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Q59VF4

- HAT1_CANAL

UniProt

Q59VF4 - HAT1_CANAL

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Protein

Histone acetyltransferase type B catalytic subunit

Gene

HAT1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei182 – 1821Interaction with histone H4 N-terminusBy similarity
Active sitei269 – 2691Proton donor/acceptorBy similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: CGD
  2. cellular response to reactive oxygen species Source: CGD
  3. chromatin silencing at telomere Source: InterPro
  4. DNA repair Source: CGD
  5. histone acetylation Source: CGD
  6. negative regulation of pseudohyphal growth Source: CGD
  7. phenotypic switching Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Gene namesi
Name:HAT1
ORF Names:CaO19.779, CaO19.8401
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001952. orf19.779.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. histone acetyltransferase complex Source: InterPro
  3. nucleus Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Histone acetyltransferase type B catalytic subunitPRO_0000227719Add
BLAST

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail (By similarity).By similarity

Protein-protein interaction databases

STRINGi5476.CAL0001952.

Structurei

3D structure databases

ProteinModelPortaliQ59VF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 533Interaction with histone H4 N-terminusBy similarity
Regioni209 – 2113Interaction with histone H4 N-terminusBy similarity
Regioni234 – 2363Acetyl-CoA bindingBy similarity
Regioni241 – 2477Acetyl-CoA bindingBy similarity

Sequence similaritiesi

Belongs to the HAT1 family.Curated

Phylogenomic databases

eggNOGiNOG326277.
InParanoidiQ59VF4.
KOiK11303.
OrthoDBiEOG7HTHSD.

Family and domain databases

Gene3Di1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59VF4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSAKEQSSV TAALQPEQWT TSSNEALKLF VTNPEAALNF QPTFTYPIFG
60 70 80 90 100
DAETIYGYKD LDIFLCFDHY TFKPFLNIKY SAKLTDDPEI IDIKKTIDEF
110 120 130 140 150
LPKSTIFKDE VKWVDSIKEE KDNGYKIPGK LIDSFSENDK EYDIYKIDLK
160 170 180 190 200
SDNGYELHQR LQILVLLFIE AGSFIDAKDE LWNLYVLYEK DNKSTSNNEP
210 220 230 240 250
SIVGFTTAYN YWKYPGAKKF DSTEQESRIK ISQFIILPIY QGQGLGQLFY
260 270 280 290 300
SHLFDKWLAQ DDIIEVVVED PNESFDDLRD RADLKRLNTS EQFDFKAVTP
310 320 330 340 350
KVDKEWVEKT RRALKLEKRQ FARLLEIILL YKLKHGYPGI TKRDVRLFIK
360 370 380 390 400
KRLYDKNKEG LATLDDNTKK DKLQTAYQAL EDDYYRILGD LKLNIKREND
410
EEETDTVSKK QKV
Length:413
Mass (Da):48,355
Last modified:April 26, 2005 - v1
Checksum:i94B7ACA991EA8747
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000123 Genomic DNA. Translation: EAK94484.1.
AACQ01000122 Genomic DNA. Translation: EAK94521.1.
RefSeqiXP_713589.1. XM_708496.1.
XP_713626.1. XM_708533.1.

Genome annotation databases

GeneIDi3644728.
3644770.
KEGGical:CaO19.779.
cal:CaO19.8401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000123 Genomic DNA. Translation: EAK94484.1 .
AACQ01000122 Genomic DNA. Translation: EAK94521.1 .
RefSeqi XP_713589.1. XM_708496.1.
XP_713626.1. XM_708533.1.

3D structure databases

ProteinModelPortali Q59VF4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0001952.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3644728.
3644770.
KEGGi cal:CaO19.779.
cal:CaO19.8401.

Organism-specific databases

CGDi CAL0001952. orf19.779.

Phylogenomic databases

eggNOGi NOG326277.
InParanoidi Q59VF4.
KOi K11303.
OrthoDBi EOG7HTHSD.

Family and domain databases

Gene3Di 1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view ]
PANTHERi PTHR12046. PTHR12046. 1 hit.
Pfami PF10394. Hat1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
SUPFAMi SSF55729. SSF55729. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiHAT1_CANAL
AccessioniPrimary (citable) accession number: Q59VF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3