Reviewed,
UniProtKB/Swiss-Prot Q59TD3 (MED8_CANAL)
Last modified
November 4, 2008.
Version 16.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Mediator of RNA polymerase II transcription subunit 8 Alternative name(s): Mediator complex subunit 8 | ||||
| Gene names |
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| Organism | Candida albicans (Yeast) | ||||
| Taxonomic identifier | 5476 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida |
Protein attributes
| Sequence length | 239 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors By similarity. |
| Subunit structure | Component of the Mediator complex By similarity. |
| Subcellular location | NucleusProbable. |
| Sequence similarities | Belongs to the Mediator complex subunit 8 family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Domain | Coiled coil |
| Molecular function | Activator |
Gene Ontology (GO) | |
| Biological process | regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314. |
Cross-references
Sequence databases | |
|---|---|
| AACQ01000142 Genomic DNA. Translation: EAK93723.1. AACQ01000141 Genomic DNA. Translation: EAK93757.1. | |
| RefSeq | XP_712891.1. XP_712923.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3645446. 3645495. |
| KEGG | cal:CaO19.11973. cal:CaO19.4497. |
Organism-specific databases | |
| CGD | CAL0079252. MED8. |
Family and domain databases | |
| ProtoNet | Search... |
Entry information
| Entry name | MED8_CANAL | ||||||||
| Accession | Primary (citable) accession number: Q59TD3 Secondary accession number(s): Q59TG7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Candida albicans Candida albicans: entries and gene names |
| SIMILARITY comments Index of protein domains and families |
| Recent format changes Overview of recent format changes |

Clusters with


