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Q59W55 (PRM1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Plasma membrane fusion protein PRM1
Gene names
Name:PRM1
ORF Names:CaO19.669, CaO19.8286
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length623 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in cell fusion during mating by stabilizing the plasma membrane fusion event By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Induction

By pheromones during mating. Ref.2 Ref.3 Ref.4

Sequence similarities

Belongs to the PRM1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 623623Plasma membrane fusion protein PRM1
PRO_0000337274

Regions

Topological domain1 – 1919Extracellular By similarity
Transmembrane20 – 4021Helical; Potential
Topological domain41 – 9252Cytoplasmic By similarity
Transmembrane93 – 11321Helical; Potential
Topological domain114 – 281168Extracellular By similarity
Transmembrane282 – 30221Helical; Potential
Topological domain303 – 36563Cytoplasmic By similarity
Transmembrane366 – 38621Helical; Potential
Topological domain387 – 537151Extracellular By similarity
Transmembrane538 – 55821Helical; Potential
Topological domain559 – 62365Cytoplasmic By similarity

Amino acid modifications

Glycosylation1321N-linked (GlcNAc...) Potential
Glycosylation1821N-linked (GlcNAc...) Potential
Glycosylation2071N-linked (GlcNAc...) Potential
Glycosylation2181N-linked (GlcNAc...) Potential
Glycosylation2431N-linked (GlcNAc...) Potential
Glycosylation4031N-linked (GlcNAc...) Potential
Glycosylation4441N-linked (GlcNAc...) Potential
Glycosylation4551N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q59W55 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 2508494BACC066FE

FASTA62370,125
        10         20         30         40         50         60 
MFRNYLNLPE ILTQVYLNKY AILLILILIK LILLETSILD NLNSVLLDNS ICDNGEIQPV 

        70         80         90        100        110        120 
LNTVHYMIVD SLQTLEAAGI VSIILTLKVI KQLALFFIEL FFGTYICLLN AALKGSTEVA 

       130        140        150        160        170        180 
LDASEGVIRA VNATVVSATN DIESALKGLS SIINDLVTGF NAIKNMFTGS KSDPTQYQNK 

       190        200        210        220        230        240 
INITLGDLKS KIMIPSEVLT KLDNFKNSSL YGLSQLGNGT QTIVSTPFEL AIKKLNTMKS 

       250        260        270        280        290        300 
SYNFTTGAPS PINFREECLK DMSKLKDVQT DLAKLVEKIS KWLFIGLVLA MVGSILYVSY 

       310        320        330        340        350        360 
IQWRHWRRMD KFINETGIDK EVQFRNQYNI YNNFLIYTIV KRMGIDLNER AIWMLSFMFS 

       370        380        390        400        410        420 
KISRNVFFFG IMGVVSVVAQ YILLNSVQSS MNNHIKSFDI TSNSTSMSAS TIYLRDMNTY 

       430        440        450        460        470        480 
IDDTQDKLNQ ELFSGIKEIS VSLNSTIVEF LDKLNETLSD IFGSTPLAGP INTVVYCTIG 

       490        500        510        520        530        540 
RKLEKVEKGL TWMNDNLNIN IPSISRDIED GLSHMTFLQP QSVLARANKI IDLYRKSILL 

       550        560        570        580        590        600 
ELYISLGLLG VWLFQIFVGS ATLTIRYWNS TRQGNNSYAI SSPHELSEQE KQVYGYPLSH 

       610        620 
PLIDGKDLTT SSSFYPTTEE KSK 

« Hide

References

« Hide 'large scale' references
[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"Unique aspects of gene expression during Candida albicans mating and possible G(1) dependency."
Zhao R., Daniels K.J., Lockhart S.R., Yeater K.M., Hoyer L.L., Soll D.R.
Eukaryot. Cell 4:1175-1190(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[3]"SST2, a regulator of G-protein signaling for the Candida albicans mating response pathway."
Dignard D., Whiteway M.
Eukaryot. Cell 5:192-202(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[4]"The role of nutrient regulation and the Gpa2 protein in the mating pheromone response of C. albicans."
Bennett R.J., Johnson A.D.
Mol. Microbiol. 62:100-119(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000117 Genomic DNA. Translation: EAK94700.1.
AACQ01000116 Genomic DNA. Translation: EAK94741.1.
RefSeqXP_713802.1. XM_708709.1.
XP_713842.1. XM_708749.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0001069.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3644488.
3644549.
KEGGcal:CaO19.669.
cal:CaO19.8286.

Phylogenomic databases

eggNOGNOG74887.
OrthoDBEOG715QCZ.

Family and domain databases

InterProIPR026777. PRM1.
[Graphical view]
PANTHERPTHR31030. PTHR31030. 1 hit.
ProtoNetSearch...

Entry information

Entry namePRM1_CANAL
AccessionPrimary (citable) accession number: Q59W55
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 26, 2005
Last modified: March 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names