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Q59VY1 (ATG5_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Autophagy protein 5
Gene names
Name:ATG5
ORF Names:CaO19.11161, CaO19.3677
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes By similarity.

Subunit structure

Conjugated with ATG12 By similarity.

Subcellular location

Preautophagosomal structure membrane; Peripheral membrane protein By similarity.

Post-translational modification

Conjugated to ATG12; which is essential for autophagy By similarity.

Sequence similarities

Belongs to the ATG5 family.

Ontologies

Keywords
   Biological processAutophagy
Protein transport
Transport
   Cellular componentMembrane
   PTMIsopeptide bond
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processautophagy

Inferred from electronic annotation. Source: UniProtKB-KW

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentpre-autophagosomal structure membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Autophagy protein 5
PRO_0000219000

Amino acid modifications

Cross-link148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q59VY1 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 1A0D70B03B064FC0

FASTA27832,189
        10         20         30         40         50         60 
MNDIDNLAEI KKKLWNGSIN VKILLNIEDQ IIEYLLTIPR NSYFPTVFPQ LIRYFQNFIT 

        70         80         90        100        110        120 
TIELSKVPIW LEFEEVPLKW NLPVGVLYDY LYLPALLNDH DLGCWTISMK YEPVYPIEYI 

       130        140        150        160        170        180 
ISFNEKLAGD GQIDYMKTMN RILMNQLKQS CFVLNGTAKP IMQLSEANTN QLWKSLISRN 

       190        200        210        220        230        240 
LGDFNVLNKK IIKTIDRIPV KIYIAGSPIV VQAPISKDQT LQEILSLHTP NLSSSSSSMS 

       250        260        270 
HPYIQGIDVT SLMNQSIREI WQLFKHLDNF LYITLIIL 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000118 Genomic DNA. Translation: EAK94668.1.
AACQ01000119 Genomic DNA. Translation: EAK94634.1.
RefSeqXP_713737.1. XM_708644.1.
XP_713771.1. XM_708678.1.

3D structure databases

ProteinModelPortalQ59VY1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0000453.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3644593.
3644619.
KEGGcal:CaO19.11161.
cal:CaO19.3677.

Organism-specific databases

CGDCAL0000453. orf19.3677.

Phylogenomic databases

eggNOGNOG271554.
KOK08339.
OrthoDBEOG73BVPZ.

Family and domain databases

InterProIPR007239. Atg5.
[Graphical view]
PANTHERPTHR13040. PTHR13040. 1 hit.
PfamPF04106. APG5. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATG5_CANAL
AccessionPrimary (citable) accession number: Q59VY1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: April 26, 2005
Last modified: March 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names