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Protein

Autophagy protein 5

Gene

ATG5

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).By similarity

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy protein 5
Gene namesi
Name:ATG5
ORF Names:CaO19.11161, CaO19.3677
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000453. orf19.3677.

Subcellular locationi

GO - Cellular componenti

  1. pre-autophagosomal structure membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Autophagy protein 5PRO_0000219000Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki148 – 148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)By similarity

Post-translational modificationi

Conjugated to ATG12; which is essential for autophagy.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Interactioni

Subunit structurei

Conjugated with ATG12.By similarity

Protein-protein interaction databases

STRINGi5476.CAL0000453.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG5 family.Curated

Phylogenomic databases

eggNOGiNOG271554.
InParanoidiQ59VY1.
KOiK08339.
OrthoDBiEOG73BVPZ.

Family and domain databases

InterProiIPR007239. Atg5.
[Graphical view]
PANTHERiPTHR13040. PTHR13040. 1 hit.
PfamiPF04106. APG5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59VY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDIDNLAEI KKKLWNGSIN VKILLNIEDQ IIEYLLTIPR NSYFPTVFPQ
60 70 80 90 100
LIRYFQNFIT TIELSKVPIW LEFEEVPLKW NLPVGVLYDY LYLPALLNDH
110 120 130 140 150
DLGCWTISMK YEPVYPIEYI ISFNEKLAGD GQIDYMKTMN RILMNQLKQS
160 170 180 190 200
CFVLNGTAKP IMQLSEANTN QLWKSLISRN LGDFNVLNKK IIKTIDRIPV
210 220 230 240 250
KIYIAGSPIV VQAPISKDQT LQEILSLHTP NLSSSSSSMS HPYIQGIDVT
260 270
SLMNQSIREI WQLFKHLDNF LYITLIIL
Length:278
Mass (Da):32,189
Last modified:April 25, 2005 - v1
Checksum:i1A0D70B03B064FC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000118 Genomic DNA. Translation: EAK94668.1.
AACQ01000119 Genomic DNA. Translation: EAK94634.1.
RefSeqiXP_713737.1. XM_708644.1.
XP_713771.1. XM_708678.1.

Genome annotation databases

GeneIDi3644593.
3644619.
KEGGical:CaO19.11161.
cal:CaO19.3677.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000118 Genomic DNA. Translation: EAK94668.1.
AACQ01000119 Genomic DNA. Translation: EAK94634.1.
RefSeqiXP_713737.1. XM_708644.1.
XP_713771.1. XM_708678.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0000453.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3644593.
3644619.
KEGGical:CaO19.11161.
cal:CaO19.3677.

Organism-specific databases

CGDiCAL0000453. orf19.3677.

Phylogenomic databases

eggNOGiNOG271554.
InParanoidiQ59VY1.
KOiK08339.
OrthoDBiEOG73BVPZ.

Family and domain databases

InterProiIPR007239. Atg5.
[Graphical view]
PANTHERiPTHR13040. PTHR13040. 1 hit.
PfamiPF04106. APG5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiATG5_CANAL
AccessioniPrimary (citable) accession number: Q59VY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 18, 2005
Last sequence update: April 25, 2005
Last modified: March 31, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.