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Q59ST1

- MTAP_CANAL

UniProt

Q59ST1 - MTAP_CANAL

Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

MEU1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

    Catalytic activityi

    S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei45 – 451PhosphateUniRule annotation
    Sitei220 – 2201Important for substrate specificityUniRule annotation
    Binding sitei238 – 2381Substrate; via amide nitrogenUniRule annotation
    Binding sitei239 – 2391PhosphateUniRule annotation
    Sitei275 – 2751Important for substrate specificityUniRule annotation

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    UniPathwayiUPA00904; UER00873.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
    Alternative name(s):
    5'-methylthioadenosine phosphorylaseUniRule annotation
    Short name:
    MTA phosphorylaseUniRule annotation
    Short name:
    MTAPUniRule annotation
    Short name:
    MTAPaseUniRule annotation
    Gene namesi
    Name:MEU1UniRule annotation
    ORF Names:CaO19.14200, CaO19.6938
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0000248. orf19.6938.

    Subcellular locationi

    Cytoplasm UniRule annotation. Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344S-methyl-5'-thioadenosine phosphorylasePRO_0000415124Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi5476.CAL0000248.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59ST1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni88 – 892Phosphate bindingUniRule annotation
    Regioni121 – 1222Phosphate bindingUniRule annotation
    Regioni262 – 2643Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0005.
    KOiK00772.
    OrthoDBiEOG77DJGM.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    HAMAPiMF_01963. MTAP.
    InterProiIPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view]
    PANTHERiPTHR11904. PTHR11904. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01694. MTAP. 1 hit.
    PROSITEiPS01240. PNP_MTAP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59ST1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKLVLKGNN LSKLIKMSVH REKIDLAKLP HHYDGPVTLA VIGGTGLYDL    50
    PNLHPVARLT ISTPWGFPSG SITISKTDSG FPVAFLARHG AHHDLLPSDV 100
    PSRANIAALK RLGVKAIIAF SAVGSLQQEI KPRDFVLPTQ IIDRTKGIRP 150
    STFFEKGFVA HAMFGEPFDL KLNKLISDAI PSKGFLEGFD TDGTPVLHTK 200
    ENTNNGEDLT IICMEGPQFS TRAESRLYRS WGGSVINMSV LPEAKLAREA 250
    EIAYQMICMS TDYDSWNESE EPVTVETVVG NLKANSANAC KLAAKLIDEF 300
    AAKGGEIGKD LQGSMKYAVS TSPHGVKKEL LEKMHFLFPG YWEV 344
    Length:344
    Mass (Da):37,618
    Last modified:April 26, 2005 - v1
    Checksum:i28EA961C08D0C36F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000148 Genomic DNA. Translation: EAK93531.1.
    AACQ01000147 Genomic DNA. Translation: EAK93568.1.
    RefSeqiXP_712702.1. XM_707609.1.
    XP_712739.1. XM_707646.1.

    Genome annotation databases

    GeneIDi3645635.
    3645671.
    KEGGical:CaO19.14200.
    cal:CaO19.6938.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000148 Genomic DNA. Translation: EAK93531.1 .
    AACQ01000147 Genomic DNA. Translation: EAK93568.1 .
    RefSeqi XP_712702.1. XM_707609.1.
    XP_712739.1. XM_707646.1.

    3D structure databases

    ProteinModelPortali Q59ST1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0000248.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3645635.
    3645671.
    KEGGi cal:CaO19.14200.
    cal:CaO19.6938.

    Organism-specific databases

    CGDi CAL0000248. orf19.6938.

    Phylogenomic databases

    eggNOGi COG0005.
    KOi K00772.
    OrthoDBi EOG77DJGM.

    Enzyme and pathway databases

    UniPathwayi UPA00904 ; UER00873 .

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    HAMAPi MF_01963. MTAP.
    InterProi IPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view ]
    PANTHERi PTHR11904. PTHR11904. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01694. MTAP. 1 hit.
    PROSITEi PS01240. PNP_MTAP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiMTAP_CANAL
    AccessioniPrimary (citable) accession number: Q59ST1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3