Q59TN9 (ATG20_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Autophagy-related protein 20

Gene names

Name:	ATG20
ORF Names:	CaO19.1297, CaO19.8877

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May be required for cytoplasm to vacuole transport (Cvt) and pexophagy By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity. Endosome membrane; Peripheral membrane protein By similarity. Note: Endosome and other perivacuolar punctate structures By similarity.
Domain	The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures By similarity.
Sequence similarities	Belongs to the sorting nexin family. Contains 1 PX (phox homology) domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm Endosome Membrane
Ligand	Lipid-binding
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW cell communication Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidylinositol binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 407	407	Autophagy-related protein 20		PRO_0000213820
Regions
	Domain	164 – 340	177	PX
	Compositional bias	92 – 131	40	Asn-rich
	Compositional bias	256 – 280	25	Gly-rich
Sites
	Binding site	205	1	Phosphatidylinositol 3-phosphate By similarity
	Binding site	207	1	Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	231	1	Phosphatidylinositol 3-phosphate By similarity
	Binding site	306	1	Phosphatidylinositol 3-phosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q59TN9 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 363F5038DAB68ACC	FASTA	407	45,013
	10 20 30 40 50 60 MSSVLRNQDN PPTISEVSST TKENTDNSNS KQEEKEKEKE ISSTIENPTF VDDEEDNNPF 70 80 90 100 110 120 SHHGEGLTSF MTANSFNEGP NTKSDKRTTK ENNNSSSNNN RGDNNDDDDD DSLLLYNTSN 130 140 150 160 170 180 NNKSNNVSRV NPMLKSTGEV FKTVNMNFES RVTKLLKPNT KIRIQITEAG NSNEGMSNSS 190 200 210 220 230 240 KKYTVYTIKL INLEDPNNDI LTRRRYSDFE SLRDVLTKIF PLIVIPPIPP KNYFDFSMLN 250 260 270 280 290 300 GLVGSNHENS SLSVAGSNGN SGGSGGGGAS GGAGSGSGNG SIITSPKTYS YINSTHLTKG 310 320 330 340 350 360 KLIEHRKRLL TNFLNNCLEI KQIRSLEFFA KFLDPNANWG DEIALIQSQL PKSIYLSNPE 370 380 390 400 NGLKTDPIYS NLPNPSNKNT ISFFKDNKKK LTKKTNKLLS NGSENHK

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000138 Genomic DNA. Translation: EAK93844.1. AACQ01000139 Genomic DNA. Translation: EAK93812.1.
RefSeq	XP_709938.1. XM_704846.1. XP_712977.1. XM_707884.1.
3D structure databases
ProteinModelPortal	Q59TN9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3645350. 3645396.
KEGG	cal:CaO19.1297. cal:CaO19.8877.
Organism-specific databases
CGD	CAL0003107. orf19.1297.
Family and domain databases
InterPro	IPR001683. Phox. [Graphical view]
Gene3D	G3DSA:3.30.1520.10. PX. 2 hits.
Pfam	PF00787. PX. 1 hit. [Graphical view]
SMART	SM00312. PX. 1 hit. [Graphical view]
SUPFAM	SSF64268. PX. 1 hit.
PROSITE	PS50195. PX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG20_CANAL

Accession

Primary (citable) accession number: Q59TN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program