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Q59VY1

- ATG5_CANAL

UniProt

Q59VY1 - ATG5_CANAL

Protein

Autophagy protein 5

Gene

ATG5

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes By similarity.By similarity

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Autophagy, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Autophagy protein 5
    Gene namesi
    Name:ATG5
    ORF Names:CaO19.11161, CaO19.3677
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0000453. orf19.3677.

    Subcellular locationi

    GO - Cellular componenti

    1. pre-autophagosomal structure membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278Autophagy protein 5PRO_0000219000Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki148 – 148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)By similarity

    Post-translational modificationi

    Conjugated to ATG12; which is essential for autophagy.By similarity

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Interactioni

    Subunit structurei

    Conjugated with ATG12.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0000453.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59VY1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATG5 family.Curated

    Phylogenomic databases

    eggNOGiNOG271554.
    KOiK08339.
    OrthoDBiEOG73BVPZ.

    Family and domain databases

    InterProiIPR007239. Atg5.
    [Graphical view]
    PANTHERiPTHR13040. PTHR13040. 1 hit.
    PfamiPF04106. APG5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59VY1-1 [UniParc]FASTAAdd to Basket

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    MNDIDNLAEI KKKLWNGSIN VKILLNIEDQ IIEYLLTIPR NSYFPTVFPQ    50
    LIRYFQNFIT TIELSKVPIW LEFEEVPLKW NLPVGVLYDY LYLPALLNDH 100
    DLGCWTISMK YEPVYPIEYI ISFNEKLAGD GQIDYMKTMN RILMNQLKQS 150
    CFVLNGTAKP IMQLSEANTN QLWKSLISRN LGDFNVLNKK IIKTIDRIPV 200
    KIYIAGSPIV VQAPISKDQT LQEILSLHTP NLSSSSSSMS HPYIQGIDVT 250
    SLMNQSIREI WQLFKHLDNF LYITLIIL 278
    Length:278
    Mass (Da):32,189
    Last modified:April 26, 2005 - v1
    Checksum:i1A0D70B03B064FC0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000118 Genomic DNA. Translation: EAK94668.1.
    AACQ01000119 Genomic DNA. Translation: EAK94634.1.
    RefSeqiXP_713737.1. XM_708644.1.
    XP_713771.1. XM_708678.1.

    Genome annotation databases

    GeneIDi3644593.
    3644619.
    KEGGical:CaO19.11161.
    cal:CaO19.3677.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000118 Genomic DNA. Translation: EAK94668.1 .
    AACQ01000119 Genomic DNA. Translation: EAK94634.1 .
    RefSeqi XP_713737.1. XM_708644.1.
    XP_713771.1. XM_708678.1.

    3D structure databases

    ProteinModelPortali Q59VY1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0000453.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3644593.
    3644619.
    KEGGi cal:CaO19.11161.
    cal:CaO19.3677.

    Organism-specific databases

    CGDi CAL0000453. orf19.3677.

    Phylogenomic databases

    eggNOGi NOG271554.
    KOi K08339.
    OrthoDBi EOG73BVPZ.

    Family and domain databases

    InterProi IPR007239. Atg5.
    [Graphical view ]
    PANTHERi PTHR13040. PTHR13040. 1 hit.
    Pfami PF04106. APG5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiATG5_CANAL
    AccessioniPrimary (citable) accession number: Q59VY1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3