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Q59W50 (CWC2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pre-mRNA-splicing factor CWC2
Gene names
Name:CWC2
ORF Names:CaO19.674, CaO19.8291
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the "nineteen complex" NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle By similarity.

Subunit structure

Associated with the spliceosome By similarity.

Subcellular location

Nucleus By similarity.

Domain

The C-terminus RRM domain and the zinc finger motif are necessary for RNA-binding By similarity.

Sequence similarities

Belongs to the RRM CWC2 family.

Contains 1 C3H1-type zinc finger.

Contains 1 RRM (RNA recognition motif) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Pre-mRNA-splicing factor CWC2
PRO_0000081541

Regions

Domain141 – 21777RRM
Zinc finger78 – 10528C3H1-type

Sequences

Sequence LengthMass (Da)Tools
Q59W50 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 4AFFBB5543523293

FASTA36341,272
        10         20         30         40         50         60 
MSRKVSISSL TLSEPMTKPA RVQVNPEDID DLDKTQQVNN HQYNIWYSKS LSDANNKSTT 

        70         80         90        100        110        120 
KSKYRVRIST DQGFTKANKN THICLFFSRG CCYLGSKCQY FHRLPKESDN FKPTQDCFGR 

       130        140        150        160        170        180 
DKTANYRDDM DGVGSLNKVN CTLYVGGIHI KPNTEQLLVK NFQEFGTVEK VRVLQGKGCA 

       190        200        210        220        230        240 
FVTMKTENQA QFAKEAMQSQ SLVEGSNEVL YVRWANEDKN PAAQKQEKKR QQELAYDTVK 

       250        260        270        280        290        300 
QLLEQESNKK PRLENGAVNR IETINIDDES EDEGAVEDDE ADDDIEETRV NSLSAGVKKN 

       310        320        330        340        350        360 
VSTHQANGTP ESSSTSDEND HNTILRNSLL KDISRLKKKM VYKREEPYLT NLLVDYSSDE 


DDD 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000117 Genomic DNA. Translation: EAK94705.1.
AACQ01000116 Genomic DNA. Translation: EAK94746.1.
RefSeqXP_713807.1. XM_708714.1.
XP_713847.1. XM_708754.1.

3D structure databases

ProteinModelPortalQ59W50.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0001095.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3644493.
3644554.
KEGGcal:CaO19.674.
cal:CaO19.8291.

Organism-specific databases

CGDCAL0001095. orf19.674.

Phylogenomic databases

eggNOGNOG288665.
OrthoDBEOG7D867D.

Family and domain databases

Gene3D3.30.70.330. 1 hit.
InterProIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR000571. Znf_CCCH.
[Graphical view]
SMARTSM00360. RRM. 1 hit.
[Graphical view]
PROSITEPS50102. RRM. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCWC2_CANAL
AccessionPrimary (citable) accession number: Q59W50
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: April 26, 2005
Last modified: November 13, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names