Q59SR6 (IRS4_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Increased rDNA silencing protein 4

Gene names

Name:	IRS4
ORF Names:	CaO19.14215, CaO19.6953

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	638 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing By similarity.
Sequence similarities	Belongs to the IRS4 family. Contains 1 EH domain.

Ontologies

Keywords
Biological process	Lipid metabolism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adhesion to host Inferred from mutant phenotype PubMed 16151204. Source: CGD cellular response to biotic stimulus Inferred from mutant phenotype PubMed 16151204. Source: CGD cellular response to starvation Inferred from mutant phenotype PubMed 16151204. Source: CGD filamentous growth of a population of unicellular organisms in response to biotic stimulus Inferred from mutant phenotype PubMed 16151204. Source: CGD filamentous growth of a population of unicellular organisms in response to starvation Inferred from mutant phenotype PubMed 16151204. Source: CGD fungal-type cell wall organization Inferred from mutant phenotype PubMed 16151204. Source: CGD lipid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from mutant phenotype PubMed 16151204. Source: CGD
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 638	638	Increased rDNA silencing protein 4		PRO_0000308752
Regions
	Domain	539 – 628	90	EH
	Compositional bias	48 – 60	13	Gln-rich

Sequences

	Sequence		Length	Mass (Da)
	Q59SR6 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: A44E10517A79A557	FASTA	638	71,744
	10 20 30 40 50 60 MSGNSAANAA ALAAFNGIGK KKKESTTKLN GTDNNTNHLG VIGSTSNQTK QHQQQQQQPQ 70 80 90 100 110 120 ALRTPLPAHP SRKKSNKFSQ LKRLNTAPAM ASLQPALQIA SPSISPTQPS APASALDSDP 130 140 150 160 170 180 DYFTLSPHTI PSKNEIAKSP QTPQDMIRNV RQSIELKAIP NNAQAKRLSV DYSPQEMLKN 190 200 210 220 230 240 LRHSLHSRTK TSPMLTTSDK MGQTMLAEMR DRLENTRRIA SNSVASLSLS PNLDFNKSTS 250 260 270 280 290 300 DVSNLSHHYD VDTVSTDSFA SFSSSINDRH LPHGISIDVT NHDSDEDEID DREREEDHEP 310 320 330 340 350 360 LDNGELKSTN NKVTVSSRLR RKPPPGEDFQ MQLNDKSRDT ISSGSYSLNP DEVYSFTDPD 370 380 390 400 410 420 SYENLVSEVE VGETTRLFPQ FPDANHYHQH SSKFRKKHQK VKPINGIYYR DMDSSNTSDT 430 440 450 460 470 480 EESTSNLPSR STTPLLGQPQ QQVHFRSTMR KANTKKDKKS RFNELKPWKN HNDLNYLTDQ 490 500 510 520 530 540 EKKRYEGIWA SNKGNYMSQV VIKLHGVNYE TQKDPKEEAK MEHSRTAALL SAAAVEDSNY 550 560 570 580 590 600 NGNNSLHNLD SVEINQLICG PVVKRIWKRS RLPSDTLEKI WNLIDFRRDG TLNKNEFLVG 610 620 630 MWLVDQCLYG RKLPKKVDNV VWDSLGGIGV NVTVKKKK

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000147 Genomic DNA. Translation: EAK93583.1. AACQ01000148 Genomic DNA. Translation: EAK93546.1.
RefSeq	XP_712717.1. XM_707624.1. XP_712754.1. XM_707661.1.
3D structure databases
HSSP	HSSP built from PDB template 1EH2 based on UniProtKB P42566.
ProteinModelPortal	Q59SR6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3645650. 3645687.
KEGG	cal:CaO19.14215. cal:CaO19.6953.
Organism-specific databases
CGD	CAL0000299. IRS4.
Phylogenomic databases
eggNOG	NOG267304.
Family and domain databases
Gene3D	1.10.238.10. 2 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR002048. EF_hand_dom. IPR000261. EPS15_homology. [Graphical view]
SMART	SM00027. EH. 1 hit. [Graphical view]
PROSITE	PS50222. EF_HAND_2. 1 hit. PS50031. EH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IRS4_CANAL

Accession

Primary (citable) accession number: Q59SR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	April 26, 2005
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program