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Q59SR6 (IRS4_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Increased rDNA silencing protein 4
Gene names
Name:IRS4
ORF Names:CaO19.14215, CaO19.6953
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length638 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing By similarity.

Sequence similarities

Belongs to the IRS4 family.

Contains 1 EH domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 638638Increased rDNA silencing protein 4
PRO_0000308752

Regions

Domain539 – 62890EH
Compositional bias48 – 6013Gln-rich

Sequences

Sequence LengthMass (Da)Tools
Q59SR6 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: A44E10517A79A557

FASTA63871,744
        10         20         30         40         50         60 
MSGNSAANAA ALAAFNGIGK KKKESTTKLN GTDNNTNHLG VIGSTSNQTK QHQQQQQQPQ 

        70         80         90        100        110        120 
ALRTPLPAHP SRKKSNKFSQ LKRLNTAPAM ASLQPALQIA SPSISPTQPS APASALDSDP 

       130        140        150        160        170        180 
DYFTLSPHTI PSKNEIAKSP QTPQDMIRNV RQSIELKAIP NNAQAKRLSV DYSPQEMLKN 

       190        200        210        220        230        240 
LRHSLHSRTK TSPMLTTSDK MGQTMLAEMR DRLENTRRIA SNSVASLSLS PNLDFNKSTS 

       250        260        270        280        290        300 
DVSNLSHHYD VDTVSTDSFA SFSSSINDRH LPHGISIDVT NHDSDEDEID DREREEDHEP 

       310        320        330        340        350        360 
LDNGELKSTN NKVTVSSRLR RKPPPGEDFQ MQLNDKSRDT ISSGSYSLNP DEVYSFTDPD 

       370        380        390        400        410        420 
SYENLVSEVE VGETTRLFPQ FPDANHYHQH SSKFRKKHQK VKPINGIYYR DMDSSNTSDT 

       430        440        450        460        470        480 
EESTSNLPSR STTPLLGQPQ QQVHFRSTMR KANTKKDKKS RFNELKPWKN HNDLNYLTDQ 

       490        500        510        520        530        540 
EKKRYEGIWA SNKGNYMSQV VIKLHGVNYE TQKDPKEEAK MEHSRTAALL SAAAVEDSNY 

       550        560        570        580        590        600 
NGNNSLHNLD SVEINQLICG PVVKRIWKRS RLPSDTLEKI WNLIDFRRDG TLNKNEFLVG 

       610        620        630 
MWLVDQCLYG RKLPKKVDNV VWDSLGGIGV NVTVKKKK 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000147 Genomic DNA. Translation: EAK93583.1.
AACQ01000148 Genomic DNA. Translation: EAK93546.1.
RefSeqXP_712717.1. XM_707624.1.
XP_712754.1. XM_707661.1.

3D structure databases

ProteinModelPortalQ59SR6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid1228743. 1 interaction.
1228780. 1 interaction.
STRING5476.CAL0000299.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3645650.
3645687.
KEGGcal:CaO19.14215.
cal:CaO19.6953.

Organism-specific databases

CGDCAL0000299. IRS4.

Phylogenomic databases

eggNOGNOG267304.
OrthoDBEOG747PVG.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR000261. EPS15_homology.
[Graphical view]
SMARTSM00027. EH. 1 hit.
[Graphical view]
PROSITEPS50222. EF_HAND_2. 1 hit.
PS50031. EH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIRS4_CANAL
AccessionPrimary (citable) accession number: Q59SR6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: April 26, 2005
Last modified: July 9, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names