SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q59VY1

- ATG5_CANAL

UniProt

Q59VY1 - ATG5_CANAL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Autophagy protein 5
Gene
ATG5, CaO19.11161, CaO19.3677
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes By similarity.

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy protein 5
Gene namesi
Name:ATG5
ORF Names:CaO19.11161, CaO19.3677
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000453. orf19.3677.

Subcellular locationi

GO - Cellular componenti

  1. pre-autophagosomal structure membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Autophagy protein 5
PRO_0000219000Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki148 – 148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12) By similarity

Post-translational modificationi

Conjugated to ATG12; which is essential for autophagy By similarity.

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Interactioni

Subunit structurei

Conjugated with ATG12 By similarity.

Protein-protein interaction databases

STRINGi5476.CAL0000453.

Structurei

3D structure databases

ProteinModelPortaliQ59VY1.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG5 family.

Phylogenomic databases

eggNOGiNOG271554.
KOiK08339.
OrthoDBiEOG73BVPZ.

Family and domain databases

InterProiIPR007239. Atg5.
[Graphical view]
PANTHERiPTHR13040. PTHR13040. 1 hit.
PfamiPF04106. APG5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59VY1-1 [UniParc]FASTAAdd to Basket

« Hide

MNDIDNLAEI KKKLWNGSIN VKILLNIEDQ IIEYLLTIPR NSYFPTVFPQ    50
LIRYFQNFIT TIELSKVPIW LEFEEVPLKW NLPVGVLYDY LYLPALLNDH 100
DLGCWTISMK YEPVYPIEYI ISFNEKLAGD GQIDYMKTMN RILMNQLKQS 150
CFVLNGTAKP IMQLSEANTN QLWKSLISRN LGDFNVLNKK IIKTIDRIPV 200
KIYIAGSPIV VQAPISKDQT LQEILSLHTP NLSSSSSSMS HPYIQGIDVT 250
SLMNQSIREI WQLFKHLDNF LYITLIIL 278
Length:278
Mass (Da):32,189
Last modified:April 26, 2005 - v1
Checksum:i1A0D70B03B064FC0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000118 Genomic DNA. Translation: EAK94668.1.
AACQ01000119 Genomic DNA. Translation: EAK94634.1.
RefSeqiXP_713737.1. XM_708644.1.
XP_713771.1. XM_708678.1.

Genome annotation databases

GeneIDi3644593.
3644619.
KEGGical:CaO19.11161.
cal:CaO19.3677.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000118 Genomic DNA. Translation: EAK94668.1 .
AACQ01000119 Genomic DNA. Translation: EAK94634.1 .
RefSeqi XP_713737.1. XM_708644.1.
XP_713771.1. XM_708678.1.

3D structure databases

ProteinModelPortali Q59VY1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0000453.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3644593.
3644619.
KEGGi cal:CaO19.11161.
cal:CaO19.3677.

Organism-specific databases

CGDi CAL0000453. orf19.3677.

Phylogenomic databases

eggNOGi NOG271554.
KOi K08339.
OrthoDBi EOG73BVPZ.

Family and domain databases

InterProi IPR007239. Atg5.
[Graphical view ]
PANTHERi PTHR13040. PTHR13040. 1 hit.
Pfami PF04106. APG5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiATG5_CANAL
AccessioniPrimary (citable) accession number: Q59VY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: April 26, 2005
Last modified: March 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi