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Protein

Autophagy protein 5

Gene

ATG5

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processAutophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy protein 5
Gene namesi
Name:ATG5
Ordered Locus Names:CAALFM_C102200CA
ORF Names:CaO19.11161, CaO19.3677
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000174020 orf19.3677

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190001 – 278Autophagy protein 5Add BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)By similarity

Post-translational modificationi

Conjugated to ATG12; which is essential for autophagy.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Interactioni

Subunit structurei

Conjugated with ATG12.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ59VY1
SMRiQ59VY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG5 family.Curated

Phylogenomic databases

InParanoidiQ59VY1
KOiK08339
OrthoDBiEOG092C3XV6

Family and domain databases

InterProiView protein in InterPro
IPR007239 Atg5
PANTHERiPTHR13040 PTHR13040, 1 hit
PfamiView protein in Pfam
PF04106 APG5, 1 hit

Sequencei

Sequence statusi: Complete.

Q59VY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDIDNLAEI KKKLWNGSIN VKILLNIEDQ IIEYLLTIPR NSYFPTVFPQ
60 70 80 90 100
LIRYFQNFIT TIELSKVPIW LEFEEVPLKW NLPVGVLYDY LYLPALLNDH
110 120 130 140 150
DLGCWTISMK YEPVYPIEYI IPFNEKLAGD GQIDYMKTMN RILMNQLKQS
160 170 180 190 200
CFVLNGTAKP IMQLSEANTN QLWKSLISRN LGDFNVLNKK IIKTIDRIPV
210 220 230 240 250
KIYIAGSPIV VQAPISKDQT LQEILSLHTP NLSSSSSSMS HPYIQGIDVT
260 270
SLMNQSIREI WQLFKHLDNF LYITLIIL
Length:278
Mass (Da):32,199
Last modified:March 15, 2017 - v2
Checksum:i35DD724D151B5020
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA Translation: AOW25905.1
RefSeqiXP_713771.2, XM_708678.2

Genome annotation databases

EnsemblFungiiAOW25905; AOW25905; CAALFM_C102200CA
GeneIDi3644593
KEGGical:CAALFM_C102200CA

Similar proteinsi

Entry informationi

Entry nameiATG5_CANAL
AccessioniPrimary (citable) accession number: Q59VY1
Secondary accession number(s): A0A1D8PCQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 15, 2017
Last modified: May 23, 2018
This is version 74 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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