Q59U81 (SWR1_CANAL) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 56.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Helicase SWR1 EC=3.6.4.12 | ||||
| Gene names |
| ||||
| Organism | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome] | ||||
| Taxonomic identifier | 237561 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida ›  |
Protein attributes
| Sequence length | 1641 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling By similarity. |
| Catalytic activity | ATP + H2O = ADP + phosphate. |
| Subunit structure | Component of the SWR1 chromatin-remodeling complex By similarity. |
| Subcellular location | Nucleus By similarity. |
| Sequence similarities | Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 1 HSA domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Domain | Coiled coil |
| Ligand | ATP-binding DNA-binding Nucleotide-binding |
| Molecular function | Activator Chromatin regulator Helicase Hydrolase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular_component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA bindingInferred from electronic annotation. Source: UniProtKB-KW helicase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1641 | 1641 | Helicase SWR1 | PRO_0000074364 | |||||
Regions | |||||||||
| Domain | 416 – 488 | 73 | HSA | ||||||
| Domain | 835 – 1000 | 166 | Helicase ATP-binding | ||||||
| Domain | 1367 – 1520 | 154 | Helicase C-terminal | ||||||
| Nucleotide binding | 848 – 855 | 8 | ATP By similarity | ||||||
| Coiled coil | 461 – 521 | 61 | Potential | ||||||
| Motif | 951 – 954 | 4 | DEAH box | ||||||
| Compositional bias | 692 – 777 | 86 | Ser-rich | ||||||
Natural variations | |||||||||
| Natural variant | 103 | 1 | E → G in allele CaO19.9427. | ||||||
| Natural variant | 164 | 1 | S → F in allele CaO19.9427. | ||||||
Sequences
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References
| [1] | "The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AACQ01000133 Genomic DNA. Translation: EAK94011.1. AACQ01000132 Genomic DNA. Translation: EAK94057.1. |
| RefSeq | XP_713128.1. XM_708035.1. XP_713174.1. XM_708081.1. |
3D structure databases | |
| ProteinModelPortal | Q59U81. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 5476.CAL0001763. |
Proteomic databases | |
| PRIDE | Q59U81. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 3645174. 3645220. |
| KEGG | cal:CaO19.1871. cal:CaO19.9427. |
Organism-specific databases | |
| CGD | CAL0001763. orf19.1871. |
Phylogenomic databases | |
| eggNOG | COG0553. |
| KO | K11681. |
Family and domain databases | |
| InterPro | IPR014012. Helicase/SANT-assoc_DNA-bd. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR006562. HSA. IPR000330. SNF2_N. [Graphical view] |
| Pfam | PF00271. Helicase_C. 1 hit. PF07529. HSA. 1 hit. PF00176. SNF2_N. 1 hit. [Graphical view] |
| SMART | SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. [Graphical view] |
| PROSITE | PS00690. DEAH_ATP_HELICASE. False negative. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS51204. HSA. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SWR1_CANAL | ||||||||
| Accession | Primary (citable) accession number: Q59U81 Secondary accession number(s): Q59UC7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Candida albicans Candida albicans: entries and gene names |
| SIMILARITY comments Index of protein domains and families |