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Protein

Pre-mRNA-splicing factor CWC2

Gene

CWC2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the "nineteen complex" NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri78 – 105C3H1-typePROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processCell cycle, mRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor CWC2
Gene namesi
Name:CWC2
Ordered Locus Names:CAALFM_C111280WA
ORF Names:CaO19.674, CaO19.8291
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000184865 orf19.674

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815411 – 363Pre-mRNA-splicing factor CWC2Add BLAST363

Proteomic databases

PRIDEiQ59W50

Interactioni

Subunit structurei

Associated with the spliceosome.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ59W50
SMRiQ59W50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 217RRMPROSITE-ProRule annotationAdd BLAST77

Domaini

The C-terminus RRM domain and the zinc finger motif are necessary for RNA-binding.By similarity

Sequence similaritiesi

Belongs to the RRM CWC2 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri78 – 105C3H1-typePROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Zinc-finger

Phylogenomic databases

InParanoidiQ59W50
OMAiAKESMAC
OrthoDBiEOG092C4KFZ

Family and domain databases

CDDicd12360 RRM_cwf2, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR034181 Cwc2_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR032297 Torus
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PF16131 Torus, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF90229 SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS50103 ZF_C3H1, 1 hit

Sequencei

Sequence statusi: Complete.

Q59W50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKVSISSL TLSEPMTKPA RVQVNPEDID DLDKTQQVNN HQYNIWYSKS
60 70 80 90 100
LSDANNKSTT KSKYRVRIST DQGFTKANKN THICLFFSRG CCYLGSKCQY
110 120 130 140 150
FHRLPKESDN FKPTQDCFGR DKTANYRDDM DGVGSLNKVN CTLYVGGIHI
160 170 180 190 200
KPNTEQLLVK NFQEFGTVEK VRVLQGKGCA FVTMKTENQA QFAKEAMQSQ
210 220 230 240 250
SLVEGSNEVL YVRWANEDKN PAAQKQEKKR QQELAYDTVK QLLEQESNKK
260 270 280 290 300
PRLENGAVNR IETINIDDES EDEGAVEDDE ADDDIEETRV NSLSAGVKKN
310 320 330 340 350
VSTHQANGTP ESSSTSDEND HNTILRNSLL KDISRLKKKM VYKREEPYLT
360
NLLVDYSSDE DDD
Length:363
Mass (Da):41,272
Last modified:April 26, 2005 - v1
Checksum:i4AFFBB5543523293
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA Translation: AOW26753.1
RefSeqiXP_713807.1, XM_708714.1

Genome annotation databases

EnsemblFungiiAOW26753; AOW26753; CAALFM_C111280WA
GeneIDi3644554
KEGGical:CAALFM_C111280WA

Similar proteinsi

Entry informationi

Entry nameiCWC2_CANAL
AccessioniPrimary (citable) accession number: Q59W50
Secondary accession number(s): A0A1D8PF37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health