Reviewed, UniProtKB/Swiss-Prot Q59TN9 (ATG20_CANAL)

Names and origin

Protein names

Recommended name:
    Autophagy-related protein 20

Gene names

Name:	ATG20
ORF Names:	CaO19.1297, CaO19.8877

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	May be required for cytoplasm to vacuole transport (Cvt) and pexophagy By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity. Endosome membrane; Peripheral membrane protein By similarity. Note: Endosome and other perivacuolar punctate structures By similarity.
Domain	The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures By similarity.
Sequence similarities	Belongs to the sorting nexin family. Contains 1 PX (phox homology) domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm Endosome Membrane
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW cell communication Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endosome Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoinositide binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 407	407	Autophagy-related protein 20		PRO_0000213820
Regions
	Domain	164 – 340	177	PX
	Compositional bias	92 – 131	40	Asn-rich
	Compositional bias	256 – 280	25	Gly-rich

Sequences

	Sequence		Length	Mass (Da)
	Q59TN9-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 363F5038DAB68ACC	FASTA	407	45,013
	10 20 30 40 50 60 MSSVLRNQDN PPTISEVSST TKENTDNSNS KQEEKEKEKE ISSTIENPTF VDDEEDNNPF 70 80 90 100 110 120 SHHGEGLTSF MTANSFNEGP NTKSDKRTTK ENNNSSSNNN RGDNNDDDDD DSLLLYNTSN 130 140 150 160 170 180 NNKSNNVSRV NPMLKSTGEV FKTVNMNFES RVTKLLKPNT KIRIQITEAG NSNEGMSNSS 190 200 210 220 230 240 KKYTVYTIKL INLEDPNNDI LTRRRYSDFE SLRDVLTKIF PLIVIPPIPP KNYFDFSMLN 250 260 270 280 290 300 GLVGSNHENS SLSVAGSNGN SGGSGGGGAS GGAGSGSGNG SIITSPKTYS YINSTHLTKG 310 320 330 340 350 360 KLIEHRKRLL TNFLNNCLEI KQIRSLEFFA KFLDPNANWG DEIALIQSQL PKSIYLSNPE 370 380 390 400 NGLKTDPIYS NLPNPSNKNT ISFFKDNKKK LTKKTNKLLS NGSENHK

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000138 Genomic DNA. Translation: EAK93844.1. AACQ01000139 Genomic DNA. Translation: EAK93812.1.
RefSeq	XP_709938.1. XP_712977.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3645350. 3645396.
KEGG	cal:CaO19.1297. cal:CaO19.8877.
Organism-specific databases
CGD	CAL0003107. orf19.1297.
Phylogenomic databases
OrthoDB	EOG9BGBC6
Family and domain databases
InterPro	IPR001683. PX. [Graphical view]
Gene3D	G3DSA:3.30.1520.10. PX. 1 hit.
Pfam	PF00787. PX. 1 hit. [Graphical view]
SMART	SM00312. PX. 1 hit. [Graphical view]
PROSITE	PS50195. PX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG20_CANAL

Accession

Primary (citable) accession number: Q59TN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	April 26, 2005
Last modified:	November 24, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)