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Q59SR6

- IRS4_CANAL

UniProt

Q59SR6 - IRS4_CANAL

Protein

Increased rDNA silencing protein 4

Gene

IRS4

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. adhesion of symbiont to host Source: CGD
    2. cellular response to starvation Source: CGD
    3. filamentous growth Source: CGD
    4. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
    5. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
    6. fungal-type cell wall organization Source: CGD
    7. lipid metabolic process Source: UniProtKB-KW
    8. pathogenesis Source: CGD

    Keywords - Biological processi

    Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Increased rDNA silencing protein 4
    Gene namesi
    Name:IRS4
    ORF Names:CaO19.14215, CaO19.6953
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0000299. IRS4.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 638638Increased rDNA silencing protein 4PRO_0000308752Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    BioGridi1228743. 1 interaction.
    1228780. 1 interaction.
    STRINGi5476.CAL0000299.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59SR6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini539 – 62890EHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi48 – 6013Gln-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the IRS4 family.Curated
    Contains 1 EH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG267304.
    OrthoDBiEOG747PVG.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR000261. EPS15_homology.
    [Graphical view]
    SMARTiSM00027. EH. 1 hit.
    [Graphical view]
    PROSITEiPS50222. EF_HAND_2. 1 hit.
    PS50031. EH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59SR6-1 [UniParc]FASTAAdd to Basket

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    MSGNSAANAA ALAAFNGIGK KKKESTTKLN GTDNNTNHLG VIGSTSNQTK    50
    QHQQQQQQPQ ALRTPLPAHP SRKKSNKFSQ LKRLNTAPAM ASLQPALQIA 100
    SPSISPTQPS APASALDSDP DYFTLSPHTI PSKNEIAKSP QTPQDMIRNV 150
    RQSIELKAIP NNAQAKRLSV DYSPQEMLKN LRHSLHSRTK TSPMLTTSDK 200
    MGQTMLAEMR DRLENTRRIA SNSVASLSLS PNLDFNKSTS DVSNLSHHYD 250
    VDTVSTDSFA SFSSSINDRH LPHGISIDVT NHDSDEDEID DREREEDHEP 300
    LDNGELKSTN NKVTVSSRLR RKPPPGEDFQ MQLNDKSRDT ISSGSYSLNP 350
    DEVYSFTDPD SYENLVSEVE VGETTRLFPQ FPDANHYHQH SSKFRKKHQK 400
    VKPINGIYYR DMDSSNTSDT EESTSNLPSR STTPLLGQPQ QQVHFRSTMR 450
    KANTKKDKKS RFNELKPWKN HNDLNYLTDQ EKKRYEGIWA SNKGNYMSQV 500
    VIKLHGVNYE TQKDPKEEAK MEHSRTAALL SAAAVEDSNY NGNNSLHNLD 550
    SVEINQLICG PVVKRIWKRS RLPSDTLEKI WNLIDFRRDG TLNKNEFLVG 600
    MWLVDQCLYG RKLPKKVDNV VWDSLGGIGV NVTVKKKK 638
    Length:638
    Mass (Da):71,744
    Last modified:April 26, 2005 - v1
    Checksum:iA44E10517A79A557
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000147 Genomic DNA. Translation: EAK93583.1.
    AACQ01000148 Genomic DNA. Translation: EAK93546.1.
    RefSeqiXP_712717.1. XM_707624.1.
    XP_712754.1. XM_707661.1.

    Genome annotation databases

    GeneIDi3645650.
    3645687.
    KEGGical:CaO19.14215.
    cal:CaO19.6953.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000147 Genomic DNA. Translation: EAK93583.1 .
    AACQ01000148 Genomic DNA. Translation: EAK93546.1 .
    RefSeqi XP_712717.1. XM_707624.1.
    XP_712754.1. XM_707661.1.

    3D structure databases

    ProteinModelPortali Q59SR6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 1228743. 1 interaction.
    1228780. 1 interaction.
    STRINGi 5476.CAL0000299.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3645650.
    3645687.
    KEGGi cal:CaO19.14215.
    cal:CaO19.6953.

    Organism-specific databases

    CGDi CAL0000299. IRS4.

    Phylogenomic databases

    eggNOGi NOG267304.
    OrthoDBi EOG747PVG.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR000261. EPS15_homology.
    [Graphical view ]
    SMARTi SM00027. EH. 1 hit.
    [Graphical view ]
    PROSITEi PS50222. EF_HAND_2. 1 hit.
    PS50031. EH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiIRS4_CANAL
    AccessioniPrimary (citable) accession number: Q59SR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3