Q59TD3 (MED8_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mediator of RNA polymerase II transcription subunit 8

Alternative name(s):
Mediator complex subunit 8

Gene names

Name:	MED8
ORF Names:	CaO19.11973, CaO19.4497

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors By similarity.
Subunit structure	Component of the Mediator complex By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the Mediator complex subunit 8 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Coiled coil
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mediator complex Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA polymerase II transcription cofactor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 239	239	Mediator of RNA polymerase II transcription subunit 8		PRO_0000304538
Regions
	Coiled coil	30 – 59	30	Potential
Natural variations
	Natural variant	121	1	R → K in allele CaO19.4497.

Sequences

	Sequence		Length	Mass (Da)
	Q59TD3 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: EFDF7C7331CBB019	FASTA	239	27,959
	10 20 30 40 50 60 MSQTPFNPNS PSVPTTTSLP STDFSQIPYD VLESIRNRLN QIRQSLTKLA DQINNHNRHP 70 80 90 100 110 120 QKIKLPSYSY FQNQFQVLIT QLMSITNQLY NNEDLLRNTN VYPTPIFPTS AHENMLTTLL 130 140 150 160 170 180 RKKVAPEVDE WINGAKLIME NETKNKLDNQ QVEIDILKID QWVQWCLAKI QDLRDEFQFY 190 200 210 220 230 GFHTVEELDH METPQGKQEI KEKKDKEFER EQIELKITAG GQKSLHPNQV LKFMCQGQI

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000142 Genomic DNA. Translation: EAK93723.1. AACQ01000141 Genomic DNA. Translation: EAK93757.1.
RefSeq	XP_712891.1. XM_707798.1. XP_712923.1. XM_707830.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0002045.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3645446. 3645495.
KEGG	cal:CaO19.11973. cal:CaO19.4497.
Organism-specific databases
CGD	CAL0079252. MED8.
Phylogenomic databases
eggNOG	NOG75044.
KO	K15130.
Family and domain databases
InterPro	IPR020178. Mediatior_Med8_fun. IPR019364. Mediatior_Med8_fun/met. [Graphical view]
Pfam	PF10232. Med8. 1 hit. [Graphical view]
ProDom	PD114219. Mediatior_Med8_fun. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

MED8_CANAL

Accession

Primary (citable) accession number: Q59TD3
Secondary accession number(s): Q59TG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program