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Protein

Increased rDNA silencing protein 4

Gene

IRS4

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • adhesion of symbiont to host Source: CGD
  • cellular response to starvation Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  • fungal-type cell wall organization Source: CGD
  • lipid metabolic process Source: UniProtKB-KW
  • pathogenesis Source: CGD

Keywordsi

Biological processLipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Increased rDNA silencing protein 4
Gene namesi
Name:IRS4
Ordered Locus Names:CAALFM_C303660WA
ORF Names:CaO19.14215, CaO19.6953
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 3

Organism-specific databases

CGDiCAL0000177117. IRS4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003087521 – 638Increased rDNA silencing protein 4Add BLAST638

Proteomic databases

PRIDEiQ59SR6.

Interactioni

Protein-protein interaction databases

BioGridi1228743. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ59SR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini539 – 628EHPROSITE-ProRule annotationAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi48 – 60Gln-richAdd BLAST13

Sequence similaritiesi

Belongs to the IRS4 family.Curated

Phylogenomic databases

InParanoidiQ59SR6.
OrthoDBiEOG092C2VMY.

Family and domain databases

InterProiView protein in InterPro
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
PfamiView protein in Pfam
PF12763. EF-hand_4. 1 hit.
SMARTiView protein in SMART
SM00027. EH. 1 hit.
PROSITEiView protein in PROSITE
PS50222. EF_HAND_2. 1 hit.
PS50031. EH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59SR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGNSAANAA ALAAFNGIGK KKKESTTKLN GTDNNTNHLG VIGSTSNQTK
60 70 80 90 100
QHQQQQQQPQ ALRTPLPAHP SRKKSNKFSQ LKRLNTAPAM ASLQPALQIA
110 120 130 140 150
SPSISPTQPS APASALDSDP DYFTLSPHTI PSKNEIAKSP QTPQDMIRNV
160 170 180 190 200
RQSIELKAIP NNAQAKRLSV DYSPQEMLKN LRHSLHSRTK TSPMLTTSDK
210 220 230 240 250
MGQTMLAEMR DRLENTRRIA SNSVASLSLS PNLDFNKSTS DVSNLSHHYD
260 270 280 290 300
VDTVSTDSFA SFNSSINDRH LPHGISIDVT NHDSDEDEID DREREEDHEP
310 320 330 340 350
LDNGELKSTN NKVTVSSRLR RKPPPGEDFQ MQLNDKSRDT ISSGSYSLNP
360 370 380 390 400
DEVYSFTDPD SYENLVSEVE VGETTRLFPQ FPDANHYHQH SSKFRKKHQK
410 420 430 440 450
VKPINGIYYR DMDSSNTSDT EESTSNLPSR STTPLLGQPQ QQVHFRSTMR
460 470 480 490 500
KANTKKDKKS RFNELKPWKN HNDLNYLTDQ EKKRYEGIWA SNKGNYMSQV
510 520 530 540 550
VIKLHGVNYE TQKDPKEEAK MEHSRTAALL SAAAVEDSNY NGNNSLHNLD
560 570 580 590 600
SVEINQLICG PVVKRIWKRS RLPSDTLEKI WNLIDFRRDG TLNKNEFLVG
610 620 630
MWLVDQCLYG RKLPKKVDNV VWDSLGGIGV NVTVKKKK
Length:638
Mass (Da):71,771
Last modified:March 15, 2017 - v2
Checksum:iC772E05653727C55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017625 Genomic DNA. Translation: AOW28394.1.
RefSeqiXP_712754.2. XM_707661.2.

Genome annotation databases

EnsemblFungiiEAK93546; EAK93546; CaO19.14215.
EAK93583; EAK93583; CaO19.6953.
GeneIDi3645650.
KEGGical:CAALFM_C303660WA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017625 Genomic DNA. Translation: AOW28394.1.
RefSeqiXP_712754.2. XM_707661.2.

3D structure databases

ProteinModelPortaliQ59SR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1228743. 2 interactors.

Proteomic databases

PRIDEiQ59SR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK93546; EAK93546; CaO19.14215.
EAK93583; EAK93583; CaO19.6953.
GeneIDi3645650.
KEGGical:CAALFM_C303660WA.

Organism-specific databases

CGDiCAL0000177117. IRS4.

Phylogenomic databases

InParanoidiQ59SR6.
OrthoDBiEOG092C2VMY.

Family and domain databases

InterProiView protein in InterPro
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
PfamiView protein in Pfam
PF12763. EF-hand_4. 1 hit.
SMARTiView protein in SMART
SM00027. EH. 1 hit.
PROSITEiView protein in PROSITE
PS50222. EF_HAND_2. 1 hit.
PS50031. EH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIRS4_CANAL
AccessioniPrimary (citable) accession number: Q59SR6
Secondary accession number(s): A0A1D8PJU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 15, 2017
Last modified: May 10, 2017
This is version 70 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.