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Q59ST1

- MTAP_CANAL

UniProt

Q59ST1 - MTAP_CANAL

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Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

MEU1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451PhosphateUniRule annotation
Sitei220 – 2201Important for substrate specificityUniRule annotation
Binding sitei238 – 2381Substrate; via amide nitrogenUniRule annotation
Binding sitei239 – 2391PhosphateUniRule annotation
Sitei275 – 2751Important for substrate specificityUniRule annotation

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
Alternative name(s):
5'-methylthioadenosine phosphorylaseUniRule annotation
Short name:
MTA phosphorylaseUniRule annotation
Short name:
MTAPUniRule annotation
Short name:
MTAPaseUniRule annotation
Gene namesi
Name:MEU1UniRule annotation
ORF Names:CaO19.14200, CaO19.6938
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000248. orf19.6938.

Subcellular locationi

Cytoplasm UniRule annotation. Nucleus UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. nucleus Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344S-methyl-5'-thioadenosine phosphorylasePRO_0000415124Add
BLAST

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi5476.CAL0000248.

Structurei

3D structure databases

ProteinModelPortaliQ59ST1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni88 – 892Phosphate bindingUniRule annotation
Regioni121 – 1222Phosphate bindingUniRule annotation
Regioni262 – 2643Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0005.
InParanoidiQ59ST1.
KOiK00772.
OrthoDBiEOG77DJGM.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.
PROSITEiPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59ST1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKLVLKGNN LSKLIKMSVH REKIDLAKLP HHYDGPVTLA VIGGTGLYDL
60 70 80 90 100
PNLHPVARLT ISTPWGFPSG SITISKTDSG FPVAFLARHG AHHDLLPSDV
110 120 130 140 150
PSRANIAALK RLGVKAIIAF SAVGSLQQEI KPRDFVLPTQ IIDRTKGIRP
160 170 180 190 200
STFFEKGFVA HAMFGEPFDL KLNKLISDAI PSKGFLEGFD TDGTPVLHTK
210 220 230 240 250
ENTNNGEDLT IICMEGPQFS TRAESRLYRS WGGSVINMSV LPEAKLAREA
260 270 280 290 300
EIAYQMICMS TDYDSWNESE EPVTVETVVG NLKANSANAC KLAAKLIDEF
310 320 330 340
AAKGGEIGKD LQGSMKYAVS TSPHGVKKEL LEKMHFLFPG YWEV
Length:344
Mass (Da):37,618
Last modified:April 26, 2005 - v1
Checksum:i28EA961C08D0C36F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000148 Genomic DNA. Translation: EAK93531.1.
AACQ01000147 Genomic DNA. Translation: EAK93568.1.
RefSeqiXP_712702.1. XM_707609.1.
XP_712739.1. XM_707646.1.

Genome annotation databases

GeneIDi3645635.
3645671.
KEGGical:CaO19.14200.
cal:CaO19.6938.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000148 Genomic DNA. Translation: EAK93531.1 .
AACQ01000147 Genomic DNA. Translation: EAK93568.1 .
RefSeqi XP_712702.1. XM_707609.1.
XP_712739.1. XM_707646.1.

3D structure databases

ProteinModelPortali Q59ST1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0000248.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3645635.
3645671.
KEGGi cal:CaO19.14200.
cal:CaO19.6938.

Organism-specific databases

CGDi CAL0000248. orf19.6938.

Phylogenomic databases

eggNOGi COG0005.
InParanoidi Q59ST1.
KOi K00772.
OrthoDBi EOG77DJGM.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
PROSITEi PS01240. PNP_MTAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiMTAP_CANAL
AccessioniPrimary (citable) accession number: Q59ST1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3