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Q59W50

- CWC2_CANAL

UniProt

Q59W50 - CWC2_CANAL

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Protein
Pre-mRNA-splicing factor CWC2
Gene
CWC2, CaO19.674, CaO19.8291
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the "nineteen complex" NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri78 – 10528C3H1-type
Add
BLAST

GO - Molecular functioni

  1. U6 snRNA binding Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. nucleotide binding Source: InterPro
  4. pre-mRNA binding Source: UniProtKB

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. mRNA cis splicing, via spliceosome Source: UniProtKB
  3. positive regulation of RNA splicing Source: UniProtKB
  4. positive regulation of cell cycle Source: UniProtKB
  5. spliceosomal snRNP assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor CWC2
Gene namesi
Name:CWC2
ORF Names:CaO19.674, CaO19.8291
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001095. orf19.674.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. Prp19 complex Source: UniProtKB
  2. spliceosomal complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Pre-mRNA-splicing factor CWC2
PRO_0000081541Add
BLAST

Interactioni

Subunit structurei

Associated with the spliceosome By similarity.

Protein-protein interaction databases

STRINGi5476.CAL0001095.

Structurei

3D structure databases

ProteinModelPortaliQ59W50.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini141 – 21777RRM
Add
BLAST

Domaini

The C-terminus RRM domain and the zinc finger motif are necessary for RNA-binding By similarity.

Sequence similaritiesi

Belongs to the RRM CWC2 family.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG288665.
OrthoDBiEOG7D867D.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR000571. Znf_CCCH.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59W50-1 [UniParc]FASTAAdd to Basket

« Hide

MSRKVSISSL TLSEPMTKPA RVQVNPEDID DLDKTQQVNN HQYNIWYSKS    50
LSDANNKSTT KSKYRVRIST DQGFTKANKN THICLFFSRG CCYLGSKCQY 100
FHRLPKESDN FKPTQDCFGR DKTANYRDDM DGVGSLNKVN CTLYVGGIHI 150
KPNTEQLLVK NFQEFGTVEK VRVLQGKGCA FVTMKTENQA QFAKEAMQSQ 200
SLVEGSNEVL YVRWANEDKN PAAQKQEKKR QQELAYDTVK QLLEQESNKK 250
PRLENGAVNR IETINIDDES EDEGAVEDDE ADDDIEETRV NSLSAGVKKN 300
VSTHQANGTP ESSSTSDEND HNTILRNSLL KDISRLKKKM VYKREEPYLT 350
NLLVDYSSDE DDD 363
Length:363
Mass (Da):41,272
Last modified:April 26, 2005 - v1
Checksum:i4AFFBB5543523293
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000117 Genomic DNA. Translation: EAK94705.1.
AACQ01000116 Genomic DNA. Translation: EAK94746.1.
RefSeqiXP_713807.1. XM_708714.1.
XP_713847.1. XM_708754.1.

Genome annotation databases

GeneIDi3644493.
3644554.
KEGGical:CaO19.674.
cal:CaO19.8291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000117 Genomic DNA. Translation: EAK94705.1 .
AACQ01000116 Genomic DNA. Translation: EAK94746.1 .
RefSeqi XP_713807.1. XM_708714.1.
XP_713847.1. XM_708754.1.

3D structure databases

ProteinModelPortali Q59W50.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0001095.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3644493.
3644554.
KEGGi cal:CaO19.674.
cal:CaO19.8291.

Organism-specific databases

CGDi CAL0001095. orf19.674.

Phylogenomic databases

eggNOGi NOG288665.
OrthoDBi EOG7D867D.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR000571. Znf_CCCH.
[Graphical view ]
SMARTi SM00360. RRM. 1 hit.
[Graphical view ]
PROSITEi PS50102. RRM. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiCWC2_CANAL
AccessioniPrimary (citable) accession number: Q59W50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: April 26, 2005
Last modified: November 13, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi