ID Q59TZ8_CANAL Unreviewed; 472 AA. AC Q59TZ8; DT 26-APR-2005, integrated into UniProtKB/TrEMBL. DT 26-APR-2005, sequence version 1. DT 24-JAN-2024, entry version 124. DE RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007}; DE EC=2.7.1.- {ECO:0000256|RuleBase:RU362007}; GN Name=GLK1 {ECO:0000313|CGD:CAL0000189805, GN ECO:0000313|EMBL:AOW31410.1}; GN OrderedLocusNames=CAALFM_CR07150WA {ECO:0000313|EMBL:AOW31410.1}, GN orf19.7686 {ECO:0000313|CGD:CAL0000189805}; OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida. OX NCBI_TaxID=237561 {ECO:0000313|EMBL:AOW31410.1, ECO:0000313|Proteomes:UP000000559}; RN [1] {ECO:0000313|EMBL:AOW31410.1, ECO:0000313|Proteomes:UP000000559} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559}; RX PubMed=15123810; DOI=10.1073/pnas.0401648101; RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., RA Scherer S.; RT "The diploid genome sequence of Candida albicans."; RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004). RN [2] {ECO:0000313|EMBL:AOW31410.1, ECO:0000313|Proteomes:UP000000559} RP GENOME REANNOTATION. RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559}; RX PubMed=17419877; DOI=.1186/gb-2007-8-4-r52; RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D., RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M., RA Chibana H., Nantel A., Magee P.T.; RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned RT on the eight chromosomes."; RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007). RN [3] {ECO:0000313|EMBL:AOW31410.1, ECO:0000313|Proteomes:UP000000559} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559}; RX PubMed=24025428; DOI=.1186/gb-2013-14-9-r97; RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.; RT "Assembly of a phased diploid Candida albicans genome facilitates allele- RT specific measurements and provides a simple model for repeat and indel RT structure."; RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013). CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- CC phosphate and glycerone phosphate from D-glucose: step 1/4. CC {ECO:0000256|ARBA:ARBA00004888}. CC -!- SIMILARITY: Belongs to the hexokinase family. CC {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|RuleBase:RU362007}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP017630; AOW31410.1; -; Genomic_DNA. DR RefSeq; XP_710176.2; XM_705084.2. DR AlphaFoldDB; Q59TZ8; -. DR SMR; Q59TZ8; -. DR STRING; 237561.Q59TZ8; -. DR EnsemblFungi; CR_07150W_A-T; CR_07150W_A-T-p1; CR_07150W_A. DR GeneID; 3648348; -. DR KEGG; cal:CAALFM_CR07150WA; -. DR CGD; CAL0000189805; GLK1. DR VEuPathDB; FungiDB:CR_07150W_A; -. DR eggNOG; KOG1369; Eukaryota. DR HOGENOM; CLU_014393_5_0_1; -. DR InParanoid; Q59TZ8; -. DR OrthoDB; 5481886at2759; -. DR UniPathway; UPA00109; UER00180. DR PHI-base; PHI:10644; -. DR PHI-base; PHI:8971; -. DR Proteomes; UP000000559; Chromosome R. DR GO; GO:0005829; C:cytosol; IBA:GO_Central. DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0008865; F:fructokinase activity; IBA:GO_Central. DR GO; GO:0004340; F:glucokinase activity; IBA:GO_Central. DR GO; GO:0005536; F:glucose binding; IEA:InterPro. DR GO; GO:0019158; F:mannokinase activity; IEA:EnsemblFungi. DR GO; GO:0046835; P:carbohydrate phosphorylation; IBA:GO_Central. DR GO; GO:0051156; P:glucose 6-phosphate metabolic process; IBA:GO_Central. DR GO; GO:0006006; P:glucose metabolic process; IBA:GO_Central. DR GO; GO:0019660; P:glycolytic fermentation; IEA:EnsemblFungi. DR GO; GO:0006096; P:glycolytic process; IBA:GO_Central. DR GO; GO:0001678; P:intracellular glucose homeostasis; IBA:GO_Central. DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1. DR Gene3D; 3.30.420.40; -; 1. DR Gene3D; 3.40.367.20; -; 1. DR InterPro; IPR043129; ATPase_NBD. DR InterPro; IPR001312; Hexokinase. DR InterPro; IPR019807; Hexokinase_BS. DR InterPro; IPR022673; Hexokinase_C. DR InterPro; IPR022672; Hexokinase_N. DR PANTHER; PTHR19443:SF30; GLUCOKINASE-1-RELATED; 1. DR PANTHER; PTHR19443; HEXOKINASE; 1. DR Pfam; PF00349; Hexokinase_1; 1. DR Pfam; PF03727; Hexokinase_2; 1. DR PRINTS; PR00475; HEXOKINASE. DR SUPFAM; SSF53067; Actin-like ATPase domain; 2. DR PROSITE; PS00378; HEXOKINASE_1; 1. DR PROSITE; PS51748; HEXOKINASE_2; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362007}; KW Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU362007}; KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362007}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, KW ECO:0000256|RuleBase:RU362007}; KW Reference proteome {ECO:0000313|Proteomes:UP000000559}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362007}. FT DOMAIN 11..212 FT /note="Hexokinase N-terminal" FT /evidence="ECO:0000259|Pfam:PF00349" FT DOMAIN 225..470 FT /note="Hexokinase C-terminal" FT /evidence="ECO:0000259|Pfam:PF03727" SQ SEQUENCE 472 AA; 52108 MW; D34E63A631143BAB CRC64; MSLSPKLEEI VSSIEKSFEI KDDFLVKATE YFIESMNVGL ESPKPSKDVM PMIPTYVTSI PTGKEVGLYL AADLGGTNFR VCSIDLKGDH TFSMKQSKYR IPVDLMKAEK SNDLFGFLAK KVQSFLLENH SEACTAKNTE PLKLGFTFSF PVNQTALNRG TLIRWTKGFD IPDTVDRDVV ELLQANLTIL EVNVKVVAIA NDTVGTLLTA AYSNDSAKTN RNTIIGCIFG TGTNGAYFES KIPKLSSSTG KSQGMVINTE WGSFDNGLKI LPSTEFDEIV DSETANPGYH LFEKRISGMF LGEILRVALI HLFKKGLIFQ ELYKARGGSL PHRIEEPWLL DAEVLSYLQI DDSTDLKTSG LILQNVLRLE TNKEEREVIQ RLTRAISQRA AHLSAIPIAA IAKKVKDQYK DDDRDFEVGC DGSVIEFYPG FRQAVLESIE KINPLKGTNK KIHLKIAKDG SGVGAALCAS TA //