Q59W41 (KAD11_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase 1-1
Short name=AK 1 1
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase 1 1
Adenylate kinase cytosolic and mitochondrial 1

Gene names

Name:	ADK1-1
ORF Names:	CaO19.683, CaO19.8301

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	249 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in cytoplasm and mitochondrion intermembrane space By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 249	249	Adenylate kinase 1-1		PRO_0000365666
Regions
	Nucleotide binding	40 – 48	9	ATP By similarity
	Nucleotide binding	63 – 92	30	AMP By similarity
Sites
	Binding site	64	1	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q59W41 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 772AB37710929CFE	FASTA	249	27,580
	10 20 30 40 50 60 MSIEDLKNTV TKLQERIQEL EKKAGIIPDV PKSVRMVLIG PPGAGKGTQA PNLKEKFCAC 70 80 90 100 110 120 HLATGDMLRA QVAAKTALGV EAKKIMDQGG LVSDEIMVNM IKSELENNQE CSKGFILDGF 130 140 150 160 170 180 PRTIPQAEKL DSMLESRKTP LEKAVELKID DELLVARITG RLVHPASGRS YHKLFNPPKK 190 200 210 220 230 240 DMTDDVTGEP LVQRSDDNED ALKKRLVTYH KQTEPIVAYY QKTGIWSGVD ASQKPTKVWS DILKCLGQN

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000116 Genomic DNA. Translation: EAK94756.1. AACQ01000117 Genomic DNA. Translation: EAK94714.1.
RefSeq	XP_713816.1. XM_708723.1. XP_713857.1. XM_708764.1.
3D structure databases
HSSP	HSSP built from PDB template 1AKY based on UniProtKB P07170.
ProteinModelPortal	Q59W41.
SMR	Q59W41. Positions 32-249.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59W41.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3644495. 3644533.
KEGG	cal:CaO19.683. cal:CaO19.8301.
Organism-specific databases
CGD	CAL0001132. orf19.683.
Phylogenomic databases
OMA	HEEFHPP.
PhylomeDB	Q59W41.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_lid-dom. [Graphical view]
KO	K00939.
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
TIGRFAMs	TIGR01351. Adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD11_CANAL

Accession

Primary (citable) accession number: Q59W41

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program