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Q59W50

- CWC2_CANAL

UniProt

Q59W50 - CWC2_CANAL

Protein

Pre-mRNA-splicing factor CWC2

Gene

CWC2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the "nineteen complex" NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri78 – 10528C3H1-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleotide binding Source: InterPro
    3. pre-mRNA binding Source: UniProtKB
    4. U6 snRNA binding Source: UniProtKB

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. mRNA cis splicing, via spliceosome Source: UniProtKB
    3. positive regulation of cell cycle Source: UniProtKB
    4. positive regulation of RNA splicing Source: UniProtKB
    5. spliceosomal snRNP assembly Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, mRNA processing, mRNA splicing

    Keywords - Ligandi

    Metal-binding, RNA-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pre-mRNA-splicing factor CWC2
    Gene namesi
    Name:CWC2
    ORF Names:CaO19.674, CaO19.8291
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0001095. orf19.674.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. Prp19 complex Source: UniProtKB
    2. spliceosomal complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Pre-mRNA-splicing factor CWC2PRO_0000081541Add
    BLAST

    Interactioni

    Subunit structurei

    Associated with the spliceosome.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0001095.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59W50.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini141 – 21777RRMPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The C-terminus RRM domain and the zinc finger motif are necessary for RNA-binding.By similarity

    Sequence similaritiesi

    Belongs to the RRM CWC2 family.Curated
    Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri78 – 10528C3H1-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG288665.
    OrthoDBiEOG7D867D.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR000571. Znf_CCCH.
    [Graphical view]
    SMARTiSM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    PS50103. ZF_C3H1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59W50-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRKVSISSL TLSEPMTKPA RVQVNPEDID DLDKTQQVNN HQYNIWYSKS    50
    LSDANNKSTT KSKYRVRIST DQGFTKANKN THICLFFSRG CCYLGSKCQY 100
    FHRLPKESDN FKPTQDCFGR DKTANYRDDM DGVGSLNKVN CTLYVGGIHI 150
    KPNTEQLLVK NFQEFGTVEK VRVLQGKGCA FVTMKTENQA QFAKEAMQSQ 200
    SLVEGSNEVL YVRWANEDKN PAAQKQEKKR QQELAYDTVK QLLEQESNKK 250
    PRLENGAVNR IETINIDDES EDEGAVEDDE ADDDIEETRV NSLSAGVKKN 300
    VSTHQANGTP ESSSTSDEND HNTILRNSLL KDISRLKKKM VYKREEPYLT 350
    NLLVDYSSDE DDD 363
    Length:363
    Mass (Da):41,272
    Last modified:April 26, 2005 - v1
    Checksum:i4AFFBB5543523293
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000117 Genomic DNA. Translation: EAK94705.1.
    AACQ01000116 Genomic DNA. Translation: EAK94746.1.
    RefSeqiXP_713807.1. XM_708714.1.
    XP_713847.1. XM_708754.1.

    Genome annotation databases

    GeneIDi3644493.
    3644554.
    KEGGical:CaO19.674.
    cal:CaO19.8291.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000117 Genomic DNA. Translation: EAK94705.1 .
    AACQ01000116 Genomic DNA. Translation: EAK94746.1 .
    RefSeqi XP_713807.1. XM_708714.1.
    XP_713847.1. XM_708754.1.

    3D structure databases

    ProteinModelPortali Q59W50.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0001095.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3644493.
    3644554.
    KEGGi cal:CaO19.674.
    cal:CaO19.8291.

    Organism-specific databases

    CGDi CAL0001095. orf19.674.

    Phylogenomic databases

    eggNOGi NOG288665.
    OrthoDBi EOG7D867D.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR000571. Znf_CCCH.
    [Graphical view ]
    SMARTi SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    PS50103. ZF_C3H1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiCWC2_CANAL
    AccessioniPrimary (citable) accession number: Q59W50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3