FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000117 Genomic DNA. Translation: EAK94700.1.
AACQ01000116 Genomic DNA. Translation: EAK94741.1.
RefSeqiXP_713802.1. XM_708709.1.
XP_713842.1. XM_708749.1.

Genome annotation databases

GeneIDi3644488.
3644549.
KEGGical:CaO19.669.
cal:CaO19.8286.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000117 Genomic DNA. Translation: EAK94700.1 .
AACQ01000116 Genomic DNA. Translation: EAK94741.1 .
RefSeqi XP_713802.1. XM_708709.1.
XP_713842.1. XM_708749.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0001069.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3644488.
3644549.
KEGGi cal:CaO19.669.
cal:CaO19.8286.

Phylogenomic databases

eggNOGi NOG74887.
InParanoidi Q59W55.
OrthoDBi EOG715QCZ.

Family and domain databases

InterProi IPR026777. PRM1.
[Graphical view ]
PANTHERi PTHR31030. PTHR31030. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Unique aspects of gene expression during Candida albicans mating and possible G(1) dependency."
    Zhao R., Daniels K.J., Lockhart S.R., Yeater K.M., Hoyer L.L., Soll D.R.
    Eukaryot. Cell 4:1175-1190(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  3. "SST2, a regulator of G-protein signaling for the Candida albicans mating response pathway."
    Dignard D., Whiteway M.
    Eukaryot. Cell 5:192-202(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  4. "The role of nutrient regulation and the Gpa2 protein in the mating pheromone response of C. albicans."
    Bennett R.J., Johnson A.D.
    Mol. Microbiol. 62:100-119(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiPRM1_CANAL
AccessioniPrimary (citable) accession number: Q59W55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3