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Q59SR6

- IRS4_CANAL

UniProt

Q59SR6 - IRS4_CANAL

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Protein
Increased rDNA silencing protein 4
Gene
IRS4, CaO19.14215, CaO19.6953
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. adhesion of symbiont to host Source: CGD
  2. cellular response to starvation Source: CGD
  3. filamentous growth Source: CGD
  4. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  5. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  6. fungal-type cell wall organization Source: CGD
  7. lipid metabolic process Source: UniProtKB-KW
  8. pathogenesis Source: CGD
Complete GO annotation...

Keywords - Biological processi

Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Increased rDNA silencing protein 4
Gene namesi
Name:IRS4
ORF Names:CaO19.14215, CaO19.6953
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000299. IRS4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 638638Increased rDNA silencing protein 4
PRO_0000308752Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi1228743. 1 interaction.
1228780. 1 interaction.
STRINGi5476.CAL0000299.

Structurei

3D structure databases

ProteinModelPortaliQ59SR6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini539 – 62890EH
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi48 – 6013Gln-rich
Add
BLAST

Sequence similaritiesi

Belongs to the IRS4 family.
Contains 1 EH domain.

Phylogenomic databases

eggNOGiNOG267304.
OrthoDBiEOG747PVG.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR000261. EPS15_homology.
[Graphical view]
SMARTiSM00027. EH. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS50031. EH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59SR6-1 [UniParc]FASTAAdd to Basket

« Hide

MSGNSAANAA ALAAFNGIGK KKKESTTKLN GTDNNTNHLG VIGSTSNQTK    50
QHQQQQQQPQ ALRTPLPAHP SRKKSNKFSQ LKRLNTAPAM ASLQPALQIA 100
SPSISPTQPS APASALDSDP DYFTLSPHTI PSKNEIAKSP QTPQDMIRNV 150
RQSIELKAIP NNAQAKRLSV DYSPQEMLKN LRHSLHSRTK TSPMLTTSDK 200
MGQTMLAEMR DRLENTRRIA SNSVASLSLS PNLDFNKSTS DVSNLSHHYD 250
VDTVSTDSFA SFSSSINDRH LPHGISIDVT NHDSDEDEID DREREEDHEP 300
LDNGELKSTN NKVTVSSRLR RKPPPGEDFQ MQLNDKSRDT ISSGSYSLNP 350
DEVYSFTDPD SYENLVSEVE VGETTRLFPQ FPDANHYHQH SSKFRKKHQK 400
VKPINGIYYR DMDSSNTSDT EESTSNLPSR STTPLLGQPQ QQVHFRSTMR 450
KANTKKDKKS RFNELKPWKN HNDLNYLTDQ EKKRYEGIWA SNKGNYMSQV 500
VIKLHGVNYE TQKDPKEEAK MEHSRTAALL SAAAVEDSNY NGNNSLHNLD 550
SVEINQLICG PVVKRIWKRS RLPSDTLEKI WNLIDFRRDG TLNKNEFLVG 600
MWLVDQCLYG RKLPKKVDNV VWDSLGGIGV NVTVKKKK 638
Length:638
Mass (Da):71,744
Last modified:April 26, 2005 - v1
Checksum:iA44E10517A79A557
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000147 Genomic DNA. Translation: EAK93583.1.
AACQ01000148 Genomic DNA. Translation: EAK93546.1.
RefSeqiXP_712717.1. XM_707624.1.
XP_712754.1. XM_707661.1.

Genome annotation databases

GeneIDi3645650.
3645687.
KEGGical:CaO19.14215.
cal:CaO19.6953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000147 Genomic DNA. Translation: EAK93583.1 .
AACQ01000148 Genomic DNA. Translation: EAK93546.1 .
RefSeqi XP_712717.1. XM_707624.1.
XP_712754.1. XM_707661.1.

3D structure databases

ProteinModelPortali Q59SR6.
ModBasei Search...

Protein-protein interaction databases

BioGridi 1228743. 1 interaction.
1228780. 1 interaction.
STRINGi 5476.CAL0000299.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3645650.
3645687.
KEGGi cal:CaO19.14215.
cal:CaO19.6953.

Organism-specific databases

CGDi CAL0000299. IRS4.

Phylogenomic databases

eggNOGi NOG267304.
OrthoDBi EOG747PVG.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR000261. EPS15_homology.
[Graphical view ]
SMARTi SM00027. EH. 1 hit.
[Graphical view ]
PROSITEi PS50222. EF_HAND_2. 1 hit.
PS50031. EH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiIRS4_CANAL
AccessioniPrimary (citable) accession number: Q59SR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: April 26, 2005
Last modified: July 9, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi