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Q59TD3 (MED8_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mediator of RNA polymerase II transcription subunit 8
Alternative name(s):
Mediator complex subunit 8
Gene names
Name:MED8
ORF Names:CaO19.11973, CaO19.4497
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors By similarity.

Subunit structure

Component of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the Mediator complex subunit 8 family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainCoiled coil
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmediator complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA polymerase II transcription cofactor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 239239Mediator of RNA polymerase II transcription subunit 8
PRO_0000304538

Regions

Coiled coil30 – 5930 Potential

Natural variations

Natural variant1211R → K in allele CaO19.4497.

Sequences

Sequence LengthMass (Da)Tools
Q59TD3 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: EFDF7C7331CBB019

FASTA23927,959
        10         20         30         40         50         60 
MSQTPFNPNS PSVPTTTSLP STDFSQIPYD VLESIRNRLN QIRQSLTKLA DQINNHNRHP 

        70         80         90        100        110        120 
QKIKLPSYSY FQNQFQVLIT QLMSITNQLY NNEDLLRNTN VYPTPIFPTS AHENMLTTLL 

       130        140        150        160        170        180 
RKKVAPEVDE WINGAKLIME NETKNKLDNQ QVEIDILKID QWVQWCLAKI QDLRDEFQFY 

       190        200        210        220        230 
GFHTVEELDH METPQGKQEI KEKKDKEFER EQIELKITAG GQKSLHPNQV LKFMCQGQI 

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References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000142 Genomic DNA. Translation: EAK93723.1.
AACQ01000141 Genomic DNA. Translation: EAK93757.1.
RefSeqXP_712891.1. XM_707798.1.
XP_712923.1. XM_707830.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING5476.CAL0002045.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3645446.
3645495.
KEGGcal:CaO19.11973.
cal:CaO19.4497.

Organism-specific databases

CGDCAL0079252. MED8.

Phylogenomic databases

eggNOGNOG75044.
KOK15130.

Family and domain databases

InterProIPR020178. Mediatior_Med8_fun.
IPR019364. Mediatior_Med8_fun/met.
[Graphical view]
PfamPF10232. Med8. 1 hit.
[Graphical view]
ProDomPD114219. Mediatior_Med8_fun. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameMED8_CANAL
AccessionPrimary (citable) accession number: Q59TD3
Secondary accession number(s): Q59TG7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 26, 2005
Last modified: April 3, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Recent format changes

Overview of recent format changes

Candida albicans

Candida albicans: entries and gene names

SIMILARITY comments

Index of protein domains and families