Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q59VF4 (HAT1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone acetyltransferase type B catalytic subunit

EC=2.3.1.48
Gene names
Name:HAT1
ORF Names:CaO19.779, CaO19.8401
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length413 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subunit structure

Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the HAT1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 413413Histone acetyltransferase type B catalytic subunit
PRO_0000227719

Sequences

Sequence LengthMass (Da)Tools
Q59VF4 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 94B7ACA991EA8747

FASTA41348,355
        10         20         30         40         50         60 
MSSAKEQSSV TAALQPEQWT TSSNEALKLF VTNPEAALNF QPTFTYPIFG DAETIYGYKD 

        70         80         90        100        110        120 
LDIFLCFDHY TFKPFLNIKY SAKLTDDPEI IDIKKTIDEF LPKSTIFKDE VKWVDSIKEE 

       130        140        150        160        170        180 
KDNGYKIPGK LIDSFSENDK EYDIYKIDLK SDNGYELHQR LQILVLLFIE AGSFIDAKDE 

       190        200        210        220        230        240 
LWNLYVLYEK DNKSTSNNEP SIVGFTTAYN YWKYPGAKKF DSTEQESRIK ISQFIILPIY 

       250        260        270        280        290        300 
QGQGLGQLFY SHLFDKWLAQ DDIIEVVVED PNESFDDLRD RADLKRLNTS EQFDFKAVTP 

       310        320        330        340        350        360 
KVDKEWVEKT RRALKLEKRQ FARLLEIILL YKLKHGYPGI TKRDVRLFIK KRLYDKNKEG 

       370        380        390        400        410 
LATLDDNTKK DKLQTAYQAL EDDYYRILGD LKLNIKREND EEETDTVSKK QKV 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000123 Genomic DNA. Translation: EAK94484.1.
AACQ01000122 Genomic DNA. Translation: EAK94521.1.
RefSeqXP_713589.1. XM_708496.1.
XP_713626.1. XM_708533.1.

3D structure databases

ProteinModelPortalQ59VF4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0001952.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3644728.
3644770.
KEGGcal:CaO19.779.
cal:CaO19.8401.

Organism-specific databases

CGDCAL0001952. orf19.779.

Phylogenomic databases

eggNOGNOG326277.
KOK11303.
OrthoDBEOG7HTHSD.

Family and domain databases

Gene3D1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view]
PANTHERPTHR12046. PTHR12046. 1 hit.
PfamPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMSSF55729. SSF55729. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHAT1_CANAL
AccessionPrimary (citable) accession number: Q59VF4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names