Q59VY1 (ATG5_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Autophagy protein 5

Gene names

Name:	ATG5
ORF Names:	CaO19.11161, CaO19.3677

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in cytoplasm to vacuole transport (Cvt) and autophagy vesicles formation. May be required for ATG8 association to the vesicle membranes By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.
Post-translational modification	Conjugated to ATG12; which is essential for autophagy By similarity.
Sequence similarities	Belongs to the ATG5 family.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm Membrane
PTM	Isopeptide bond Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Autophagy protein 5		PRO_0000219000
Amino acid modifications
	Cross-link	148		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q59VY1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 1A0D70B03B064FC0	FASTA	278	32,189
	10 20 30 40 50 60 MNDIDNLAEI KKKLWNGSIN VKILLNIEDQ IIEYLLTIPR NSYFPTVFPQ LIRYFQNFIT 70 80 90 100 110 120 TIELSKVPIW LEFEEVPLKW NLPVGVLYDY LYLPALLNDH DLGCWTISMK YEPVYPIEYI 130 140 150 160 170 180 ISFNEKLAGD GQIDYMKTMN RILMNQLKQS CFVLNGTAKP IMQLSEANTN QLWKSLISRN 190 200 210 220 230 240 LGDFNVLNKK IIKTIDRIPV KIYIAGSPIV VQAPISKDQT LQEILSLHTP NLSSSSSSMS 250 260 270 HPYIQGIDVT SLMNQSIREI WQLFKHLDNF LYITLIIL

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000118 Genomic DNA. Translation: EAK94668.1. AACQ01000119 Genomic DNA. Translation: EAK94634.1.
RefSeq	XP_713737.1. XM_708644.1. XP_713771.1. XM_708678.1.
3D structure databases
ProteinModelPortal	Q59VY1.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0000453.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3644593. 3644619.
KEGG	cal:CaO19.11161. cal:CaO19.3677.
Organism-specific databases
CGD	CAL0000453. orf19.3677.
Phylogenomic databases
eggNOG	NOG271554.
KO	K08339.
Family and domain databases
InterPro	IPR007239. Atg5. [Graphical view]
PANTHER	PTHR13040. PTHR13040. 1 hit.
Pfam	PF04106. APG5. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG5_CANAL

Accession

Primary (citable) accession number: Q59VY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program