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Protein

Helicase SWR1

Gene

SWR1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi848 – 855ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • covalent chromatin modification Source: UniProtKB-KW
  • histone exchange Source: CGD
  • regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter Source: CGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Helicase SWR1 (EC:3.6.4.12)
Gene namesi
Name:SWR1
Ordered Locus Names:CAALFM_C207560WA
ORF Names:CaO19.1871, CaO19.9427
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 2

Organism-specific databases

CGDiCAL0000190429. SWR1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000743641 – 1641Helicase SWR1Add BLAST1641

Proteomic databases

PRIDEiQ59U81.

Interactioni

Subunit structurei

Component of the SWR1 chromatin-remodeling complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ59U81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini416 – 488HSAPROSITE-ProRule annotationAdd BLAST73
Domaini835 – 1000Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini1367 – 1520Helicase C-terminalPROSITE-ProRule annotationAdd BLAST154

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili461 – 521Sequence analysisAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi951 – 954DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi692 – 777Ser-richAdd BLAST86

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiQ59U81.
KOiK11681.
OrthoDBiEOG092C1YH4.

Family and domain databases

InterProiView protein in InterPro
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014012. HSA_dom.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
PfamiView protein in Pfam
PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF00176. SNF2_N. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 4 hits.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59U81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPENGRLRRT SARLTQNGTS TSSSTIYQNG KRTSQHAQET STASNKKRKV
60 70 80 90 100
STQSKEDKLS DIIVDFNLAV NELYQLKEYK SIISWDPIEN SSANDRGIKA
110 120 130 140 150
EFEEFVKNND YRLVWDKEIE NNSNIDSLPL RFQKKKLAEQ NKLLDDKFSI
160 170 180 190 200
RQNVLASSKM LEESLVNKTR DEVKIESTFK AIQSQEKAGS KLKTPSQTSN
210 220 230 240 250
AKTNIRKSGS TTPKRGNENG SRKQALEDQD EIIELSDDSS VVEIESDLSD
260 270 280 290 300
AETHYRIKCI KKTVPPPLVT HPSHIPQWRP ENLEDGNRST GRLIQLKDSS
310 320 330 340 350
SSSKIINFDP TPLEIIQLKD EVIAAPKLTE KLQNFLNNDF KTPIIDESNV
360 370 380 390 400
PDYNFTRDEY NTIMSQQEKL LRKLYHKVNI ENSLELNGDK IERRKVILPQ
410 420 430 440 450
SNIKLTDPFR NTFSVKPKLH GAANNATHQD YLLAQGMAFS KVHQQMRKQH
460 470 480 490 500
HLRTRKIAAM IDQHFKKKKG EKERLAKERE QNLKKMSRLT MQAVKKRWNQ
510 520 530 540 550
AQKVYQIIQN EKEEELKKIK GRQHLSEMLE HSTQLLEAQL TSSREPTVEA
560 570 580 590 600
ESDDNSTTFD DNTNDSDNFS SSEEEENEED NTQQQINGNK KYDVNGKSND
610 620 630 640 650
ENDMSLSVEE LRKKYADLET SVEPLSSNVT SDKERESETS SEDAESSDDD
660 670 680 690 700
DTDVTRGLAS LYQNDEVADF ATTTFEYSAE EKKLIEDLNQ ESDSRMNSLL
710 720 730 740 750
DSDSVSSISD SESSEESSSD TEMDQSNVSE PPRSSETGSN TGLASLFTNG
760 770 780 790 800
TIVSDEEDDA SISSNFENES DESMNSSDRE LEVNGNGKID KIASTDEDDS
810 820 830 840 850
NVEIVNGSKV KDVPIPSLLR GTLRPYQKQG LNWLASLYNN NTNGILADEM
860 870 880 890 900
GLGKTIQTIS LLAYLACEHH KWGPHLIIVP TSVMLNWEME FKKFAPGFKV
910 920 930 940 950
LTYYGSPQQR AQKRKGWNKP DAFHVCITSY QLVVQDQQSF KRRRWTYMIL
960 970 980 990 1000
DEAHNIKNFR STRWRALLNF NTENRLLLTG TPLQNNLMEL WSLLYFLMPS
1010 1020 1030 1040 1050
SKVNQAMPEG FANLDDFQQW FGKPVDRILE QTSAGNSDLI DENERTTQKM
1060 1070 1080 1090 1100
DEETRNTVAR LHQVLRPYLL RRLKKDVEKQ MPGKYEHIVY CRLSKRQRFL
1110 1120 1130 1140 1150
YDDFMSRAKT KETLASGNFL SIINCLMQLR KVCNHPDLFE VRPIVTSFAM
1160 1170 1180 1190 1200
PRSIPSYYQS TNELVKRQFN KDEKVSFQAL NLDVTGCENM NYFVCQSTGK
1210 1220 1230 1240 1250
LMTTEPFQDQ INKLKILLVE FENSDPINYV SYYQRLRREE QAEIKEKLEH
1260 1270 1280 1290 1300
VVYLNNLRCG RKPIYGESLL RLLTVNAHDF SDEPYNKYCL TLSGRVDKMN
1310 1320 1330 1340 1350
DTIEKYSIIT PAAVALDMKD QLIPISTKQR ILHEVAENKI DNPFHKAQVK
1360 1370 1380 1390 1400
LSIAFPDKTL LQYDCGKLQK LATLLQELTS QGHRALIFTQ MTKVLDILEQ
1410 1420 1430 1440 1450
FLNIHGYRYM RLDGATKIED RQLLTEKFNR DPKIPVFILS TRSGGLGINL
1460 1470 1480 1490 1500
TGADTVIFYD SDWNPAMDKQ CQDRCHRIGQ VRDVHIYRFV SEYTIESNII
1510 1520 1530 1540 1550
KKANQKRQLD NVVIQEGEFT TDYFGKFSVR DLVSDSNIGK EITDRTIDFS
1560 1570 1580 1590 1600
GDAKMGNVLA QAEDEEDRVA AGAALKEVAI DDDDFKEETR SATTGATPAP
1610 1620 1630 1640
TETNALSTTD GDAAFIDVDY EDGIGHIDEY MLRFISDGYY L
Length:1,641
Mass (Da):187,725
Last modified:March 15, 2017 - v2
Checksum:i2FB794E82D3F78F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017624 Genomic DNA. Translation: AOW27754.1.
RefSeqiXP_713128.2. XM_708035.2.

Genome annotation databases

GeneIDi3645220.
KEGGical:CAALFM_C207560WA.

Similar proteinsi

Entry informationi

Entry nameiSWR1_CANAL
AccessioniPrimary (citable) accession number: Q59U81
Secondary accession number(s): A0A1D8PHY5, Q59UC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 15, 2017
Last modified: June 7, 2017
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families