Q59VF4 (HAT1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone acetyltransferase type B catalytic subunit
EC=2.3.1.48

Gene names

Name:	HAT1
ORF Names:	CaO19.779, CaO19.8401

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	413 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subunit structure	Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the HAT1 family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm Nucleus
Molecular function	Acyltransferase Chromatin regulator Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from mutant phenotype PubMed 23075292. Source: CGD cellular response to reactive oxygen species Inferred from mutant phenotype PubMed 23075292. Source: CGD chromatin silencing at telomere Inferred from electronic annotation. Source: InterPro histone acetylation Inferred from direct assay PubMed 23075292. Source: CGD negative regulation of pseudohyphal growth Inferred from mutant phenotype PubMed 23075292. Source: CGD phenotypic switching Inferred from mutant phenotype PubMed 23075292. Source: CGD
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell histone acetyltransferase complex Inferred from electronic annotation. Source: InterPro nucleus Inferred from direct assay PubMed 23075292. Source: CGD
Molecular_function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 413	413	Histone acetyltransferase type B catalytic subunit		PRO_0000227719

Sequences

	Sequence		Length	Mass (Da)
	Q59VF4 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 94B7ACA991EA8747	FASTA	413	48,355
	10 20 30 40 50 60 MSSAKEQSSV TAALQPEQWT TSSNEALKLF VTNPEAALNF QPTFTYPIFG DAETIYGYKD 70 80 90 100 110 120 LDIFLCFDHY TFKPFLNIKY SAKLTDDPEI IDIKKTIDEF LPKSTIFKDE VKWVDSIKEE 130 140 150 160 170 180 KDNGYKIPGK LIDSFSENDK EYDIYKIDLK SDNGYELHQR LQILVLLFIE AGSFIDAKDE 190 200 210 220 230 240 LWNLYVLYEK DNKSTSNNEP SIVGFTTAYN YWKYPGAKKF DSTEQESRIK ISQFIILPIY 250 260 270 280 290 300 QGQGLGQLFY SHLFDKWLAQ DDIIEVVVED PNESFDDLRD RADLKRLNTS EQFDFKAVTP 310 320 330 340 350 360 KVDKEWVEKT RRALKLEKRQ FARLLEIILL YKLKHGYPGI TKRDVRLFIK KRLYDKNKEG 370 380 390 400 410 LATLDDNTKK DKLQTAYQAL EDDYYRILGD LKLNIKREND EEETDTVSKK QKV

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000123 Genomic DNA. Translation: EAK94484.1. AACQ01000122 Genomic DNA. Translation: EAK94521.1.
RefSeq	XP_713589.1. XM_708496.1. XP_713626.1. XM_708533.1.
3D structure databases
ProteinModelPortal	Q59VF4.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0001952.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3644728. 3644770.
KEGG	cal:CaO19.779. cal:CaO19.8401.
Organism-specific databases
CGD	CAL0001952. orf19.779.
Phylogenomic databases
eggNOG	NOG326277.
KO	K11303.
Family and domain databases
Gene3D	1.10.10.390. 1 hit. 3.40.630.30. 1 hit. 3.90.360.10. 1 hit.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR019467. Hat1_N. IPR017380. Hist_AcTrfase_B-typ_cat-su. IPR013523. Hist_AcTrfase_HAT1_C. [Graphical view]
PANTHER	PTHR12046. PTHR12046. 1 hit.
Pfam	PF10394. Hat1_N. 1 hit. [Graphical view]
PIRSF	PIRSF038084. HAT-B_cat. 1 hit.
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HAT1_CANAL

Accession

Primary (citable) accession number: Q59VF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program