ID   MED8_CANAL              Reviewed;         239 AA.
AC   Q59TD3; Q59TG7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   24-NOV-2009, entry version 22.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 8;
DE   AltName: Full=Mediator complex subunit 8;
GN   Name=MED8; ORFNames=CaO19.4497, CaO19.11973;
OS   Candida albicans (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales;
OC   Candida.
OX   NCBI_TaxID=5476;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S.,
RA   Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T.,
RA   Davis R.W., Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator
CC       involved in the regulated transcription of nearly all RNA
CC       polymerase II-dependent genes. Mediator functions as a bridge to
CC       convey information from gene-specific regulatory proteins to the
CC       basal RNA polymerase II transcription machinery. Mediator is
CC       recruited to promoters by direct interactions with regulatory
CC       proteins and serves as a scaffold for the assembly of a functional
CC       preinitiation complex with RNA polymerase II and the general
CC       transcription factors (By similarity).
CC   -!- SUBUNIT: Component of the Mediator complex (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 8 family.
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DR   EMBL; AACQ01000142; EAK93723.1; -; Genomic_DNA.
DR   EMBL; AACQ01000141; EAK93757.1; -; Genomic_DNA.
DR   RefSeq; XP_712891.1; -.
DR   RefSeq; XP_712923.1; -.
DR   GeneID; 3645446; -.
DR   GeneID; 3645495; -.
DR   KEGG; cal:CaO19.11973; -.
DR   KEGG; cal:CaO19.4497; -.
DR   CGD; CAL0079252; MED8.
DR   OMA; LPEVDEW; -.
DR   OrthoDB; EOG9G1NZV; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0045449; P:regulation of transcription; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR020178; Mediatior_Med8_fun.
DR   ProDom; PD114219; Mediatior_Med8_fun; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    239       Mediator of RNA polymerase II
FT                                transcription subunit 8.
FT                                /FTId=PRO_0000304538.
FT   COILED       30     59       Potential.
FT   VARIANT     121    121       R -> K (in allele CaO19.4497).
SQ   SEQUENCE   239 AA;  27959 MW;  EFDF7C7331CBB019 CRC64;
     MSQTPFNPNS PSVPTTTSLP STDFSQIPYD VLESIRNRLN QIRQSLTKLA DQINNHNRHP
     QKIKLPSYSY FQNQFQVLIT QLMSITNQLY NNEDLLRNTN VYPTPIFPTS AHENMLTTLL
     RKKVAPEVDE WINGAKLIME NETKNKLDNQ QVEIDILKID QWVQWCLAKI QDLRDEFQFY
     GFHTVEELDH METPQGKQEI KEKKDKEFER EQIELKITAG GQKSLHPNQV LKFMCQGQI
//