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Q59VF4

- HAT1_CANAL

UniProt

Q59VF4 - HAT1_CANAL

Protein

Histone acetyltransferase type B catalytic subunit

Gene

HAT1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular response to DNA damage stimulus Source: CGD
    2. cellular response to reactive oxygen species Source: CGD
    3. chromatin silencing at telomere Source: InterPro
    4. DNA repair Source: CGD
    5. histone acetylation Source: CGD
    6. negative regulation of pseudohyphal growth Source: CGD
    7. phenotypic switching Source: CGD

    Keywords - Molecular functioni

    Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    DNA damage, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48)
    Gene namesi
    Name:HAT1
    ORF Names:CaO19.779, CaO19.8401
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0001952. orf19.779.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. histone acetyltransferase complex Source: InterPro
    3. nucleus Source: CGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 413413Histone acetyltransferase type B catalytic subunitPRO_0000227719Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0001952.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59VF4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HAT1 family.Curated

    Phylogenomic databases

    eggNOGiNOG326277.
    KOiK11303.
    OrthoDBiEOG7HTHSD.

    Family and domain databases

    Gene3Di1.10.10.390. 1 hit.
    3.40.630.30. 1 hit.
    3.90.360.10. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR019467. Hat1_N.
    IPR017380. Hist_AcTrfase_B-typ_cat-su.
    IPR013523. Hist_AcTrfase_HAT1_C.
    [Graphical view]
    PANTHERiPTHR12046. PTHR12046. 1 hit.
    PfamiPF10394. Hat1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
    SUPFAMiSSF55729. SSF55729. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q59VF4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSAKEQSSV TAALQPEQWT TSSNEALKLF VTNPEAALNF QPTFTYPIFG    50
    DAETIYGYKD LDIFLCFDHY TFKPFLNIKY SAKLTDDPEI IDIKKTIDEF 100
    LPKSTIFKDE VKWVDSIKEE KDNGYKIPGK LIDSFSENDK EYDIYKIDLK 150
    SDNGYELHQR LQILVLLFIE AGSFIDAKDE LWNLYVLYEK DNKSTSNNEP 200
    SIVGFTTAYN YWKYPGAKKF DSTEQESRIK ISQFIILPIY QGQGLGQLFY 250
    SHLFDKWLAQ DDIIEVVVED PNESFDDLRD RADLKRLNTS EQFDFKAVTP 300
    KVDKEWVEKT RRALKLEKRQ FARLLEIILL YKLKHGYPGI TKRDVRLFIK 350
    KRLYDKNKEG LATLDDNTKK DKLQTAYQAL EDDYYRILGD LKLNIKREND 400
    EEETDTVSKK QKV 413
    Length:413
    Mass (Da):48,355
    Last modified:April 26, 2005 - v1
    Checksum:i94B7ACA991EA8747
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000123 Genomic DNA. Translation: EAK94484.1.
    AACQ01000122 Genomic DNA. Translation: EAK94521.1.
    RefSeqiXP_713589.1. XM_708496.1.
    XP_713626.1. XM_708533.1.

    Genome annotation databases

    GeneIDi3644728.
    3644770.
    KEGGical:CaO19.779.
    cal:CaO19.8401.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000123 Genomic DNA. Translation: EAK94484.1 .
    AACQ01000122 Genomic DNA. Translation: EAK94521.1 .
    RefSeqi XP_713589.1. XM_708496.1.
    XP_713626.1. XM_708533.1.

    3D structure databases

    ProteinModelPortali Q59VF4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0001952.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3644728.
    3644770.
    KEGGi cal:CaO19.779.
    cal:CaO19.8401.

    Organism-specific databases

    CGDi CAL0001952. orf19.779.

    Phylogenomic databases

    eggNOGi NOG326277.
    KOi K11303.
    OrthoDBi EOG7HTHSD.

    Family and domain databases

    Gene3Di 1.10.10.390. 1 hit.
    3.40.630.30. 1 hit.
    3.90.360.10. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR019467. Hat1_N.
    IPR017380. Hist_AcTrfase_B-typ_cat-su.
    IPR013523. Hist_AcTrfase_HAT1_C.
    [Graphical view ]
    PANTHERi PTHR12046. PTHR12046. 1 hit.
    Pfami PF10394. Hat1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
    SUPFAMi SSF55729. SSF55729. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiHAT1_CANAL
    AccessioniPrimary (citable) accession number: Q59VF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3